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Entry version 155 (13 Feb 2019)
Sequence version 2 (24 Jul 2007)
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Protein

Guanine nucleotide-binding protein-like 1

Gene

GNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible regulatory or functional link with the histocompatibility cluster.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi225 – 228GTPSequence analysis4
Nucleotide bindingi367 – 374GTPSequence analysis8
Nucleotide bindingi411 – 415GTPSequence analysis5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTP binding Source: UniProtKB
  • structural molecule activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein-like 1
Alternative name(s):
GTP-binding protein HSR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNL1
Synonyms:HSR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204590.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4413 GNL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
143024 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P36915

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2794

Open Targets

More...
OpenTargetsi
ENSG00000204590

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28792

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GNL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158939140

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001224411 – 607Guanine nucleotide-binding protein-like 1Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei48PhosphothreonineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei562PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P36915

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P36915

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P36915

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36915

PeptideAtlas

More...
PeptideAtlasi
P36915

PRoteomics IDEntifications database

More...
PRIDEi
P36915

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55237
55238 [P36915-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36915

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P36915

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P36915

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204590 Expressed in 229 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P36915 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P36915 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033575
HPA043338
HPA050455

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109056, 34 interactors

Protein interaction database and analysis system

More...
IntActi
P36915, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365806

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P36915

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini178 – 418CP-type GPROSITE-ProRule annotationAdd BLAST241

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi551 – 607Asp/Glu-rich (highly acidic)Add BLAST57

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1424 Eukaryota
COG1161 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158047

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007598

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005865

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36915

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPVRPPW

Database of Orthologous Groups

More...
OrthoDBi
839833at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P36915

TreeFam database of animal gene trees

More...
TreeFami
TF324569

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030378 G_CP_dom
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01926 MMR_HSR1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51721 G_CP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P36915-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRKKPFSVK QKKKQLQDKR ERKRGLQDGL RSSSNSRSGS RERREEQTDT
60 70 80 90 100
SDGESVTHHI RRLNQQPSQG LGPRGYDPNR YRLHFERDSR EEVERRKRAA
110 120 130 140 150
REQVLQPVSA ELLELDIREV YQPGSVLDFP RRPPWSYEMS KEQLMSQEER
160 170 180 190 200
SFQDYLGKIH GAYSSEKLSY FEHNLETWRQ LWRVLEMSDI VLLITDIRHP
210 220 230 240 250
VVNFPPALYE YVTGELGLAL VLVLNKVDLA PPALVVAWKH YFHQHYPQLH
260 270 280 290 300
VVLFTSFPRD PRTPQDPSSV LKKSRRRGRG WTRALGPEQL LRACEAITVG
310 320 330 340 350
KVDLSSWREK IARDVAGATW GNGSGEEEEE EDGPAVLVEQ QTDSAMEPTG
360 370 380 390 400
PTQERYKDGV VTIGCVGFPN VGKSSLINGL VGRKVVSVSR TPGHTRYFQT
410 420 430 440 450
YFLTPSVKLC DCPGLIFPSL LPRQLQVLAG IYPIAQIQEP YTAVGYLASR
460 470 480 490 500
IPVQALLHLR HPEAEDPSAE HPWCAWDICE AWAEKRGYKT AKAARNDVYR
510 520 530 540 550
AANSLLRLAV DGRLSLCFHP PGYSEQKGTW ESHPETTELV VLQGRVGPAG
560 570 580 590 600
DEEEEEEEEL SSSCEEEGEE DRDADEEGEG DEETPTSAPG SSLAGRNPYA

LLGEDEC
Length:607
Mass (Da):68,661
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8EBB4EDBB73D929
GO
Isoform 2 (identifier: P36915-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     178-183: WRQLWR → MEAAVA

Show »
Length:430
Mass (Da):47,306
Checksum:iDCCC3C4763631295
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AB27A2AB27_HUMAN
Guanine nucleotide-binding protein-...
GNL1
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8Y2A0A140T8Y2_HUMAN
Guanine nucleotide-binding protein-...
GNL1
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T994A0A140T994_HUMAN
Guanine nucleotide-binding protein-...
GNL1
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti232 – 233PA → RR in AAA66492 (PubMed:8180467).Curated2
Sequence conflicti315Missing in AAA66492 (PubMed:8180467).Curated1
Sequence conflicti339E → EQ in AAA66492 (PubMed:8180467).Curated1
Sequence conflicti514L → V in AAA66492 (PubMed:8180467).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0269921 – 177Missing in isoform 2. 1 PublicationAdd BLAST177
Alternative sequenceiVSP_026993178 – 183WRQLWR → MEAAVA in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L25665 mRNA Translation: AAA66492.1
BT006648 mRNA Translation: AAP35294.1
AL662800 Genomic DNA No translation available.
AL662825 Genomic DNA No translation available.
BX000357 Genomic DNA No translation available.
BX248518 Genomic DNA No translation available.
BX927220 Genomic DNA No translation available.
CR388372 Genomic DNA No translation available.
CR936927 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03294.1
BC013959 mRNA Translation: AAH13959.1
BC018366 mRNA Translation: AAH18366.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4680.1 [P36915-1]

Protein sequence database of the Protein Information Resource

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PIRi
I57013

NCBI Reference Sequences

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RefSeqi
NP_005266.2, NM_005275.3 [P36915-1]
XP_005249072.1, XM_005249015.3 [P36915-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.118354
Hs.83147

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376621; ENSP00000365806; ENSG00000204590 [P36915-1]
ENST00000383596; ENSP00000373090; ENSG00000206492 [P36915-1]
ENST00000417834; ENSP00000403576; ENSG00000226882 [P36915-1]
ENST00000428189; ENSP00000409074; ENSG00000229470 [P36915-1]
ENST00000437917; ENSP00000411162; ENSG00000228581 [P36915-1]
ENST00000441604; ENSP00000394290; ENSG00000235986 [P36915-1]
ENST00000454829; ENSP00000409367; ENSG00000232143 [P36915-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2794

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2794

UCSC genome browser

More...
UCSCi
uc003nqh.4 human [P36915-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25665 mRNA Translation: AAA66492.1
BT006648 mRNA Translation: AAP35294.1
AL662800 Genomic DNA No translation available.
AL662825 Genomic DNA No translation available.
BX000357 Genomic DNA No translation available.
BX248518 Genomic DNA No translation available.
BX927220 Genomic DNA No translation available.
CR388372 Genomic DNA No translation available.
CR936927 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03294.1
BC013959 mRNA Translation: AAH13959.1
BC018366 mRNA Translation: AAH18366.1
CCDSiCCDS4680.1 [P36915-1]
PIRiI57013
RefSeqiNP_005266.2, NM_005275.3 [P36915-1]
XP_005249072.1, XM_005249015.3 [P36915-1]
UniGeneiHs.118354
Hs.83147

3D structure databases

ProteinModelPortaliP36915
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109056, 34 interactors
IntActiP36915, 4 interactors
STRINGi9606.ENSP00000365806

PTM databases

iPTMnetiP36915
PhosphoSitePlusiP36915

Polymorphism and mutation databases

BioMutaiGNL1
DMDMi158939140

Proteomic databases

EPDiP36915
jPOSTiP36915
MaxQBiP36915
PaxDbiP36915
PeptideAtlasiP36915
PRIDEiP36915
ProteomicsDBi55237
55238 [P36915-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2794
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376621; ENSP00000365806; ENSG00000204590 [P36915-1]
ENST00000383596; ENSP00000373090; ENSG00000206492 [P36915-1]
ENST00000417834; ENSP00000403576; ENSG00000226882 [P36915-1]
ENST00000428189; ENSP00000409074; ENSG00000229470 [P36915-1]
ENST00000437917; ENSP00000411162; ENSG00000228581 [P36915-1]
ENST00000441604; ENSP00000394290; ENSG00000235986 [P36915-1]
ENST00000454829; ENSP00000409367; ENSG00000232143 [P36915-1]
GeneIDi2794
KEGGihsa:2794
UCSCiuc003nqh.4 human [P36915-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2794
DisGeNETi2794
EuPathDBiHostDB:ENSG00000204590.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GNL1
HGNCiHGNC:4413 GNL1
HPAiCAB033575
HPA043338
HPA050455
MIMi143024 gene
neXtProtiNX_P36915
OpenTargetsiENSG00000204590
PharmGKBiPA28792

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1424 Eukaryota
COG1161 LUCA
GeneTreeiENSGT00940000158047
HOGENOMiHOG000007598
HOVERGENiHBG005865
InParanoidiP36915
OMAiFPVRPPW
OrthoDBi839833at2759
PhylomeDBiP36915
TreeFamiTF324569

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GNL1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2794
PMAP-CutDBiP36915

Protein Ontology

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PROi
PR:P36915

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000204590 Expressed in 229 organ(s), highest expression level in testis
ExpressionAtlasiP36915 baseline and differential
GenevisibleiP36915 HS

Family and domain databases

InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36915
Secondary accession number(s): B0S838, Q96CT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 24, 2007
Last modified: February 13, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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