UniProtKB - P37013 (NORR_ECOLI)
Protein
Anaerobic nitric oxide reductase transcription regulator NorR
Gene
norR
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. Not required for induction of the aerobic NO-detoxifying enzyme NO dioxygenase. Binds to the promoter region of norVW, to a consensus target sequence, GT-(N7)-AC, which is highly conserved among proteobacteria.2 Publications
: nitric oxide reduction Pathwayi
This protein is involved in the pathway nitric oxide reduction, which is part of Nitrogen metabolism.View all proteins of this organism that are known to be involved in the pathway nitric oxide reduction and in Nitrogen metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 215 – 222 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 278 – 287 | ATPSequence analysis | 10 | |
DNA bindingi | 479 – 498 | H-T-H motifBy similarityAdd BLAST | 20 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- bacterial-type cis-regulatory region sequence-specific DNA binding Source: EcoCyc
- DNA-binding transcription factor activity Source: EcoCyc
- ferrous iron binding Source: EcoCyc
- identical protein binding Source: EcoCyc
- nitric oxide binding Source: EcoCyc
- transcription factor binding Source: InterPro
GO - Biological processi
- phosphorelay signal transduction system Source: UniProtKB-UniRule
- positive regulation of DNA-templated transcription, initiation Source: EcoCyc
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12108-MONOMER |
UniPathwayi | UPA00638 |
Names & Taxonomyi
Protein namesi | Recommended name: Anaerobic nitric oxide reductase transcription regulator NorR |
Gene namesi | Name:norR Synonyms:ygaA Ordered Locus Names:b2709, JW5843 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081153 | 1 – 504 | Anaerobic nitric oxide reductase transcription regulator NorRAdd BLAST | 504 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 57 | 4-aspartylphosphateBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P37013 |
PRIDEi | P37013 |
Expressioni
Inductioni
By anaerobic conditions, however not induced by NO alone.
Interactioni
GO - Molecular functioni
- identical protein binding Source: EcoCyc
- transcription factor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 4262260, 3 interactors |
DIPi | DIP-12092N |
STRINGi | 511145.b2709 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 187 – 416 | Sigma-54 factor interactionAdd BLAST | 230 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 186 | NO sensor or transducerCuratedAdd BLAST | 186 |
Domaini
Deletion of amino acids 30-164 allows induction of NO reductase activity even in the absence of NO, i.e. the need for an NO-induced signal has been bypassed.
Phylogenomic databases
eggNOGi | COG3604, Bacteria |
HOGENOMi | CLU_000445_125_0_6 |
InParanoidi | P37013 |
PhylomeDBi | P37013 |
Family and domain databases
Gene3Di | 3.30.450.40, 1 hit |
HAMAPi | MF_01314, NorR, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003018, GAF IPR029016, GAF-like_dom_sf IPR009057, Homeobox-like_sf IPR023944, NorR IPR027417, P-loop_NTPase IPR002078, Sigma_54_int IPR025662, Sigma_54_int_dom_ATP-bd_1 IPR025943, Sigma_54_int_dom_ATP-bd_2 IPR025944, Sigma_54_int_dom_CS |
Pfami | View protein in Pfam PF01590, GAF, 1 hit PF00158, Sigma54_activat, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00065, GAF, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00675, SIGMA54_INTERACT_1, 1 hit PS00676, SIGMA54_INTERACT_2, 1 hit PS00688, SIGMA54_INTERACT_3, 1 hit PS50045, SIGMA54_INTERACT_4, 1 hit |
i Sequence
Sequence statusi: Complete.
P37013-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFSVDVLAN IAIELQRGIG HQDRFQRLIT TLRQVLECDA SALLRYDSRQ
60 70 80 90 100
FIPLAIDGLA KDVLGRRFAL EGHPRLEAIA RAGDVVRFPA DSELPDPYDG
110 120 130 140 150
LIPGQESLKV HACVGLPLFA GQNLIGALTL DGMQPDQFDV FSDEELRLIA
160 170 180 190 200
ALAAGALSNA LLIEQLESQN MLPGDATPFE AVKQTQMIGL SPGMTQLKKE
210 220 230 240 250
IEIVAASDLN VLISGETGTG KELVAKAIHE ASPRAVNPLV YLNCAALPES
260 270 280 290 300
VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL
310 320 330 340 350
RVLQYGDIQR VGDDRCLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV
360 370 380 390 400
FPLSVPPLRE RGDDVILLAG YFCEQCRLRQ GLSRVVLSAG ARNLLQHYSF
410 420 430 440 450
PGNVRELEHA IHRAVVLARA TRSGDEVILE AQHFAFPEVT LPTPEVAAVP
460 470 480 490 500
VVKQNLREAT EAFQRETIRQ ALAQNHHNWA ACARMLETDV ANLHRLAKRL
GLKD
Sequence cautioni
The sequence AAA69218 differs from that shown. Reason: Frameshift.Curated
The sequence AAA69219 differs from that shown. Reason: Frameshift.Curated
The sequence AAA92665 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03846 Genomic DNA Translation: AAA92665.1 Different initiation. U03846 Genomic DNA Translation: AAA92666.1 D28595 Genomic DNA Translation: BAA05931.1 U29579 Genomic DNA Translation: AAA69219.1 Frameshift. U29579 Genomic DNA Translation: AAA69218.1 Frameshift. U00096 Genomic DNA Translation: AAC75751.2 AP009048 Genomic DNA Translation: BAE76786.1 |
PIRi | A65051 |
RefSeqi | NP_417189.2, NC_000913.3 WP_000010749.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75751; AAC75751; b2709 BAE76786; BAE76786; BAE76786 |
GeneIDi | 947186 |
KEGGi | ecj:JW5843 eco:b2709 |
PATRICi | fig|1411691.4.peg.4033 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03846 Genomic DNA Translation: AAA92665.1 Different initiation. U03846 Genomic DNA Translation: AAA92666.1 D28595 Genomic DNA Translation: BAA05931.1 U29579 Genomic DNA Translation: AAA69219.1 Frameshift. U29579 Genomic DNA Translation: AAA69218.1 Frameshift. U00096 Genomic DNA Translation: AAC75751.2 AP009048 Genomic DNA Translation: BAE76786.1 |
PIRi | A65051 |
RefSeqi | NP_417189.2, NC_000913.3 WP_000010749.1, NZ_LN832404.1 |
3D structure databases
SMRi | P37013 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262260, 3 interactors |
DIPi | DIP-12092N |
STRINGi | 511145.b2709 |
Proteomic databases
PaxDbi | P37013 |
PRIDEi | P37013 |
Genome annotation databases
EnsemblBacteriai | AAC75751; AAC75751; b2709 BAE76786; BAE76786; BAE76786 |
GeneIDi | 947186 |
KEGGi | ecj:JW5843 eco:b2709 |
PATRICi | fig|1411691.4.peg.4033 |
Organism-specific databases
EchoBASEi | EB2032 |
Phylogenomic databases
eggNOGi | COG3604, Bacteria |
HOGENOMi | CLU_000445_125_0_6 |
InParanoidi | P37013 |
PhylomeDBi | P37013 |
Enzyme and pathway databases
UniPathwayi | UPA00638 |
BioCyci | EcoCyc:EG12108-MONOMER |
Miscellaneous databases
PROi | PR:P37013 |
Family and domain databases
Gene3Di | 3.30.450.40, 1 hit |
HAMAPi | MF_01314, NorR, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003018, GAF IPR029016, GAF-like_dom_sf IPR009057, Homeobox-like_sf IPR023944, NorR IPR027417, P-loop_NTPase IPR002078, Sigma_54_int IPR025662, Sigma_54_int_dom_ATP-bd_1 IPR025943, Sigma_54_int_dom_ATP-bd_2 IPR025944, Sigma_54_int_dom_CS |
Pfami | View protein in Pfam PF01590, GAF, 1 hit PF00158, Sigma54_activat, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00065, GAF, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00675, SIGMA54_INTERACT_1, 1 hit PS00676, SIGMA54_INTERACT_2, 1 hit PS00688, SIGMA54_INTERACT_3, 1 hit PS50045, SIGMA54_INTERACT_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NORR_ECOLI | |
Accessioni | P37013Primary (citable) accession number: P37013 Secondary accession number(s): Q2MAC0, Q46875, Q46876 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | March 25, 2003 | |
Last modified: | December 2, 2020 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways