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Protein

Adenine phosphoribosyltransferase

Gene

Aprt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (Aprt)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

  • adenine binding Source: Ensembl
  • adenine phosphoribosyltransferase activity Source: UniProtKB-EC
  • AMP binding Source: RGD

GO - Biological processi

  • adenine salvage Source: Ensembl
  • AMP salvage Source: UniProtKB-UniPathway
  • cellular response to insulin stimulus Source: RGD
  • grooming behavior Source: Ensembl
  • lactation Source: RGD
  • purine ribonucleoside salvage Source: UniProtKB-KW

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation
R-RNO-74217 Purine salvage
SABIO-RKiP36972
UniPathwayiUPA00588; UER00646

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
Name:Aprt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1307758 Aprt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001495092 – 180Adenine phosphoribosyltransferaseAdd BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei4PhosphoserineBy similarity1
Modified residuei15PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei60PhosphotyrosineBy similarity1
Modified residuei66PhosphoserineCombined sources1
Modified residuei114N6-acetyllysineBy similarity1
Modified residuei135PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP36972
PRIDEiP36972

PTM databases

iPTMnetiP36972
PhosphoSitePlusiP36972

Expressioni

Gene expression databases

BgeeiENSRNOG00000014405
GenevisibleiP36972 RN

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP36972, 3 interactors
MINTiP36972
STRINGi10116.ENSRNOP00000061449

Structurei

3D structure databases

ProteinModelPortaliP36972
SMRiP36972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1712 Eukaryota
COG0503 LUCA
GeneTreeiENSGT00390000017259
HOGENOMiHOG000036776
HOVERGENiHBG003144
InParanoidiP36972
KOiK00759
OMAiCAPIRKK
OrthoDBiEOG091G0XZC

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_00004 Aden_phosphoribosyltr, 1 hit
InterProiView protein in InterPro
IPR005764 Ade_phspho_trans
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01090 apt, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESELQLVA RRIRSFPDFP IPGVLFRDIS PLLKDPDSFR ASIRLLAGHL
60 70 80 90 100
KSTHGGKIDY IAGLDSRGFL FGPSLAQELG VGCVLIRKRG KLPGPTVSAS
110 120 130 140 150
YSLEYGKAEL EIQKDALEPG QKVVIVDDLL ATGGTMCAAC ELLSQLRAEV
160 170 180
VECVSLVELT SLKGREKLGP VPFFSLLQYE
Length:180
Mass (Da):19,546
Last modified:June 1, 1994 - v1
Checksum:iD5563374DDEBB3EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04970 Genomic DNA Translation: AAA40757.1
RefSeqiNP_001013079.1, NM_001013061.1
UniGeneiRn.2498

Genome annotation databases

EnsembliENSRNOT00000064180; ENSRNOP00000061449; ENSRNOG00000014405
GeneIDi292072
KEGGirno:292072
UCSCiRGD:1307758 rat

Similar proteinsi

Entry informationi

Entry nameiAPT_RAT
AccessioniPrimary (citable) accession number: P36972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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