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Protein

Interleukin-8

Gene

CXCL8

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene namesi
Name:CXCL8
Synonyms:IL8
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000513623 – 101Interleukin-8Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27CitrullineBy similarity1
Disulfide bondi34 ↔ 61By similarity
Disulfide bondi36 ↔ 77By similarity

Post-translational modificationi

Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Expressioni

Gene expression databases

ExpressionAtlasiP36925 baseline

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP36925
SMRiP36925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00530000062901
HOVERGENiHBG107789
KOiK10030
OMAiPRCANSE
OrthoDBiEOG091G13J8

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR028469 Interleukin-8
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF70 PTHR10179:SF70, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36925-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSKLAVALL AAFLLSAALC EAAVLSRMST ELRCQCIKTH STPFHPKFIK
60 70 80 90 100
ELRVIESGPH CENSEIIVKL TNGKEVCLDP KEKWVQKVVQ AFLKRAEKQD

P
Length:101
Mass (Da):11,292
Last modified:June 1, 1994 - v1
Checksum:i40E8418B57C56A5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78306 mRNA Translation: CAA55115.1
S74436 mRNA Translation: AAB33241.1
PIRiS42496
RefSeqiNP_001009401.1, NM_001009401.2
UniGeneiOar.485

Genome annotation databases

EnsembliENSOART00000015785; ENSOARP00000015557; ENSOARG00000014496
GeneIDi443418
KEGGioas:443418

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78306 mRNA Translation: CAA55115.1
S74436 mRNA Translation: AAB33241.1
PIRiS42496
RefSeqiNP_001009401.1, NM_001009401.2
UniGeneiOar.485

3D structure databases

ProteinModelPortaliP36925
SMRiP36925
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000015785; ENSOARP00000015557; ENSOARG00000014496
GeneIDi443418
KEGGioas:443418

Organism-specific databases

CTDi3576

Phylogenomic databases

GeneTreeiENSGT00530000062901
HOVERGENiHBG107789
KOiK10030
OMAiPRCANSE
OrthoDBiEOG091G13J8

Gene expression databases

ExpressionAtlasiP36925 baseline

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR028469 Interleukin-8
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF70 PTHR10179:SF70, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL8_SHEEP
AccessioniPrimary (citable) accession number: P36925
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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