UniProtKB - P36959 (GMPR1_HUMAN)
Protein
GMP reductase 1
Gene
GMPR
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation
Caution
The N-terminus was initially (PubMed:2758468) thought to be fused with glucose-6-phosphate-dehydrogenase (G6PD) protein in vivo. However, PubMed:2570640 showed that it encodes a GMP reductase, and PubMed:1694726 showed that the chimeric protein is an artifact.1 Publication
Catalytic activityi
- EC:1.7.1.7UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 78 | NADPUniRule annotation | 1 | |
Metal bindingi | 181 | Potassium; via carbonyl oxygenUniRule annotation1 Publication | 1 | |
Metal bindingi | 183 | Potassium; via carbonyl oxygenUniRule annotation1 Publication | 1 | |
Active sitei | 186 | Thioimidate intermediateUniRule annotation | 1 | |
Metal bindingi | 186 | Potassium; via carbonyl oxygenUniRule annotation1 Publication | 1 | |
Active sitei | 188 | Proton donor/acceptorUniRule annotation | 1 | |
Metal bindingi | 189 | PotassiumUniRule annotation1 Publication | 1 | |
Binding sitei | 269 | NADP; via carbonyl oxygenUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 26 – 27 | NADP; shared with neighboring subunitUniRule annotation | 2 | |
Nucleotide bindingi | 129 – 131 | NADPUniRule annotation | 3 | |
Nucleotide bindingi | 180 – 181 | NADPUniRule annotation | 2 | |
Nucleotide bindingi | 285 – 286 | NADPUniRule annotation | 2 | |
Nucleotide bindingi | 314 – 317 | NADP; shared with neighboring subunitUniRule annotation | 4 |
GO - Molecular functioni
- GMP reductase activity Source: ProtInc
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- purine-containing compound salvage Source: Reactome
- purine nucleobase metabolic process Source: UniProtKB-KW
- purine nucleotide metabolic process Source: UniProtKB-UniRule
- response to cold Source: ProtInc
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Purine metabolism |
Ligand | Metal-binding, NADP, Potassium |
Enzyme and pathway databases
PathwayCommonsi | P36959 |
Reactomei | R-HSA-74217, Purine salvage |
Names & Taxonomyi
Protein namesi | Recommended name: GMP reductase 1UniRule annotation (EC:1.7.1.7UniRule annotation)Short name: GMPR 1UniRule annotation Alternative name(s): Guanosine 5'-monophosphate oxidoreductase 1UniRule annotation Short name: Guanosine monophosphate reductase 1UniRule annotation |
Gene namesi | Name:GMPR Synonyms:GMPR1UniRule annotation |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4376, GMPR |
MIMi | 139265, gene |
neXtProti | NX_P36959 |
VEuPathDBi | HostDB:ENSG00000137198.9 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Other locations
- GMP reductase complex Source: InterPro
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 2766 |
OpenTargetsi | ENSG00000137198 |
PharmGKBi | PA28761 |
Miscellaneous databases
Pharosi | P36959, Tbio |
Chemistry databases
DrugBanki | DB01972, Guanosine-5'-Monophosphate |
Genetic variation databases
BioMutai | GMPR |
DMDMi | 544455 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093723 | 1 – 345 | GMP reductase 1Add BLAST | 345 |
Proteomic databases
jPOSTi | P36959 |
MassIVEi | P36959 |
MaxQBi | P36959 |
PaxDbi | P36959 |
PeptideAtlasi | P36959 |
PRIDEi | P36959 |
ProteomicsDBi | 55249 |
PTM databases
iPTMneti | P36959 |
PhosphoSitePlusi | P36959 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137198, Expressed in gastrocnemius and 201 other tissues |
Genevisiblei | P36959, HS |
Organism-specific databases
HPAi | ENSG00000137198, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Homotetramer.
UniRule annotation1 PublicationProtein-protein interaction databases
BioGRIDi | 109028, 2 interactors |
IntActi | P36959, 1 interactor |
STRINGi | 9606.ENSP00000259727 |
Miscellaneous databases
RNActi | P36959, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P36959 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P36959 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 219 – 221 | GMP bindingUniRule annotation1 Publication | 3 | |
Regioni | 242 – 243 | GMP bindingUniRule annotation1 Publication | 2 | |
Regioni | 268 – 270 | GMP bindingUniRule annotation1 Publication | 3 | |
Regioni | 286 – 290 | GMP bindingUniRule annotation1 Publication | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2550, Eukaryota |
GeneTreei | ENSGT00940000156595 |
HOGENOMi | CLU_022552_5_3_1 |
InParanoidi | P36959 |
OMAi | GSHCTTR |
OrthoDBi | 618077at2759 |
PhylomeDBi | P36959 |
TreeFami | TF300378 |
Family and domain databases
CDDi | cd00381, IMPDH, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_00596, GMP_reduct_type1, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR005993, GMPR IPR015875, IMP_DH/GMP_Rdtase_CS IPR001093, IMP_DH_GMPRt |
Pfami | View protein in Pfam PF00478, IMPDH, 1 hit |
PIRSFi | PIRSF000235, GMP_reductase, 1 hit |
TIGRFAMsi | TIGR01305, GMP_reduct_1, 1 hit |
PROSITEi | View protein in PROSITE PS00487, IMP_DH_GMP_RED, 1 hit |
i Sequence
Sequence statusi: Complete.
P36959-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI
60 70 80 90 100
IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA
110 120 130 140 150
VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP
160 170 180 190 200
EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS
210 220 230 240 250
AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE
260 270 280 290 300
CAGEVFERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD
310 320 330 340
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS
Polymorphismi
At least two different alleles are known.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003969 | 234 | A → T1 PublicationCorresponds to variant dbSNP:rs760571328Ensembl. | 1 | |
Natural variantiVAR_003970 | 256 | F → I2 PublicationsCorresponds to variant dbSNP:rs1042391EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35304 Genomic DNA Translation: AAA52503.1 M27941 Genomic DNA Translation: AAA53106.1 M24470 mRNA Translation: AAA52498.1 AL009031 Genomic DNA No translation available. AL138883 Genomic DNA No translation available. BC008281 mRNA Translation: AAH08281.1 |
CCDSi | CCDS4537.1 |
PIRi | B32902 |
RefSeqi | NP_006868.3, NM_006877.3 |
Genome annotation databases
Ensembli | ENST00000259727; ENSP00000259727; ENSG00000137198 |
GeneIDi | 2766 |
KEGGi | hsa:2766 |
UCSCi | uc003nbs.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35304 Genomic DNA Translation: AAA52503.1 M27941 Genomic DNA Translation: AAA53106.1 M24470 mRNA Translation: AAA52498.1 AL009031 Genomic DNA No translation available. AL138883 Genomic DNA No translation available. BC008281 mRNA Translation: AAH08281.1 |
CCDSi | CCDS4537.1 |
PIRi | B32902 |
RefSeqi | NP_006868.3, NM_006877.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BLE | X-ray | 1.90 | A | 1-345 | [»] | |
2BWG | X-ray | 2.40 | A/B/C/D | 1-345 | [»] | |
SMRi | P36959 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109028, 2 interactors |
IntActi | P36959, 1 interactor |
STRINGi | 9606.ENSP00000259727 |
Chemistry databases
DrugBanki | DB01972, Guanosine-5'-Monophosphate |
PTM databases
iPTMneti | P36959 |
PhosphoSitePlusi | P36959 |
Genetic variation databases
BioMutai | GMPR |
DMDMi | 544455 |
Proteomic databases
jPOSTi | P36959 |
MassIVEi | P36959 |
MaxQBi | P36959 |
PaxDbi | P36959 |
PeptideAtlasi | P36959 |
PRIDEi | P36959 |
ProteomicsDBi | 55249 |
Protocols and materials databases
Antibodypediai | 10292, 153 antibodies |
DNASUi | 2766 |
Genome annotation databases
Ensembli | ENST00000259727; ENSP00000259727; ENSG00000137198 |
GeneIDi | 2766 |
KEGGi | hsa:2766 |
UCSCi | uc003nbs.3, human |
Organism-specific databases
CTDi | 2766 |
DisGeNETi | 2766 |
GeneCardsi | GMPR |
HGNCi | HGNC:4376, GMPR |
HPAi | ENSG00000137198, Tissue enhanced (skeletal) |
MIMi | 139265, gene |
neXtProti | NX_P36959 |
OpenTargetsi | ENSG00000137198 |
PharmGKBi | PA28761 |
VEuPathDBi | HostDB:ENSG00000137198.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2550, Eukaryota |
GeneTreei | ENSGT00940000156595 |
HOGENOMi | CLU_022552_5_3_1 |
InParanoidi | P36959 |
OMAi | GSHCTTR |
OrthoDBi | 618077at2759 |
PhylomeDBi | P36959 |
TreeFami | TF300378 |
Enzyme and pathway databases
PathwayCommonsi | P36959 |
Reactomei | R-HSA-74217, Purine salvage |
Miscellaneous databases
BioGRID-ORCSi | 2766, 2 hits in 872 CRISPR screens |
ChiTaRSi | GMPR, human |
EvolutionaryTracei | P36959 |
GenomeRNAii | 2766 |
Pharosi | P36959, Tbio |
PROi | PR:P36959 |
RNActi | P36959, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137198, Expressed in gastrocnemius and 201 other tissues |
Genevisiblei | P36959, HS |
Family and domain databases
CDDi | cd00381, IMPDH, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_00596, GMP_reduct_type1, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR005993, GMPR IPR015875, IMP_DH/GMP_Rdtase_CS IPR001093, IMP_DH_GMPRt |
Pfami | View protein in Pfam PF00478, IMPDH, 1 hit |
PIRSFi | PIRSF000235, GMP_reductase, 1 hit |
TIGRFAMsi | TIGR01305, GMP_reduct_1, 1 hit |
PROSITEi | View protein in PROSITE PS00487, IMP_DH_GMP_RED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GMPR1_HUMAN | |
Accessioni | P36959Primary (citable) accession number: P36959 Secondary accession number(s): Q96HQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families