The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P36975 (SNP25_DROME)
Protein
Synaptosomal-associated protein 25
Gene
Snap25
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity).
By similarityGO - Molecular functioni
- SNAP receptor activity Source: FlyBase
- SNARE binding Source: FlyBase
- syntaxin binding Source: GO_Central
GO - Biological processi
- exocytosis Source: GO_Central
- neuromuscular synaptic transmission Source: FlyBase
- neurotransmitter secretion Source: FlyBase
- regulation of short-term neuronal synaptic plasticity Source: FlyBase
- synaptic vesicle docking Source: FlyBase
- synaptic vesicle fusion to presynaptic active zone membrane Source: FlyBase
- synaptic vesicle priming Source: FlyBase
- synaptic vesicle transport Source: FlyBase
- vesicle fusion Source: FlyBase
- vesicle-mediated transport Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-181429, Serotonin Neurotransmitter Release Cycle R-DME-181430, Norepinephrine Neurotransmitter Release Cycle R-DME-199992, trans-Golgi Network Vesicle Budding R-DME-210500, Glutamate Neurotransmitter Release Cycle R-DME-212676, Dopamine Neurotransmitter Release Cycle R-DME-264642, Acetylcholine Neurotransmitter Release Cycle R-DME-449836, Other interleukin signaling R-DME-6798695, Neutrophil degranulation R-DME-888590, GABA synthesis, release, reuptake and degradation R-DME-8980692, RHOA GTPase cycle R-DME-9013026, RHOB GTPase cycle R-DME-9013149, RAC1 GTPase cycle R-DME-9035034, RHOF GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptosomal-associated protein 25Short name: SNAP-25 Alternative name(s): Synaptosomal-associated 25 kDa protein |
Gene namesi | Name:Snap25 ORF Names:CG40452 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0011288, Snap25 |
VEuPathDBi | VectorBase:FBgn0011288 |
Subcellular locationi
Other locations
- synaptosome By similarity
Note: Complexed with macromolecular elements of the nerve terminal.By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- membrane Source: UniProtKB
- SNARE complex Source: FlyBase
- terminal bouton Source: FlyBase
Keywords - Cellular componenti
Cell junction, Synapse, SynaptosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213594 | 1 – 212 | Synaptosomal-associated protein 25Add BLAST | 212 |
Proteomic databases
PaxDbi | P36975 |
PeptideAtlasi | P36975 |
PRIDEi | P36975 |
PTM databases
SwissPalmi | P36975 |
Expressioni
Tissue specificityi
Exclusively found in brain and ganglia.1 Publication
Gene expression databases
Bgeei | FBgn0011288, Expressed in brain and 27 other tissues |
Genevisiblei | P36975, DM |
Interactioni
GO - Molecular functioni
- SNARE binding Source: FlyBase
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 78209, 27 interactors |
DIPi | DIP-23273N |
STRINGi | 7227.FBpp0110435 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 88 | t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 148 – 210 | t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd BLAST | 63 |
Sequence similaritiesi
Belongs to the SNAP-25 family.Curated
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG3065, Eukaryota |
GeneTreei | ENSGT00950000182843 |
HOGENOMi | CLU_096939_0_0_1 |
InParanoidi | P36975 |
OMAi | WKASEDG |
PhylomeDBi | P36975 |
Family and domain databases
InterProi | View protein in InterPro IPR000928, SNAP-25_dom IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF00835, SNAP-25, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 2 hits |
PROSITEi | View protein in PROSITE PS50192, T_SNARE, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform A (identifier: P36975-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPADPSEEVA PQVPKTELEE LQINAQGVAD ESLESTRRML ALCEESKEAG
60 70 80 90 100
IRTLVALDDQ GEQLDRIEEG MDQINADMRE AEKNLSGMEK CCGICVLPCN
110 120 130 140 150
KSQSFKEDDG TWKGNDDGKV VNNQPQRVMD DRNGMMAQAG YIGRITNDAR
160 170 180 190 200
EDEMEENMGQ VNTMIGNLRN MALDMGSELE NQNRQIDRIN RKGESNEARI
210
AVANQRAHQL LK
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054454 | 47 – 59 | KEAGI…VALDD → AEVGMRSIVMLDE in isoform C. CuratedAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22021 mRNA Translation: AAA16059.1 U81153 , U81147, U81148, U81149, U81150, U81151, U81152 Genomic DNA Translation: AAB39757.1 AE014296 Genomic DNA Translation: EAA46071.2 AE014296 Genomic DNA Translation: EAL24571.2 BT023789 mRNA Translation: AAZ41798.1 BT126217 mRNA Translation: AEB22096.1 |
RefSeqi | NP_001036641.1, NM_001043176.2 [P36975-1] NP_001036642.2, NM_001043177.3 [P36975-3] |
Genome annotation databases
EnsemblMetazoai | FBtr0111143; FBpp0110435; FBgn0011288 [P36975-1] FBtr0304625; FBpp0293167; FBgn0011288 [P36975-3] |
GeneIDi | 3355084 |
KEGGi | dme:Dmel_CG40452 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22021 mRNA Translation: AAA16059.1 U81153 , U81147, U81148, U81149, U81150, U81151, U81152 Genomic DNA Translation: AAB39757.1 AE014296 Genomic DNA Translation: EAA46071.2 AE014296 Genomic DNA Translation: EAL24571.2 BT023789 mRNA Translation: AAZ41798.1 BT126217 mRNA Translation: AEB22096.1 |
RefSeqi | NP_001036641.1, NM_001043176.2 [P36975-1] NP_001036642.2, NM_001043177.3 [P36975-3] |
3D structure databases
AlphaFoldDBi | P36975 |
SMRi | P36975 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 78209, 27 interactors |
DIPi | DIP-23273N |
STRINGi | 7227.FBpp0110435 |
PTM databases
SwissPalmi | P36975 |
Proteomic databases
PaxDbi | P36975 |
PeptideAtlasi | P36975 |
PRIDEi | P36975 |
Protocols and materials databases
DNASUi | 3355084 |
Genome annotation databases
EnsemblMetazoai | FBtr0111143; FBpp0110435; FBgn0011288 [P36975-1] FBtr0304625; FBpp0293167; FBgn0011288 [P36975-3] |
GeneIDi | 3355084 |
KEGGi | dme:Dmel_CG40452 |
Organism-specific databases
CTDi | 6616 |
FlyBasei | FBgn0011288, Snap25 |
VEuPathDBi | VectorBase:FBgn0011288 |
Phylogenomic databases
eggNOGi | KOG3065, Eukaryota |
GeneTreei | ENSGT00950000182843 |
HOGENOMi | CLU_096939_0_0_1 |
InParanoidi | P36975 |
OMAi | WKASEDG |
PhylomeDBi | P36975 |
Enzyme and pathway databases
Reactomei | R-DME-181429, Serotonin Neurotransmitter Release Cycle R-DME-181430, Norepinephrine Neurotransmitter Release Cycle R-DME-199992, trans-Golgi Network Vesicle Budding R-DME-210500, Glutamate Neurotransmitter Release Cycle R-DME-212676, Dopamine Neurotransmitter Release Cycle R-DME-264642, Acetylcholine Neurotransmitter Release Cycle R-DME-449836, Other interleukin signaling R-DME-6798695, Neutrophil degranulation R-DME-888590, GABA synthesis, release, reuptake and degradation R-DME-8980692, RHOA GTPase cycle R-DME-9013026, RHOB GTPase cycle R-DME-9013149, RAC1 GTPase cycle R-DME-9035034, RHOF GTPase cycle |
Miscellaneous databases
BioGRID-ORCSi | 3355084, 0 hits in 3 CRISPR screens |
ChiTaRSi | Snap25, fly |
GenomeRNAii | 3355084 |
PROi | PR:P36975 |
Gene expression databases
Bgeei | FBgn0011288, Expressed in brain and 27 other tissues |
Genevisiblei | P36975, DM |
Family and domain databases
InterProi | View protein in InterPro IPR000928, SNAP-25_dom IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF00835, SNAP-25, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 2 hits |
PROSITEi | View protein in PROSITE PS50192, T_SNARE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SNP25_DROME | |
Accessioni | P36975Primary (citable) accession number: P36975 Secondary accession number(s): F3YD56, Q5LJU6, Q7PLV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families