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UniProtKB - P36897 (TGFR1_HUMAN)

Protein

TGF-beta receptor type-1

Gene

TGFBR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.7 Publications

Caution

One report originally reported variant Ile-375 (PubMed:22113417). This variant has been subsequently corrected to Arg-375 by the same authors (Ref. 48).2 Publications

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Activity regulationi

Kept in an inactive conformation by FKBP1A preventing receptor activation in absence of ligand. CD109 is another inhibitor of the receptor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei232ATPPROSITE-ProRule annotation1
Active sitei333Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 219ATPPROSITE-ProRule annotation9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Differentiation, Growth regulation
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
2.7.11.30 2681
ReactomeiR-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer
R-HSA-3656532 TGFBR1 KD Mutants in Cancer
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
SignaLinkiP36897
SIGNORiP36897

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta receptor type-1 (EC:2.7.11.30)
Short name:
TGFR-1
Alternative name(s):
Activin A receptor type II-like protein kinase of 53kD
Activin receptor-like kinase 5
Short name:
ALK-5
Short name:
ALK5
Serine/threonine-protein kinase receptor R4
Short name:
SKR4
TGF-beta type I receptor
Transforming growth factor-beta receptor type I
Short name:
TGF-beta receptor type I
Short name:
TbetaR-I
Gene namesi
Name:TGFBR1
Synonyms:ALK5, SKR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106799.12
HGNCiHGNC:11772 TGFBR1
MIMi190181 gene
neXtProtiNX_P36897

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 126ExtracellularSequence analysisAdd BLAST93
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 503CytoplasmicSequence analysisAdd BLAST356

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

Loeys-Dietz syndrome 1 (LDS1)6 Publications
The disease is caused by mutations affecting the gene represented in this entry. TGFBR1 mutation Gln-487 has been reported to be associated with thoracic aortic aneurysms and dissection (TAAD) (PubMed:16791849). This phenotype, also known as thoracic aortic aneurysms type 5 (AAT5), is distinguised from LDS1 by having aneurysms restricted to thoracic aorta. It is unclear, however, if this condition is fulfilled in individuals bearing Gln-487 mutation, that is why they are considered as LDS1 by the OMIM resource.1 Publication
Disease descriptionAn aortic aneurysm syndrome with widespread systemic involvement, characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Physical findings include prominent joint laxity, easy bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of the spleen or bowel, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the arteries, either during pregnancy or in the immediate postpartum period. Some patients have craniosynostosis, exotropy, micrognathia and retrognathia, structural brain abnormalities, and intellectual deficit.
See also OMIM:609192
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022344200T → I in LDS1. 1 PublicationCorresponds to variant dbSNP:rs121918712EnsemblClinVar.1
Natural variantiVAR_029481232K → E in LDS1. 1 Publication1
Natural variantiVAR_029482241S → L in LDS1. 2 PublicationsCorresponds to variant dbSNP:rs111854391EnsemblClinVar.1
Natural variantiVAR_066720266D → Y in LDS1. 1 Publication1
Natural variantiVAR_022345318M → R in LDS1. 1 PublicationCorresponds to variant dbSNP:rs121918710EnsemblClinVar.1
Natural variantiVAR_066721351D → G in LDS1. 1 Publication1
Natural variantiVAR_066722375T → R in LDS1. 1 Publication1
Natural variantiVAR_022346400D → G in LDS1. 1 PublicationCorresponds to variant dbSNP:rs121918711EnsemblClinVar.1
Natural variantiVAR_022347487R → P in LDS1. 2 PublicationsCorresponds to variant dbSNP:rs113605875EnsemblClinVar.1
Natural variantiVAR_029484487R → Q in LDS1. 3 PublicationsCorresponds to variant dbSNP:rs113605875EnsemblClinVar.1
Natural variantiVAR_029485487R → W in LDS1. 1 PublicationCorresponds to variant dbSNP:rs111426349EnsemblClinVar.1
Multiple self-healing squamous epithelioma (MSSE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by multiple skin tumors that undergo spontaneous regression. Tumors appear most often on sun-exposed regions, are locally invasive, and undergo spontaneous resolution over a period of months leaving pitted scars.
See also OMIM:132800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06582641C → Y in MSSE; hypomorphic mutation. 1 Publication1
Natural variantiVAR_06582745N → S in MSSE; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs387906696EnsemblClinVar.1
Natural variantiVAR_06582852G → R in MSSE; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs587776865EnsemblClinVar.1
Natural variantiVAR_06582983P → L in MSSE; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs757374917Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi185 – 186TT → VV: Loss of phosphorylation on threonine residues. Loss of threonine phosphorylation, reduced phosphorylation on serine residues and loss of response to TGF-beta; when associated with A-187; A-189 and A-191. 1 Publication2
Mutagenesisi187S → A: Loss of threonine phosphorylation, reduced phosphorylation on serine residues and loss of response to TGF-beta; when associated with 185-VV-186; A-189 and A-191. 1 Publication1
Mutagenesisi189S → A: Loss of threonine phosphorylation, reduced phosphorylation on serine residues and loss of response to TGF-beta; when associated with 185-VV-186; A-187 and A-191. 1 Publication1
Mutagenesisi191S → A: Loss of threonine phosphorylation, reduced phosphorylation on serine residues and loss of response to TGF-beta; when associated with 185-VV-186; A-187 and A-189. 1 Publication1
Mutagenesisi193L → G: Loss of interaction with FKBP1A. 1 Publication1
Mutagenesisi194P → K: Loss of interaction with FKBP1A. 1 Publication1
Mutagenesisi200T → D: Loss of response to TGF-beta. 1 Publication1
Mutagenesisi200T → V: Loss of phosphorylation. Loss of response to TGF-beta. 1 Publication1
Mutagenesisi204T → D: Constitutive activation. 1 Publication1
Mutagenesisi204T → V: Reduced phosphorylation. Reduced response to TGF-beta. 1 Publication1

Keywords - Diseasei

Aortic aneurysm, Craniosynostosis, Disease mutation

Organism-specific databases

DisGeNETi7046
GeneReviewsiTGFBR1
MalaCardsiTGFBR1
MIMi132800 phenotype
609192 phenotype
OpenTargetsiENSG00000106799
Orphaneti91387 Familial thoracic aortic aneurysm and aortic dissection
60030 Loeys-Dietz syndrome
65748 Multiple self-healing squamous epithelioma
PharmGKBiPA36485

Chemistry databases

ChEMBLiCHEMBL4439
DrugBankiDB07267 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
DB03921 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
DB08450 N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
DB07152 N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
DB04434 Naphthyridine Inhibitor
GuidetoPHARMACOLOGYi1788

Polymorphism and mutation databases

BioMutaiTGFBR1
DMDMi547777

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000002442334 – 503TGF-beta receptor type-1Add BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 542 Publications
Disulfide bondi38 ↔ 412 Publications
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 712 Publications
Disulfide bondi86 ↔ 1002 Publications
Disulfide bondi101 ↔ 1062 Publications
Modified residuei165PhosphoserineCombined sources1
Modified residuei185Phosphothreonine; by TGFBR21 Publication1
Modified residuei186Phosphothreonine; by TGFBR21 Publication1
Modified residuei187Phosphoserine; by TGFBR21 Publication1
Modified residuei189Phosphoserine; by TGFBR21 Publication1
Modified residuei191Phosphoserine; by TGFBR21 Publication1
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Phosphorylated at basal levels in the absence of ligand. Activated upon phosphorylation by TGFBR2, mainly in the GS domain. Phosphorylation in the GS domain abrogates FKBP1A-binding.2 Publications
N-Glycosylated.1 Publication
Ubiquitinated; undergoes ubiquitination catalyzed by several E3 ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the proteasomal and/or lysosomal degradation of the receptor thereby negatively regulating its activity. Deubiquitinated by USP15, leading to stabilization of the protein and enhanced TGF-beta signal. Its ubiquitination and proteasome-mediated degradation is negatively regulated by SDCBP (PubMed:25893292).3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP36897
PaxDbiP36897
PeptideAtlasiP36897
PRIDEiP36897
ProteomicsDBi55234
55235 [P36897-2]
55236 [P36897-3]

PTM databases

iPTMnetiP36897
PhosphoSitePlusiP36897

Expressioni

Tissue specificityi

Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292).1 Publication

Gene expression databases

BgeeiENSG00000106799 Expressed in 205 organ(s), highest expression level in decidua
CleanExiHS_TGFBR1
ExpressionAtlasiP36897 baseline and differential
GenevisibleiP36897 HS

Organism-specific databases

HPAiCAB002441
CAB031481
HPA056473

Interactioni

Subunit structurei

Homodimer; in the endoplasmic reticulum but also at the cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits TGF-beta receptor activation in keratinocytes. Interacts with RBPMS. Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to the TGF-beta receptor. Interacts with USP15 and VPS39. Interacts with SDCBP (via C-terminus) (PubMed:25893292) Interacts with CAV1 and this interaction is impaired in the presence of SDCBP (PubMed:25893292).21 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112904, 187 interactors
ComplexPortaliCPX-2544 TGF-beta-3-TGFR complex
CPX-529 TGF-beta-1-TGFR complex
CPX-834 TGF-beta-2-TGFR complex
CORUMiP36897
DIPiDIP-5935N
IntActiP36897, 22 interactors
MINTiP36897
STRINGi9606.ENSP00000364133

Chemistry databases

BindingDBiP36897

Structurei

Secondary structure

1503
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP36897
SMRiP36897
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36897

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 204GSPROSITE-ProRule annotationAdd BLAST30
Domaini205 – 495Protein kinasePROSITE-ProRule annotationAdd BLAST291

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi193 – 194FKBP1A-binding2

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502
InParanoidiP36897
KOiK04674
OMAiCTTDGVC
OrthoDBiEOG091G0BIU
PhylomeDBiP36897
TreeFamiTF314724

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P36897-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAAVAAPRP RLLLLVLAAA AAAAAALLPG ATALQCFCHL CTKDNFTCVT 
        60         70         80         90        100
DGLCFVSVTE TTDKVIHNSM CIAEIDLIPR DRPFVCAPSS KTGSVTTTYC 
       110        120        130        140        150
CNQDHCNKIE LPTTVKSSPG LGPVELAAVI AGPVCFVCIS LMLMVYICHN 
       160        170        180        190        200
RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT 
       210        220        230        240        250
IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ 
       260        270        280        290        300
TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 
       310        320        330        340        350
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA 
       360        370        380        390        400
DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD 
       410        420        430        440        450
IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL 
       460        470        480        490        500
RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG 

IKM
Length:503
Mass (Da):55,960
Last modified:June 1, 1994 - v1
Checksum:i179F11404725DDCB
GO
Isoform 2 (identifier: P36897-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     114-114: T → TGPFS

Show »
Length:507
Mass (Da):56,348
Checksum:i9EFAF4435F30E4C2
GO
Isoform 3 (identifier: P36897-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-191: Missing.

Show »
Length:426
Mass (Da):47,690
Checksum:i97EA2F587AFA08F6
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DY26B4DY26_HUMAN
Receptor protein serine/threonine k...
TGFBR1
434Annotation score:
F8W1R9F8W1R9_HUMAN
Receptor protein serine/threonine k...
TGFBR1
383Annotation score:
F8VXZ5F8VXZ5_HUMAN
Receptor protein serine/threonine k...
TGFBR1
114Annotation score:
F8W0K6F8W0K6_HUMAN
TGF-beta receptor type-1
TGFBR1
126Annotation score:
F8VVC4F8VVC4_HUMAN
TGF-beta receptor type-1
TGFBR1
118Annotation score:
F8VRH6F8VRH6_HUMAN
TGF-beta receptor type-1
TGFBR1
114Annotation score:
H0YHS4H0YHS4_HUMAN
TGF-beta receptor type-1
TGFBR1
122Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02234224 – 26Missing in allele TGFBR1*6A; could be a tumor susceptibility allele. 3
Natural variantiVAR_02234326A → AA in allele TGFBR1*10A; rare polymorphism. 1 Publication1
Natural variantiVAR_06582641C → Y in MSSE; hypomorphic mutation. 1 Publication1
Natural variantiVAR_06582745N → S in MSSE; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs387906696EnsemblClinVar.1
Natural variantiVAR_06582852G → R in MSSE; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs587776865EnsemblClinVar.1
Natural variantiVAR_06582983P → L in MSSE; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs757374917Ensembl.1
Natural variantiVAR_054160139I → V1 PublicationCorresponds to variant dbSNP:rs148176750EnsemblClinVar.1
Natural variantiVAR_041412153V → I1 PublicationCorresponds to variant dbSNP:rs56014374EnsemblClinVar.1
Natural variantiVAR_022344200T → I in LDS1. 1 PublicationCorresponds to variant dbSNP:rs121918712EnsemblClinVar.1
Natural variantiVAR_029481232K → E in LDS1. 1 Publication1
Natural variantiVAR_029482241S → L in LDS1. 2 PublicationsCorresponds to variant dbSNP:rs111854391EnsemblClinVar.1
Natural variantiVAR_066720266D → Y in LDS1. 1 Publication1
Natural variantiVAR_029483267N → H in a patient with Marfan syndrome. 1 Publication1
Natural variantiVAR_041413291Y → C1 PublicationCorresponds to variant dbSNP:rs35974499Ensembl.1
Natural variantiVAR_022345318M → R in LDS1. 1 PublicationCorresponds to variant dbSNP:rs121918710EnsemblClinVar.1
Natural variantiVAR_066721351D → G in LDS1. 1 Publication1
Natural variantiVAR_066722375T → R in LDS1. 1 Publication1
Natural variantiVAR_022346400D → G in LDS1. 1 PublicationCorresponds to variant dbSNP:rs121918711EnsemblClinVar.1
Natural variantiVAR_022347487R → P in LDS1. 2 PublicationsCorresponds to variant dbSNP:rs113605875EnsemblClinVar.1
Natural variantiVAR_029484487R → Q in LDS1. 3 PublicationsCorresponds to variant dbSNP:rs113605875EnsemblClinVar.1
Natural variantiVAR_029485487R → W in LDS1. 1 PublicationCorresponds to variant dbSNP:rs111426349EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041326114T → TGPFS in isoform 2. 1 Publication1
Alternative sequenceiVSP_041327115 – 191Missing in isoform 3. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11695 mRNA Translation: AAA16073.1
AF054598
, AF054590, AF054591, AF054592, AF054593, AF054594, AF054595, AF054596, AF054597 Genomic DNA Translation: AAC08998.1
AF035670
, AF035662, AF035663, AF035664, AF035665, AF035666, AF035667, AF035668, AF035669 Genomic DNA Translation: AAD02042.1
AY497473 Genomic DNA Translation: AAR32097.1
AL162427 Genomic DNA No translation available.
BC071181 mRNA Translation: AAH71181.1
AJ619019 mRNA Translation: CAF02096.2
AJ619020 mRNA Translation: CAF02097.1
CCDSiCCDS47998.1 [P36897-3]
CCDS6738.1 [P36897-1]
CCDS78413.1 [P36897-2]
PIRiA49432
RefSeqiNP_001124388.1, NM_001130916.2 [P36897-3]
NP_001293139.1, NM_001306210.1 [P36897-2]
NP_004603.1, NM_004612.3 [P36897-1]
UniGeneiHs.494622

Genome annotation databases

EnsembliENST00000374990; ENSP00000364129; ENSG00000106799 [P36897-3]
ENST00000374994; ENSP00000364133; ENSG00000106799 [P36897-1]
ENST00000552516; ENSP00000447297; ENSG00000106799 [P36897-2]
GeneIDi7046
KEGGihsa:7046
UCSCiuc004azd.4 human [P36897-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11695 mRNA Translation: AAA16073.1
AF054598
, AF054590, AF054591, AF054592, AF054593, AF054594, AF054595, AF054596, AF054597 Genomic DNA Translation: AAC08998.1
AF035670
, AF035662, AF035663, AF035664, AF035665, AF035666, AF035667, AF035668, AF035669 Genomic DNA Translation: AAD02042.1
AY497473 Genomic DNA Translation: AAR32097.1
AL162427 Genomic DNA No translation available.
BC071181 mRNA Translation: AAH71181.1
AJ619019 mRNA Translation: CAF02096.2
AJ619020 mRNA Translation: CAF02097.1
CCDSiCCDS47998.1 [P36897-3]
CCDS6738.1 [P36897-1]
CCDS78413.1 [P36897-2]
PIRiA49432
RefSeqiNP_001124388.1, NM_001130916.2 [P36897-3]
NP_001293139.1, NM_001306210.1 [P36897-2]
NP_004603.1, NM_004612.3 [P36897-1]
UniGeneiHs.494622

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B6CX-ray2.60B/D/F/H162-503[»]
1IASX-ray2.90A/B/C/D/E162-503[»]
1PY5X-ray2.30A175-500[»]
1RW8X-ray2.40A200-500[»]
1TBImodel-A34-114[»]
1VJYX-ray2.00A201-503[»]
2L5SNMR-A31-115[»]
2PJYX-ray3.00C33-111[»]
2WOTX-ray1.85A200-503[»]
2WOUX-ray2.30A200-503[»]
2X7OX-ray3.70A/B/C/D/E162-503[»]
3FAAX-ray3.35A/B/C/D/E162-503[»]
3GXLX-ray1.80A201-503[»]
3HMMX-ray1.70A201-503[»]
3KCFX-ray2.80A/B/C/D/E162-503[»]
3KFDX-ray3.00I/J/K/L31-115[»]
3TZMX-ray1.70A200-503[»]
4X0MX-ray1.68A200-503[»]
4X2FX-ray1.49A200-503[»]
4X2GX-ray1.51A200-503[»]
4X2JX-ray1.69A200-503[»]
4X2KX-ray1.69A200-503[»]
4X2NX-ray1.80A200-503[»]
5E8SX-ray1.45A200-503[»]
5E8TX-ray1.70A200-503[»]
5E8UX-ray2.03A200-503[»]
5E8WX-ray1.86A200-503[»]
5E8XX-ray1.45A200-503[»]
5E8ZX-ray1.51A200-503[»]
5E90X-ray2.05A200-503[»]
5FRIX-ray2.00A200-498[»]
5USQX-ray2.55A200-498[»]
6B8YX-ray1.65A200-503[»]
ProteinModelPortaliP36897
SMRiP36897
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112904, 187 interactors
ComplexPortaliCPX-2544 TGF-beta-3-TGFR complex
CPX-529 TGF-beta-1-TGFR complex
CPX-834 TGF-beta-2-TGFR complex
CORUMiP36897
DIPiDIP-5935N
IntActiP36897, 22 interactors
MINTiP36897
STRINGi9606.ENSP00000364133

Chemistry databases

BindingDBiP36897
ChEMBLiCHEMBL4439
DrugBankiDB07267 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
DB03921 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
DB08450 N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
DB07152 N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
DB04434 Naphthyridine Inhibitor
GuidetoPHARMACOLOGYi1788

PTM databases

iPTMnetiP36897
PhosphoSitePlusiP36897

Polymorphism and mutation databases

BioMutaiTGFBR1
DMDMi547777

Proteomic databases

EPDiP36897
PaxDbiP36897
PeptideAtlasiP36897
PRIDEiP36897
ProteomicsDBi55234
55235 [P36897-2]
55236 [P36897-3]

Protocols and materials databases

DNASUi7046
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374990; ENSP00000364129; ENSG00000106799 [P36897-3]
ENST00000374994; ENSP00000364133; ENSG00000106799 [P36897-1]
ENST00000552516; ENSP00000447297; ENSG00000106799 [P36897-2]
GeneIDi7046
KEGGihsa:7046
UCSCiuc004azd.4 human [P36897-1]

Organism-specific databases

CTDi7046
DisGeNETi7046
EuPathDBiHostDB:ENSG00000106799.12
GeneCardsiTGFBR1
GeneReviewsiTGFBR1
HGNCiHGNC:11772 TGFBR1
HPAiCAB002441
CAB031481
HPA056473
MalaCardsiTGFBR1
MIMi132800 phenotype
190181 gene
609192 phenotype
neXtProtiNX_P36897
OpenTargetsiENSG00000106799
Orphaneti91387 Familial thoracic aortic aneurysm and aortic dissection
60030 Loeys-Dietz syndrome
65748 Multiple self-healing squamous epithelioma
PharmGKBiPA36485
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502
InParanoidiP36897
KOiK04674
OMAiCTTDGVC
OrthoDBiEOG091G0BIU
PhylomeDBiP36897
TreeFamiTF314724

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
2.7.11.30 2681
ReactomeiR-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer
R-HSA-3656532 TGFBR1 KD Mutants in Cancer
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
SignaLinkiP36897
SIGNORiP36897

Miscellaneous databases

ChiTaRSiTGFBR1 human
EvolutionaryTraceiP36897
GeneWikiiTGF_beta_receptor_1
GenomeRNAii7046
PROiPR:P36897
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106799 Expressed in 205 organ(s), highest expression level in decidua
CleanExiHS_TGFBR1
ExpressionAtlasiP36897 baseline and differential
GenevisibleiP36897 HS

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTGFR1_HUMAN
AccessioniPrimary (citable) accession number: P36897
Secondary accession number(s): Q6IR47, Q706C0, Q706C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 214 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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