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Entry version 163 (29 Sep 2021)
Sequence version 3 (26 Feb 2008)
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Protein

Phospholipid hydroperoxide glutathione peroxidase

Gene

Gpx4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity).

Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity).

Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (PubMed:1556123, PubMed:9988735).

Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity).

The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity).

The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity).

May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity).

Required for normal sperm development and male fertility (By similarity).

Essential for maturation and survival of photoreceptor cells (By similarity).

Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity).

Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity).

Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).

By similarity2 Publications

Specifically able to suppress the production of leukotriene and prostaglandin in response to several stimuli by reducing fatty acid hydroperoxide (PubMed:9442035, PubMed:11010961).

2 Publications

Specifically required to prevent mitochondrial cell death by mediating reduction of cardiolipin hydroperoxide (PubMed:9988735, PubMed:10506188, PubMed:10998361).

Also required for normal sperm development and male fertility (By similarity).

By similarity3 Publications

Required for male fertility by stabilizing the condensed chromatin in sperm nuclei.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei73By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Oxidoreductase, Peroxidase
Biological processLipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.11.1.12, 5301

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2142712, Synthesis of 12-eicosatetraenoic acid derivatives
R-RNO-2142770, Synthesis of 15-eicosatetraenoic acid derivatives
R-RNO-9018676, Biosynthesis of D-series resolvins
R-RNO-9018896, Biosynthesis of E-series 18(S)-resolvins
R-RNO-9020265, Biosynthesis of aspirin-triggered D-series resolvins
R-RNO-9023661, Biosynthesis of E-series 18(R)-resolvins

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
3733, RnoGPx04-A
3812, RnoGPx04-B
3813, RnoGPx04-C

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid hydroperoxide glutathione peroxidase1 Publication (EC:1.11.1.121 Publication)
Short name:
PHGPx1 Publication
Alternative name(s):
Glutathione peroxidase 4By similarity
Short name:
GPx-4By similarity
Short name:
GSHPx-4By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gpx4By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
69226, Gpx4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000013073? – 197Phospholipid hydroperoxide glutathione peroxidase

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineCombined sources1
Isoform Nuclear (identifier: P36970-3)
Modified residuei78PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P36970

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36970

PRoteomics IDEntifications database

More...
PRIDEi
P36970

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36970

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P36970

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present primarily in testis (PubMed:1556123). Expressed in flagella of epididymal sperm (PubMed:19423663). Isoform Cytoplasmic: Highly expressed in testis (PubMed:14575705). Present in spermatogonia, spermatocyte and spermatid (at protein level) (PubMed:14575705).3 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P36970, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q76LU9, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Has a tendency to form higher mass oligomers.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000018691

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1651, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161913

Database of Orthologous Groups

More...
OrthoDBi
1483113at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P36970

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00340, GSH_Peroxidase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000889, Glutathione_peroxidase
IPR029759, GPX_AS
IPR029760, GPX_CS
IPR036249, Thioredoxin-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11592, PTHR11592, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00255, GSHPx, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000303, Glutathion_perox, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01011, GLUTPROXDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833, SSF52833, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00460, GLUTATHIONE_PEROXID_1, 1 hit
PS00763, GLUTATHIONE_PEROXID_2, 1 hit
PS51355, GLUTATHIONE_PEROXID_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Mitochondrial (identifier: P36970-1) [UniParc]FASTAAdd to basket
Also known as: L-form1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWGRLSRLL KPALLCGALA VPGLAGTMCA SRDDWRCARS MHEFAAKDID
60 70 80 90 100
GHMVCLDKYR GCVCIVTNVA SQUGKTDVNY TQLVDLHARY AECGLRILAF
110 120 130 140 150
PCNQFGRQEP GSNQEIKEFA AGYNVRFDMY SKICVNGDDA HPLWKWMKVQ
160 170 180 190
PKGRGMLGNA IKWNFTKFLI DKNGCVVKRY GPMEEPQVIE KDLPCYL
Length:197
Mass (Da):22,225
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83FF001A5A42F814
GO
Isoform Cytoplasmic (identifier: P36970-2) [UniParc]FASTAAdd to basket
Also known as: S-form1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Note: Produced by alternative initiation at Met-28 of isoform Mitochondrial.Curated
Show »
Length:170
Mass (Da):19,490
Checksum:iA882EE0827902EA0
GO
Isoform Nuclear (identifier: P36970-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MSWGRLSRLLKPALLCGALAVPGLAGTM → MGRAAARKRG...TSNSHEFLGL

Show »
Length:253
Mass (Da):29,335
Checksum:iD108602E22DAD29A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WFK6F8WFK6_RAT
Glutathione peroxidase
Gpx4
252Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K398A0A0G2K398_RAT
Glutathione peroxidase
Gpx4
196Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45A → S in AAC52503 (PubMed:7592947).Curated1
Sequence conflicti45A → S in CAD61276 (PubMed:12819198).Curated1
Sequence conflicti45A → S in CAD61277 (PubMed:12819198).Curated1
Sequence conflicti45A → S in CAD61278 (PubMed:12819198).Curated1
Sequence conflicti133I → V in BAC87836 (PubMed:14575705).Curated1
Sequence conflicti136N → S in AAS76675 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0593501 – 28MSWGR…LAGTM → MGRAAARKRGRCRQRGRSPG GRRRREPGRQSPRKRPGPRR RRARARRRRRARPRRMEPIP EPFNPRPLLQDLPQTSNSHE FLGL in isoform Nuclear. Add BLAST28
Alternative sequenceiVSP_0187461 – 27Missing in isoform Cytoplasmic. CuratedAdd BLAST27

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei73Selenocysteine1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U37427 mRNA Translation: AAC52503.2
AB072798 mRNA Translation: BAC87836.1
AJ537598 Genomic DNA Translation: CAD61276.1
AJ537598 Genomic DNA Translation: CAD61277.1
AJ537598 Genomic DNA Translation: CAD61278.1
X82679 mRNA Translation: CAA57996.1
AY570513 mRNA Translation: AAS76675.1
AF274028 mRNA Translation: AAK74113.1
L24896 mRNA Translation: AAA41842.2

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4332

NCBI Reference Sequences

More...
RefSeqi
NP_001034938.1, NM_001039849.2 [P36970-3]
NP_058861.3, NM_017165.3 [P36970-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000093376; ENSRNOP00000076198; ENSRNOG00000013604 [P36970-1]
ENSRNOT00000093426; ENSRNOP00000076309; ENSRNOG00000013604 [P36970-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29328

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:29328

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Selenocysteine

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37427 mRNA Translation: AAC52503.2
AB072798 mRNA Translation: BAC87836.1
AJ537598 Genomic DNA Translation: CAD61276.1
AJ537598 Genomic DNA Translation: CAD61277.1
AJ537598 Genomic DNA Translation: CAD61278.1
X82679 mRNA Translation: CAA57996.1
AY570513 mRNA Translation: AAS76675.1
AF274028 mRNA Translation: AAK74113.1
L24896 mRNA Translation: AAA41842.2
PIRiJC4332
RefSeqiNP_001034938.1, NM_001039849.2 [P36970-3]
NP_058861.3, NM_017165.3 [P36970-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018691

Protein family/group databases

PeroxiBasei3733, RnoGPx04-A
3812, RnoGPx04-B
3813, RnoGPx04-C

PTM databases

iPTMnetiP36970
SwissPalmiP36970

Proteomic databases

jPOSTiP36970
PaxDbiP36970
PRIDEiP36970

Genome annotation databases

EnsembliENSRNOT00000093376; ENSRNOP00000076198; ENSRNOG00000013604 [P36970-1]
ENSRNOT00000093426; ENSRNOP00000076309; ENSRNOG00000013604 [P36970-3]
GeneIDi29328
KEGGirno:29328

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2879
RGDi69226, Gpx4

Phylogenomic databases

eggNOGiKOG1651, Eukaryota
GeneTreeiENSGT00940000161913
OrthoDBi1483113at2759
PhylomeDBiP36970

Enzyme and pathway databases

BRENDAi1.11.1.12, 5301
ReactomeiR-RNO-2142712, Synthesis of 12-eicosatetraenoic acid derivatives
R-RNO-2142770, Synthesis of 15-eicosatetraenoic acid derivatives
R-RNO-9018676, Biosynthesis of D-series resolvins
R-RNO-9018896, Biosynthesis of E-series 18(S)-resolvins
R-RNO-9020265, Biosynthesis of aspirin-triggered D-series resolvins
R-RNO-9023661, Biosynthesis of E-series 18(R)-resolvins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P36970

Gene expression databases

ExpressionAtlasiP36970, baseline and differential
GenevisibleiQ76LU9, RN

Family and domain databases

CDDicd00340, GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889, Glutathione_peroxidase
IPR029759, GPX_AS
IPR029760, GPX_CS
IPR036249, Thioredoxin-like_sf
PANTHERiPTHR11592, PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255, GSHPx, 1 hit
PIRSFiPIRSF000303, Glutathion_perox, 1 hit
PRINTSiPR01011, GLUTPROXDASE
SUPFAMiSSF52833, SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460, GLUTATHIONE_PEROXID_1, 1 hit
PS00763, GLUTATHIONE_PEROXID_2, 1 hit
PS51355, GLUTATHIONE_PEROXID_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPX4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36970
Secondary accession number(s): Q6PZ55, Q76LU9, Q91XR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 26, 2008
Last modified: September 29, 2021
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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