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Protein

Serpin B5

Gene

SERPINB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei340 – 341Reactive bond homologBy similarity2

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SIGNORiP36952

Protein family/group databases

MEROPSiI04.980

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B5
Alternative name(s):
Maspin
Peptidase inhibitor 5
Short name:
PI-5
Gene namesi
Name:SERPINB5
Synonyms:PI5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000206075.13
HGNCiHGNC:8949 SERPINB5
MIMi154790 gene
neXtProtiNX_P36952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5268
OpenTargetsiENSG00000206075
PharmGKBiPA35515

Polymorphism and mutation databases

BioMutaiSERPINB5
DMDMi229462757

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000324861 – 375Serpin B5Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP36952
MaxQBiP36952
PaxDbiP36952
PeptideAtlasiP36952
PRIDEiP36952
ProteomicsDBi55240
55241 [P36952-2]
TopDownProteomicsiP36952-1 [P36952-1]

PTM databases

iPTMnetiP36952
PhosphoSitePlusiP36952

Expressioni

Tissue specificityi

Normal mammary epithelial cells.

Gene expression databases

BgeeiENSG00000206075 Expressed in 122 organ(s), highest expression level in squamous epithelium
CleanExiHS_SERPINB5
ExpressionAtlasiP36952 baseline and differential
GenevisibleiP36952 HS

Organism-specific databases

HPAiCAB009570
HPA019025
HPA019132
HPA020136

Interactioni

Subunit structurei

Interacts with IRF6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRSS21Q9Y6M07EBI-2371394,EBI-7054564

Protein-protein interaction databases

BioGridi111286, 104 interactors
IntActiP36952, 13 interactors
MINTiP36952
STRINGi9606.ENSP00000372221

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP36952
SMRiP36952
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36952

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP36952
KOiK10139
OMAiIHRVCLE
OrthoDBiEOG091G0ION
PhylomeDBiP36952
TreeFamiTF352619

Family and domain databases

CDDicd02057 maspin_like, 1 hit
InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR033836 SERPINB5
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: P36952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT
60 70 80 90 100
ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL
110 120 130 140 150
STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD
160 170 180 190 200
NSVNDQTKIL VVNAAYFVGK WMKKFSESET KECPFRVNKT DTKPVQMMNM
210 220 230 240 250
EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL
260 270 280 290 300
NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED
310 320 330 340 350
TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA
360 370
DHPFIYIIRH NKTRNIIFFG KFCSP
Length:375
Mass (Da):42,100
Last modified:May 5, 2009 - v2
Checksum:i9F24E18505912804
GO
Isoform 2 (identifier: P36952-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-231: TDTKPVQMMN...QNKHLSMFIL → VCGAACSSKR...LRARPAKCLS
     232-375: Missing.

Show »
Length:231
Mass (Da):25,763
Checksum:i62DF767BBA9B5471
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JLM5C9JLM5_HUMAN
Serpin B5
SERPINB5
129Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66V → I in AAA18957 (PubMed:8290962).Curated1
Sequence conflicti245K → Q in CAE45703 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055223176S → PCombined sources3 PublicationsCorresponds to variant dbSNP:rs2289519Ensembl.1
Natural variantiVAR_055224187V → L1 PublicationCorresponds to variant dbSNP:rs2289520Ensembl.1
Natural variantiVAR_022115319I → V1 PublicationCorresponds to variant dbSNP:rs1455555Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037145190 – 231TDTKP…SMFIL → VCGAACSSKRSPIIDVKNDR DRVGHKSIPMRNLRARPAKC LS in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_037146232 – 375Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04313 mRNA Translation: AAA18957.1
AK312765 mRNA Translation: BAG35631.1
AC036176 Genomic DNA No translation available.
BC020713 mRNA Translation: AAH20713.1
BX640597 mRNA Translation: CAE45703.1
CCDSiCCDS32839.1 [P36952-1]
PIRiA36898
RefSeqiNP_002630.2, NM_002639.4 [P36952-1]
UniGeneiHs.55279

Genome annotation databases

EnsembliENST00000382771; ENSP00000372221; ENSG00000206075 [P36952-1]
ENST00000489441; ENSP00000467158; ENSG00000206075 [P36952-2]
GeneIDi5268
KEGGihsa:5268
UCSCiuc002liy.3 human [P36952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04313 mRNA Translation: AAA18957.1
AK312765 mRNA Translation: BAG35631.1
AC036176 Genomic DNA No translation available.
BC020713 mRNA Translation: AAH20713.1
BX640597 mRNA Translation: CAE45703.1
CCDSiCCDS32839.1 [P36952-1]
PIRiA36898
RefSeqiNP_002630.2, NM_002639.4 [P36952-1]
UniGeneiHs.55279

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WZ9X-ray2.10A/B1-375[»]
1XQGX-ray3.10A/B1-375[»]
1XQJX-ray3.10A1-375[»]
1XU8X-ray2.80A/B1-375[»]
ProteinModelPortaliP36952
SMRiP36952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111286, 104 interactors
IntActiP36952, 13 interactors
MINTiP36952
STRINGi9606.ENSP00000372221

Protein family/group databases

MEROPSiI04.980

PTM databases

iPTMnetiP36952
PhosphoSitePlusiP36952

Polymorphism and mutation databases

BioMutaiSERPINB5
DMDMi229462757

Proteomic databases

EPDiP36952
MaxQBiP36952
PaxDbiP36952
PeptideAtlasiP36952
PRIDEiP36952
ProteomicsDBi55240
55241 [P36952-2]
TopDownProteomicsiP36952-1 [P36952-1]

Protocols and materials databases

DNASUi5268
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382771; ENSP00000372221; ENSG00000206075 [P36952-1]
ENST00000489441; ENSP00000467158; ENSG00000206075 [P36952-2]
GeneIDi5268
KEGGihsa:5268
UCSCiuc002liy.3 human [P36952-1]

Organism-specific databases

CTDi5268
DisGeNETi5268
EuPathDBiHostDB:ENSG00000206075.13
GeneCardsiSERPINB5
H-InvDBiHIX0014501
HGNCiHGNC:8949 SERPINB5
HPAiCAB009570
HPA019025
HPA019132
HPA020136
MIMi154790 gene
neXtProtiNX_P36952
OpenTargetsiENSG00000206075
PharmGKBiPA35515
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP36952
KOiK10139
OMAiIHRVCLE
OrthoDBiEOG091G0ION
PhylomeDBiP36952
TreeFamiTF352619

Enzyme and pathway databases

SIGNORiP36952

Miscellaneous databases

ChiTaRSiSERPINB5 human
EvolutionaryTraceiP36952
GeneWikiiMaspin
GenomeRNAii5268
PROiPR:P36952
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206075 Expressed in 122 organ(s), highest expression level in squamous epithelium
CleanExiHS_SERPINB5
ExpressionAtlasiP36952 baseline and differential
GenevisibleiP36952 HS

Family and domain databases

CDDicd02057 maspin_like, 1 hit
InterProiView protein in InterPro
IPR000240 Serpin_B9/Maspin
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR033836 SERPINB5
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
PRINTSiPR00676 MASPIN
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB5_HUMAN
AccessioniPrimary (citable) accession number: P36952
Secondary accession number(s): B2R6Y4, Q6N0B4, Q8WW89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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