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Entry version 167 (07 Oct 2020)
Sequence version 1 (01 Jun 1994)
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Protein

Phosphoglucomutase

Gene

pgm

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme participates in both the breakdown and synthesis of glucose.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=50 µM for D-glucose-1-phosphate1 Publication

    pH dependencei

    Optimum pH is 9.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei146Phosphoserine intermediateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi146Magnesium; via phosphate groupBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei156SubstrateBy similarity1
    Metal bindingi304MagnesiumBy similarity1
    Metal bindingi306MagnesiumBy similarity1
    Metal bindingi308MagnesiumBy similarity1
    Binding sitei409SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • magnesium ion binding Source: InterPro
    • phosphoglucomutase activity Source: EcoCyc

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase
    Biological processCarbohydrate metabolism, Glucose metabolism
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:PHOSPHOGLUCMUT-MONOMER
    MetaCyc:PHOSPHOGLUCMUT-MONOMER

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phosphoglucomutase (EC:5.4.2.2)
    Short name:
    PGM
    Alternative name(s):
    Glucose phosphomutase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:pgm
    Ordered Locus Names:b0688, JW0675
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001478091 – 546PhosphoglucomutaseAdd BLAST546

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P36938

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P36938

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P36938

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4261910, 31 interactors
    849650, 1 interactor

    Database of interacting proteins

    More...
    DIPi
    DIP-10472N

    Protein interaction database and analysis system

    More...
    IntActi
    P36938, 9 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b0688

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P36938

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni146 – 147Substrate bindingBy similarity2
    Regioni308 – 309Substrate bindingBy similarity2
    Regioni390 – 392Substrate bindingBy similarity3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG0033, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_016950_8_1_6

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P36938

    KEGG Orthology (KO)

    More...
    KOi
    K01835

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P36938

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd05801, PGM_like3, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR005844, A-D-PHexomutase_a/b/a-I
    IPR016055, A-D-PHexomutase_a/b/a-I/II/III
    IPR005845, A-D-PHexomutase_a/b/a-II
    IPR005846, A-D-PHexomutase_a/b/a-III
    IPR005843, A-D-PHexomutase_C
    IPR036900, A-D-PHexomutase_C_sf
    IPR016066, A-D-PHexomutase_CS
    IPR005852, PGlcMutase_a-D-Glc-sp

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02878, PGM_PMM_I, 1 hit
    PF02879, PGM_PMM_II, 1 hit
    PF02880, PGM_PMM_III, 1 hit
    PF00408, PGM_PMM_IV, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53738, SSF53738, 3 hits
    SSF55957, SSF55957, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01132, pgm, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00710, PGM_PMM, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P36938-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAIHNRAGQP AQQSDLINVA QLTAQYYVLK PEAGNAEHAV KFGTSGHRGS
    60 70 80 90 100
    AARHSFNEPH ILAIAQAIAE ERAKNGITGP CYVGKDTHAL SEPAFISVLE
    110 120 130 140 150
    VLAANGVDVI VQENNGFTPT PAVSNAILVH NKKGGPLADG IVITPSHNPP
    160 170 180 190 200
    EDGGIKYNPP NGGPADTNVT KVVEDRANAL LADGLKGVKR ISLDEAMASG
    210 220 230 240 250
    HVKEQDLVQP FVEGLADIVD MAAIQKAGLT LGVDPLGGSG IEYWKRIGEY
    260 270 280 290 300
    YNLNLTIVND QVDQTFRFMH LDKDGAIRMD CSSECAMAGL LALRDKFDLA
    310 320 330 340 350
    FANDPDYDRH GIVTPAGLMN PNHYLAVAIN YLFQHRPQWG KDVAVGKTLV
    360 370 380 390 400
    SSAMIDRVVN DLGRKLVEVP VGFKWFVDGL FDGSFGFGGE ESAGASFLRF
    410 420 430 440 450
    DGTPWSTDKD GIIMCLLAAE ITAVTGKNPQ EHYNELAKRF GAPSYNRLQA
    460 470 480 490 500
    AATSAQKAAL SKLSPEMVSA STLAGDPITA RLTAAPGNGA SIGGLKVMTD
    510 520 530 540
    NGWFAARPSG TEDAYKIYCE SFLGEEHRKQ IEKEAVEIVS EVLKNA
    Length:546
    Mass (Da):58,361
    Last modified:June 1, 1994 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i666B6B9C2F2ECD59
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U08369 Genomic DNA Translation: AAA57067.1
    U00096 Genomic DNA Translation: AAC73782.1
    AP009048 Genomic DNA Translation: BAA35337.1
    U07651 Unassigned RNA No translation available.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    G64803

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_415214.1, NC_000913.3
    WP_001297249.1, NZ_SSZK01000045.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC73782; AAC73782; b0688
    BAA35337; BAA35337; BAA35337

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    52076001
    945271

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW0675
    eco:b0688

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.1588

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U08369 Genomic DNA Translation: AAA57067.1
    U00096 Genomic DNA Translation: AAC73782.1
    AP009048 Genomic DNA Translation: BAA35337.1
    U07651 Unassigned RNA No translation available.
    PIRiG64803
    RefSeqiNP_415214.1, NC_000913.3
    WP_001297249.1, NZ_SSZK01000045.1

    3D structure databases

    SMRiP36938
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4261910, 31 interactors
    849650, 1 interactor
    DIPiDIP-10472N
    IntActiP36938, 9 interactors
    STRINGi511145.b0688

    Proteomic databases

    jPOSTiP36938
    PaxDbiP36938
    PRIDEiP36938

    Genome annotation databases

    EnsemblBacteriaiAAC73782; AAC73782; b0688
    BAA35337; BAA35337; BAA35337
    GeneIDi52076001
    945271
    KEGGiecj:JW0675
    eco:b0688
    PATRICifig|1411691.4.peg.1588

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB2065

    Phylogenomic databases

    eggNOGiCOG0033, Bacteria
    HOGENOMiCLU_016950_8_1_6
    InParanoidiP36938
    KOiK01835
    PhylomeDBiP36938

    Enzyme and pathway databases

    BioCyciEcoCyc:PHOSPHOGLUCMUT-MONOMER
    MetaCyc:PHOSPHOGLUCMUT-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P36938

    Family and domain databases

    CDDicd05801, PGM_like3, 1 hit
    InterProiView protein in InterPro
    IPR005844, A-D-PHexomutase_a/b/a-I
    IPR016055, A-D-PHexomutase_a/b/a-I/II/III
    IPR005845, A-D-PHexomutase_a/b/a-II
    IPR005846, A-D-PHexomutase_a/b/a-III
    IPR005843, A-D-PHexomutase_C
    IPR036900, A-D-PHexomutase_C_sf
    IPR016066, A-D-PHexomutase_CS
    IPR005852, PGlcMutase_a-D-Glc-sp
    PfamiView protein in Pfam
    PF02878, PGM_PMM_I, 1 hit
    PF02879, PGM_PMM_II, 1 hit
    PF02880, PGM_PMM_III, 1 hit
    PF00408, PGM_PMM_IV, 1 hit
    SUPFAMiSSF53738, SSF53738, 3 hits
    SSF55957, SSF55957, 1 hit
    TIGRFAMsiTIGR01132, pgm, 1 hit
    PROSITEiView protein in PROSITE
    PS00710, PGM_PMM, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGM_ECOLI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36938
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 7, 2020
    This is version 167 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families
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