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UniProtKB - P36938 (PGM_ECOLI)
Protein
Phosphoglucomutase
Gene
pgm
Organism
Escherichia coli (strain K12)
Status
Functioni
This enzyme participates in both the breakdown and synthesis of glucose.
1 PublicationCatalytic activityi
- EC:5.4.2.21 Publication
Cofactori
Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication
Kineticsi
- KM=50 µM for D-glucose-1-phosphate1 Publication
pH dependencei
Optimum pH is 9.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 146 | Phosphoserine intermediateBy similarity | 1 | |
Metal bindingi | 146 | Magnesium; via phosphate groupBy similarity | 1 | |
Binding sitei | 156 | SubstrateBy similarity | 1 | |
Metal bindingi | 304 | MagnesiumBy similarity | 1 | |
Metal bindingi | 306 | MagnesiumBy similarity | 1 | |
Metal bindingi | 308 | MagnesiumBy similarity | 1 | |
Binding sitei | 409 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- magnesium ion binding Source: InterPro
- phosphoglucomutase activity Source: EcoCyc
GO - Biological processi
- carbohydrate metabolic process Source: GO_Central
- glucose metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:PHOSPHOGLUCMUT-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoglucomutase (EC:5.4.2.2)Short name: PGM Alternative name(s): Glucose phosphomutase |
Gene namesi | Name:pgm Ordered Locus Names:b0688, JW0675 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: EcoCyc
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000147809 | 1 – 546 | PhosphoglucomutaseAdd BLAST | 546 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P36938 |
PaxDbi | P36938 |
PRIDEi | P36938 |
Interactioni
Binary interactionsi
P36938
With | #Exp. | IntAct |
---|---|---|
ghrB [P37666] | 2 | EBI-542427,EBI-562547 |
Protein-protein interaction databases
BioGRIDi | 4261910, 31 interactors 849650, 1 interactor |
DIPi | DIP-10472N |
IntActi | P36938, 9 interactors |
STRINGi | 511145.b0688 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 146 – 147 | Substrate bindingBy similarity | 2 | |
Regioni | 308 – 309 | Substrate bindingBy similarity | 2 | |
Regioni | 390 – 392 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the phosphohexose mutase family.Curated
Phylogenomic databases
eggNOGi | COG0033, Bacteria |
HOGENOMi | CLU_016950_8_1_6 |
InParanoidi | P36938 |
PhylomeDBi | P36938 |
Family and domain databases
CDDi | cd05801, PGM_like3, 1 hit |
InterProi | View protein in InterPro IPR005844, A-D-PHexomutase_a/b/a-I IPR016055, A-D-PHexomutase_a/b/a-I/II/III IPR005845, A-D-PHexomutase_a/b/a-II IPR005846, A-D-PHexomutase_a/b/a-III IPR005843, A-D-PHexomutase_C IPR036900, A-D-PHexomutase_C_sf IPR016066, A-D-PHexomutase_CS IPR045244, PGM IPR005852, PGM_a-D-Glc-sp |
PANTHERi | PTHR22573, PTHR22573, 1 hit |
Pfami | View protein in Pfam PF02878, PGM_PMM_I, 1 hit PF02879, PGM_PMM_II, 1 hit PF02880, PGM_PMM_III, 1 hit PF00408, PGM_PMM_IV, 1 hit |
SUPFAMi | SSF53738, SSF53738, 3 hits SSF55957, SSF55957, 1 hit |
TIGRFAMsi | TIGR01132, pgm, 1 hit |
PROSITEi | View protein in PROSITE PS00710, PGM_PMM, 1 hit |
i Sequence
Sequence statusi: Complete.
P36938-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIHNRAGQP AQQSDLINVA QLTAQYYVLK PEAGNAEHAV KFGTSGHRGS
60 70 80 90 100
AARHSFNEPH ILAIAQAIAE ERAKNGITGP CYVGKDTHAL SEPAFISVLE
110 120 130 140 150
VLAANGVDVI VQENNGFTPT PAVSNAILVH NKKGGPLADG IVITPSHNPP
160 170 180 190 200
EDGGIKYNPP NGGPADTNVT KVVEDRANAL LADGLKGVKR ISLDEAMASG
210 220 230 240 250
HVKEQDLVQP FVEGLADIVD MAAIQKAGLT LGVDPLGGSG IEYWKRIGEY
260 270 280 290 300
YNLNLTIVND QVDQTFRFMH LDKDGAIRMD CSSECAMAGL LALRDKFDLA
310 320 330 340 350
FANDPDYDRH GIVTPAGLMN PNHYLAVAIN YLFQHRPQWG KDVAVGKTLV
360 370 380 390 400
SSAMIDRVVN DLGRKLVEVP VGFKWFVDGL FDGSFGFGGE ESAGASFLRF
410 420 430 440 450
DGTPWSTDKD GIIMCLLAAE ITAVTGKNPQ EHYNELAKRF GAPSYNRLQA
460 470 480 490 500
AATSAQKAAL SKLSPEMVSA STLAGDPITA RLTAAPGNGA SIGGLKVMTD
510 520 530 540
NGWFAARPSG TEDAYKIYCE SFLGEEHRKQ IEKEAVEIVS EVLKNA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08369 Genomic DNA Translation: AAA57067.1 U00096 Genomic DNA Translation: AAC73782.1 AP009048 Genomic DNA Translation: BAA35337.1 U07651 Unassigned RNA No translation available. |
PIRi | G64803 |
RefSeqi | NP_415214.1, NC_000913.3 WP_001297249.1, NZ_SSZK01000045.1 |
Genome annotation databases
EnsemblBacteriai | AAC73782; AAC73782; b0688 BAA35337; BAA35337; BAA35337 |
GeneIDi | 60901214 945271 |
KEGGi | ecj:JW0675 eco:b0688 |
PATRICi | fig|1411691.4.peg.1588 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08369 Genomic DNA Translation: AAA57067.1 U00096 Genomic DNA Translation: AAC73782.1 AP009048 Genomic DNA Translation: BAA35337.1 U07651 Unassigned RNA No translation available. |
PIRi | G64803 |
RefSeqi | NP_415214.1, NC_000913.3 WP_001297249.1, NZ_SSZK01000045.1 |
3D structure databases
SMRi | P36938 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261910, 31 interactors 849650, 1 interactor |
DIPi | DIP-10472N |
IntActi | P36938, 9 interactors |
STRINGi | 511145.b0688 |
Proteomic databases
jPOSTi | P36938 |
PaxDbi | P36938 |
PRIDEi | P36938 |
Genome annotation databases
EnsemblBacteriai | AAC73782; AAC73782; b0688 BAA35337; BAA35337; BAA35337 |
GeneIDi | 60901214 945271 |
KEGGi | ecj:JW0675 eco:b0688 |
PATRICi | fig|1411691.4.peg.1588 |
Organism-specific databases
EchoBASEi | EB2065 |
Phylogenomic databases
eggNOGi | COG0033, Bacteria |
HOGENOMi | CLU_016950_8_1_6 |
InParanoidi | P36938 |
PhylomeDBi | P36938 |
Enzyme and pathway databases
BioCyci | EcoCyc:PHOSPHOGLUCMUT-MONOMER |
Miscellaneous databases
PROi | PR:P36938 |
Family and domain databases
CDDi | cd05801, PGM_like3, 1 hit |
InterProi | View protein in InterPro IPR005844, A-D-PHexomutase_a/b/a-I IPR016055, A-D-PHexomutase_a/b/a-I/II/III IPR005845, A-D-PHexomutase_a/b/a-II IPR005846, A-D-PHexomutase_a/b/a-III IPR005843, A-D-PHexomutase_C IPR036900, A-D-PHexomutase_C_sf IPR016066, A-D-PHexomutase_CS IPR045244, PGM IPR005852, PGM_a-D-Glc-sp |
PANTHERi | PTHR22573, PTHR22573, 1 hit |
Pfami | View protein in Pfam PF02878, PGM_PMM_I, 1 hit PF02879, PGM_PMM_II, 1 hit PF02880, PGM_PMM_III, 1 hit PF00408, PGM_PMM_IV, 1 hit |
SUPFAMi | SSF53738, SSF53738, 3 hits SSF55957, SSF55957, 1 hit |
TIGRFAMsi | TIGR01132, pgm, 1 hit |
PROSITEi | View protein in PROSITE PS00710, PGM_PMM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGM_ECOLI | |
Accessioni | P36938Primary (citable) accession number: P36938 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families