UniProtKB - P36888 (FLT3_HUMAN)
Receptor-type tyrosine-protein kinase FLT3
FLT3
Functioni
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
11 PublicationsMiscellaneous
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation1 PublicationEC:2.7.10.1PROSITE-ProRule annotation1 Publication
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 644 | ATPCurated | 1 | |
Active sitei | 811 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 616 – 624 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cytokine receptor activity Source: UniProtKB
- glucocorticoid receptor binding Source: Ensembl
- growth factor binding Source: GO_Central
- protein-containing complex binding Source: Ensembl
- protein self-association Source: CAFA
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: Reactome
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
- vascular endothelial growth factor-activated receptor activity Source: ProtInc
GO - Biological processi
- animal organ regeneration Source: Ensembl
- B cell differentiation Source: UniProtKB
- cellular response to cytokine stimulus Source: UniProtKB
- cellular response to glucocorticoid stimulus Source: Ensembl
- common myeloid progenitor cell proliferation Source: UniProtKB
- cytokine-mediated signaling pathway Source: UniProtKB
- dendritic cell differentiation Source: UniProtKB
- hemopoiesis Source: MGI
- leukocyte homeostasis Source: UniProtKB
- lymphocyte proliferation Source: UniProtKB
- myeloid progenitor cell differentiation Source: UniProtKB
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of MAP kinase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- pro-B cell differentiation Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- regulation of apoptotic process Source: UniProtKB
- response to organonitrogen compound Source: Ensembl
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Host-virus interaction |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | P36888 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9607240, FLT3 Signaling R-HSA-9645135, STAT5 Activation R-HSA-9702509, FLT3 mutants bind TKIs R-HSA-9702518, STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702569, KW2449-resistant FLT3 mutants R-HSA-9702577, semaxanib-resistant FLT3 mutants R-HSA-9702581, crenolanib-resistant FLT3 mutants R-HSA-9702590, gilteritinib-resistant FLT3 mutants R-HSA-9702596, lestaurtinib-resistant FLT3 mutants R-HSA-9702600, midostaurin-resistant FLT3 mutants R-HSA-9702605, pexidartinib-resistant FLT3 mutants R-HSA-9702614, ponatinib-resistant FLT3 mutants R-HSA-9702620, quizartinib-resistant FLT3 mutants R-HSA-9702624, sorafenib-resistant FLT3 mutants R-HSA-9702632, sunitinib-resistant FLT3 mutants R-HSA-9702636, tandutinib-resistant FLT3 mutants R-HSA-9702998, linifanib-resistant FLT3 mutants R-HSA-9703009, tamatinib-resistant FLT3 mutants R-HSA-9703648, Signaling by FLT3 ITD and TKD mutants R-HSA-9706369, Negative regulation of FLT3 R-HSA-9706374, FLT3 signaling through SRC family kinases R-HSA-9706377, FLT3 signaling by CBL mutants |
SignaLinki | P36888 |
SIGNORi | P36888 |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-type tyrosine-protein kinase FLT3 (EC:2.7.10.1)Alternative name(s): FL cytokine receptor Fetal liver kinase-2 Short name: FLK-2 Fms-like tyrosine kinase 3 Short name: FLT-3 Stem cell tyrosine kinase 1 Short name: STK-1 CD_antigen: CD135 |
Gene namesi | Name:FLT3 Synonyms:CD135, FLK2, STK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3765, FLT3 |
MIMi | 136351, gene |
neXtProti | NX_P36888 |
VEuPathDBi | HostDB:ENSG00000122025 |
Subcellular locationi
Endoplasmic reticulum
Other locations
Note: Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
Cytosol
- cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Endosome
- endosome membrane Source: Reactome
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 543 | ExtracellularSequence analysisAdd BLAST | 517 | |
Transmembranei | 544 – 563 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 564 – 993 | CytoplasmicSequence analysisAdd BLAST | 430 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Involvement in diseasei
Leukemia, acute myelogenous (AML)8 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 589 | Y → F: Reduced phosphorylation of the wild-type kinase in response to ligand binding. No effect on the phosphorylation of the constitutively activated mutant kinase variants. Abolishes activation of STAT5A. 3 Publications | 1 | |
Mutagenesisi | 591 | Y → F: No significant effect on tyrosine phosphorylation. Abolishes activation of STAT5A. 2 Publications | 1 | |
Mutagenesisi | 599 | Y → F: Abolishes interaction with PTPN11/SHP2 and phosphorylation of PTPN11/SHP2. 1 Publication | 1 | |
Mutagenesisi | 644 | K → A: Abolishes kinase activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 2322 |
MalaCardsi | FLT3 |
MIMi | 601626, phenotype |
OpenTargetsi | ENSG00000122025 |
Orphaneti | 98834, Acute myeloblastic leukemia with maturation 98833, Acute myeloblastic leukemia without maturation 98829, Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 98832, Acute myeloid leukemia with minimal differentiation 102724, Acute myeloid leukemia with t(8;21)(q22;q22) translocation 530995, Mixed phenotype acute leukemia 99860, Precursor B-cell acute lymphoblastic leukemia 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA28181 |
Miscellaneous databases
Pharosi | P36888, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1974 |
DrugBanki | DB06080, ABT-869 DB12742, Amuvatinib DB12267, Brigatinib DB12500, Fedratinib DB12010, Fostamatinib DB12141, Gilteritinib DB06469, Lestaurtinib DB06595, Midostaurin DB09079, Nintedanib DB12978, Pexidartinib DB08901, Ponatinib DB15822, Pralsetinib DB12874, Quizartinib DB00398, Sorafenib DB01268, Sunitinib DB05465, Tandutinib DB05014, XL999 |
DrugCentrali | P36888 |
GuidetoPHARMACOLOGYi | 1807 |
Genetic variation databases
BioMutai | FLT3 |
DMDMi | 156630887 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000016778 | 27 – 993 | Receptor-type tyrosine-protein kinase FLT3Add BLAST | 967 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 65 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 43 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 100 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 103 ↔ 114 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 199 ↔ 206 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 232 ↔ 241 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 272 ↔ 330 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 306 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 323 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 351 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 354 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 368 ↔ 407 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 381 ↔ 392 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 473 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 502 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 541 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 572 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 574 | Phosphoserine1 Publication | 1 | |
Modified residuei | 589 | Phosphotyrosine; by autocatalysis3 Publications | 1 | |
Modified residuei | 591 | Phosphotyrosine; by autocatalysis5 Publications | 1 | |
Modified residuei | 599 | Phosphotyrosine; by autocatalysis3 Publications | 1 | |
Modified residuei | 726 | Phosphotyrosine; by autocatalysis2 Publications | 1 | |
Modified residuei | 759 | PhosphoserineCombined sources | 1 | |
Modified residuei | 768 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 793 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 842 | Phosphotyrosine; by autocatalysis3 Publications | 1 | |
Modified residuei | 955 | Phosphotyrosine; by autocatalysis3 Publications | 1 | |
Modified residuei | 969 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 993 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-2792 |
jPOSTi | P36888 |
MassIVEi | P36888 |
MaxQBi | P36888 |
PaxDbi | P36888 |
PeptideAtlasi | P36888 |
PRIDEi | P36888 |
ProteomicsDBi | 55226 [P36888-1] 55227 [P36888-2] |
PTM databases
GlyGeni | P36888, 10 sites |
iPTMneti | P36888 |
PhosphoSitePlusi | P36888 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000122025, Expressed in cerebellar hemisphere and 121 other tissues |
ExpressionAtlasi | P36888, baseline and differential |
Genevisiblei | P36888, HS |
Organism-specific databases
HPAi | ENSG00000122025, Tissue enhanced (bone marrow, brain, lymphoid tissue) |
Interactioni
Subunit structurei
Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG.
Interacts with FIZ1 following ligand activation (By similarity).
Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2.
Interacts with PTPRJ/DEP-1 and PTPN11/SHP2.
Interacts with RNF115 and RNF126 (By similarity).
By similarity6 Publications(Microbial infection) Interacts with human cytomegalovirus protein UL7.
1 PublicationBinary interactionsi
P36888
GO - Molecular functioni
- glucocorticoid receptor binding Source: Ensembl
- growth factor binding Source: GO_Central
- protein self-association Source: CAFA
Protein-protein interaction databases
BioGRIDi | 108610, 140 interactors |
DIPi | DIP-59769N |
IntActi | P36888, 57 interactors |
MINTi | P36888 |
STRINGi | 9606.ENSP00000241453 |
Chemistry databases
BindingDBi | P36888 |
Miscellaneous databases
RNActi | P36888, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P36888 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P36888 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 253 – 343 | Ig-like C2-typeAdd BLAST | 91 | |
Domaini | 610 – 943 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 334 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 591 – 597 | Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand | 7 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000160575 |
HOGENOMi | CLU_000288_49_1_1 |
InParanoidi | P36888 |
OMAi | EVQIHQD |
OrthoDBi | 719800at2759 |
PhylomeDBi | P36888 |
TreeFami | TF325768 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR030118, FLT3 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS |
PANTHERi | PTHR24416:SF356, PTHR24416:SF356, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
SMARTi | View protein in SMART SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS
60 70 80 90 100
SSYPMVSESP EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN
110 120 130 140 150
ISCLWVFKHS SLNCQPHFDL QNRGVVSMVI LKMTETQAGE YLLFIQSEAT
160 170 180 190 200
NYTILFTVSI RNTLLYTLRR PYFRKMENQD ALVCISESVP EPIVEWVLCD
210 220 230 240 250
SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE CTRLFTIDLN
260 270 280 290 300
QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM
310 320 330 340 350
STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI
360 370 380 390 400
NATNSSEDYE IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG
410 420 430 440 450
YSISKFCNHK HQPGEYIFHA ENDDAQFTKM FTLNIRRKPQ VLAEASASQA
460 470 480 490 500
SCFSDGYPLP SWTWKKCSDK SPNCTEEITE GVWNRKANRK VFGQWVSSST
510 520 530 540 550
LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD NISFYATIGV
560 570 580 590 600
CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD
610 620 630 640 650
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA
660 670 680 690 700
DSSEREALMS ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL
710 720 730 740 750
NYLRSKREKF HRTWTEIFKE HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD
760 770 780 790 800
QISGLHGNSF HSEDEIEYEN QKRLEEEEDL NVLTFEDLLC FAYQVAKGME
810 820 830 840 850
FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS NYVVRGNARL
860 870 880 890 900
PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK
910 920 930 940 950
LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA
960 970 980 990
EEAMYQNVDG RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE7ER61 | E7ER61_HUMAN | Receptor protein-tyrosine kinase | FLT3 | 739 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | G → A in AAA18947 (PubMed:7507245).Curated | 1 | |
Sequence conflicti | 10 – 11 | QL → TV in AAA18947 (PubMed:7507245).Curated | 2 | |
Sequence conflicti | 71 | S → N in AAI44040 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 78 | A → R in CAA81393 (PubMed:8394751).Curated | 1 | |
Sequence conflicti | 346 | E → G in AAA18947 (PubMed:7507245).Curated | 1 | |
Sequence conflicti | 940 | T → H in AAA35487 (PubMed:2004790).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034677 | 7 | D → G. Corresponds to variant dbSNP:rs12872889Ensembl. | 1 | |
Natural variantiVAR_042069 | 158 | V → A1 PublicationCorresponds to variant dbSNP:rs56321896Ensembl. | 1 | |
Natural variantiVAR_054149 | 194 | V → M1 PublicationCorresponds to variant dbSNP:rs146030737EnsemblClinVar. | 1 | |
Natural variantiVAR_034678 | 227 | T → M4 PublicationsCorresponds to variant dbSNP:rs1933437EnsemblClinVar. | 1 | |
Natural variantiVAR_042070 | 324 | D → N1 PublicationCorresponds to variant dbSNP:rs35602083EnsemblClinVar. | 1 | |
Natural variantiVAR_042071 | 358 | D → V1 PublicationCorresponds to variant dbSNP:rs34172843EnsemblClinVar. | 1 | |
Natural variantiVAR_061291 | 417 | I → L. Corresponds to variant dbSNP:rs56090538EnsemblClinVar. | 1 | |
Natural variantiVAR_042072 | 557 | V → I1 PublicationCorresponds to variant dbSNP:rs35958982EnsemblClinVar. | 1 | |
Natural variantiVAR_065679 | 835 | D → E in acute lymphoblastic leukemia patients and acute myelogenous leukemia patients; somatic mutation; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121913487EnsemblClinVar. | 1 | |
Natural variantiVAR_065680 | 835 | D → H in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated. 3 PublicationsCorresponds to variant dbSNP:rs121913488EnsemblClinVar. | 1 | |
Natural variantiVAR_065681 | 835 | D → N in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated. 1 PublicationCorresponds to variant dbSNP:rs121913488EnsemblClinVar. | 1 | |
Natural variantiVAR_065682 | 835 | D → V in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated. 1 PublicationCorresponds to variant dbSNP:rs121909646EnsemblClinVar. | 1 | |
Natural variantiVAR_065683 | 835 | D → Y in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated. 3 PublicationsCorresponds to variant dbSNP:rs121913488EnsemblClinVar. | 1 | |
Natural variantiVAR_065684 | 836 | I → M in acute lymphoblastic leukemia patients; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913232EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041796 | 807 – 847 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02687 mRNA Translation: AAA18947.1 Z26652 mRNA Translation: CAA81393.1 AL356915 Genomic DNA No translation available. AL445262 Genomic DNA No translation available. AL591024 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08424.1 BC126350 mRNA Translation: AAI26351.1 BC144039 mRNA Translation: AAI44040.1 BC144040 mRNA Translation: AAI44041.1 L36162 mRNA Translation: AAA35487.1 |
CCDSi | CCDS31953.1 [P36888-1] |
PIRi | A36873 A39061 |
RefSeqi | NP_004110.2, NM_004119.2 [P36888-1] |
Genome annotation databases
Ensembli | ENST00000241453; ENSP00000241453; ENSG00000122025 |
GeneIDi | 2322 |
KEGGi | hsa:2322 |
MANE-Selecti | ENST00000241453.12; ENSP00000241453.7; NM_004119.3; NP_004110.2 |
UCSCi | uc001urw.3, human [P36888-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02687 mRNA Translation: AAA18947.1 Z26652 mRNA Translation: CAA81393.1 AL356915 Genomic DNA No translation available. AL445262 Genomic DNA No translation available. AL591024 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08424.1 BC126350 mRNA Translation: AAI26351.1 BC144039 mRNA Translation: AAI44040.1 BC144040 mRNA Translation: AAI44041.1 L36162 mRNA Translation: AAA35487.1 |
CCDSi | CCDS31953.1 [P36888-1] |
PIRi | A36873 A39061 |
RefSeqi | NP_004110.2, NM_004119.2 [P36888-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RJB | X-ray | 2.10 | A | 564-958 | [»] | |
3QS7 | X-ray | 4.30 | E/F/G/H | 27-436 | [»] | |
3QS9 | X-ray | 7.80 | E/F/G/H | 27-540 | [»] | |
4RT7 | X-ray | 3.10 | A | 564-958 | [»] | |
4XUF | X-ray | 3.20 | A/B | 600-947 | [»] | |
5X02 | X-ray | 2.40 | A | 564-958 | [»] | |
6IL3 | X-ray | 2.50 | A | 564-958 | [»] | |
6JQR | X-ray | 2.20 | A | 571-951 | [»] | |
SMRi | P36888 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108610, 140 interactors |
DIPi | DIP-59769N |
IntActi | P36888, 57 interactors |
MINTi | P36888 |
STRINGi | 9606.ENSP00000241453 |
Chemistry databases
BindingDBi | P36888 |
ChEMBLi | CHEMBL1974 |
DrugBanki | DB06080, ABT-869 DB12742, Amuvatinib DB12267, Brigatinib DB12500, Fedratinib DB12010, Fostamatinib DB12141, Gilteritinib DB06469, Lestaurtinib DB06595, Midostaurin DB09079, Nintedanib DB12978, Pexidartinib DB08901, Ponatinib DB15822, Pralsetinib DB12874, Quizartinib DB00398, Sorafenib DB01268, Sunitinib DB05465, Tandutinib DB05014, XL999 |
DrugCentrali | P36888 |
GuidetoPHARMACOLOGYi | 1807 |
PTM databases
GlyGeni | P36888, 10 sites |
iPTMneti | P36888 |
PhosphoSitePlusi | P36888 |
Genetic variation databases
BioMutai | FLT3 |
DMDMi | 156630887 |
Proteomic databases
CPTACi | CPTAC-2792 |
jPOSTi | P36888 |
MassIVEi | P36888 |
MaxQBi | P36888 |
PaxDbi | P36888 |
PeptideAtlasi | P36888 |
PRIDEi | P36888 |
ProteomicsDBi | 55226 [P36888-1] 55227 [P36888-2] |
Protocols and materials databases
ABCDi | P36888, 40 sequenced antibodies |
Antibodypediai | 4334, 1600 antibodies from 51 providers |
DNASUi | 2322 |
Genome annotation databases
Ensembli | ENST00000241453; ENSP00000241453; ENSG00000122025 |
GeneIDi | 2322 |
KEGGi | hsa:2322 |
MANE-Selecti | ENST00000241453.12; ENSP00000241453.7; NM_004119.3; NP_004110.2 |
UCSCi | uc001urw.3, human [P36888-1] |
Organism-specific databases
CTDi | 2322 |
DisGeNETi | 2322 |
GeneCardsi | FLT3 |
HGNCi | HGNC:3765, FLT3 |
HPAi | ENSG00000122025, Tissue enhanced (bone marrow, brain, lymphoid tissue) |
MalaCardsi | FLT3 |
MIMi | 136351, gene 601626, phenotype |
neXtProti | NX_P36888 |
OpenTargetsi | ENSG00000122025 |
Orphaneti | 98834, Acute myeloblastic leukemia with maturation 98833, Acute myeloblastic leukemia without maturation 98829, Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 98832, Acute myeloid leukemia with minimal differentiation 102724, Acute myeloid leukemia with t(8;21)(q22;q22) translocation 530995, Mixed phenotype acute leukemia 99860, Precursor B-cell acute lymphoblastic leukemia 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA28181 |
VEuPathDBi | HostDB:ENSG00000122025 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000160575 |
HOGENOMi | CLU_000288_49_1_1 |
InParanoidi | P36888 |
OMAi | EVQIHQD |
OrthoDBi | 719800at2759 |
PhylomeDBi | P36888 |
TreeFami | TF325768 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | P36888 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9607240, FLT3 Signaling R-HSA-9645135, STAT5 Activation R-HSA-9702509, FLT3 mutants bind TKIs R-HSA-9702518, STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702569, KW2449-resistant FLT3 mutants R-HSA-9702577, semaxanib-resistant FLT3 mutants R-HSA-9702581, crenolanib-resistant FLT3 mutants R-HSA-9702590, gilteritinib-resistant FLT3 mutants R-HSA-9702596, lestaurtinib-resistant FLT3 mutants R-HSA-9702600, midostaurin-resistant FLT3 mutants R-HSA-9702605, pexidartinib-resistant FLT3 mutants R-HSA-9702614, ponatinib-resistant FLT3 mutants R-HSA-9702620, quizartinib-resistant FLT3 mutants R-HSA-9702624, sorafenib-resistant FLT3 mutants R-HSA-9702632, sunitinib-resistant FLT3 mutants R-HSA-9702636, tandutinib-resistant FLT3 mutants R-HSA-9702998, linifanib-resistant FLT3 mutants R-HSA-9703009, tamatinib-resistant FLT3 mutants R-HSA-9703648, Signaling by FLT3 ITD and TKD mutants R-HSA-9706369, Negative regulation of FLT3 R-HSA-9706374, FLT3 signaling through SRC family kinases R-HSA-9706377, FLT3 signaling by CBL mutants |
SignaLinki | P36888 |
SIGNORi | P36888 |
Miscellaneous databases
BioGRID-ORCSi | 2322, 15 hits in 1069 CRISPR screens |
ChiTaRSi | FLT3, human |
EvolutionaryTracei | P36888 |
GeneWikii | CD135 |
GenomeRNAii | 2322 |
Pharosi | P36888, Tclin |
PROi | PR:P36888 |
RNActi | P36888, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122025, Expressed in cerebellar hemisphere and 121 other tissues |
ExpressionAtlasi | P36888, baseline and differential |
Genevisiblei | P36888, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR030118, FLT3 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS |
PANTHERi | PTHR24416:SF356, PTHR24416:SF356, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
SMARTi | View protein in SMART SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FLT3_HUMAN | |
Accessioni | P36888Primary (citable) accession number: P36888 Secondary accession number(s): A0AVG9 Q13414 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | August 21, 2007 | |
Last modified: | February 23, 2022 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families