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Protein

H(+)/Cl(-) exchange transporter ClcA

Gene

clcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.5 Publications

Caution

Was originally thought to be a voltage-gated ClC-type chloride channel.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei107ChlorideCombined sources2 Publications1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei148Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport1
Sitei203Mediates proton transfer from the protein to the inner aqueous phase1
Binding sitei356Chloride; via amide nitrogenCombined sources1 Publication1
Binding sitei357Chloride; via amide nitrogenCombined sources1 Publication1
Binding sitei445ChlorideCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • anion binding Source: EcoCyc
  • chloride ion binding Source: EcoCyc
  • identical protein binding Source: IntAct
  • solute:proton antiporter activity Source: EcoCyc
  • voltage-gated chloride channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Stress response, Transport
LigandChloride

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:YADQ-MONOMER
MetaCyc:YADQ-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.49.5.1 the chloride carrier/channel (clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
H(+)/Cl(-) exchange transporter ClcA
Alternative name(s):
ClC-ec1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clcA
Synonyms:eriC, yadQ
Ordered Locus Names:b0155, JW5012
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG12331 clcA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32CytoplasmicAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 69HelicalAdd BLAST37
Topological domaini70 – 76Periplasmic7
Transmembranei77 – 100HelicalAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei109 – 116Helical8
Topological domaini117 – 123Cytoplasmic7
Transmembranei124 – 141HelicalAdd BLAST18
Transmembranei148 – 166HelicalAdd BLAST19
Topological domaini167 – 176Cytoplasmic10
Intramembranei177 – 189HelicalAdd BLAST13
Intramembranei193 – 201Helical9
Topological domaini202 – 214CytoplasmicAdd BLAST13
Transmembranei215 – 232HelicalAdd BLAST18
Topological domaini233 – 252PeriplasmicAdd BLAST20
Transmembranei253 – 281HelicalAdd BLAST29
Topological domaini282 – 287Cytoplasmic6
Transmembranei288 – 309HelicalAdd BLAST22
Topological domaini310 – 329PeriplasmicAdd BLAST20
Transmembranei330 – 349HelicalAdd BLAST20
Transmembranei355 – 376HelicalAdd BLAST22
Topological domaini377 – 386Periplasmic10
Intramembranei387 – 401HelicalAdd BLAST15
Intramembranei402 – 404Note=Loop between two helices3
Intramembranei405 – 416HelicalAdd BLAST12
Intramembranei417 – 421Note=Loop between two helices5
Transmembranei422 – 438HelicalAdd BLAST17
Topological domaini439 – 473CytoplasmicAdd BLAST35

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi107S → A: Uncouples chloride transport from proton transport. 1 Publication1
Mutagenesisi148E → A or Q: Abolishes proton transport, but permits the transit of chloride ions. Abolishes gating, permitting continuous rapid transit of chloride ions; when associated with A-445. 4 Publications1
Mutagenesisi203E → A, G, Q, S or T: Abolishes proton transport, and reduces chloride transport. 1 Publication1
Mutagenesisi203E → C, I, L or V: Abolishes proton and chloride transport. 1 Publication1
Mutagenesisi203E → D or H: No effect on proton and chloride transport. 1 Publication1
Mutagenesisi203E → K or R: Decreased proton and chloride transport. 1 Publication1
Mutagenesisi445Y → A: Abolishes gating, permitting continuous rapid transit of chloride ions; when associated with A-148. 3 Publications1
Mutagenesisi445Y → F or W: No effect. 3 Publications1
Mutagenesisi445Y → L: Alters stoichiometry of proton/chloride exchange. 3 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944731 – 473H(+)/Cl(-) exchange transporter ClcAAdd BLAST473

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P37019

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37019

PRoteomics IDEntifications database

More...
PRIDEi
P37019

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By acid-shock conditions.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself7EBI-15719361,EBI-15719361

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259368, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-9523N

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_0135

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1473
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPKX-ray3.50A/B/C/D/E/F1-473[»]
1OTSX-ray2.51A/B1-465[»]
1OTTX-ray3.00A/B1-465[»]
1OTUX-ray3.30A/B1-465[»]
2EXWX-ray3.20A/B1-473[»]
2EXYX-ray3.10A/B1-473[»]
2EZ0X-ray3.54A/B1-473[»]
2FECX-ray3.97A/B1-465[»]
2FEDX-ray3.32A/B1-465[»]
2FEEX-ray3.20A/B1-465[»]
2H2PX-ray3.10A/B1-465[»]
2H2SX-ray3.10A/B1-465[»]
2HLFX-ray3.30A/B17-460[»]
2HT2X-ray3.32A/B1-473[»]
2HT3X-ray3.30A/B1-473[»]
2HT4X-ray3.20A/B1-473[»]
2HTKX-ray3.41A/B1-473[»]
2HTLX-ray3.40A/B1-473[»]
2R9HX-ray3.10A/B17-460[»]
3DETX-ray2.80A/B1-473[»]
3EJYX-ray3.20A/B1-473[»]
3EJZX-ray2.90A/B1-473[»]
3NMOX-ray3.10A1-465[»]
4ENEX-ray2.40A/B17-460[»]
4FTPX-ray3.21A1-465[»]
4KJPX-ray3.20A/B17-460[»]
4KJQX-ray2.88A/B17-460[»]
4KJWX-ray3.03A/B17-460[»]
4KK5X-ray3.17A/B17-460[»]
4KK6X-ray3.18A/B17-460[»]
4KK8X-ray2.86A/B17-460[»]
4KK9X-ray3.00A/B17-460[»]
4KKAX-ray3.00A/B17-460[»]
4KKBX-ray3.02A/B17-460[»]
4KKCX-ray3.18A/B17-460[»]
4KKLX-ray2.85A/B17-460[»]
4LOUX-ray2.98A/B17-460[»]
4MQXX-ray3.52A/B1-465[»]
5HD8X-ray3.15A/B17-465[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P37019

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P37019

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P37019

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi106 – 110Selectivity filter part_15
Motifi146 – 150Selectivity filter part_25
Motifi355 – 359Selectivity filter part_35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CMQ Bacteria
COG0038 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000257546

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37019

KEGG Orthology (KO)

More...
KOi
K03281

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P37019

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3080.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01128 CLC_ClcA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023861 Cl-channel_ClcA
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00654 Voltage_CLC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00762 CLCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81340 SSF81340, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P37019-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTDTPSLET PQAARLRRRQ LIRQLLERDK TPLAILFMAA VVGTLVGLAA
60 70 80 90 100
VAFDKGVAWL QNQRMGALVH TADNYPLLLT VAFLCSAVLA MFGYFLVRKY
110 120 130 140 150
APEAGGSGIP EIEGALEDQR PVRWWRVLPV KFFGGLGTLG GGMVLGREGP
160 170 180 190 200
TVQIGGNIGR MVLDIFRLKG DEARHTLLAT GAAAGLAAAF NAPLAGILFI
210 220 230 240 250
IEEMRPQFRY TLISIKAVFI GVIMSTIMYR IFNHEVALID VGKLSDAPLN
260 270 280 290 300
TLWLYLILGI IFGIFGPIFN KWVLGMQDLL HRVHGGNITK WVLMGGAIGG
310 320 330 340 350
LCGLLGFVAP ATSGGGFNLI PIATAGNFSM GMLVFIFVAR VITTLLCFSS
360 370 380 390 400
GAPGGIFAPM LALGTVLGTA FGMVAVELFP QYHLEAGTFA IAGMGALLAA
410 420 430 440 450
SIRAPLTGII LVLEMTDNYQ LILPMIITGL GATLLAQFTG GKPLYSAILA
460 470
RTLAKQEAEQ LARSKAASAS ENT
Length:473
Mass (Da):50,349
Last modified:April 27, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B1BC39B417E9690
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32P → Q (PubMed:8202364).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70214 Genomic DNA Translation: AAB08585.1
U00096 Genomic DNA Translation: AAC73266.1
AP009048 Genomic DNA Translation: BAB96732.2

Protein sequence database of the Protein Information Resource

More...
PIRi
C64739

NCBI Reference Sequences

More...
RefSeqi
NP_414697.1, NC_000913.3
WP_000845394.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73266; AAC73266; b0155
BAB96732; BAB96732; BAB96732

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946715

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5012
eco:b0155

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2125

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70214 Genomic DNA Translation: AAB08585.1
U00096 Genomic DNA Translation: AAC73266.1
AP009048 Genomic DNA Translation: BAB96732.2
PIRiC64739
RefSeqiNP_414697.1, NC_000913.3
WP_000845394.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KPKX-ray3.50A/B/C/D/E/F1-473[»]
1OTSX-ray2.51A/B1-465[»]
1OTTX-ray3.00A/B1-465[»]
1OTUX-ray3.30A/B1-465[»]
2EXWX-ray3.20A/B1-473[»]
2EXYX-ray3.10A/B1-473[»]
2EZ0X-ray3.54A/B1-473[»]
2FECX-ray3.97A/B1-465[»]
2FEDX-ray3.32A/B1-465[»]
2FEEX-ray3.20A/B1-465[»]
2H2PX-ray3.10A/B1-465[»]
2H2SX-ray3.10A/B1-465[»]
2HLFX-ray3.30A/B17-460[»]
2HT2X-ray3.32A/B1-473[»]
2HT3X-ray3.30A/B1-473[»]
2HT4X-ray3.20A/B1-473[»]
2HTKX-ray3.41A/B1-473[»]
2HTLX-ray3.40A/B1-473[»]
2R9HX-ray3.10A/B17-460[»]
3DETX-ray2.80A/B1-473[»]
3EJYX-ray3.20A/B1-473[»]
3EJZX-ray2.90A/B1-473[»]
3NMOX-ray3.10A1-465[»]
4ENEX-ray2.40A/B17-460[»]
4FTPX-ray3.21A1-465[»]
4KJPX-ray3.20A/B17-460[»]
4KJQX-ray2.88A/B17-460[»]
4KJWX-ray3.03A/B17-460[»]
4KK5X-ray3.17A/B17-460[»]
4KK6X-ray3.18A/B17-460[»]
4KK8X-ray2.86A/B17-460[»]
4KK9X-ray3.00A/B17-460[»]
4KKAX-ray3.00A/B17-460[»]
4KKBX-ray3.02A/B17-460[»]
4KKCX-ray3.18A/B17-460[»]
4KKLX-ray2.85A/B17-460[»]
4LOUX-ray2.98A/B17-460[»]
4MQXX-ray3.52A/B1-465[»]
5HD8X-ray3.15A/B17-465[»]
ProteinModelPortaliP37019
SMRiP37019
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259368, 6 interactors
DIPiDIP-9523N
STRINGi316385.ECDH10B_0135

Protein family/group databases

TCDBi2.A.49.5.1 the chloride carrier/channel (clc) family

Proteomic databases

jPOSTiP37019
PaxDbiP37019
PRIDEiP37019

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73266; AAC73266; b0155
BAB96732; BAB96732; BAB96732
GeneIDi946715
KEGGiecj:JW5012
eco:b0155
PATRICifig|1411691.4.peg.2125

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

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EchoBASEi
EB2235
EcoGeneiEG12331 clcA

Phylogenomic databases

eggNOGiENOG4105CMQ Bacteria
COG0038 LUCA
HOGENOMiHOG000257546
InParanoidiP37019
KOiK03281
PhylomeDBiP37019

Enzyme and pathway databases

BioCyciEcoCyc:YADQ-MONOMER
MetaCyc:YADQ-MONOMER

Miscellaneous databases

EvolutionaryTraceiP37019

Protein Ontology

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PROi
PR:P37019

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
HAMAPiMF_01128 CLC_ClcA, 1 hit
InterProiView protein in InterPro
IPR023861 Cl-channel_ClcA
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
PfamiView protein in Pfam
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
SUPFAMiSSF81340 SSF81340, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLCA_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37019
Secondary accession number(s): P77394
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: January 16, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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