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UniProtKB - P36894 (BMR1A_HUMAN)

Entry version 231 (12 Aug 2020)
Sequence version 2 (15 Mar 2005)
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Protein

Bone morphogenetic protein receptor type-1A

Gene

BMPR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei261ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei362Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi240 – 248ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.10.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P36894

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201451, Signaling by BMP

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P36894

SIGNOR Signaling Network Open Resource

More...SIGNORi		P36894

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)
Short name:
BMP type-1A receptor
Short name:
BMPR-1A
Alternative name(s):
Activin receptor-like kinase 3
Short name:
ALK-3
Serine/threonine-protein kinase receptor R5
Short name:
SKR5
CD_antigen: CD292
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BMPR1A
Synonyms:ACVRLK3, ALK3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000107779.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:1076, BMPR1A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601299, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P36894

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 152ExtracellularSequence analysisAdd BLAST129
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei153 – 176HelicalSequence analysisAdd BLAST24
Topological domaini177 – 532CytoplasmicSequence analysisAdd BLAST356

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Juvenile polyposis syndrome (JPS)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02282862Y → D in JPS. 1 Publication1
Natural variantiVAR_02282982C → Y in JPS. 1 Publication1
Natural variantiVAR_015533124C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476087EnsemblClinVar.1
Natural variantiVAR_022830130C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs1131691168EnsemblClinVar.1
Natural variantiVAR_015534338A → D in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476086EnsemblClinVar.1
Natural variantiVAR_015535376C → Y in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476088EnsemblClinVar.1
Natural variantiVAR_022831443R → C in JPS. 2 PublicationsCorresponds to variant dbSNP:rs35619497EnsemblClinVar.1
Natural variantiVAR_022832470M → T in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476089EnsemblClinVar.1
Polyposis syndrome, mixed hereditary 2 (HMPS2)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas.
Related information in OMIM
A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi107 – 109DFQ → REL: Affinity for BMP2 decreased by over 200-fold. 1 Publication3

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		657

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		BMPR1A

MalaCards human disease database

More...MalaCardsi		BMPR1A
MIMi174900, phenotype
610069, phenotype
612242, phenotype

Open Targets

More...OpenTargetsi		ENSG00000107779

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		440437, Familial colorectal cancer Type X
329971, Generalized juvenile polyposis/juvenile polyposis coli
157794, Hereditary mixed polyposis syndrome
79076, Juvenile polyposis of infancy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25386

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P36894, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5275

Drug and drug target database

More...DrugBanki		DB11639, Dibotermin alfa

DrugCentral

More...DrugCentrali		P36894

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1786

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BMPR1A

Domain mapping of disease mutations (DMDM)

More...DMDMi		61252444

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002441024 – 532Bone morphogenetic protein receptor type-1AAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi61 ↔ 822 Publications
Disulfide bondi63 ↔ 672 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi76 ↔ 1002 Publications
Disulfide bondi110 ↔ 1242 Publications
Disulfide bondi125 ↔ 1302 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P36894

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P36894

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P36894

MaxQB - The MaxQuant DataBase

More...MaxQBi		P36894

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P36894

PeptideAtlas

More...PeptideAtlasi		P36894

PRoteomics IDEntifications database

More...PRIDEi		P36894

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55228

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P36894, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P36894

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P36894

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107779, Expressed in intestine and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P36894, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P36894, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107779, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BMP2 (PubMed:10881198, PubMed:18937504).

Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation (PubMed:24098149).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107125, 127 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P36894

Database of interacting proteins

More...DIPi		DIP-5793N

Protein interaction database and analysis system

More...IntActi		P36894, 60 interactors

Molecular INTeraction database

More...MINTi		P36894

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361107

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P36894

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P36894, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1532
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P36894

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P36894

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini204 – 233GSPROSITE-ProRule annotationAdd BLAST30
Domaini234 – 525Protein kinasePROSITE-ProRule annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni107 – 109Mediates specificity for BMP ligand1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2052, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156225

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_8_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P36894

KEGG Orthology (KO)

More...KOi		K04673

Identification of Orthologs from Complete Genome Data

More...OMAi		GGMVEDY

Database of Orthologous Groups

More...OrthoDBi		776697at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P36894

TreeFam database of animal gene trees

More...TreeFami		TF314724

Family and domain databases

Database of protein disorder

More...DisProti		DP01990

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000472, Activin_recp
IPR003605, GS_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008271, Ser/Thr_kinase_AS
IPR000333, TGFB_receptor

The PANTHER Classification System

More...PANTHERi		PTHR23255, PTHR23255, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01064, Activin_recp, 1 hit
PF07714, Pkinase_Tyr, 1 hit
PF08515, TGF_beta_GS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00467, GS, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51256, GS, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P36894-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL 
        60         70         80         90        100
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC 
       110        120        130        140        150
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS 
       160        170        180        190        200
IRWLVLLISM AVCIIAMIIF SSCFCYKHYC KSISSRRRYN RDLEQDEAFI 
       210        220        230        240        250
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM 
       260        270        280        290        300
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 
       310        320        330        340        350
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY 
       360        370        380        390        400
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT 
       410        420        430        440        450
RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV 
       460        470        480        490        500
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM 
       510        520        530 
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
Length:532
Mass (Da):60,198
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00CE2DDDA3A44170
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0P8A0A087X0P8_HUMAN
Bone morphogenetic protein receptor...
BMPR1A
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0413972P → T3 PublicationsCorresponds to variant dbSNP:rs11528010EnsemblClinVar.1
Natural variantiVAR_04139858F → Y in a renal clear cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_02282862Y → D in JPS. 1 Publication1
Natural variantiVAR_02282982C → Y in JPS. 1 Publication1
Natural variantiVAR_015533124C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476087EnsemblClinVar.1
Natural variantiVAR_022830130C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs1131691168EnsemblClinVar.1
Natural variantiVAR_015534338A → D in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476086EnsemblClinVar.1
Natural variantiVAR_015535376C → Y in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476088EnsemblClinVar.1
Natural variantiVAR_022831443R → C in JPS. 2 PublicationsCorresponds to variant dbSNP:rs35619497EnsemblClinVar.1
Natural variantiVAR_041399450V → M1 PublicationCorresponds to variant dbSNP:rs55932635EnsemblClinVar.1
Natural variantiVAR_077353460M → T Found in a patient with tubular adenoma and rectal neuroendocrine tumor; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs758309022EnsemblClinVar.1
Natural variantiVAR_022832470M → T in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476089EnsemblClinVar.1
Natural variantiVAR_041400486R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs752802257EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z22535 mRNA Translation: CAA80257.1
AK291764 mRNA Translation: BAF84453.1
BC028383 mRNA Translation: AAH28383.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7378.1

Protein sequence database of the Protein Information Resource

More...PIRi		I37163

NCBI Reference Sequences

More...RefSeqi		NP_004320.2, NM_004329.2
XP_011538405.1, XM_011540103.2
XP_011538406.1, XM_011540104.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372037; ENSP00000361107; ENSG00000107779
ENST00000635816; ENSP00000489707; ENSG00000107779
ENST00000636056; ENSP00000490273; ENSG00000107779
ENST00000638429; ENSP00000492290; ENSG00000107779

Database of genes from NCBI RefSeq genomes

More...GeneIDi		657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:657

UCSC genome browser

More...UCSCi		uc001kdy.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22535 mRNA Translation: CAA80257.1
AK291764 mRNA Translation: BAF84453.1
BC028383 mRNA Translation: AAH28383.1
CCDSiCCDS7378.1
PIRiI37163
RefSeqiNP_004320.2, NM_004329.2
XP_011538405.1, XM_011540103.2
XP_011538406.1, XM_011540104.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ES7X-ray2.90B/D55-143[»]
1REWX-ray1.86C/D24-152[»]
2GOOX-ray2.20B/E24-152[»]
2H62X-ray1.85C24-152[»]
2H64X-ray1.92B24-152[»]
2K3GNMR-A51-152[»]
2QJ9X-ray2.44C/D24-152[»]
2QJAX-ray2.60C/D24-152[»]
2QJBX-ray2.50C/D24-152[»]
3NH7X-ray2.70A/B/C/D24-152[»]
3QB4X-ray2.28B/D24-152[»]
SMRiP36894
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107125, 127 interactors
CORUMiP36894
DIPiDIP-5793N
IntActiP36894, 60 interactors
MINTiP36894
STRINGi9606.ENSP00000361107

Chemistry databases

BindingDBiP36894
ChEMBLiCHEMBL5275
DrugBankiDB11639, Dibotermin alfa
DrugCentraliP36894
GuidetoPHARMACOLOGYi1786

PTM databases

GlyGeniP36894, 1 site
iPTMnetiP36894
PhosphoSitePlusiP36894

Polymorphism and mutation databases

BioMutaiBMPR1A
DMDMi61252444

Proteomic databases

EPDiP36894
jPOSTiP36894
MassIVEiP36894
MaxQBiP36894
PaxDbiP36894
PeptideAtlasiP36894
PRIDEiP36894
ProteomicsDBi55228

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P36894, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4524, 755 antibodies

The DNASU plasmid repository

More...DNASUi		657

Genome annotation databases

EnsembliENST00000372037; ENSP00000361107; ENSG00000107779
ENST00000635816; ENSP00000489707; ENSG00000107779
ENST00000636056; ENSP00000490273; ENSG00000107779
ENST00000638429; ENSP00000492290; ENSG00000107779
GeneIDi657
KEGGihsa:657
UCSCiuc001kdy.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		657
DisGeNETi657
EuPathDBiHostDB:ENSG00000107779.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		BMPR1A
GeneReviewsiBMPR1A
HGNCiHGNC:1076, BMPR1A
HPAiENSG00000107779, Low tissue specificity
MalaCardsiBMPR1A
MIMi174900, phenotype
601299, gene
610069, phenotype
612242, phenotype
neXtProtiNX_P36894
OpenTargetsiENSG00000107779
Orphaneti440437, Familial colorectal cancer Type X
329971, Generalized juvenile polyposis/juvenile polyposis coli
157794, Hereditary mixed polyposis syndrome
79076, Juvenile polyposis of infancy
PharmGKBiPA25386

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2052, Eukaryota
GeneTreeiENSGT00940000156225
HOGENOMiCLU_000288_8_1_1
InParanoidiP36894
KOiK04673
OMAiGGMVEDY
OrthoDBi776697at2759
PhylomeDBiP36894
TreeFamiTF314724

Enzyme and pathway databases

BRENDAi2.7.10.2, 2681
PathwayCommonsiP36894
ReactomeiR-HSA-201451, Signaling by BMP
SignaLinkiP36894
SIGNORiP36894

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		657, 64 hits in 902 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BMPR1A, human
EvolutionaryTraceiP36894

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BMPR1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		657
PharosiP36894, Tchem

Protein Ontology

More...PROi		PR:P36894
RNActiP36894, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000107779, Expressed in intestine and 240 other tissues
ExpressionAtlasiP36894, baseline and differential
GenevisibleiP36894, HS

Family and domain databases

DisProtiDP01990
InterProiView protein in InterPro
IPR000472, Activin_recp
IPR003605, GS_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008271, Ser/Thr_kinase_AS
IPR000333, TGFB_receptor
PANTHERiPTHR23255, PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064, Activin_recp, 1 hit
PF07714, Pkinase_Tyr, 1 hit
PF08515, TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467, GS, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256, GS, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBMR1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36894
Secondary accession number(s): A8K6U9, Q8NEN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 15, 2005
Last modified: August 12, 2020
This is version 231 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  8. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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