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Entry version 110 (29 Sep 2021)
Sequence version 1 (01 Jun 1994)
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Protein

Endo-1,4-beta-xylanase A

Gene

xynA

Organism
Thermoanaerobacterium saccharolyticum
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endo-acting enzyme that randomly cleaves the internal xylosidic linkages of the xylan backbone, yielding xylooligosaccharides of various lengths which are further hydrolyzed to xylose molecules by beta-xylosidase (EC 3.2.1.37). Requires at least three xylose residues for catalytic activity. Does not have activity against xylobiose.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. EC:3.2.1.8

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 5.5.

Temperature dependencei

Optimum temperature is 70 degrees Celsius.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei495Proton donorBy similarity1
Active sitei5371 Publication1
Active sitei600NucleophilePROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00114

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM22, Carbohydrate-Binding Module Family 22
CBM9, Carbohydrate-Binding Module Family 9
GH10, Glycoside Hydrolase Family 10

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endo-1,4-beta-xylanase A (EC:3.2.1.8)
Short name:
Xylanase A
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xynA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermoanaerobacterium saccharolyticum
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28896 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisThermoanaerobacterium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi537D → N: Loss of activity. 1 Publication1
Mutagenesisi600E → Q: Loss of activity. 1 Publication1
Mutagenesisi602D → N: Loss of activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 331 PublicationAdd BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000798034 – 1157Endo-1,4-beta-xylanase AAdd BLAST1124

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P36917

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By xylan and xylose.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P36917

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 189CBM-cenC 1Add BLAST152
Domaini195 – 343CBM-cenC 2Add BLAST149
Domaini352 – 675GH10PROSITE-ProRule annotationAdd BLAST324
Domaini1051 – 1114SLH 1PROSITE-ProRule annotationAdd BLAST64
Domaini1115 – 1157SLH 2PROSITE-ProRule annotationAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010502, Carb-bd_dom_fam9
IPR003305, CenC_carb-bd
IPR008979, Galactose-bd-like_sf
IPR044846, GH10
IPR031158, GH10_AS
IPR001000, GH10_dom
IPR018087, Glyco_hydro_5_CS
IPR017853, Glycoside_hydrolase_SF
IPR001119, SLH_dom

The PANTHER Classification System

More...
PANTHERi
PTHR31490, PTHR31490, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06452, CBM9_1, 2 hits
PF02018, CBM_4_9, 2 hits
PF00331, Glyco_hydro_10, 1 hit
PF00395, SLH, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00134, GLHYDRLASE10

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00633, Glyco_10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 2 hits
SSF51445, SSF51445, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00591, GH10_1, 1 hit
PS51760, GH10_2, 1 hit
PS00659, GLYCOSYL_HYDROL_F5, 1 hit
PS51272, SLH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P36917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKNNVDRIV SIVTALIMIF GASLFSPPIR VFADDTNINL VSNGDFESGT
60 70 80 90 100
IDGWIKQGNP TLAVTTEQAI GQYSMKVTGR TQTYEGPAYS FLGKMQKGES
110 120 130 140 150
YSVSLKVRLV SGQNSSNPLI TVTMFREDDN GKHYDTIVWQ KQVSEDSWTT
160 170 180 190 200
VSGTYTLDYI GTLKTLYMYV ESPDPTLEYY IDDVVVTTQN PIQVGNVIAN
210 220 230 240 250
ETFENGNTSG WIGTGSSVVK AVYGVAHSGD YSLLTTGRTA NWNGPSYDLT
260 270 280 290 300
GKIVPGQQYN VDFWVKFVNG NDTEQIKATV KATSDKDNYI QVNDFANVNK
310 320 330 340 350
GEWTEIKGSF TLPVADYSGI SIYVESQNPT LEFYIDDFSV IGEISNNQIT
360 370 380 390 400
IQNDIPDLYS VFKDYFPIGV AVDPSRLNDA DPHAQLTAKH FNMLVAENAM
410 420 430 440 450
KPESLQPTEG NFTFDNADKI VDYAIAHNMK MRGHTLLWHN QVPDWFFQDP
460 470 480 490 500
SDPSKSASRD LLLQRLKTHI TTVLDHFKTK YGSQNPIIGW DVVNEVLDDN
510 520 530 540 550
GNLRNSKWLQ IIGPDYIEKA FEYAHEADPS MKLFINDYNI ENNGVKTQAM
560 570 580 590 600
YDLVKKLKSE GVPIDGIGMQ MHININSNID NIKASIEKLA SLGVEIQVTE
610 620 630 640 650
LDMNMNGNIS NEALLKQARL YKQLFDLFKA EKQYITAVVF WGVSDDVTWL
660 670 680 690 700
SKPNAPLLFD SKLQAKPAFW AVVDPSKAIP DIQSAKALEG SPTIGANVDS
710 720 730 740 750
SWKLVKPLYV NTYVEGTVGA TATVKSMWDT KNLYLLVQVS DNTPSNNDGI
760 770 780 790 800
EIFVDKNDDK STSYETDDER YTIKRDGTGS SDITKYVTSN ADGYVAQLAI
810 820 830 840 850
PIEDISPAVN DKIGFDIRIN DDKGNGKIDA ITVWNDYTNS QNTNTSYFGD
860 870 880 890 900
IVLSKSAQIA TAIYGTPVID GKVDDIWNNV EPISTNTWIL GSNGATATQK
910 920 930 940 950
MMWDDKYLYV LADVTDSNLN KSSINPYEQD SVEVFVDQNN DKTTYYENDD
960 970 980 990 1000
GQYRVNYDNE QSFGGSTNSN GFKSATSLTQ SGYIVEEAIP WTSITPSNGT
1010 1020 1030 1040 1050
IIGFDLQVNN ADENGKRTGI VTWCDPSGNS WQDTSGFGNL LLTGKPSGAL
1060 1070 1080 1090 1100
KKGVTFDDIK NSWAKDAIEV LASRHIVEGM TDTQYEPNKT VTRAEFTAMI
1110 1120 1130 1140 1150
LRLLNIKEEQ YSGEFSDVNS GDWYANAIEA AYKAGIIEGD GKNARPNDSI

TREEMTQ
Length:1,157
Mass (Da):128,380
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51FA6004497EC58B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M97882 Genomic DNA Translation: AAA21812.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
A48490

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97882 Genomic DNA Translation: AAA21812.1 Sequence problems.
PIRiA48490

3D structure databases

SMRiP36917
ModBaseiSearch...

Protein family/group databases

CAZyiCBM22, Carbohydrate-Binding Module Family 22
CBM9, Carbohydrate-Binding Module Family 9
GH10, Glycoside Hydrolase Family 10

Proteomic databases

PRIDEiP36917

Enzyme and pathway databases

UniPathwayiUPA00114

Family and domain databases

InterProiView protein in InterPro
IPR010502, Carb-bd_dom_fam9
IPR003305, CenC_carb-bd
IPR008979, Galactose-bd-like_sf
IPR044846, GH10
IPR031158, GH10_AS
IPR001000, GH10_dom
IPR018087, Glyco_hydro_5_CS
IPR017853, Glycoside_hydrolase_SF
IPR001119, SLH_dom
PANTHERiPTHR31490, PTHR31490, 2 hits
PfamiView protein in Pfam
PF06452, CBM9_1, 2 hits
PF02018, CBM_4_9, 2 hits
PF00331, Glyco_hydro_10, 1 hit
PF00395, SLH, 2 hits
PRINTSiPR00134, GLHYDRLASE10
SMARTiView protein in SMART
SM00633, Glyco_10, 1 hit
SUPFAMiSSF49785, SSF49785, 2 hits
SSF51445, SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00591, GH10_1, 1 hit
PS51760, GH10_2, 1 hit
PS00659, GLYCOSYL_HYDROL_F5, 1 hit
PS51272, SLH, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXYNA_THESA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36917
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 29, 2021
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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