UniProtKB - P36894 (BMR1A_HUMAN)
Protein
Bone morphogenetic protein receptor type-1A
Gene
BMPR1A
Organism
Homo sapiens (Human)
Status
Functioni
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.By similarity
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 261 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 362 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 240 – 248 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: HGNC-UCL
- BMP receptor activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein homodimerization activity Source: BHF-UCL
- protein serine/threonine kinase activity Source: HGNC-UCL
- SMAD binding Source: HGNC-UCL
- transforming growth factor beta receptor activity, type I Source: GO_Central
GO - Biological processi
- atrioventricular node cell development Source: BHF-UCL
- atrioventricular valve development Source: BHF-UCL
- BMP signaling pathway Source: BHF-UCL
- BMP signaling pathway involved in heart development Source: BHF-UCL
- cardiac conduction system development Source: BHF-UCL
- cardiac right ventricle morphogenesis Source: BHF-UCL
- cellular response to BMP stimulus Source: BHF-UCL
- cellular response to growth factor stimulus Source: GO_Central
- chondrocyte differentiation Source: Ensembl
- developmental growth Source: Ensembl
- dorsal/ventral axis specification Source: Ensembl
- dorsal/ventral pattern formation Source: GO_Central
- dorsal aorta morphogenesis Source: BHF-UCL
- ectoderm development Source: Ensembl
- embryonic digit morphogenesis Source: Ensembl
- embryonic organ development Source: BHF-UCL
- endocardial cushion formation Source: BHF-UCL
- endocardial cushion morphogenesis Source: BHF-UCL
- fibrous ring of heart morphogenesis Source: BHF-UCL
- heart formation Source: Ensembl
- hindlimb morphogenesis Source: Ensembl
- immune response Source: BHF-UCL
- in utero embryonic development Source: Ensembl
- lateral mesoderm development Source: Ensembl
- lung development Source: Ensembl
- mesendoderm development Source: Ensembl
- mesoderm formation Source: Ensembl
- mitral valve morphogenesis Source: BHF-UCL
- Mullerian duct regression Source: Ensembl
- negative regulation of BMP signaling pathway Source: Reactome
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of neurogenesis Source: Ensembl
- negative regulation of smooth muscle cell migration Source: BHF-UCL
- neural crest cell development Source: Ensembl
- neural plate mediolateral regionalization Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- outflow tract morphogenesis Source: BHF-UCL
- outflow tract septum morphogenesis Source: BHF-UCL
- paraxial mesoderm structural organization Source: Ensembl
- pharyngeal arch artery morphogenesis Source: BHF-UCL
- pituitary gland development Source: Ensembl
- positive regulation of BMP signaling pathway Source: Reactome
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of cardiac ventricle development Source: BHF-UCL
- positive regulation of epithelial cell proliferation Source: Ensembl
- positive regulation of mesenchymal cell proliferation Source: Ensembl
- positive regulation of osteoblast differentiation Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
- positive regulation of SMAD protein signal transduction Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transforming growth factor beta2 production Source: BHF-UCL
- positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- protein phosphorylation Source: HGNC-UCL
- regulation of cardiac muscle cell proliferation Source: BHF-UCL
- regulation of cellular senescence Source: Ensembl
- regulation of lateral mesodermal cell fate specification Source: Ensembl
- roof of mouth development Source: Ensembl
- somitogenesis Source: Ensembl
- stem cell population maintenance Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: ProtInc
- tricuspid valve morphogenesis Source: BHF-UCL
- ventricular compact myocardium morphogenesis Source: BHF-UCL
- ventricular septum morphogenesis Source: BHF-UCL
- ventricular trabecula myocardium morphogenesis Source: BHF-UCL
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P36894 |
Reactomei | R-HSA-201451, Signaling by BMP |
SignaLinki | P36894 |
SIGNORi | P36894 |
Names & Taxonomyi
Protein namesi | Recommended name: Bone morphogenetic protein receptor type-1A (EC:2.7.11.30)Short name: BMP type-1A receptor Short name: BMPR-1A Alternative name(s): Activin receptor-like kinase 3 Short name: ALK-3 Serine/threonine-protein kinase receptor R5 Short name: SKR5 CD_antigen: CD292 |
Gene namesi | Name:BMPR1A Synonyms:ACVRLK3, ALK3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1076, BMPR1A |
MIMi | 601299, gene |
neXtProti | NX_P36894 |
VEuPathDBi | HostDB:ENSG00000107779.11 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Other locations
- Cell surface By similarity
Plasma Membrane
- external side of plasma membrane Source: BHF-UCL
- HFE-transferrin receptor complex Source: BHF-UCL
- plasma membrane Source: BHF-UCL
Other locations
- dendrite Source: Ensembl
- integral component of membrane Source: ProtInc
- neuronal cell body Source: Ensembl
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 152 | ExtracellularSequence analysisAdd BLAST | 129 | |
Transmembranei | 153 – 176 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 177 – 532 | CytoplasmicSequence analysisAdd BLAST | 356 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Juvenile polyposis syndrome (JPS)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022828 | 62 | Y → D in JPS. 1 Publication | 1 | |
Natural variantiVAR_022829 | 82 | C → Y in JPS. 1 Publication | 1 | |
Natural variantiVAR_015533 | 124 | C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476087EnsemblClinVar. | 1 | |
Natural variantiVAR_022830 | 130 | C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs1131691168EnsemblClinVar. | 1 | |
Natural variantiVAR_015534 | 338 | A → D in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476086EnsemblClinVar. | 1 | |
Natural variantiVAR_015535 | 376 | C → Y in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476088EnsemblClinVar. | 1 | |
Natural variantiVAR_022831 | 443 | R → C in JPS. 2 PublicationsCorresponds to variant dbSNP:rs35619497EnsemblClinVar. | 1 | |
Natural variantiVAR_022832 | 470 | M → T in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476089EnsemblClinVar. | 1 |
Polyposis syndrome, mixed hereditary 2 (HMPS2)
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas.
Related information in OMIMA microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 107 – 109 | DFQ → REL: Affinity for BMP2 decreased by over 200-fold. 1 Publication | 3 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 657 |
GeneReviewsi | BMPR1A |
MalaCardsi | BMPR1A |
MIMi | 174900, phenotype 610069, phenotype 612242, phenotype |
OpenTargetsi | ENSG00000107779 |
Orphaneti | 440437, Familial colorectal cancer Type X 329971, Generalized juvenile polyposis/juvenile polyposis coli 157794, Hereditary mixed polyposis syndrome 79076, Juvenile polyposis of infancy |
PharmGKBi | PA25386 |
Miscellaneous databases
Pharosi | P36894, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5275 |
DrugBanki | DB11639, Dibotermin alfa |
DrugCentrali | P36894 |
GuidetoPHARMACOLOGYi | 1786 |
Genetic variation databases
BioMutai | BMPR1A |
DMDMi | 61252444 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000024410 | 24 – 532 | Bone morphogenetic protein receptor type-1AAdd BLAST | 509 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 61 ↔ 82 | 2 Publications | ||
Disulfide bondi | 63 ↔ 67 | 2 Publications | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 76 ↔ 100 | 2 Publications | ||
Disulfide bondi | 110 ↔ 124 | 2 Publications | ||
Disulfide bondi | 125 ↔ 130 | 2 Publications |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P36894 |
jPOSTi | P36894 |
MassIVEi | P36894 |
MaxQBi | P36894 |
PaxDbi | P36894 |
PeptideAtlasi | P36894 |
PRIDEi | P36894 |
ProteomicsDBi | 55228 |
PTM databases
GlyGeni | P36894, 1 site |
iPTMneti | P36894 |
PhosphoSitePlusi | P36894 |
Expressioni
Tissue specificityi
Highly expressed in skeletal muscle.
Gene expression databases
Bgeei | ENSG00000107779, Expressed in intestine and 240 other tissues |
ExpressionAtlasi | P36894, baseline and differential |
Genevisiblei | P36894, HS |
Organism-specific databases
HPAi | ENSG00000107779, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP36894
With | #Exp. | IntAct |
---|---|---|
BMP2 [P12643] | 17 | EBI-1029237,EBI-1029262 |
BMP4 [P12644] | 2 | EBI-1029237,EBI-1998134 |
GDF5 [P43026] | 4 | EBI-1029237,EBI-8571476 |
GO - Molecular functioni
- protein homodimerization activity Source: BHF-UCL
- SMAD binding Source: HGNC-UCL
Protein-protein interaction databases
BioGRIDi | 107125, 153 interactors |
CORUMi | P36894 |
DIPi | DIP-5793N |
IntActi | P36894, 65 interactors |
MINTi | P36894 |
STRINGi | 9606.ENSP00000361107 |
Chemistry databases
BindingDBi | P36894 |
Miscellaneous databases
RNActi | P36894, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P36894 |
SMRi | P36894 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P36894 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 204 – 233 | GSPROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 234 – 525 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 292 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 107 – 109 | Mediates specificity for BMP ligand1 Publication | 3 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000156225 |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | P36894 |
OMAi | GGMVEDY |
OrthoDBi | 776697at2759 |
PhylomeDBi | P36894 |
TreeFami | TF314724 |
Family and domain databases
DisProti | DP01990 |
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P36894-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL
60 70 80 90 100
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC
110 120 130 140 150
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS
160 170 180 190 200
IRWLVLLISM AVCIIAMIIF SSCFCYKHYC KSISSRRRYN RDLEQDEAFI
210 220 230 240 250
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM
260 270 280 290 300
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
310 320 330 340 350
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY
360 370 380 390 400
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT
410 420 430 440 450
RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV
460 470 480 490 500
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM
510 520 530
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X0P8 | A0A087X0P8_HUMAN | Bone morphogenetic protein receptor... | BMPR1A | 41 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041397 | 2 | P → T3 PublicationsCorresponds to variant dbSNP:rs11528010EnsemblClinVar. | 1 | |
Natural variantiVAR_041398 | 58 | F → Y in a renal clear cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_022828 | 62 | Y → D in JPS. 1 Publication | 1 | |
Natural variantiVAR_022829 | 82 | C → Y in JPS. 1 Publication | 1 | |
Natural variantiVAR_015533 | 124 | C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476087EnsemblClinVar. | 1 | |
Natural variantiVAR_022830 | 130 | C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs1131691168EnsemblClinVar. | 1 | |
Natural variantiVAR_015534 | 338 | A → D in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476086EnsemblClinVar. | 1 | |
Natural variantiVAR_015535 | 376 | C → Y in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476088EnsemblClinVar. | 1 | |
Natural variantiVAR_022831 | 443 | R → C in JPS. 2 PublicationsCorresponds to variant dbSNP:rs35619497EnsemblClinVar. | 1 | |
Natural variantiVAR_041399 | 450 | V → M1 PublicationCorresponds to variant dbSNP:rs55932635EnsemblClinVar. | 1 | |
Natural variantiVAR_077353 | 460 | M → T Found in a patient with tubular adenoma and rectal neuroendocrine tumor; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs758309022EnsemblClinVar. | 1 | |
Natural variantiVAR_022832 | 470 | M → T in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476089EnsemblClinVar. | 1 | |
Natural variantiVAR_041400 | 486 | R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs752802257EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22535 mRNA Translation: CAA80257.1 AK291764 mRNA Translation: BAF84453.1 BC028383 mRNA Translation: AAH28383.1 |
CCDSi | CCDS7378.1 |
PIRi | I37163 |
RefSeqi | NP_004320.2, NM_004329.2 XP_011538405.1, XM_011540103.2 XP_011538406.1, XM_011540104.2 |
Genome annotation databases
Ensembli | ENST00000372037; ENSP00000361107; ENSG00000107779 ENST00000635816; ENSP00000489707; ENSG00000107779 ENST00000636056; ENSP00000490273; ENSG00000107779 ENST00000638429; ENSP00000492290; ENSG00000107779 |
GeneIDi | 657 |
KEGGi | hsa:657 |
UCSCi | uc001kdy.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22535 mRNA Translation: CAA80257.1 AK291764 mRNA Translation: BAF84453.1 BC028383 mRNA Translation: AAH28383.1 |
CCDSi | CCDS7378.1 |
PIRi | I37163 |
RefSeqi | NP_004320.2, NM_004329.2 XP_011538405.1, XM_011540103.2 XP_011538406.1, XM_011540104.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ES7 | X-ray | 2.90 | B/D | 55-143 | [»] | |
1REW | X-ray | 1.86 | C/D | 24-152 | [»] | |
2GOO | X-ray | 2.20 | B/E | 24-152 | [»] | |
2H62 | X-ray | 1.85 | C | 24-152 | [»] | |
2H64 | X-ray | 1.92 | B | 24-152 | [»] | |
2K3G | NMR | - | A | 51-152 | [»] | |
2QJ9 | X-ray | 2.44 | C/D | 24-152 | [»] | |
2QJA | X-ray | 2.60 | C/D | 24-152 | [»] | |
2QJB | X-ray | 2.50 | C/D | 24-152 | [»] | |
3NH7 | X-ray | 2.70 | A/B/C/D | 24-152 | [»] | |
3QB4 | X-ray | 2.28 | B/D | 24-152 | [»] | |
BMRBi | P36894 | |||||
SMRi | P36894 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107125, 153 interactors |
CORUMi | P36894 |
DIPi | DIP-5793N |
IntActi | P36894, 65 interactors |
MINTi | P36894 |
STRINGi | 9606.ENSP00000361107 |
Chemistry databases
BindingDBi | P36894 |
ChEMBLi | CHEMBL5275 |
DrugBanki | DB11639, Dibotermin alfa |
DrugCentrali | P36894 |
GuidetoPHARMACOLOGYi | 1786 |
PTM databases
GlyGeni | P36894, 1 site |
iPTMneti | P36894 |
PhosphoSitePlusi | P36894 |
Genetic variation databases
BioMutai | BMPR1A |
DMDMi | 61252444 |
Proteomic databases
EPDi | P36894 |
jPOSTi | P36894 |
MassIVEi | P36894 |
MaxQBi | P36894 |
PaxDbi | P36894 |
PeptideAtlasi | P36894 |
PRIDEi | P36894 |
ProteomicsDBi | 55228 |
Protocols and materials databases
ABCDi | P36894, 1 sequenced antibody |
Antibodypediai | 4524, 788 antibodies |
DNASUi | 657 |
Genome annotation databases
Ensembli | ENST00000372037; ENSP00000361107; ENSG00000107779 ENST00000635816; ENSP00000489707; ENSG00000107779 ENST00000636056; ENSP00000490273; ENSG00000107779 ENST00000638429; ENSP00000492290; ENSG00000107779 |
GeneIDi | 657 |
KEGGi | hsa:657 |
UCSCi | uc001kdy.4, human |
Organism-specific databases
CTDi | 657 |
DisGeNETi | 657 |
GeneCardsi | BMPR1A |
GeneReviewsi | BMPR1A |
HGNCi | HGNC:1076, BMPR1A |
HPAi | ENSG00000107779, Low tissue specificity |
MalaCardsi | BMPR1A |
MIMi | 174900, phenotype 601299, gene 610069, phenotype 612242, phenotype |
neXtProti | NX_P36894 |
OpenTargetsi | ENSG00000107779 |
Orphaneti | 440437, Familial colorectal cancer Type X 329971, Generalized juvenile polyposis/juvenile polyposis coli 157794, Hereditary mixed polyposis syndrome 79076, Juvenile polyposis of infancy |
PharmGKBi | PA25386 |
VEuPathDBi | HostDB:ENSG00000107779.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000156225 |
HOGENOMi | CLU_000288_8_1_1 |
InParanoidi | P36894 |
OMAi | GGMVEDY |
OrthoDBi | 776697at2759 |
PhylomeDBi | P36894 |
TreeFami | TF314724 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P36894 |
Reactomei | R-HSA-201451, Signaling by BMP |
SignaLinki | P36894 |
SIGNORi | P36894 |
Miscellaneous databases
BioGRID-ORCSi | 657, 76 hits in 1020 CRISPR screens |
ChiTaRSi | BMPR1A, human |
EvolutionaryTracei | P36894 |
GeneWikii | BMPR1A |
GenomeRNAii | 657 |
Pharosi | P36894, Tchem |
PROi | PR:P36894 |
RNActi | P36894, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107779, Expressed in intestine and 240 other tissues |
ExpressionAtlasi | P36894, baseline and differential |
Genevisiblei | P36894, HS |
Family and domain databases
DisProti | DP01990 |
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMR1A_HUMAN | |
Accessioni | P36894Primary (citable) accession number: P36894 Secondary accession number(s): A8K6U9, Q8NEN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | March 15, 2005 | |
Last modified: | April 7, 2021 | |
This is version 235 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families