BMPR1A

Functionⁱ

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.By similarity

Catalytic activityⁱ

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactorⁱ

Mg²⁺By similarity, Mn²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	261	ATPPROSITE-ProRule annotation		1
Active siteⁱ	362	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	240 – 248	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding
Source: HGNC
Inferred from direct assayⁱ
- 12065756
BMP receptor activity Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific Source: Ensembl
growth factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18436533
protein serine/threonine kinase activity
Source: HGNC
Inferred from direct assayⁱ
- 12065756
SMAD binding
Source: HGNC
Inferred from direct assayⁱ
- 12065756
transforming growth factor beta-activated receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transforming growth factor beta receptor activity, type I
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transmembrane receptor protein serine/threonine kinase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

BMP signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 18436533
- 9389648
BMP signaling pathway involved in heart development Source: BHF-UCL
cardiac conduction system development Source: BHF-UCL
cardiac right ventricle morphogenesis Source: BHF-UCL
cellular response to BMP stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18326817
chondrocyte differentiation Source: Ensembl
developmental growth Source: Ensembl
dorsal/ventral axis specification Source: Ensembl
dorsal aorta morphogenesis Source: BHF-UCL
ectoderm development Source: Ensembl
embryonic digit morphogenesis Source: Ensembl
embryonic organ development Source: Ensembl
endocardial cushion formation Source: BHF-UCL
endocardial cushion morphogenesis Source: BHF-UCL
fibrous ring of heart morphogenesis Source: BHF-UCL
heart formation Source: Ensembl
hindlimb morphogenesis Source: Ensembl
immune response
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16886151
in utero embryonic development Source: Ensembl
lateral mesoderm development Source: Ensembl
lung development Source: Ensembl
mesendoderm development Source: Ensembl
mesoderm formation Source: Ensembl
mitral valve morphogenesis Source: BHF-UCL
Mullerian duct regression Source: Ensembl
negative regulation of neurogenesis Source: Ensembl
negative regulation of smooth muscle cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18667463
neural crest cell development Source: Ensembl
neural plate mediolateral regionalization Source: Ensembl
odontogenesis of dentin-containing tooth Source: Ensembl
outflow tract morphogenesis Source: BHF-UCL
outflow tract septum morphogenesis Source: BHF-UCL
paraxial mesoderm structural organization Source: Ensembl
pattern specification process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
pharyngeal arch artery morphogenesis Source: BHF-UCL
pituitary gland development Source: Ensembl
positive regulation of bone mineralization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18436533
positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
positive regulation of cardiac ventricle development Source: BHF-UCL
positive regulation of epithelial cell proliferation Source: Ensembl
positive regulation of mesenchymal cell proliferation Source: Ensembl
positive regulation of osteoblast differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18436533
positive regulation of pathway-restricted SMAD protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 24904118
- 9389648
positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
positive regulation of SMAD protein signal transduction
Source: BHF-UCL
Inferred from direct assayⁱ
- 9389648
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18326817
positive regulation of vascular smooth muscle cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18667463
protein phosphorylation
Source: HGNC
Inferred from direct assayⁱ
- 12065756
regulation of cardiac muscle cell proliferation Source: BHF-UCL
regulation of cellular senescence Source: Ensembl
regulation of lateral mesodermal cell fate specification Source: Ensembl
roof of mouth development Source: Ensembl
somitogenesis Source: Ensembl
stem cell population maintenance Source: Ensembl
transforming growth factor beta receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
tricuspid valve morphogenesis Source: BHF-UCL
ventricular compact myocardium morphogenesis Source: BHF-UCL
ventricular trabecula myocardium morphogenesis Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-201451 Signaling by BMP
SignaLinkⁱ	P36894
SIGNORⁱ	P36894

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bone morphogenetic protein receptor type-1A (EC:2.7.11.30) Short name: BMP type-1A receptor Short name: BMPR-1A Alternative name(s): Activin receptor-like kinase 3 Short name: ALK-3 Serine/threonine-protein kinase receptor R5 Short name: SKR5 CD_antigen: CD292
Gene namesⁱ	Name:BMPR1A Synonyms:ACVRLK3, ALK3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107779.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1076 BMPR1A
MIMⁱ	601299 gene
neXtProtⁱ	NX_P36894

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 152	ExtracellularSequence analysisAdd BLAST	129
Transmembraneⁱ	153 – 176	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	177 – 532	CytoplasmicSequence analysisAdd BLAST	356

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Juvenile polyposis syndrome (JPS)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_022828	62	Y → D in JPS. 1 Publication	1
Natural variantⁱVAR_022829	82	C → Y in JPS. 1 Publication	1
Natural variantⁱVAR_015533	124	C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476087EnsemblClinVar.	1
Natural variantⁱVAR_022830	130	C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs1131691168Ensembl.	1
Natural variantⁱVAR_015534	338	A → D in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476086EnsemblClinVar.	1
Natural variantⁱVAR_015535	376	C → Y in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476088EnsemblClinVar.	1
Natural variantⁱVAR_022831	443	R → C in JPS. 2 PublicationsCorresponds to variant dbSNP:rs35619497EnsemblClinVar.	1
Natural variantⁱVAR_022832	470	M → T in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476089EnsemblClinVar.	1

Polyposis syndrome, mixed hereditary 2 (HMPS2)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	107 – 109	DFQ → REL: Affinity for BMP2 decreased by over 200-fold. 1 Publication		3

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	657
GeneReviewsⁱ	BMPR1A
MalaCards human disease database More...MalaCardsⁱ	BMPR1A
MIMⁱ	174900 phenotype 610069 phenotype 612242 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000107779
Orphanetⁱ	440437 Familial colorectal cancer Type X 329971 Generalized juvenile polyposis/juvenile polyposis coli 157794 Hereditary mixed polyposis syndrome 79076 Juvenile polyposis of infancy
PharmGKBⁱ	PA25386

Chemistry databases

ChEMBLⁱ	CHEMBL5275
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1786

Polymorphism and mutation databases

BioMutaⁱ	BMPR1A
DMDMⁱ	61252444

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000024410	24 – 532	Bone morphogenetic protein receptor type-1AAdd BLAST		509

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	61 ↔ 82	2 Publications
Disulfide bondⁱ	63 ↔ 67	2 Publications
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	76 ↔ 100	2 Publications
Disulfide bondⁱ	110 ↔ 124	2 Publications
Disulfide bondⁱ	125 ↔ 130	2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P36894
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36894
PaxDbⁱ	P36894
PeptideAtlas More...PeptideAtlasⁱ	P36894
PRIDEⁱ	P36894
ProteomicsDBⁱ	55228

PTM databases

iPTMnetⁱ	P36894
PhosphoSitePlusⁱ	P36894

Expressionⁱ

Tissue specificityⁱ

Highly expressed in skeletal muscle.

Gene expression databases

Bgeeⁱ	ENSG00000107779 Expressed in 226 organ(s), highest expression level in intestine
CleanExⁱ	HS_BMPR1A
ExpressionAtlasⁱ	P36894 baseline and differential
Genevisibleⁱ	P36894 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB019398

HPAⁱ

CAB019398

Interactionⁱ

Subunit structureⁱ

Interacts with BMP2 (PubMed:10881198, PubMed:18937504). Interacts with low affinity with GDF5; positively regulates chondrocyte differentiation (PubMed:24098149).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BMP2	P12643	17	EBI-1029237,EBI-1029262
BMP4	P12644	2	EBI-1029237,EBI-1998134
GDF5	P43026	3	EBI-1029237,EBI-8571476

GO - Molecular functionⁱ

growth factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18436533
SMAD binding
Source: HGNC
Inferred from direct assayⁱ
- 12065756

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107125, 78 interactors
CORUMⁱ	P36894
Database of interacting proteins More...DIPⁱ	DIP-5793N
IntActⁱ	P36894, 31 interactors
Molecular INTeraction database More...MINTⁱ	P36894
STRINGⁱ	9606.ENSP00000224764

Chemistry databases

BindingDBⁱ

P36894

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	59 – 62	Combined sources	4
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	75 – 88	Combined sources	14
Beta strandⁱ	90 – 92	Combined sources	3
Beta strandⁱ	94 – 101	Combined sources	8
Helixⁱ	106 – 111	Combined sources	6
Beta strandⁱ	116 – 118	Combined sources	3
Beta strandⁱ	120 – 125	Combined sources	6
Helixⁱ	130 – 133	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P36894
SMRⁱ	P36894
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P36894

EvolutionaryTraceⁱ

P36894

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	204 – 233	GSPROSITE-ProRule annotationAdd BLAST		30
Domainⁱ	234 – 525	Protein kinasePROSITE-ProRule annotationAdd BLAST		292

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	107 – 109	Mediates specificity for BMP ligand1 Publication		3

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2052 Eukaryota ENOG410XQT0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000230587
HOVERGENⁱ	HBG054502
InParanoidⁱ	P36894
KEGG Orthology (KO) More...KOⁱ	K04673
OMAⁱ	EVVCVKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BIU
PhylomeDBⁱ	P36894
TreeFamⁱ	TF314724

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR003605 GS_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF07714 Pkinase_Tyr, 1 hit PF08515 TGF_beta_GS, 1 hit
SMARTⁱ	View protein in SMART SM00467 GS, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51256 GS, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P36894-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL 
        60         70         80         90        100
APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC 
       110        120        130        140        150
MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS 
       160        170        180        190        200
IRWLVLLISM AVCIIAMIIF SSCFCYKHYC KSISSRRRYN RDLEQDEAFI 
       210        220        230        240        250
PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM 
       260        270        280        290        300
GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 
       310        320        330        340        350
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY 
       360        370        380        390        400
GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT 
       410        420        430        440        450
RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV 
       460        470        480        490        500
EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM 
       510        520        530 
SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

Length:532

Mass (Da):60,198

Last modified:March 15, 2005 - v2

Checksum:ⁱ00CE2DDDA3A44170

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087X0P8	A0A087X0P8_HUMAN		Bone morphogenetic protein receptor... Bone morphogenetic protein receptor type-1A	BMPR1A	41	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041397	2	P → T3 PublicationsCorresponds to variant dbSNP:rs11528010EnsemblClinVar.	1
Natural variantⁱVAR_041398	58	F → Y in a renal clear cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_022828	62	Y → D in JPS. 1 Publication	1
Natural variantⁱVAR_022829	82	C → Y in JPS. 1 Publication	1
Natural variantⁱVAR_015533	124	C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476087EnsemblClinVar.	1
Natural variantⁱVAR_022830	130	C → R in JPS. 1 PublicationCorresponds to variant dbSNP:rs1131691168Ensembl.	1
Natural variantⁱVAR_015534	338	A → D in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476086EnsemblClinVar.	1
Natural variantⁱVAR_015535	376	C → Y in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476088EnsemblClinVar.	1
Natural variantⁱVAR_022831	443	R → C in JPS. 2 PublicationsCorresponds to variant dbSNP:rs35619497EnsemblClinVar.	1
Natural variantⁱVAR_041399	450	V → M1 PublicationCorresponds to variant dbSNP:rs55932635EnsemblClinVar.	1
Natural variantⁱVAR_077353	460	M → T Found in a patient with tubular adenoma and rectal neuroendocrine tumor; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs758309022EnsemblClinVar.	1
Natural variantⁱVAR_022832	470	M → T in JPS. 1 PublicationCorresponds to variant dbSNP:rs199476089EnsemblClinVar.	1
Natural variantⁱVAR_041400	486	R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs752802257EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z22535 mRNA Translation: CAA80257.1 AK291764 mRNA Translation: BAF84453.1 BC028383 mRNA Translation: AAH28383.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7378.1
PIRⁱ	I37163
NCBI Reference Sequences More...RefSeqⁱ	NP_004320.2, NM_004329.2 XP_011538405.1, XM_011540103.2 XP_011538406.1, XM_011540104.2
UniGeneⁱ	Hs.524477

Genome annotation databases

Ensemblⁱ	ENST00000372037; ENSP00000361107; ENSG00000107779 ENST00000635816; ENSP00000489707; ENSG00000107779 ENST00000636056; ENSP00000490273; ENSG00000107779 ENST00000638429; ENSP00000492290; ENSG00000107779
GeneIDⁱ	657
KEGGⁱ	hsa:657
UCSC genome browser More...UCSCⁱ	uc001kdy.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P36894	Receptor protein serine/threonine kinase		SAIBB		432	UniRef100_P36894
Bone morphogenetic protein receptor type-1A (Fragment)		HUMAN		41
UPI000041B00A		RHIRO		504

Protein	Similar proteins		Species	Score	Length	Source
P36894	Receptor protein serine/threonine kinase		SAIBB		432	UniRef90_P36894
Bone morphogenetic protein receptor type-1A (Fragment)		HUMAN		41
Receptor protein serine/threonine kinase		ALLMI		600
Receptor protein serine/threonine kinase		CARIC		541
Receptor protein serine/threonine kinase		FICAL		533
+195

Protein	Similar proteins		Species	Score	Length	Source
P36894	Bone morphogenetic protein receptor type-1A		MOUSE		532	UniRef50_P36895
Bone morphogenetic protein receptor type-1A		RAT		532
Bone morphogenetic protein receptor type-1B	)	HUMAN		502
Bone morphogenetic protein receptor type-1B		CHICK		502
Receptor protein serine/threonine kinase		PIG		561
+1114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z22535 mRNA Translation: CAA80257.1 AK291764 mRNA Translation: BAF84453.1 BC028383 mRNA Translation: AAH28383.1
CCDSⁱ	CCDS7378.1
PIRⁱ	I37163
RefSeqⁱ	NP_004320.2, NM_004329.2 XP_011538405.1, XM_011540103.2 XP_011538406.1, XM_011540104.2
UniGeneⁱ	Hs.524477

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ES7	X-ray	2.90	B/D	55-143	[»]
	1REW	X-ray	1.86	C/D	24-152	[»]
	2GOO	X-ray	2.20	B/E	24-152	[»]
	2H62	X-ray	1.85	C	24-152	[»]
	2H64	X-ray	1.92	B	24-152	[»]
	2K3G	NMR	-	A	51-152	[»]
	2QJ9	X-ray	2.44	C/D	24-152	[»]
	2QJA	X-ray	2.60	C/D	24-152	[»]
	2QJB	X-ray	2.50	C/D	24-152	[»]
	3NH7	X-ray	2.70	A/B/C/D	24-152	[»]
	3QB4	X-ray	2.28	B/D	24-152	[»]
ProteinModelPortalⁱ	P36894
SMRⁱ	P36894
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107125, 78 interactors
CORUMⁱ	P36894
DIPⁱ	DIP-5793N
IntActⁱ	P36894, 31 interactors
MINTⁱ	P36894
STRINGⁱ	9606.ENSP00000224764

Chemistry databases

BindingDBⁱ	P36894
ChEMBLⁱ	CHEMBL5275
GuidetoPHARMACOLOGYⁱ	1786

PTM databases

iPTMnetⁱ	P36894
PhosphoSitePlusⁱ	P36894

Polymorphism and mutation databases

BioMutaⁱ	BMPR1A
DMDMⁱ	61252444

Proteomic databases

EPDⁱ	P36894
MaxQBⁱ	P36894
PaxDbⁱ	P36894
PeptideAtlasⁱ	P36894
PRIDEⁱ	P36894
ProteomicsDBⁱ	55228

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	657
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000372037; ENSP00000361107; ENSG00000107779 ENST00000635816; ENSP00000489707; ENSG00000107779 ENST00000636056; ENSP00000490273; ENSG00000107779 ENST00000638429; ENSP00000492290; ENSG00000107779
GeneIDⁱ	657
KEGGⁱ	hsa:657
UCSCⁱ	uc001kdy.4 human

Organism-specific databases

CTDⁱ	657
DisGeNETⁱ	657
EuPathDBⁱ	HostDB:ENSG00000107779.11
GeneCardsⁱ	BMPR1A
GeneReviewsⁱ	BMPR1A
HGNCⁱ	HGNC:1076 BMPR1A
HPAⁱ	CAB019398
MalaCardsⁱ	BMPR1A
MIMⁱ	174900 phenotype 601299 gene 610069 phenotype 612242 phenotype
neXtProtⁱ	NX_P36894
OpenTargetsⁱ	ENSG00000107779
Orphanetⁱ	440437 Familial colorectal cancer Type X 329971 Generalized juvenile polyposis/juvenile polyposis coli 157794 Hereditary mixed polyposis syndrome 79076 Juvenile polyposis of infancy
PharmGKBⁱ	PA25386
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2052 Eukaryota ENOG410XQT0 LUCA
GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000230587
HOVERGENⁱ	HBG054502
InParanoidⁱ	P36894
KOⁱ	K04673
OMAⁱ	EVVCVKG
OrthoDBⁱ	EOG091G0BIU
PhylomeDBⁱ	P36894
TreeFamⁱ	TF314724

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-201451 Signaling by BMP
SignaLinkⁱ	P36894
SIGNORⁱ	P36894

Miscellaneous databases

ChiTaRSⁱ	BMPR1A human
EvolutionaryTraceⁱ	P36894
GeneWikiⁱ	BMPR1A
GenomeRNAiⁱ	657
Protein Ontology More...PROⁱ	PR:P36894
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107779 Expressed in 226 organ(s), highest expression level in intestine
CleanExⁱ	HS_BMPR1A
ExpressionAtlasⁱ	P36894 baseline and differential
Genevisibleⁱ	P36894 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR003605 GS_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF07714 Pkinase_Tyr, 1 hit PF08515 TGF_beta_GS, 1 hit
SMARTⁱ	View protein in SMART SM00467 GS, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51256 GS, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BMR1A_HUMAN
Accessionⁱ	P36894Primary (citable) accession number: P36894 Secondary accession number(s): A8K6U9, Q8NEN8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	March 15, 2005
	Last modified:	November 7, 2018
	This is version 217 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P36894 (BMR1A_HUMAN)

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Bone morphogenetic protein receptor type-1A

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Polyposis syndrome, mixed hereditary 2 (HMPS2)

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Keywords - Diseaseⁱ

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