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Protein

Sterol regulatory element-binding protein 1

Gene

SREBF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1368082 RORA activates gene expression
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P36956

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P36956

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sterol regulatory element-binding protein 1
Short name:
SREBP-1
Alternative name(s):
Class D basic helix-loop-helix protein 1
Short name:
bHLHd1
Sterol regulatory element-binding transcription factor 1
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SREBF1
Synonyms:BHLHD1, SREBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000072310.16

Human Gene Nomenclature Database

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HGNCi
HGNC:11289 SREBF1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
184756 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P36956

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 487CytoplasmicSequence analysisAdd BLAST487
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 547LumenalSequence analysisAdd BLAST39
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 1147CytoplasmicSequence analysisAdd BLAST579

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi455S → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi456D → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi457S → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi460D → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi466D → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi481G → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi482M → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi483L → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi484 – 487DRSR → AS: Strong reduction of proteolytic processing in response to low sterol. 1 Publication4
Mutagenesisi484D → A: Loss of proteolytic processing in response to low sterol. 1 Publication1
Mutagenesisi485R → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi527R → A: Loss of proteolytic processing in response to low sterol. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6720

Open Targets

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OpenTargetsi
ENSG00000072310

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA335

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SREBF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166897633

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001274471 – 1147Sterol regulatory element-binding protein 1Add BLAST1147
ChainiPRO_00003140291 – 490Processed sterol regulatory element-binding protein 1Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei98PhosphoserineBy similarity1
Modified residuei117PhosphoserineCombined sources1
Modified residuei337Phosphoserine; by SIK1By similarity1
Modified residuei338Phosphoserine; by SIK1By similarity1
Modified residuei396Phosphoserine; by AMPKBy similarity1
Modified residuei402Phosphoserine; by SIK1By similarity1
Modified residuei457PhosphoserineBy similarity1
Modified residuei1060PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-402 by SIK1 represses activity possibly by inhibiting DNA-binding (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei460 – 461Cleavage; by caspase-3 and caspase-7By similarity2
Sitei490 – 491Cleavage; by S2PBy similarity2
Sitei530 – 531Cleavage; by S1PCurated2

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P36956

MaxQB - The MaxQuant DataBase

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MaxQBi
P36956

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P36956

PeptideAtlas

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PeptideAtlasi
P36956

PRoteomics IDEntifications database

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PRIDEi
P36956

ProteomicsDB human proteome resource

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ProteomicsDBi
55244
55245 [P36956-2]
55246 [P36956-3]
55247 [P36956-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36956

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P36956

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P36956

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000072310 Expressed in 188 organ(s), highest expression level in right adrenal gland

CleanEx database of gene expression profiles

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CleanExi
HS_SREBF1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P36956 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P36956 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005406
HPA043343
HPA043878

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Interacts with CEBPA, the interaction produces a transcriptional synergy (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112598, 65 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P36956

Database of interacting proteins

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DIPi
DIP-331N

Protein interaction database and analysis system

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IntActi
P36956, 22 interactors

Molecular INTeraction database

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MINTi
P36956

STRING: functional protein association networks

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STRINGi
9606.ENSP00000348069

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P36956

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P36956

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P36956

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini323 – 373bHLHPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60Transcriptional activation (acidic)Add BLAST60
Regioni234 – 497Interaction with LMNABy similarityAdd BLAST264
Regioni373 – 394Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi61 – 178Pro/Ser-richAdd BLAST118
Compositional biasi427 – 462Gly/Pro/Ser-richAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SREBP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2588 Eukaryota
ENOG410XSVP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159156

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007091

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG061592

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P36956

KEGG Orthology (KO)

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KOi
K07197

Identification of Orthologs from Complete Genome Data

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OMAi
LHQLHMT

Database of Orthologous Groups

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OrthoDBi
EOG091G01RE

Database for complete collections of gene phylogenies

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PhylomeDBi
P36956

TreeFam database of animal gene trees

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TreeFami
TF313894

Family and domain databases

Conserved Domains Database

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CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf

The PANTHER Classification System

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PANTHERi
PTHR12565 PTHR12565, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform SREBP-1A (identifier: P36956-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP
60 70 80 90 100
YAGSGAGGTD PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP
110 120 130 140 150
QPAPTPLKMY PSMPAFSPGP GIKEESVPLS ILQTPTPQPL PGALLPQSFP
160 170 180 190 200
APAPPQFSST PVLGYPSPPG GFSTGSPPGN TQQPLPGLPL ASPPGVPPVS
210 220 230 240 250
LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL QPHFIKADSL
260 270 280 290 300
LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
310 320 330 340 350
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV
360 370 380 390 400
VGTEAKLNKS AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL
410 420 430 440 450
VSACGSGGNT DVLMEGVKTE VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS
460 470 480 490 500
GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR GMLDRSRLAL CTLVFLCLSC
510 520 530 540 550
NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW AQWLLPPVVW
560 570 580 590 600
LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
610 620 630 640 650
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG
660 670 680 690 700
GLQQDCALRV DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL
710 720 730 740 750
NLAECAGDAV SVATLAEIYV AAALRVKTSL PRALHFLTRF FLSSARQACL
760 770 780 790 800
AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL STPWESLYSL AGNPVDPLAQ
810 820 830 840 850
VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL QLLNSCSDAA
860 870 880 890 900
GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
910 920 930 940 950
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG
960 970 980 990 1000
YLQDSLATTP ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT
1010 1020 1030 1040 1050
SSRPQASALE LRGFQRDLSS LRRLAQSFRP AMRRVFLHEA TARLMAGASP
1060 1070 1080 1090 1100
TRTHQLLDRS LRRRAGPGGK GGAVAELEPR PTRREHAEAL LLASCYLPPG
1110 1120 1130 1140
FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG GTTVTSS
Length:1,147
Mass (Da):121,675
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58F28870739FF259
GO
Isoform SREBP-1B (identifier: P36956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD

Show »
Length:1,071
Mass (Da):113,562
Checksum:iB71B6010CDB8D1ED
GO
Isoform SREBP-1C (identifier: P36956-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
     1035-1147: VFLHEATARL...LGGGTTVTSS → LMDVLTSESA...KVPGWHGRMD

Note: Predominantly expressed in liver and adipose tissues.
Show »
Length:1,047
Mass (Da):111,102
Checksum:i05CF039C7707AFB9
GO
Isoform 4 (identifier: P36956-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: E → EGEVGAGRGRANGLDAPRAGADRGAMDCTFE

Note: No experimental confirmation available.
Show »
Length:1,177
Mass (Da):124,635
Checksum:i1C9257FFC7FC7FEB
GO
Isoform SREBP-1aDelta (identifier: P36956-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     469-470: AK → TE
     471-1147: Missing.

Note: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.
Show »
Length:470
Mass (Da):48,276
Checksum:iB6BEDC238A020B8F
GO
Isoform SREBP-1cDelta (identifier: P36956-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MDEPPFSEAALEQALGEPCDLDAALLTDI → MDCTF
     469-470: AK → TE
     471-1147: Missing.

Note: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.
Show »
Length:446
Mass (Da):45,816
Checksum:iB1C64DDD71DEEDEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMT8K7EMT8_HUMAN
Sterol regulatory element-binding p...
SREBF1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MD58B5MD58_HUMAN
Sterol regulatory element-binding p...
SREBF1
893Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RBE4X6RBE4_HUMAN
Sterol regulatory element-binding p...
SREBF1
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V242F6V242_HUMAN
Sterol regulatory element-binding p...
SREBF1
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIW8K7EIW8_HUMAN
Sterol regulatory element-binding p...
SREBF1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3B4S4R3B4_HUMAN
Sterol regulatory element-binding p...
SREBF1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLB6J3QLB6_HUMAN
Sterol regulatory element-binding p...
SREBF1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMD1K7EMD1_HUMAN
Sterol regulatory element-binding p...
SREBF1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKR7K7EKR7_HUMAN
Sterol regulatory element-binding p...
SREBF1
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB28522 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD92846 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038468306N → S1 PublicationCorresponds to variant dbSNP:rs17855793Ensembl.1
Natural variantiVAR_038469309A → T. Corresponds to variant dbSNP:rs35188700Ensembl.1
Natural variantiVAR_038470417V → M. Corresponds to variant dbSNP:rs2229590Ensembl.1
Natural variantiVAR_038471580V → M. Corresponds to variant dbSNP:rs36215896Ensembl.1
Natural variantiVAR_038472746R → H. Corresponds to variant dbSNP:rs2228461Ensembl.1
Natural variantiVAR_038473834S → L1 PublicationCorresponds to variant dbSNP:rs17855792Ensembl.1
Natural variantiVAR_0384741000T → A2 PublicationsCorresponds to variant dbSNP:rs1042017Ensembl.1
Natural variantiVAR_0384751008A → P. Corresponds to variant dbSNP:rs35014224Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0021491 – 29MDEPP…LLTDI → MDCTF in isoform SREBP-1C and isoform SREBP-1cDelta. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_03085930E → EGEVGAGRGRANGLDAPRAG ADRGAMDCTFE in isoform 4. 1 Publication1
Alternative sequenceiVSP_047598469 – 470AK → TE in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 Publication2
Alternative sequenceiVSP_047599471 – 1147Missing in isoform SREBP-1aDelta and isoform SREBP-1cDelta. 1 PublicationAdd BLAST677
Alternative sequenceiVSP_0021501035 – 1147VFLHE…TVTSS → LMDVLTSESAWALPQHLGKG FPSPSGHKVPGWHGRMD in isoform SREBP-1B and isoform SREBP-1C. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00968 mRNA Translation: AAC50051.2
S66167 mRNA Translation: AAB28522.2 Different initiation.
S66168 mRNA Translation: AAB28523.1
AB373958 mRNA Translation: BAG06742.1
AB373959 mRNA Translation: BAG06743.1
AC122129 Genomic DNA No translation available.
CH471196 Genomic DNA Translation: EAW55689.1
CH471196 Genomic DNA Translation: EAW55690.1
BC023621 mRNA Translation: AAH23621.1
BC026962 mRNA Translation: AAH26962.1
BC057388 mRNA Translation: AAH57388.1
BC063281 mRNA Translation: AAH63281.1
AB209609 mRNA Translation: BAD92846.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11189.1 [P36956-1]
CCDS32583.1 [P36956-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A48845

NCBI Reference Sequences

More...
RefSeqi
NP_001005291.1, NM_001005291.2 [P36956-4]
NP_004167.3, NM_004176.4 [P36956-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.592123
Hs.733635

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261646; ENSP00000261646; ENSG00000072310 [P36956-1]
ENST00000355815; ENSP00000348069; ENSG00000072310 [P36956-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6720

UCSC genome browser

More...
UCSCi
uc002grt.3 human [P36956-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Sterol regulatory element-binding protein entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00968 mRNA Translation: AAC50051.2
S66167 mRNA Translation: AAB28522.2 Different initiation.
S66168 mRNA Translation: AAB28523.1
AB373958 mRNA Translation: BAG06742.1
AB373959 mRNA Translation: BAG06743.1
AC122129 Genomic DNA No translation available.
CH471196 Genomic DNA Translation: EAW55689.1
CH471196 Genomic DNA Translation: EAW55690.1
BC023621 mRNA Translation: AAH23621.1
BC026962 mRNA Translation: AAH26962.1
BC057388 mRNA Translation: AAH57388.1
BC063281 mRNA Translation: AAH63281.1
AB209609 mRNA Translation: BAD92846.1 Sequence problems.
CCDSiCCDS11189.1 [P36956-1]
CCDS32583.1 [P36956-4]
PIRiA48845
RefSeqiNP_001005291.1, NM_001005291.2 [P36956-4]
NP_004167.3, NM_004176.4 [P36956-1]
UniGeneiHs.592123
Hs.733635

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AM9X-ray2.30A/B/C/D319-400[»]
ProteinModelPortaliP36956
SMRiP36956
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112598, 65 interactors
CORUMiP36956
DIPiDIP-331N
IntActiP36956, 22 interactors
MINTiP36956
STRINGi9606.ENSP00000348069

PTM databases

iPTMnetiP36956
PhosphoSitePlusiP36956

Polymorphism and mutation databases

BioMutaiSREBF1
DMDMi166897633

Proteomic databases

EPDiP36956
MaxQBiP36956
PaxDbiP36956
PeptideAtlasiP36956
PRIDEiP36956
ProteomicsDBi55244
55245 [P36956-2]
55246 [P36956-3]
55247 [P36956-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261646; ENSP00000261646; ENSG00000072310 [P36956-1]
ENST00000355815; ENSP00000348069; ENSG00000072310 [P36956-4]
GeneIDi6720
KEGGihsa:6720
UCSCiuc002grt.3 human [P36956-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6720
DisGeNETi6720
EuPathDBiHostDB:ENSG00000072310.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SREBF1
HGNCiHGNC:11289 SREBF1
HPAiCAB005406
HPA043343
HPA043878
MIMi184756 gene
neXtProtiNX_P36956
OpenTargetsiENSG00000072310
PharmGKBiPA335

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2588 Eukaryota
ENOG410XSVP LUCA
GeneTreeiENSGT00940000159156
HOGENOMiHOG000007091
HOVERGENiHBG061592
InParanoidiP36956
KOiK07197
OMAiLHQLHMT
OrthoDBiEOG091G01RE
PhylomeDBiP36956
TreeFamiTF313894

Enzyme and pathway databases

ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-1989781 PPARA activates gene expression
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkiP36956
SIGNORiP36956

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SREBF1 human
EvolutionaryTraceiP36956

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SREBF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6720
PMAP-CutDBiP36956

Protein Ontology

More...
PROi
PR:P36956

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000072310 Expressed in 188 organ(s), highest expression level in right adrenal gland
CleanExiHS_SREBF1
ExpressionAtlasiP36956 baseline and differential
GenevisibleiP36956 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR12565 PTHR12565, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRBP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36956
Secondary accession number(s): B0I4X3
, B0I4X4, D3DXC4, Q16062, Q59F52, Q6P4R7, Q6PFW7, Q6PJ36, Q8TAK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 5, 2008
Last modified: December 5, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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