UniProtKB - P36956 (SRBP1_HUMAN)
Sterol regulatory element-binding protein 1
SREBF1
Functioni
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: HGNC-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- nuclear receptor activity Source: ParkinsonsUK-UCL
- protein-containing complex binding Source: Ensembl
- protein dimerization activity Source: InterPro
- protein kinase binding Source: Ensembl
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: GO_Central
- RNA polymerase II regulatory region sequence-specific DNA binding Source: ParkinsonsUK-UCL
- sterol response element binding Source: HGNC-UCL
GO - Biological processi
- aging Source: Ensembl
- cellular response to fatty acid Source: Ensembl
- cellular response to starvation Source: HGNC-UCL
- cholesterol metabolic process Source: UniProtKB-KW
- circadian rhythm Source: Reactome
- fat cell differentiation Source: Ensembl
- insulin receptor signaling pathway Source: Ensembl
- lipid biosynthetic process Source: UniProtKB
- lipid metabolic process Source: ProtInc
- lung development Source: Ensembl
- mRNA transcription by RNA polymerase II Source: Ensembl
- negative regulation of insulin secretion Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of cholesterol biosynthetic process Source: Ensembl
- positive regulation of histone deacetylation Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of triglyceride biosynthetic process Source: UniProtKB
- regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
- regulation of cholesterol biosynthetic process Source: Reactome
- regulation of fatty acid metabolic process Source: Ensembl
- regulation of heart rate by chemical signal Source: Ensembl
- regulation of protein stability Source: ParkinsonsUK-UCL
- regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
- regulation of transcription by RNA polymerase II Source: ProtInc
- response to cAMP Source: Ensembl
- response to food Source: Ensembl
- response to glucagon Source: Ensembl
- response to glucose Source: Ensembl
- response to lipid Source: GO_Central
- response to progesterone Source: Ensembl
- response to retinoic acid Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-1368082 RORA activates gene expression R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1989781 PPARA activates gene expression R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-381340 Transcriptional regulation of white adipocyte differentiation [P36956-1] R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis [P36956-3] R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
SignaLinki | P36956 |
SIGNORi | P36956 |
Names & Taxonomyi
Protein namesi | Recommended name: Sterol regulatory element-binding protein 1Short name: SREBP-1 Alternative name(s): Class D basic helix-loop-helix protein 1 Short name: bHLHd1 Sterol regulatory element-binding transcription factor 1 Cleaved into the following chain: |
Gene namesi | Name:SREBF1 Synonyms:BHLHD1, SREBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11289 SREBF1 |
MIMi | 184756 gene |
neXtProti | NX_P36956 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- COPII-coated vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.By similarity
Nucleus
- Nucleus By similarity
Nucleus
- Nucleus 1 Publication
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Golgi apparatus
- Golgi membrane Source: Reactome
Nucleus
- nuclear chromatin Source: NTNU_SB
- nuclear envelope Source: ProtInc
- nucleoplasm Source: Reactome
- nucleus Source: BHF-UCL
Other locations
- cytoplasm Source: UniProtKB
- ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 487 | CytoplasmicSequence analysisAdd BLAST | 487 | |
Transmembranei | 488 – 508 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 509 – 547 | LumenalSequence analysisAdd BLAST | 39 | |
Transmembranei | 548 – 568 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 569 – 1147 | CytoplasmicSequence analysisAdd BLAST | 579 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 455 | S → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 456 | D → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 457 | S → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 460 | D → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 466 | D → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 481 | G → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 482 | M → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 483 | L → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 484 – 487 | DRSR → AS: Strong reduction of proteolytic processing in response to low sterol. 1 Publication | 4 | |
Mutagenesisi | 484 | D → A: Loss of proteolytic processing in response to low sterol. 1 Publication | 1 | |
Mutagenesisi | 485 | R → A: No effect on proteolytic processing. 1 Publication | 1 | |
Mutagenesisi | 527 | R → A: Loss of proteolytic processing in response to low sterol. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6720 |
OpenTargetsi | ENSG00000072310 |
PharmGKBi | PA335 |
Miscellaneous databases
Pharosi | P36956 |
Chemistry databases
DrugBanki | DB03756 Doconexent DB13961 Fish oil DB11133 Omega-3 fatty acids DB09539 Omega-3-acid ethyl esters |
Polymorphism and mutation databases
BioMutai | SREBF1 |
DMDMi | 166897633 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127447 | 1 – 1147 | Sterol regulatory element-binding protein 1Add BLAST | 1147 | |
ChainiPRO_0000314029 | 1 – 490 | Processed sterol regulatory element-binding protein 1Add BLAST | 490 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 98 | PhosphoserineBy similarity | 1 | |
Modified residuei | 117 | PhosphoserineCombined sources | 1 | |
Modified residuei | 337 | Phosphoserine; by SIK1By similarity | 1 | |
Modified residuei | 338 | Phosphoserine; by SIK1By similarity | 1 | |
Modified residuei | 396 | Phosphoserine; by AMPKBy similarity | 1 | |
Modified residuei | 402 | Phosphoserine; by SIK1By similarity | 1 | |
Modified residuei | 457 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1060 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 460 – 461 | Cleavage; by caspase-3 and caspase-7By similarity | 2 | |
Sitei | 490 – 491 | Cleavage; by S2PBy similarity | 2 | |
Sitei | 530 – 531 | Cleavage; by S1PCurated | 2 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P36956 |
jPOSTi | P36956 |
MassIVEi | P36956 |
MaxQBi | P36956 |
PaxDbi | P36956 |
PeptideAtlasi | P36956 |
PRIDEi | P36956 |
ProteomicsDBi | 2552 55244 [P36956-1] 55245 [P36956-2] 55246 [P36956-3] 55247 [P36956-4] |
PTM databases
iPTMneti | P36956 |
PhosphoSitePlusi | P36956 |
Miscellaneous databases
PMAP-CutDBi | P36956 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000072310 Expressed in 188 organ(s), highest expression level in right adrenal gland |
ExpressionAtlasi | P36956 baseline and differential |
Genevisiblei | P36956 HS |
Organism-specific databases
HPAi | CAB005406 HPA043343 HPA043878 |
Interactioni
Subunit structurei
Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein.
Interacts with LMNA.
Interacts with CEBPA, the interaction produces a transcriptional synergy (By similarity).
By similarityBinary interactionsi
GO - Molecular functioni
- protein dimerization activity Source: InterPro
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 112598, 66 interactors |
CORUMi | P36956 |
DIPi | DIP-331N |
IntActi | P36956, 24 interactors |
MINTi | P36956 |
STRINGi | 9606.ENSP00000348069 |
Structurei
Secondary structure
3D structure databases
SMRi | P36956 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P36956 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 323 – 373 | bHLHPROSITE-ProRule annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | Transcriptional activation (acidic)Add BLAST | 60 | |
Regioni | 234 – 497 | Interaction with LMNABy similarityAdd BLAST | 264 | |
Regioni | 373 – 394 | Leucine-zipperAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 27 – 35 | 9aaTAD1 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 61 – 178 | Pro/Ser-richAdd BLAST | 118 | |
Compositional biasi | 427 – 462 | Gly/Pro/Ser-richAdd BLAST | 36 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2588 Eukaryota ENOG410XSVP LUCA |
GeneTreei | ENSGT00940000159156 |
HOGENOMi | HOG000007091 |
InParanoidi | P36956 |
KOi | K07197 |
OMAi | IMAGATP |
OrthoDBi | 330300at2759 |
PhylomeDBi | P36956 |
TreeFami | TF313894 |
Family and domain databases
CDDi | cd00083 HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010 HLH, 1 hit |
SMARTi | View protein in SMART SM00353 HLH, 1 hit |
SUPFAMi | SSF47459 SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888 BHLH, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP
60 70 80 90 100
YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP
110 120 130 140 150
QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP
160 170 180 190 200
APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS
210 220 230 240 250
LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL
260 270 280 290 300
LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
310 320 330 340 350
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV
360 370 380 390 400
VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL
410 420 430 440 450
VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS
460 470 480 490 500
GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR GMLDRSRLAL CTLVFLCLSC
510 520 530 540 550
NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW AQWLLPPVVW
560 570 580 590 600
LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
610 620 630 640 650
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG
660 670 680 690 700
GLQQDCALRV DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL
710 720 730 740 750
NLAECAGDAV SVATLAEIYV AAALRVKTSL PRALHFLTRF FLSSARQACL
760 770 780 790 800
AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL STPWESLYSL AGNPVDPLAQ
810 820 830 840 850
VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL QLLNSCSDAA
860 870 880 890 900
GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
910 920 930 940 950
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG
960 970 980 990 1000
YLQDSLATTP ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT
1010 1020 1030 1040 1050
SSRPQASALE LRGFQRDLSS LRRLAQSFRP AMRRVFLHEA TARLMAGASP
1060 1070 1080 1090 1100
TRTHQLLDRS LRRRAGPGGK GGAVAELEPR PTRREHAEAL LLASCYLPPG
1110 1120 1130 1140
FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG GTTVTSS
The sequence of this isoform differs from the canonical sequence as follows:
1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD
The sequence of this isoform differs from the canonical sequence as follows:
1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD
The sequence of this isoform differs from the canonical sequence as follows:
469-470: AK → TE
471-1147: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
469-470: AK → TE
471-1147: Missing.
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EMT8 | K7EMT8_HUMAN | Sterol regulatory element-binding p... | SREBF1 | 110 | Annotation score: | ||
B5MD58 | B5MD58_HUMAN | Sterol regulatory element-binding p... | SREBF1 | 893 | Annotation score: | ||
F6V242 | F6V242_HUMAN | Sterol regulatory element-binding p... | SREBF1 | 325 | Annotation score: | ||
S4R3B4 | S4R3B4_HUMAN | Sterol regulatory element-binding p... | SREBF1 | 113 | Annotation score: | ||
K7EIW8 | K7EIW8_HUMAN | Sterol regulatory element-binding p... | SREBF1 | 163 | Annotation score: | ||
K7EKR7 | K7EKR7_HUMAN | Sterol regulatory element-binding p... | SREBF1 | 31 | Annotation score: | ||
K7EMD1 | K7EMD1_HUMAN | Sterol regulatory element-binding p... | SREBF1 | 157 | Annotation score: | ||
J3QLB6 | J3QLB6_HUMAN | Sterol regulatory element-binding p... | SREBF1 | 72 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038468 | 306 | N → S1 PublicationCorresponds to variant dbSNP:rs17855793Ensembl. | 1 | |
Natural variantiVAR_038469 | 309 | A → T. Corresponds to variant dbSNP:rs35188700Ensembl. | 1 | |
Natural variantiVAR_038470 | 417 | V → M. Corresponds to variant dbSNP:rs2229590Ensembl. | 1 | |
Natural variantiVAR_038471 | 580 | V → M. Corresponds to variant dbSNP:rs36215896Ensembl. | 1 | |
Natural variantiVAR_038472 | 746 | R → H. Corresponds to variant dbSNP:rs2228461Ensembl. | 1 | |
Natural variantiVAR_038473 | 834 | S → L1 PublicationCorresponds to variant dbSNP:rs17855792Ensembl. | 1 | |
Natural variantiVAR_038474 | 1000 | T → A2 PublicationsCorresponds to variant dbSNP:rs1042017Ensembl. | 1 | |
Natural variantiVAR_038475 | 1008 | A → P. Corresponds to variant dbSNP:rs35014224Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002149 | 1 – 29 | MDEPP…LLTDI → MDCTF in isoform SREBP-1C and isoform SREBP-1cDelta. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_030859 | 30 | E → EGEVGAGRGRANGLDAPRAG ADRGAMDCTFE in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_047598 | 469 – 470 | AK → TE in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 Publication | 2 | |
Alternative sequenceiVSP_047599 | 471 – 1147 | Missing in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 PublicationAdd BLAST | 677 | |
Alternative sequenceiVSP_002150 | 1035 – 1147 | VFLHE…TVTSS → LMDVLTSESAWALPQHLGKG FPSPSGHKVPGWHGRMD in isoform SREBP-1B and isoform SREBP-1C. 1 PublicationAdd BLAST | 113 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00968 mRNA Translation: AAC50051.2 S66167 mRNA Translation: AAB28522.2 Different initiation. S66168 mRNA Translation: AAB28523.1 AB373958 mRNA Translation: BAG06742.1 AB373959 mRNA Translation: BAG06743.1 AC122129 Genomic DNA No translation available. CH471196 Genomic DNA Translation: EAW55689.1 CH471196 Genomic DNA Translation: EAW55690.1 BC023621 mRNA Translation: AAH23621.1 BC026962 mRNA Translation: AAH26962.1 BC057388 mRNA Translation: AAH57388.1 BC063281 mRNA Translation: AAH63281.1 AB209609 mRNA Translation: BAD92846.1 Sequence problems. |
CCDSi | CCDS11189.1 [P36956-1] CCDS32583.1 [P36956-4] |
PIRi | A48845 |
RefSeqi | NP_001005291.1, NM_001005291.2 [P36956-4] NP_004167.3, NM_004176.4 [P36956-1] |
Genome annotation databases
Ensembli | ENST00000261646; ENSP00000261646; ENSG00000072310 [P36956-1] ENST00000355815; ENSP00000348069; ENSG00000072310 [P36956-4] ENST00000395757; ENSP00000379106; ENSG00000072310 [P36956-2] |
GeneIDi | 6720 |
KEGGi | hsa:6720 |
UCSCi | uc002grt.3 human [P36956-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Sterol regulatory element-binding protein entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00968 mRNA Translation: AAC50051.2 S66167 mRNA Translation: AAB28522.2 Different initiation. S66168 mRNA Translation: AAB28523.1 AB373958 mRNA Translation: BAG06742.1 AB373959 mRNA Translation: BAG06743.1 AC122129 Genomic DNA No translation available. CH471196 Genomic DNA Translation: EAW55689.1 CH471196 Genomic DNA Translation: EAW55690.1 BC023621 mRNA Translation: AAH23621.1 BC026962 mRNA Translation: AAH26962.1 BC057388 mRNA Translation: AAH57388.1 BC063281 mRNA Translation: AAH63281.1 AB209609 mRNA Translation: BAD92846.1 Sequence problems. |
CCDSi | CCDS11189.1 [P36956-1] CCDS32583.1 [P36956-4] |
PIRi | A48845 |
RefSeqi | NP_001005291.1, NM_001005291.2 [P36956-4] NP_004167.3, NM_004176.4 [P36956-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AM9 | X-ray | 2.30 | A/B/C/D | 319-400 | [»] | |
SMRi | P36956 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 112598, 66 interactors |
CORUMi | P36956 |
DIPi | DIP-331N |
IntActi | P36956, 24 interactors |
MINTi | P36956 |
STRINGi | 9606.ENSP00000348069 |
Chemistry databases
DrugBanki | DB03756 Doconexent DB13961 Fish oil DB11133 Omega-3 fatty acids DB09539 Omega-3-acid ethyl esters |
PTM databases
iPTMneti | P36956 |
PhosphoSitePlusi | P36956 |
Polymorphism and mutation databases
BioMutai | SREBF1 |
DMDMi | 166897633 |
Proteomic databases
EPDi | P36956 |
jPOSTi | P36956 |
MassIVEi | P36956 |
MaxQBi | P36956 |
PaxDbi | P36956 |
PeptideAtlasi | P36956 |
PRIDEi | P36956 |
ProteomicsDBi | 2552 55244 [P36956-1] 55245 [P36956-2] 55246 [P36956-3] 55247 [P36956-4] |
Genome annotation databases
Ensembli | ENST00000261646; ENSP00000261646; ENSG00000072310 [P36956-1] ENST00000355815; ENSP00000348069; ENSG00000072310 [P36956-4] ENST00000395757; ENSP00000379106; ENSG00000072310 [P36956-2] |
GeneIDi | 6720 |
KEGGi | hsa:6720 |
UCSCi | uc002grt.3 human [P36956-1] |
Organism-specific databases
CTDi | 6720 |
DisGeNETi | 6720 |
GeneCardsi | SREBF1 |
HGNCi | HGNC:11289 SREBF1 |
HPAi | CAB005406 HPA043343 HPA043878 |
MIMi | 184756 gene |
neXtProti | NX_P36956 |
OpenTargetsi | ENSG00000072310 |
PharmGKBi | PA335 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2588 Eukaryota ENOG410XSVP LUCA |
GeneTreei | ENSGT00940000159156 |
HOGENOMi | HOG000007091 |
InParanoidi | P36956 |
KOi | K07197 |
OMAi | IMAGATP |
OrthoDBi | 330300at2759 |
PhylomeDBi | P36956 |
TreeFami | TF313894 |
Enzyme and pathway databases
Reactomei | R-HSA-1368082 RORA activates gene expression R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1989781 PPARA activates gene expression R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-381340 Transcriptional regulation of white adipocyte differentiation [P36956-1] R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis [P36956-3] R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
SignaLinki | P36956 |
SIGNORi | P36956 |
Miscellaneous databases
ChiTaRSi | SREBF1 human |
EvolutionaryTracei | P36956 |
GeneWikii | SREBF1 |
GenomeRNAii | 6720 |
Pharosi | P36956 |
PMAP-CutDBi | P36956 |
PROi | PR:P36956 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072310 Expressed in 188 organ(s), highest expression level in right adrenal gland |
ExpressionAtlasi | P36956 baseline and differential |
Genevisiblei | P36956 HS |
Family and domain databases
CDDi | cd00083 HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010 HLH, 1 hit |
SMARTi | View protein in SMART SM00353 HLH, 1 hit |
SUPFAMi | SSF47459 SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888 BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRBP1_HUMAN | |
Accessioni | P36956Primary (citable) accession number: P36956 Secondary accession number(s): B0I4X3 Q8TAK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | February 5, 2008 | |
Last modified: | November 13, 2019 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references