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Protein

GMP reductase 1

Gene

GMPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation

Caution

The N-terminus was initially (PubMed:2758468) thought to be fused with glucose-6-phosphate-dehydrogenase (G6PD) protein in vivo. However, PubMed:2570640 showed that it encodes a GMP reductase, and PubMed:1694726 showed that the chimeric protein is an artifact.1 Publication

Catalytic activityi

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78NADPUniRule annotation1
Metal bindingi181Potassium; via carbonyl oxygenUniRule annotation1 Publication1
Metal bindingi183Potassium; via carbonyl oxygenUniRule annotation1 Publication1
Active sitei186Thioimidate intermediateUniRule annotation1
Metal bindingi186Potassium; via carbonyl oxygenUniRule annotation1 Publication1
Active sitei188Proton donor/acceptorUniRule annotation1
Metal bindingi189PotassiumUniRule annotation1 Publication1
Binding sitei269NADP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 27NADP; shared with neighboring subunitUniRule annotation2
Nucleotide bindingi129 – 131NADPUniRule annotation3
Nucleotide bindingi180 – 181NADPUniRule annotation2
Nucleotide bindingi285 – 286NADPUniRule annotation2
Nucleotide bindingi314 – 317NADP; shared with neighboring subunitUniRule annotation4

GO - Molecular functioni

GO - Biological processi

  • purine-containing compound salvage Source: Reactome
  • purine nucleobase metabolic process Source: UniProtKB-KW
  • purine ribonucleotide interconversion Source: GO_Central
  • response to cold Source: ProtInc

Keywordsi

Molecular functionOxidoreductase
Biological processPurine metabolism
LigandMetal-binding, NADP, Potassium

Enzyme and pathway databases

ReactomeiR-HSA-74217 Purine salvage

Names & Taxonomyi

Protein namesi
Recommended name:
GMP reductase 1UniRule annotation (EC:1.7.1.7UniRule annotation)
Short name:
GMPR 1UniRule annotation
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase 1UniRule annotation
Short name:
Guanosine monophosphate reductase 1UniRule annotation
Gene namesi
Name:GMPR
Synonyms:GMPR1UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137198.9
HGNCiHGNC:4376 GMPR
MIMi139265 gene
neXtProtiNX_P36959

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi2766
OpenTargetsiENSG00000137198
PharmGKBiPA28761

Chemistry databases

DrugBankiDB01972 Guanosine-5'-Monophosphate

Polymorphism and mutation databases

BioMutaiGMPR
DMDMi544455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000937231 – 345GMP reductase 1Add BLAST345

Proteomic databases

EPDiP36959
MaxQBiP36959
PaxDbiP36959
PeptideAtlasiP36959
PRIDEiP36959
ProteomicsDBi55249

PTM databases

iPTMnetiP36959
PhosphoSitePlusiP36959

Expressioni

Gene expression databases

BgeeiENSG00000137198 Expressed in 183 organ(s), highest expression level in gastrocnemius
CleanExiHS_GMPR
GenevisibleiP36959 HS

Organism-specific databases

HPAiHPA000904
HPA021476

Interactioni

Subunit structurei

Homotetramer.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi109028, 2 interactors
STRINGi9606.ENSP00000259727

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP36959
SMRiP36959
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36959

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 221GMP bindingUniRule annotation1 Publication3
Regioni242 – 243GMP bindingUniRule annotation1 Publication2
Regioni268 – 270GMP bindingUniRule annotation1 Publication3
Regioni286 – 290GMP bindingUniRule annotation1 Publication5

Sequence similaritiesi

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2550 Eukaryota
COG0516 LUCA
GeneTreeiENSGT00530000062923
HOGENOMiHOG000165756
HOVERGENiHBG051744
InParanoidiP36959
KOiK00364
OMAiGSHCTTR
OrthoDBiEOG091G09KQ
PhylomeDBiP36959
TreeFamiTF300378

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00596 GMP_reduct_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR005993 GMPR
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00478 IMPDH, 1 hit
PIRSFiPIRSF000235 GMP_reductase, 1 hit
TIGRFAMsiTIGR01305 GMP_reduct_1, 1 hit
PROSITEiView protein in PROSITE
PS00487 IMP_DH_GMP_RED, 1 hit

Sequencei

Sequence statusi: Complete.

P36959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI
60 70 80 90 100
IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA
110 120 130 140 150
VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP
160 170 180 190 200
EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS
210 220 230 240 250
AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE
260 270 280 290 300
CAGEVFERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD
310 320 330 340
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS
Length:345
Mass (Da):37,419
Last modified:June 1, 1994 - v1
Checksum:i217E1A5A599CA510
GO

Polymorphismi

At least two different alleles are known.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003969234A → T1 PublicationCorresponds to variant dbSNP:rs760571328Ensembl.1
Natural variantiVAR_003970256F → I2 PublicationsCorresponds to variant dbSNP:rs1042391EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35304 Genomic DNA Translation: AAA52503.1
M27941 Genomic DNA Translation: AAA53106.1
M24470 mRNA Translation: AAA52498.1
AL009031 Genomic DNA No translation available.
AL138883 Genomic DNA No translation available.
BC008281 mRNA Translation: AAH08281.1
CCDSiCCDS4537.1
PIRiB32902
RefSeqiNP_006868.3, NM_006877.3
UniGeneiHs.484741

Genome annotation databases

EnsembliENST00000259727; ENSP00000259727; ENSG00000137198
GeneIDi2766
KEGGihsa:2766
UCSCiuc003nbs.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35304 Genomic DNA Translation: AAA52503.1
M27941 Genomic DNA Translation: AAA53106.1
M24470 mRNA Translation: AAA52498.1
AL009031 Genomic DNA No translation available.
AL138883 Genomic DNA No translation available.
BC008281 mRNA Translation: AAH08281.1
CCDSiCCDS4537.1
PIRiB32902
RefSeqiNP_006868.3, NM_006877.3
UniGeneiHs.484741

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BLEX-ray1.90A1-345[»]
2BWGX-ray2.40A/B/C/D1-345[»]
ProteinModelPortaliP36959
SMRiP36959
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109028, 2 interactors
STRINGi9606.ENSP00000259727

Chemistry databases

DrugBankiDB01972 Guanosine-5'-Monophosphate

PTM databases

iPTMnetiP36959
PhosphoSitePlusiP36959

Polymorphism and mutation databases

BioMutaiGMPR
DMDMi544455

Proteomic databases

EPDiP36959
MaxQBiP36959
PaxDbiP36959
PeptideAtlasiP36959
PRIDEiP36959
ProteomicsDBi55249

Protocols and materials databases

DNASUi2766
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259727; ENSP00000259727; ENSG00000137198
GeneIDi2766
KEGGihsa:2766
UCSCiuc003nbs.3 human

Organism-specific databases

CTDi2766
DisGeNETi2766
EuPathDBiHostDB:ENSG00000137198.9
GeneCardsiGMPR
HGNCiHGNC:4376 GMPR
HPAiHPA000904
HPA021476
MIMi139265 gene
neXtProtiNX_P36959
OpenTargetsiENSG00000137198
PharmGKBiPA28761
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2550 Eukaryota
COG0516 LUCA
GeneTreeiENSGT00530000062923
HOGENOMiHOG000165756
HOVERGENiHBG051744
InParanoidiP36959
KOiK00364
OMAiGSHCTTR
OrthoDBiEOG091G09KQ
PhylomeDBiP36959
TreeFamiTF300378

Enzyme and pathway databases

ReactomeiR-HSA-74217 Purine salvage

Miscellaneous databases

ChiTaRSiGMPR human
EvolutionaryTraceiP36959
GenomeRNAii2766
PROiPR:P36959
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137198 Expressed in 183 organ(s), highest expression level in gastrocnemius
CleanExiHS_GMPR
GenevisibleiP36959 HS

Family and domain databases

CDDicd00381 IMPDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00596 GMP_reduct_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR005993 GMPR
IPR015875 IMP_DH/GMP_Rdtase_CS
IPR001093 IMP_DH_GMPRt
PfamiView protein in Pfam
PF00478 IMPDH, 1 hit
PIRSFiPIRSF000235 GMP_reductase, 1 hit
TIGRFAMsiTIGR01305 GMP_reduct_1, 1 hit
PROSITEiView protein in PROSITE
PS00487 IMP_DH_GMP_RED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGMPR1_HUMAN
AccessioniPrimary (citable) accession number: P36959
Secondary accession number(s): Q96HQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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