SREBF1

Functionⁱ

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').By similarity

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA binding Source: UniProtKB
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from direct assayⁱ
- "Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake."
  Yang M., Liu W., Pellicane C., Sahyoun C., Joseph B.K., Gallo-Ebert C., Donigan M., Pandya D., Giordano C., Bata A., Nickels J.T. Jr.
  J. Lipid Res. 55:226-238(2014) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription factor activity
Source: HGNC-UCL
Inferred from direct assayⁱ
- "Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c."
  Costet P., Cariou B., Lambert G., Lalanne F., Lardeux B., Jarnoux A.L., Grefhorst A., Staels B., Krempf M.
  J. Biol. Chem. 281:6211-6218(2006) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
nuclear receptor activity
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- "cAMP-stimulated transcription of DGKtheta requires steroidogenic factor 1 and sterol regulatory element binding protein 1."
  Cai K., Sewer M.B.
  J. Lipid Res. 54:2121-2132(2013) [PubMed] [Europe PMC] [Abstract]
protein-containing complex binding Source: Ensembl
protein dimerization activity Source: InterPro
protein kinase binding Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
RNA polymerase II regulatory region sequence-specific DNA binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- "cAMP-stimulated transcription of DGKtheta requires steroidogenic factor 1 and sterol regulatory element binding protein 1."
  Cai K., Sewer M.B.
  J. Lipid Res. 54:2121-2132(2013) [PubMed] [Europe PMC] [Abstract]
sterol response element binding
Source: HGNC-UCL
Inferred from direct assayⁱ
- "Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c."
  Costet P., Cariou B., Lambert G., Lalanne F., Lardeux B., Jarnoux A.L., Grefhorst A., Staels B., Krempf M.
  J. Biol. Chem. 281:6211-6218(2006) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368082 RORA activates gene expression R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1989781 PPARA activates gene expression R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-381340 Transcriptional regulation of white adipocyte differentiation [P36956-1] R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis [P36956-3] R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
SignaLinkⁱ	P36956
SIGNORⁱ	P36956

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sterol regulatory element-binding protein 1 Short name: SREBP-1 Alternative name(s): Class D basic helix-loop-helix protein 1 Short name: bHLHd1 Sterol regulatory element-binding transcription factor 1 Cleaved into the following chain: Processed sterol regulatory element-binding protein 1
Gene namesⁱ	Name:SREBF1 Synonyms:BHLHD1, SREBP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11289 SREBF1
MIMⁱ	184756 gene
neXtProtⁱ	NX_P36956

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 487	CytoplasmicSequence analysisAdd BLAST	487
Transmembraneⁱ	488 – 508	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	509 – 547	LumenalSequence analysisAdd BLAST	39
Transmembraneⁱ	548 – 568	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	569 – 1147	CytoplasmicSequence analysisAdd BLAST	579

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	455	S → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	456	D → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	457	S → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	460	D → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	466	D → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	481	G → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	482	M → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	483	L → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	484 – 487	DRSR → AS: Strong reduction of proteolytic processing in response to low sterol. 1 Publication	4
Mutagenesisⁱ	484	D → A: Loss of proteolytic processing in response to low sterol. 1 Publication	1
Mutagenesisⁱ	485	R → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	527	R → A: Loss of proteolytic processing in response to low sterol. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6720
Open Targets More...OpenTargetsⁱ	ENSG00000072310
PharmGKBⁱ	PA335

Miscellaneous databases

Pharosⁱ	P36956

Pharosⁱ

P36956

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB03756 Doconexent DB13961 Fish oil DB11133 Omega-3 fatty acids DB09539 Omega-3-acid ethyl esters

DrugBankⁱ

DB03756 Doconexent
DB13961 Fish oil
DB11133 Omega-3 fatty acids
DB09539 Omega-3-acid ethyl esters

Polymorphism and mutation databases

BioMutaⁱ	SREBF1
DMDMⁱ	166897633

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127447	1 – 1147	Sterol regulatory element-binding protein 1Add BLAST		1147
ChainⁱPRO_0000314029	1 – 490	Processed sterol regulatory element-binding protein 1Add BLAST		490

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	98	PhosphoserineBy similarity	1
Modified residueⁱ	117	PhosphoserineCombined sources	1
Modified residueⁱ	337	Phosphoserine; by SIK1By similarity	1
Modified residueⁱ	338	Phosphoserine; by SIK1By similarity	1
Modified residueⁱ	396	Phosphoserine; by AMPKBy similarity	1
Modified residueⁱ	402	Phosphoserine; by SIK1By similarity	1
Modified residueⁱ	457	PhosphoserineBy similarity	1
Modified residueⁱ	1060	PhosphoserineCombined sources	1

Post-translational modificationⁱ

At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.

Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-402 by SIK1 represses activity possibly by inhibiting DNA-binding (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	460 – 461	Cleavage; by caspase-3 and caspase-7By similarity	2
Siteⁱ	490 – 491	Cleavage; by S2PBy similarity	2
Siteⁱ	530 – 531	Cleavage; by S1PCurated	2

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P36956
jPOSTⁱ	P36956
MassIVEⁱ	P36956
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36956
PaxDbⁱ	P36956
PeptideAtlas More...PeptideAtlasⁱ	P36956
PRIDEⁱ	P36956
ProteomicsDBⁱ	2552 55244 [P36956-1] 55245 [P36956-2] 55246 [P36956-3] 55247 [P36956-4]

PTM databases

iPTMnetⁱ	P36956
PhosphoSitePlusⁱ	P36956

Miscellaneous databases

PMAP-CutDBⁱ	P36956

PMAP-CutDBⁱ

P36956

Expressionⁱ

Tissue specificityⁱ

Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.

Gene expression databases

Bgeeⁱ	ENSG00000072310 Expressed in 188 organ(s), highest expression level in right adrenal gland
ExpressionAtlasⁱ	P36956 baseline and differential
Genevisibleⁱ	P36956 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005406 HPA043343 HPA043878

HPAⁱ

CAB005406
HPA043343
HPA043878

Interactionⁱ

Subunit structureⁱ

Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein.

Interacts with LMNA.

Interacts with CEBPA, the interaction produces a transcriptional synergy (By similarity).

By similarity

Binary interactionsⁱ

Entry	#Exp.	IntAct	Notes
Q92793	3	EBI-948328,EBI-81215
P19659	3	EBI-948328,EBI-7305	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
Q96RN5	7	EBI-948328,EBI-394506
Q96EB6	2	EBI-948338,EBI-1802965

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
protein kinase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112598, 66 interactors
CORUMⁱ	P36956
Database of interacting proteins More...DIPⁱ	DIP-331N
IntActⁱ	P36956, 24 interactors
Molecular INTeraction database More...MINTⁱ	P36956
STRINGⁱ	9606.ENSP00000348069

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	321 – 350	Combined sources		30
Helixⁱ	359 – 396	Combined sources		38

Show more details

3D structure databases

SMRⁱ	P36956
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P36956

EvolutionaryTraceⁱ

P36956

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	323 – 373	bHLHPROSITE-ProRule annotationAdd BLAST		51

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 60	Transcriptional activation (acidic)Add BLAST	60
Regionⁱ	234 – 497	Interaction with LMNABy similarityAdd BLAST	264
Regionⁱ	373 – 394	Leucine-zipperAdd BLAST	22

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	27 – 35	9aaTAD1 Publication		9

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	61 – 178	Pro/Ser-richAdd BLAST		118
Compositional biasⁱ	427 – 462	Gly/Pro/Ser-richAdd BLAST		36

Domainⁱ

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

Sequence similaritiesⁱ

Belongs to the SREBP family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2588 Eukaryota ENOG410XSVP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159156
HOGENOMⁱ	HOG000007091
InParanoidⁱ	P36956
KEGG Orthology (KO) More...KOⁱ	K07197
OMAⁱ	IMAGATP
Database of Orthologous Groups More...OrthoDBⁱ	330300at2759
PhylomeDBⁱ	P36956
TreeFamⁱ	TF313894

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform SREBP-1A (identifier: P36956-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP 
        60         70         80         90        100
YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP 
       110        120        130        140        150
QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP 
       160        170        180        190        200
APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS 
       210        220        230        240        250
LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL 
       260        270        280        290        300
LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA 
       310        320        330        340        350
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV 
       360        370        380        390        400
VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL 
       410        420        430        440        450
VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS 
       460        470        480        490        500
GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR GMLDRSRLAL CTLVFLCLSC 
       510        520        530        540        550
NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW AQWLLPPVVW 
       560        570        580        590        600
LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ 
       610        620        630        640        650
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG 
       660        670        680        690        700
GLQQDCALRV DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL 
       710        720        730        740        750
NLAECAGDAV SVATLAEIYV AAALRVKTSL PRALHFLTRF FLSSARQACL 
       760        770        780        790        800
AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL STPWESLYSL AGNPVDPLAQ 
       810        820        830        840        850
VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL QLLNSCSDAA 
       860        870        880        890        900
GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL 
       910        920        930        940        950
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG 
       960        970        980        990       1000
YLQDSLATTP ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT 
      1010       1020       1030       1040       1050
SSRPQASALE LRGFQRDLSS LRRLAQSFRP AMRRVFLHEA TARLMAGASP 
      1060       1070       1080       1090       1100
TRTHQLLDRS LRRRAGPGGK GGAVAELEPR PTRREHAEAL LLASCYLPPG 
      1110       1120       1130       1140 
FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG GTTVTSS

Length:1,147

Mass (Da):121,675

Last modified:February 5, 2008 - v2

Checksum:ⁱ58F28870739FF259

GO

Isoform SREBP-1B (identifier: P36956-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD

« Hide

        10         20         30         40         50
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP 
        60         70         80         90        100
YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP 
       110        120        130        140        150
QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP 
       160        170        180        190        200
APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS 
       210        220        230        240        250
LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL 
       260        270        280        290        300
LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA 
       310        320        330        340        350
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV 
       360        370        380        390        400
VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL 
       410        420        430        440        450
VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS 
       460        470        480        490        500
GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR GMLDRSRLAL CTLVFLCLSC 
       510        520        530        540        550
NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW AQWLLPPVVW 
       560        570        580        590        600
LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ 
       610        620        630        640        650
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG 
       660        670        680        690        700
GLQQDCALRV DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL 
       710        720        730        740        750
NLAECAGDAV SVATLAEIYV AAALRVKTSL PRALHFLTRF FLSSARQACL 
       760        770        780        790        800
AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL STPWESLYSL AGNPVDPLAQ 
       810        820        830        840        850
VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL QLLNSCSDAA 
       860        870        880        890        900
GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL 
       910        920        930        940        950
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG 
       960        970        980        990       1000
YLQDSLATTP ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT 
      1010       1020       1030       1040       1050
SSRPQASALE LRGFQRDLSS LRRLAQSFRP AMRRLMDVLT SESAWALPQH 
      1060       1070 
LGKGFPSPSG HKVPGWHGRM D

Show »

Length:1,071

Mass (Da):113,562

Checksum:ⁱB71B6010CDB8D1ED

GO

Isoform SREBP-1C (identifier: P36956-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD

« Hide

        10         20         30         40         50
MDCTFEDMLQ LINNQDSDFP GLFDPPYAGS GAGGTDPASP DTSSPGSLSP 
        60         70         80         90        100
PPATLSSSLE AFLSGPQAAP SPLSPPQPAP TPLKMYPSMP AFSPGPGIKE 
       110        120        130        140        150
ESVPLSILQT PTPQPLPGAL LPQSFPAPAP PQFSSTPVLG YPSPPGGFST 
       160        170        180        190        200
GSPPGNTQQP LPGLPLASPP GVPPVSLHTQ VQSVVPQQLL TVTAAPTAAP 
       210        220        230        240        250
VTTTVTSQIQ QVPVLLQPHF IKADSLLLTA MKTDGATVKA AGLSPLVSGT 
       260        270        280        290        300
TVQTGPLPTL VSGGTILATV PLVVDAEKLP INRLAAGSKA PASAQSRGEK 
       310        320        330        340        350
RTAHNAIEKR YRSSINDKII ELKDLVVGTE AKLNKSAVLR KAIDYIRFLQ 
       360        370        380        390        400
HSNQKLKQEN LSLRTAVHKS KSLKDLVSAC GSGGNTDVLM EGVKTEVEDT 
       410        420        430        440        450
LTPPPSDAGS PFQSSPLSLG SRGSGSGGSG SDSEPDSPVF EDSKAKPEQR 
       460        470        480        490        500
PSLHSRGMLD RSRLALCTLV FLCLSCNPLA SLLGARGLPS PSDTTSVYHS 
       510        520        530        540        550
PGRNVLGTES RDGPGWAQWL LPPVVWLLNG LLVLVSLVLL FVYGEPVTRP 
       560        570        580        590        600
HSGPAVYFWR HRKQADLDLA RGDFAQAAQQ LWLALRALGR PLPTSHLDLA 
       610        620        630        640        650
CSLLWNLIRH LLQRLWVGRW LAGRAGGLQQ DCALRVDASA SARDAALVYH 
       660        670        680        690        700
KLHQLHTMGK HTGGHLTATN LALSALNLAE CAGDAVSVAT LAEIYVAAAL 
       710        720        730        740        750
RVKTSLPRAL HFLTRFFLSS ARQACLAQSG SVPPAMQWLC HPVGHRFFVD 
       760        770        780        790        800
GDWSVLSTPW ESLYSLAGNP VDPLAQVTQL FREHLLERAL NCVTQPNPSP 
       810        820        830        840        850
GSADGDKEFS DALGYLQLLN SCSDAAGAPA YSFSISSSMA TTTGVDPVAK 
       860        870        880        890        900
WWASLTAVVI HWLRRDEEAA ERLCPLVEHL PRVLQESERP LPRAALHSFK 
       910        920        930        940        950
AARALLGCAK AESGPASLTI CEKASGYLQD SLATTPASSS IDKAVQLFLC 
       960        970        980        990       1000
DLLLVVRTSL WRQQQPPAPA PAAQGTSSRP QASALELRGF QRDLSSLRRL 
      1010       1020       1030       1040 
AQSFRPAMRR LMDVLTSESA WALPQHLGKG FPSPSGHKVP GWHGRMD

Note: Predominantly expressed in liver and adipose tissues.

Show »

Length:1,047

Mass (Da):111,102

Checksum:ⁱ05CF039C7707AFB9

GO

Isoform 4 (identifier: P36956-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
30-30: E → EGEVGAGRGRANGLDAPRAGADRGAMDCTFE

« Hide

        10         20         30         40         50
MDEPPFSEAA LEQALGEPCD LDAALLTDIE GEVGAGRGRA NGLDAPRAGA 
        60         70         80         90        100
DRGAMDCTFE DMLQLINNQD SDFPGLFDPP YAGSGAGGTD PASPDTSSPG 
       110        120        130        140        150
SLSPPPATLS SSLEAFLSGP QAAPSPLSPP QPAPTPLKMY PSMPAFSPGP 
       160        170        180        190        200
GIKEESVPLS ILQTPTPQPL PGALLPQSFP APAPPQFSST PVLGYPSPPG 
       210        220        230        240        250
GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS LHTQVQSVVP QQLLTVTAAP 
       260        270        280        290        300
TAAPVTTTVT SQIQQVPVLL QPHFIKADSL LLTAMKTDGA TVKAAGLSPL 
       310        320        330        340        350
VSGTTVQTGP LPTLVSGGTI LATVPLVVDA EKLPINRLAA GSKAPASAQS 
       360        370        380        390        400
RGEKRTAHNA IEKRYRSSIN DKIIELKDLV VGTEAKLNKS AVLRKAIDYI 
       410        420        430        440        450
RFLQHSNQKL KQENLSLRTA VHKSKSLKDL VSACGSGGNT DVLMEGVKTE 
       460        470        480        490        500
VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK 
       510        520        530        540        550
PEQRPSLHSR GMLDRSRLAL CTLVFLCLSC NPLASLLGAR GLPSPSDTTS 
       560        570        580        590        600
VYHSPGRNVL GTESRDGPGW AQWLLPPVVW LLNGLLVLVS LVLLFVYGEP 
       610        620        630        640        650
VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ AAQQLWLALR ALGRPLPTSH 
       660        670        680        690        700
LDLACSLLWN LIRHLLQRLW VGRWLAGRAG GLQQDCALRV DASASARDAA 
       710        720        730        740        750
LVYHKLHQLH TMGKHTGGHL TATNLALSAL NLAECAGDAV SVATLAEIYV 
       760        770        780        790        800
AAALRVKTSL PRALHFLTRF FLSSARQACL AQSGSVPPAM QWLCHPVGHR 
       810        820        830        840        850
FFVDGDWSVL STPWESLYSL AGNPVDPLAQ VTQLFREHLL ERALNCVTQP 
       860        870        880        890        900
NPSPGSADGD KEFSDALGYL QLLNSCSDAA GAPAYSFSIS SSMATTTGVD 
       910        920        930        940        950
PVAKWWASLT AVVIHWLRRD EEAAERLCPL VEHLPRVLQE SERPLPRAAL 
       960        970        980        990       1000
HSFKAARALL GCAKAESGPA SLTICEKASG YLQDSLATTP ASSSIDKAVQ 
      1010       1020       1030       1040       1050
LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT SSRPQASALE LRGFQRDLSS 
      1060       1070       1080       1090       1100
LRRLAQSFRP AMRRVFLHEA TARLMAGASP TRTHQLLDRS LRRRAGPGGK 
      1110       1120       1130       1140       1150
GGAVAELEPR PTRREHAEAL LLASCYLPPG FLSAPGQRVG MLAEAARTLE 
      1160       1170 
KLGDRRLLHD CQQMLMRLGG GTTVTSS

Note: No experimental confirmation available.

Show »

Length:1,177

Mass (Da):124,635

Checksum:ⁱ1C9257FFC7FC7FEB

GO

Isoform SREBP-1aDelta (identifier: P36956-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
469-470: AK → TE
471-1147: Missing.

« Hide

        10         20         30         40         50
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP 
        60         70         80         90        100
YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP 
       110        120        130        140        150
QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP 
       160        170        180        190        200
APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS 
       210        220        230        240        250
LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL 
       260        270        280        290        300
LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA 
       310        320        330        340        350
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV 
       360        370        380        390        400
VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL 
       410        420        430        440        450
VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS 
       460        470
GGSGSDSEPD SPVFEDSKTE

Note: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.

Show »

Length:470

Mass (Da):48,276

Checksum:ⁱB6BEDC238A020B8F

GO

Isoform SREBP-1cDelta (identifier: P36956-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
     469-470: AK → TE
     471-1147: Missing.

« Hide

        10         20         30         40         50
MDCTFEDMLQ LINNQDSDFP GLFDPPYAGS GAGGTDPASP DTSSPGSLSP 
        60         70         80         90        100
PPATLSSSLE AFLSGPQAAP SPLSPPQPAP TPLKMYPSMP AFSPGPGIKE 
       110        120        130        140        150
ESVPLSILQT PTPQPLPGAL LPQSFPAPAP PQFSSTPVLG YPSPPGGFST 
       160        170        180        190        200
GSPPGNTQQP LPGLPLASPP GVPPVSLHTQ VQSVVPQQLL TVTAAPTAAP 
       210        220        230        240        250
VTTTVTSQIQ QVPVLLQPHF IKADSLLLTA MKTDGATVKA AGLSPLVSGT 
       260        270        280        290        300
TVQTGPLPTL VSGGTILATV PLVVDAEKLP INRLAAGSKA PASAQSRGEK 
       310        320        330        340        350
RTAHNAIEKR YRSSINDKII ELKDLVVGTE AKLNKSAVLR KAIDYIRFLQ 
       360        370        380        390        400
HSNQKLKQEN LSLRTAVHKS KSLKDLVSAC GSGGNTDVLM EGVKTEVEDT 
       410        420        430        440 
LTPPPSDAGS PFQSSPLSLG SRGSGSGGSG SDSEPDSPVF EDSKTE

Note: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.

Show »

Length:446

Mass (Da):45,816

Checksum:ⁱB1C64DDD71DEEDEC

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EMT8	K7EMT8_HUMAN	Sterol regulatory element-binding p... Sterol regulatory element-binding protein 1	SREBF1	110	Annotation score:
B5MD58	B5MD58_HUMAN	Sterol regulatory element-binding p... Sterol regulatory element-binding protein 1	SREBF1	893	Annotation score:
F6V242	F6V242_HUMAN	Sterol regulatory element-binding p... Sterol regulatory element-binding protein 1	SREBF1	325	Annotation score:
S4R3B4	S4R3B4_HUMAN	Sterol regulatory element-binding p... Sterol regulatory element-binding protein 1	SREBF1	113	Annotation score:
K7EIW8	K7EIW8_HUMAN	Sterol regulatory element-binding p... Sterol regulatory element-binding protein 1	SREBF1	163	Annotation score:
K7EKR7	K7EKR7_HUMAN	Sterol regulatory element-binding p... Sterol regulatory element-binding protein 1	SREBF1	31	Annotation score:
K7EMD1	K7EMD1_HUMAN	Sterol regulatory element-binding p... Sterol regulatory element-binding protein 1	SREBF1	157	Annotation score:
J3QLB6	J3QLB6_HUMAN	Sterol regulatory element-binding p... Sterol regulatory element-binding protein 1	SREBF1	72	Annotation score:

Sequence cautionⁱ

The sequence AAB28522 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

The sequence BAD92846 differs from that shown. Intron retention.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_038468	306	N → S1 PublicationCorresponds to variant dbSNP:rs17855793Ensembl.	1
Natural variantⁱVAR_038469	309	A → T. Corresponds to variant dbSNP:rs35188700Ensembl.	1
Natural variantⁱVAR_038470	417	V → M. Corresponds to variant dbSNP:rs2229590Ensembl.	1
Natural variantⁱVAR_038471	580	V → M. Corresponds to variant dbSNP:rs36215896Ensembl.	1
Natural variantⁱVAR_038472	746	R → H. Corresponds to variant dbSNP:rs2228461Ensembl.	1
Natural variantⁱVAR_038473	834	S → L1 PublicationCorresponds to variant dbSNP:rs17855792Ensembl.	1
Natural variantⁱVAR_038474	1000	T → A2 PublicationsCorresponds to variant dbSNP:rs1042017Ensembl.	1
Natural variantⁱVAR_038475	1008	A → P. Corresponds to variant dbSNP:rs35014224Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002149	1 – 29	MDEPP…LLTDI → MDCTF in isoform SREBP-1C and isoform SREBP-1cDelta. 2 PublicationsAdd BLAST	29
Alternative sequenceⁱVSP_030859	30	E → EGEVGAGRGRANGLDAPRAG ADRGAMDCTFE in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_047598	469 – 470	AK → TE in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 Publication	2
Alternative sequenceⁱVSP_047599	471 – 1147	Missing in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 PublicationAdd BLAST	677
Alternative sequenceⁱVSP_002150	1035 – 1147	VFLHE…TVTSS → LMDVLTSESAWALPQHLGKG FPSPSGHKVPGWHGRMD in isoform SREBP-1B and isoform SREBP-1C. 1 PublicationAdd BLAST	113

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00968 mRNA Translation: AAC50051.2 S66167 mRNA Translation: AAB28522.2 Different initiation. S66168 mRNA Translation: AAB28523.1 AB373958 mRNA Translation: BAG06742.1 AB373959 mRNA Translation: BAG06743.1 AC122129 Genomic DNA No translation available. CH471196 Genomic DNA Translation: EAW55689.1 CH471196 Genomic DNA Translation: EAW55690.1 BC023621 mRNA Translation: AAH23621.1 BC026962 mRNA Translation: AAH26962.1 BC057388 mRNA Translation: AAH57388.1 BC063281 mRNA Translation: AAH63281.1 AB209609 mRNA Translation: BAD92846.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11189.1 [P36956-1] CCDS32583.1 [P36956-4]
PIRⁱ	A48845
NCBI Reference Sequences More...RefSeqⁱ	NP_001005291.1, NM_001005291.2 [P36956-4] NP_004167.3, NM_004176.4 [P36956-1]

Genome annotation databases

Ensemblⁱ	ENST00000261646; ENSP00000261646; ENSG00000072310 [P36956-1] ENST00000355815; ENSP00000348069; ENSG00000072310 [P36956-4] ENST00000395757; ENSP00000379106; ENSG00000072310 [P36956-2]
GeneIDⁱ	6720
KEGGⁱ	hsa:6720
UCSC genome browser More...UCSCⁱ	uc002grt.3 human [P36956-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P36956-4	Sterol regulatory element-binding protein 1		HUMAN		893	UniRef100_B5MD58
UPI0000E59E67		HUMAN		1123
UPI00024CD410		HUMAN		666
P36956-5	SREBF1 isoform 4		PANTR		216	UniRef100_P36956-5
BHLH domain-containing protein		PANPA		216

Protein	Similar proteins		Species	Score	Length	Source
P36956	BHLH domain-containing protein		Cebus capucinus imitator		1185	UniRef90_P36956
BHLH domain-containing protein		MACFA		1177
SREBF1 isoform 6		PANTR		1177
Sterol regulatory element binding transcription factor 1		GORGO		1177
BHLH domain-containing protein		MACNE		1177
+93
P36956-5	SREBF1 isoform 4		PANTR		216	UniRef90_P36956-5
BHLH domain-containing protein		PANPA		216
Isoform SREBP-1cDelta of Sterol regulatory element-binding protein 1		HUMAN		446

Protein	Similar proteins		Species	Score	Length	Source
P36956	BHLH domain-containing protein		Cebus capucinus imitator		1185	UniRef50_P36956
SREBF1 isoform 2		PONAB		1177
Sterol regulatory element binding transcription factor 1		PANTR		1177
Sterol regulatory element binding transcription factor 1		GORGO		1177
BHLH domain-containing protein		RHIRO		1177
+120
P36956-5	SREBF1 isoform 4		PANTR		216	UniRef50_P36956-5
BHLH domain-containing protein		PANPA		216
Isoform SREBP-1cDelta of Sterol regulatory element-binding protein 1		HUMAN		446
Sterol regulatory element binding transcription factor 1 (Fragment)		NEOVI		446
Sterol regulatory element binding transcription factor 1 (Fragment)		CAPHI		449
+1

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Sterol regulatory element-binding protein entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00968 mRNA Translation: AAC50051.2 S66167 mRNA Translation: AAB28522.2 Different initiation. S66168 mRNA Translation: AAB28523.1 AB373958 mRNA Translation: BAG06742.1 AB373959 mRNA Translation: BAG06743.1 AC122129 Genomic DNA No translation available. CH471196 Genomic DNA Translation: EAW55689.1 CH471196 Genomic DNA Translation: EAW55690.1 BC023621 mRNA Translation: AAH23621.1 BC026962 mRNA Translation: AAH26962.1 BC057388 mRNA Translation: AAH57388.1 BC063281 mRNA Translation: AAH63281.1 AB209609 mRNA Translation: BAD92846.1 Sequence problems.
CCDSⁱ	CCDS11189.1 [P36956-1] CCDS32583.1 [P36956-4]
PIRⁱ	A48845
RefSeqⁱ	NP_001005291.1, NM_001005291.2 [P36956-4] NP_004167.3, NM_004176.4 [P36956-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AM9	X-ray	2.30	A/B/C/D	319-400	[»]
SMRⁱ	P36956
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112598, 66 interactors
CORUMⁱ	P36956
DIPⁱ	DIP-331N
IntActⁱ	P36956, 24 interactors
MINTⁱ	P36956
STRINGⁱ	9606.ENSP00000348069

Chemistry databases

DrugBankⁱ	DB03756 Doconexent DB13961 Fish oil DB11133 Omega-3 fatty acids DB09539 Omega-3-acid ethyl esters

DrugBankⁱ

DB03756 Doconexent
DB13961 Fish oil
DB11133 Omega-3 fatty acids
DB09539 Omega-3-acid ethyl esters

PTM databases

iPTMnetⁱ	P36956
PhosphoSitePlusⁱ	P36956

Polymorphism and mutation databases

BioMutaⁱ	SREBF1
DMDMⁱ	166897633

Proteomic databases

EPDⁱ	P36956
jPOSTⁱ	P36956
MassIVEⁱ	P36956
MaxQBⁱ	P36956
PaxDbⁱ	P36956
PeptideAtlasⁱ	P36956
PRIDEⁱ	P36956
ProteomicsDBⁱ	2552 55244 [P36956-1] 55245 [P36956-2] 55246 [P36956-3] 55247 [P36956-4]

Genome annotation databases

Ensemblⁱ	ENST00000261646; ENSP00000261646; ENSG00000072310 [P36956-1] ENST00000355815; ENSP00000348069; ENSG00000072310 [P36956-4] ENST00000395757; ENSP00000379106; ENSG00000072310 [P36956-2]
GeneIDⁱ	6720
KEGGⁱ	hsa:6720
UCSCⁱ	uc002grt.3 human [P36956-1]

Organism-specific databases

CTDⁱ	6720
DisGeNETⁱ	6720
GeneCardsⁱ	SREBF1
HGNCⁱ	HGNC:11289 SREBF1
HPAⁱ	CAB005406 HPA043343 HPA043878
MIMⁱ	184756 gene
neXtProtⁱ	NX_P36956
OpenTargetsⁱ	ENSG00000072310
PharmGKBⁱ	PA335
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2588 Eukaryota ENOG410XSVP LUCA
GeneTreeⁱ	ENSGT00940000159156
HOGENOMⁱ	HOG000007091
InParanoidⁱ	P36956
KOⁱ	K07197
OMAⁱ	IMAGATP
OrthoDBⁱ	330300at2759
PhylomeDBⁱ	P36956
TreeFamⁱ	TF313894

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368082 RORA activates gene expression R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1989781 PPARA activates gene expression R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-381340 Transcriptional regulation of white adipocyte differentiation [P36956-1] R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis [P36956-3] R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
SignaLinkⁱ	P36956
SIGNORⁱ	P36956

Miscellaneous databases

ChiTaRSⁱ	SREBF1 human
EvolutionaryTraceⁱ	P36956
GeneWikiⁱ	SREBF1
GenomeRNAiⁱ	6720
Pharosⁱ	P36956
PMAP-CutDBⁱ	P36956
Protein Ontology More...PROⁱ	PR:P36956
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000072310 Expressed in 188 organ(s), highest expression level in right adrenal gland
ExpressionAtlasⁱ	P36956 baseline and differential
Genevisibleⁱ	P36956 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRBP1_HUMAN
Accessionⁱ	P36956Primary (citable) accession number: P36956 Secondary accession number(s): B0I4X3 Q8TAK9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	February 5, 2008
	Last modified:	November 13, 2019
	This is version 208 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P36956 (SRBP1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Sterol regulatory element-binding protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Other locations

Nucleus

Nucleus

Nucleus

Cytosol

Endoplasmic reticulum

Golgi apparatus

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ