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UniProtKB - P36959 (GMPR1_HUMAN)

Entry version 185 (10 Feb 2021)
Sequence version 1 (01 Jun 1994)
Previous versions | rss
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Protein

GMP reductase 1

Gene

GMPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Caution

The N-terminus was initially (PubMed:2758468) thought to be fused with glucose-6-phosphate-dehydrogenase (G6PD) protein in vivo. However, PubMed:2570640 showed that it encodes a GMP reductase, and PubMed:1694726 showed that the chimeric protein is an artifact.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei78NADPUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1 Publication1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei186Thioimidate intermediateUniRule annotation1
Metal bindingi186Potassium; via carbonyl oxygenUniRule annotation1 Publication1
Active sitei188Proton donor/acceptorUniRule annotation1
Metal bindingi189PotassiumUniRule annotation1 Publication1
Binding sitei269NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation2
Nucleotide bindingi129 – 131NADPUniRule annotation3
Nucleotide bindingi180 – 181NADPUniRule annotation2
Nucleotide bindingi285 – 286NADPUniRule annotation2
Nucleotide bindingi314 – 317NADP; shared with neighboring subunitUniRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GMP reductase activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism
LigandMetal-binding, NADP, Potassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P36959

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-74217, Purine salvage

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GMP reductase 1UniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPR 1UniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase 1UniRule annotation
Short name:
Guanosine monophosphate reductase 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GMPR
Synonyms:GMPR1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4376, GMPR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		139265, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P36959

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000137198.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2766

Open Targets

More...OpenTargetsi		ENSG00000137198

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28761

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P36959, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01972, Guanosine-5'-Monophosphate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GMPR

Domain mapping of disease mutations (DMDM)

More...DMDMi		544455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000937231 – 345GMP reductase 1Add BLAST345

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P36959

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P36959

MaxQB - The MaxQuant DataBase

More...MaxQBi		P36959

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P36959

PeptideAtlas

More...PeptideAtlasi		P36959

PRoteomics IDEntifications database

More...PRIDEi		P36959

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55249

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P36959

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P36959

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137198, Expressed in gastrocnemius and 201 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P36959, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137198, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

UniRule annotation1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109028, 2 interactors

Protein interaction database and analysis system

More...IntActi		P36959, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000259727

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P36959, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P36959

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P36959

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni219 – 221GMP bindingUniRule annotation1 Publication3
Regioni242 – 243GMP bindingUniRule annotation1 Publication2
Regioni268 – 270GMP bindingUniRule annotation1 Publication3
Regioni286 – 290GMP bindingUniRule annotation1 Publication5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2550, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156595

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022552_5_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P36959

Identification of Orthologs from Complete Genome Data

More...OMAi		GSHCTTR

Database of Orthologous Groups

More...OrthoDBi		618077at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P36959

TreeFam database of animal gene trees

More...TreeFami		TF300378

Family and domain databases

Conserved Domains Database

More...CDDi		cd00381, IMPDH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.70, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00596, GMP_reduct_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013785, Aldolase_TIM
IPR005993, GMPR
IPR015875, IMP_DH/GMP_Rdtase_CS
IPR001093, IMP_DH_GMPRt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00478, IMPDH, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000235, GMP_reductase, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01305, GMP_reduct_1, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00487, IMP_DH_GMP_RED, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI 
        60         70         80         90        100
IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA 
       110        120        130        140        150
VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP 
       160        170        180        190        200
EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS 
       210        220        230        240        250
AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE 
       260        270        280        290        300
CAGEVFERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD 
       310        320        330        340 
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS
Length:345
Mass (Da):37,419
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i217E1A5A599CA510
GO

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

At least two different alleles are known.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_003969234A → T1 PublicationCorresponds to variant dbSNP:rs760571328Ensembl.1
Natural variantiVAR_003970256F → I2 PublicationsCorresponds to variant dbSNP:rs1042391EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L35304 Genomic DNA Translation: AAA52503.1
M27941 Genomic DNA Translation: AAA53106.1
M24470 mRNA Translation: AAA52498.1
AL009031 Genomic DNA No translation available.
AL138883 Genomic DNA No translation available.
BC008281 mRNA Translation: AAH08281.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4537.1

Protein sequence database of the Protein Information Resource

More...PIRi		B32902

NCBI Reference Sequences

More...RefSeqi		NP_006868.3, NM_006877.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000259727; ENSP00000259727; ENSG00000137198

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2766

UCSC genome browser

More...UCSCi		uc003nbs.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35304 Genomic DNA Translation: AAA52503.1
M27941 Genomic DNA Translation: AAA53106.1
M24470 mRNA Translation: AAA52498.1
AL009031 Genomic DNA No translation available.
AL138883 Genomic DNA No translation available.
BC008281 mRNA Translation: AAH08281.1
CCDSiCCDS4537.1
PIRiB32902
RefSeqiNP_006868.3, NM_006877.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BLEX-ray1.90A1-345[»]
2BWGX-ray2.40A/B/C/D1-345[»]
SMRiP36959
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109028, 2 interactors
IntActiP36959, 1 interactor
STRINGi9606.ENSP00000259727

Chemistry databases

DrugBankiDB01972, Guanosine-5'-Monophosphate

PTM databases

iPTMnetiP36959
PhosphoSitePlusiP36959

Genetic variation databases

BioMutaiGMPR
DMDMi544455

Proteomic databases

jPOSTiP36959
MassIVEiP36959
MaxQBiP36959
PaxDbiP36959
PeptideAtlasiP36959
PRIDEiP36959
ProteomicsDBi55249

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10292, 153 antibodies

The DNASU plasmid repository

More...DNASUi		2766

Genome annotation databases

EnsembliENST00000259727; ENSP00000259727; ENSG00000137198
GeneIDi2766
KEGGihsa:2766
UCSCiuc003nbs.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2766
DisGeNETi2766

GeneCards: human genes, protein and diseases

More...GeneCardsi		GMPR
HGNCiHGNC:4376, GMPR
HPAiENSG00000137198, Tissue enhanced (skeletal)
MIMi139265, gene
neXtProtiNX_P36959
OpenTargetsiENSG00000137198
PharmGKBiPA28761
VEuPathDBiHostDB:ENSG00000137198.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2550, Eukaryota
GeneTreeiENSGT00940000156595
HOGENOMiCLU_022552_5_3_1
InParanoidiP36959
OMAiGSHCTTR
OrthoDBi618077at2759
PhylomeDBiP36959
TreeFamiTF300378

Enzyme and pathway databases

PathwayCommonsiP36959
ReactomeiR-HSA-74217, Purine salvage

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2766, 2 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GMPR, human
EvolutionaryTraceiP36959

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2766
PharosiP36959, Tbio

Protein Ontology

More...PROi		PR:P36959
RNActiP36959, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137198, Expressed in gastrocnemius and 201 other tissues
GenevisibleiP36959, HS

Family and domain databases

CDDicd00381, IMPDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00596, GMP_reduct_type1, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR005993, GMPR
IPR015875, IMP_DH/GMP_Rdtase_CS
IPR001093, IMP_DH_GMPRt
PfamiView protein in Pfam
PF00478, IMPDH, 1 hit
PIRSFiPIRSF000235, GMP_reductase, 1 hit
TIGRFAMsiTIGR01305, GMP_reduct_1, 1 hit
PROSITEiView protein in PROSITE
PS00487, IMP_DH_GMP_RED, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGMPR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36959
Secondary accession number(s): Q96HQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 10, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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