FLT3

Functionⁱ

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.11 Publications

Miscellaneous

Can be used as diagnostic tool to establish the exact cause of acute myeloid leukemia, and to determine the optimal therapy.

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation1 Publication

Activity regulationⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	644	ATPCurated		1
Active siteⁱ	811	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	616 – 624	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

1-phosphatidylinositol-3-kinase activity Source: Reactome
ATP binding Source: UniProtKB-KW
cytokine receptor activity Source: UniProtKB
glucocorticoid receptor binding Source: Ensembl
protein-containing complex binding Source: Ensembl
protein homodimerization activity
Source: UniProtKB
Traceable author statementⁱ
- 19549778
protein self-association
Source: CAFA
Inferred from mutant phenotypeⁱ
- 14759363
Ras guanyl-nucleotide exchange factor activity Source: Reactome
transmembrane receptor protein tyrosine kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 19549778
vascular endothelial growth factor-activated receptor activity
Source: ProtInc
Traceable author statementⁱ
- 8394751

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ regeneration Source: Ensembl
B cell differentiation Source: UniProtKB
cellular response to cytokine stimulus Source: UniProtKB
cellular response to glucocorticoid stimulus Source: Ensembl
common myeloid progenitor cell proliferation Source: UniProtKB
cytokine-mediated signaling pathway Source: UniProtKB
dendritic cell differentiation Source: UniProtKB
hemopoiesis
Source: MGI
Inferred from direct assayⁱ
- 7507245
leukocyte homeostasis Source: UniProtKB
lymphocyte proliferation Source: UniProtKB
MAPK cascade Source: Reactome
myeloid progenitor cell differentiation Source: UniProtKB
peptidyl-tyrosine phosphorylation
Source: UniProtKB
Traceable author statementⁱ
- 19549778
positive regulation of cell proliferation
Source: UniProtKB
Traceable author statementⁱ
- 19549778
positive regulation of MAPK cascade
Source: UniProtKB
Traceable author statementⁱ
- 19549778
positive regulation of MAP kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 19549778
positive regulation of phosphatidylinositol 3-kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 12951584
positive regulation of phosphatidylinositol 3-kinase signaling
Source: UniProtKB
Traceable author statementⁱ
- 12951584
positive regulation of tyrosine phosphorylation of STAT protein
Source: UniProtKB
Traceable author statementⁱ
- 19549778
pro-B cell differentiation Source: UniProtKB
protein autophosphorylation
Source: UniProtKB
Traceable author statementⁱ
- 19549778
regulation of apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 19549778
response to organonitrogen compound Source: Ensembl
transmembrane receptor protein tyrosine kinase signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 7507245

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological process	Host-virus interaction
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 2681
Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-449836 Other interleukin signaling R-HSA-5673001 RAF/MAP kinase cascade
SignaLinkⁱ	P36888
SIGNORⁱ	P36888

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor-type tyrosine-protein kinase FLT3 (EC:2.7.10.1) Alternative name(s): FL cytokine receptor Fetal liver kinase-2 Short name: FLK-2 Fms-like tyrosine kinase 3 Short name: FLT-3 Stem cell tyrosine kinase 1 Short name: STK-1 CD_antigen: CD135
Gene namesⁱ	Name:FLT3 Synonyms:CD135, FLK2, STK1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122025.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3765 FLT3
MIMⁱ	136351 gene
neXtProtⁱ	NX_P36888

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 543	ExtracellularSequence analysisAdd BLAST	517
Transmembraneⁱ	544 – 563	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	564 – 993	CytoplasmicSequence analysisAdd BLAST	430

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Leukemia, acute myelogenous (AML)8 Publications

The gene represented in this entry may be involved in disease pathogenesis. Somatic mutations that lead to constitutive activation of FLT3 are frequent in AML patients. These mutations fall into two classes, the most common being in-frame internal tandem duplications of variable length in the juxtamembrane region that disrupt the normal regulation of the kinase activity. Likewise, point mutations in the activation loop of the kinase domain can result in a constitutively activated kinase.

Disease descriptionA subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	589	Y → F: Reduced phosphorylation of the wild-type kinase in response to ligand binding. No effect on the phosphorylation of the constitutively activated mutant kinase variants. Abolishes activation of STAT5A. 3 Publications	1
Mutagenesisⁱ	591	Y → F: No significant effect on tyrosine phosphorylation. Abolishes activation of STAT5A. 2 Publications	1
Mutagenesisⁱ	599	Y → F: Abolishes interaction with PTPN11/SHP2 and phosphorylation of PTPN11/SHP2. 1 Publication	1
Mutagenesisⁱ	644	K → A: Abolishes kinase activity. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2322
MalaCards human disease database More...MalaCardsⁱ	FLT3
MIMⁱ	601626 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122025
Orphanetⁱ	98829 'Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)' 102724 'Acute myeloid leukemia with t(8;21)(q22;q22) translocation' 98837 Acute biphenotypic leukemia 98834 Acute myeloblastic leukemia with maturation 98833 Acute myeloblastic leukemia without maturation 98832 Minimally differentiated acute myeloblastic leukemia 99860 Precursor B-cell acute lymphoblastic leukemia 99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBⁱ	PA28181

Chemistry databases

ChEMBLⁱ	CHEMBL1974
Drug and drug target database More...DrugBankⁱ	DB06080 ABT-869 DB05213 AC220 DB05465 MLN-518 DB05216 MP470 DB09079 Nintedanib DB08901 Ponatinib DB00398 Sorafenib DB01268 Sunitinib DB05014 XL999
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1807

Polymorphism and mutation databases

BioMutaⁱ	FLT3
DMDMⁱ	156630887

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000016778	27 – 993	Receptor-type tyrosine-protein kinase FLT3Add BLAST		967

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	35 ↔ 65	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	43	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	100	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	103 ↔ 114	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	151	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	199 ↔ 206	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	232 ↔ 241	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	272 ↔ 330	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	306	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	323	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	351	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	354	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	368 ↔ 407	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	381 ↔ 392	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	473	N-linked (GlcNAc...) asparagine	1
Glycosylationⁱ	502	N-linked (GlcNAc...) asparagine	1
Glycosylationⁱ	541	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	572	Phosphotyrosine2 Publications	1
Modified residueⁱ	574	Phosphoserine1 Publication	1
Modified residueⁱ	589	Phosphotyrosine; by autocatalysis3 Publications	1
Modified residueⁱ	591	Phosphotyrosine; by autocatalysis5 Publications	1
Modified residueⁱ	599	Phosphotyrosine; by autocatalysis3 Publications	1
Modified residueⁱ	726	Phosphotyrosine; by autocatalysis2 Publications	1
Modified residueⁱ	759	PhosphoserineCombined sources	1
Modified residueⁱ	768	Phosphotyrosine2 Publications	1
Modified residueⁱ	793	Phosphotyrosine2 Publications	1
Modified residueⁱ	842	Phosphotyrosine; by autocatalysis3 Publications	1
Modified residueⁱ	955	Phosphotyrosine; by autocatalysis3 Publications	1
Modified residueⁱ	969	Phosphotyrosine; by autocatalysis1 Publication	1
Modified residueⁱ	993	PhosphoserineCombined sources	1

Post-translational modificationⁱ

N-glycosylated, contains complex N-glycans with sialic acid.3 Publications

Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1, PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic reticulum and location at the cell membrane.

Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to its proteasomal degradation.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36888
PaxDbⁱ	P36888
PeptideAtlas More...PeptideAtlasⁱ	P36888
PRIDEⁱ	P36888
ProteomicsDBⁱ	55226 55227 [P36888-2]

PTM databases

iPTMnetⁱ	P36888
PhosphoSitePlusⁱ	P36888

Expressionⁱ

Tissue specificityⁱ

Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000122025 Expressed in 100 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_FLT3
ExpressionAtlasⁱ	P36888 baseline and differential
Genevisibleⁱ	P36888 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047539

HPAⁱ

HPA047539

Interactionⁱ

Subunit structureⁱ

Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1 following ligand activation (By similarity). Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2. Interacts with RNF115 and RNF126 (By similarity).By similarity6 Publications

(Microbial infection) Interacts with human cytomegalovirus protein UL7.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GRB10	Q13322	6	EBI-3946257,EBI-80275
IKBKG	Q9Y6K9	2	EBI-3946257,EBI-81279
PIK3R1	P27986	2	EBI-3946257,EBI-79464
PTPRJ	Q12913	3	EBI-3946257,EBI-2264500
SYK	P43405	21	EBI-3946257,EBI-78302

GO - Molecular functionⁱ

glucocorticoid receptor binding Source: Ensembl
protein homodimerization activity
Source: UniProtKB
Traceable author statementⁱ
- 19549778
protein self-association
Source: CAFA
Inferred from mutant phenotypeⁱ
- 14759363
Ras guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108610, 14 interactors
Database of interacting proteins More...DIPⁱ	DIP-59769N
IntActⁱ	P36888, 7 interactors
Molecular INTeraction database More...MINTⁱ	P36888
STRINGⁱ	9606.ENSP00000241453

Chemistry databases

BindingDBⁱ

P36888

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	575 – 581	Combined sources	7
Beta strandⁱ	583 – 585	Combined sources	3
Beta strandⁱ	589 – 591	Combined sources	3
Helixⁱ	594 – 596	Combined sources	3
Helixⁱ	601 – 603	Combined sources	3
Helixⁱ	607 – 609	Combined sources	3
Beta strandⁱ	610 – 618	Combined sources	9
Beta strandⁱ	620 – 631	Combined sources	12
Beta strandⁱ	633 – 636	Combined sources	4
Beta strandⁱ	638 – 646	Combined sources	9
Helixⁱ	656 – 668	Combined sources	13
Beta strandⁱ	677 – 681	Combined sources	5
Beta strandⁱ	683 – 686	Combined sources	4
Beta strandⁱ	688 – 692	Combined sources	5
Helixⁱ	699 – 704	Combined sources	6
Turnⁱ	705 – 708	Combined sources	4
Helixⁱ	785 – 804	Combined sources	20
Beta strandⁱ	807 – 809	Combined sources	3
Helixⁱ	814 – 816	Combined sources	3
Beta strandⁱ	817 – 820	Combined sources	4
Turnⁱ	821 – 823	Combined sources	3
Beta strandⁱ	824 – 827	Combined sources	4
Helixⁱ	831 – 833	Combined sources	3
Helixⁱ	836 – 838	Combined sources	3
Beta strandⁱ	842 – 845	Combined sources	4
Beta strandⁱ	848 – 850	Combined sources	3
Helixⁱ	852 – 854	Combined sources	3
Helixⁱ	857 – 862	Combined sources	6
Helixⁱ	867 – 881	Combined sources	15
Turnⁱ	882 – 884	Combined sources	3
Helixⁱ	896 – 903	Combined sources	8
Helixⁱ	916 – 925	Combined sources	10
Helixⁱ	930 – 932	Combined sources	3
Helixⁱ	936 – 946	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P36888
SMRⁱ	P36888
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P36888

EvolutionaryTraceⁱ

P36888

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	253 – 343	Ig-like C2-typeAdd BLAST		91
Domainⁱ	610 – 943	Protein kinasePROSITE-ProRule annotationAdd BLAST		334

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	591 – 597	Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand		7

Domainⁱ

The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated further by FLT3LG binding.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0200 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118923
HOVERGENⁱ	HBG005735
InParanoidⁱ	P36888
KEGG Orthology (KO) More...KOⁱ	K05092
OMAⁱ	FHRTWTE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01TL
PhylomeDBⁱ	P36888
TreeFamⁱ	TF325768

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR030118 FLT3 IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013151 Immunoglobulin IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR001824 Tyr_kinase_rcpt_3_CS
PANTHERⁱ	PTHR24416:SF356 PTHR24416:SF356, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00047 ig, 1 hit PF07714 Pkinase_Tyr, 1 hit
SMARTⁱ	View protein in SMART SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P36888-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS 
        60         70         80         90        100
SSYPMVSESP EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN 
       110        120        130        140        150
ISCLWVFKHS SLNCQPHFDL QNRGVVSMVI LKMTETQAGE YLLFIQSEAT 
       160        170        180        190        200
NYTILFTVSI RNTLLYTLRR PYFRKMENQD ALVCISESVP EPIVEWVLCD 
       210        220        230        240        250
SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE CTRLFTIDLN 
       260        270        280        290        300
QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM 
       310        320        330        340        350
STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI 
       360        370        380        390        400
NATNSSEDYE IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG 
       410        420        430        440        450
YSISKFCNHK HQPGEYIFHA ENDDAQFTKM FTLNIRRKPQ VLAEASASQA 
       460        470        480        490        500
SCFSDGYPLP SWTWKKCSDK SPNCTEEITE GVWNRKANRK VFGQWVSSST 
       510        520        530        540        550
LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD NISFYATIGV 
       560        570        580        590        600
CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD 
       610        620        630        640        650
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA 
       660        670        680        690        700
DSSEREALMS ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL 
       710        720        730        740        750
NYLRSKREKF HRTWTEIFKE HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD 
       760        770        780        790        800
QISGLHGNSF HSEDEIEYEN QKRLEEEEDL NVLTFEDLLC FAYQVAKGME 
       810        820        830        840        850
FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS NYVVRGNARL 
       860        870        880        890        900
PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK 
       910        920        930        940        950
LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA 
       960        970        980        990 
EEAMYQNVDG RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS

Length:993

Mass (Da):112,903

Last modified:August 21, 2007 - v2

Checksum:ⁱ6C1995718F352ECE

GO

Isoform 2 (identifier: P36888-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
807-847: Missing.

« Hide

        10         20         30         40         50
MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS 
        60         70         80         90        100
SSYPMVSESP EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN 
       110        120        130        140        150
ISCLWVFKHS SLNCQPHFDL QNRGVVSMVI LKMTETQAGE YLLFIQSEAT 
       160        170        180        190        200
NYTILFTVSI RNTLLYTLRR PYFRKMENQD ALVCISESVP EPIVEWVLCD 
       210        220        230        240        250
SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE CTRLFTIDLN 
       260        270        280        290        300
QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM 
       310        320        330        340        350
STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI 
       360        370        380        390        400
NATNSSEDYE IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG 
       410        420        430        440        450
YSISKFCNHK HQPGEYIFHA ENDDAQFTKM FTLNIRRKPQ VLAEASASQA 
       460        470        480        490        500
SCFSDGYPLP SWTWKKCSDK SPNCTEEITE GVWNRKANRK VFGQWVSSST 
       510        520        530        540        550
LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD NISFYATIGV 
       560        570        580        590        600
CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD 
       610        620        630        640        650
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA 
       660        670        680        690        700
DSSEREALMS ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL 
       710        720        730        740        750
NYLRSKREKF HRTWTEIFKE HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD 
       760        770        780        790        800
QISGLHGNSF HSEDEIEYEN QKRLEEEEDL NVLTFEDLLC FAYQVAKGME 
       810        820        830        840        850
FLEFKSARLP VKWMAPESLF EGIYTIKSDV WSYGILLWEI FSLGVNPYPG 
       860        870        880        890        900
IPVDANFYKL IQNGFKMDQP FYATEEIYII MQSCWAFDSR KRPSFPNLTS 
       910        920        930        940        950
FLGCQLADAE EAMYQNVDGR VSECPHTYQN RRPFSREMDL GLLSPQAQVE 

DS

Show »

Length:952

Mass (Da):108,378

Checksum:ⁱ1C384B292EDEB144

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E7ER61	E7ER61_HUMAN		Receptor-type tyrosine-protein kina... Receptor-type tyrosine-protein kinase FLT3	FLT3	739	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	8	G → A in AAA18947 (PubMed:7507245).Curated	1
Sequence conflictⁱ	10 – 11	QL → TV in AAA18947 (PubMed:7507245).Curated	2
Sequence conflictⁱ	71	S → N in AAI44040 (PubMed:15489334).Curated	1
Sequence conflictⁱ	78	A → R in CAA81393 (PubMed:8394751).Curated	1
Sequence conflictⁱ	346	E → G in AAA18947 (PubMed:7507245).Curated	1
Sequence conflictⁱ	940	T → H in AAA35487 (PubMed:2004790).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034677	7	D → G. Corresponds to variant dbSNP:rs12872889Ensembl.	1
Natural variantⁱVAR_042069	158	V → A1 PublicationCorresponds to variant dbSNP:rs56321896Ensembl.	1
Natural variantⁱVAR_054149	194	V → M1 PublicationCorresponds to variant dbSNP:rs146030737EnsemblClinVar.	1
Natural variantⁱVAR_034678	227	T → M4 PublicationsCorresponds to variant dbSNP:rs1933437EnsemblClinVar.	1
Natural variantⁱVAR_042070	324	D → N1 PublicationCorresponds to variant dbSNP:rs35602083EnsemblClinVar.	1
Natural variantⁱVAR_042071	358	D → V1 PublicationCorresponds to variant dbSNP:rs34172843EnsemblClinVar.	1
Natural variantⁱVAR_061291	417	I → L. Corresponds to variant dbSNP:rs56090538EnsemblClinVar.	1
Natural variantⁱVAR_042072	557	V → I1 PublicationCorresponds to variant dbSNP:rs35958982EnsemblClinVar.	1
Natural variantⁱVAR_065679	835	D → E in acute lymphoblastic leukemia patients and acute myelogenous leukemia patients; somatic mutation; constitutively activated. 2 PublicationsCorresponds to variant dbSNP:rs121913487EnsemblClinVar.	1
Natural variantⁱVAR_065680	835	D → H in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated. 3 PublicationsCorresponds to variant dbSNP:rs121913488EnsemblClinVar.	1
Natural variantⁱVAR_065681	835	D → N in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated. 1 PublicationCorresponds to variant dbSNP:rs121913488EnsemblClinVar.	1
Natural variantⁱVAR_065682	835	D → V in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated. 1 PublicationCorresponds to variant dbSNP:rs121909646EnsemblClinVar.	1
Natural variantⁱVAR_065683	835	D → Y in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated. 3 PublicationsCorresponds to variant dbSNP:rs121913488EnsemblClinVar.	1
Natural variantⁱVAR_065684	836	I → M in acute lymphoblastic leukemia patients; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913232EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041796	807 – 847	Missing in isoform 2. 1 PublicationAdd BLAST		41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U02687 mRNA Translation: AAA18947.1 Z26652 mRNA Translation: CAA81393.1 AL356915 Genomic DNA No translation available. AL445262 Genomic DNA No translation available. AL591024 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08424.1 BC126350 mRNA Translation: AAI26351.1 BC144039 mRNA Translation: AAI44040.1 BC144040 mRNA Translation: AAI44041.1 L36162 mRNA Translation: AAA35487.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31953.1 [P36888-1]
PIRⁱ	A36873 A39061
NCBI Reference Sequences More...RefSeqⁱ	NP_004110.2, NM_004119.2 [P36888-1]
UniGeneⁱ	Hs.507590

Genome annotation databases

Ensemblⁱ	ENST00000241453; ENSP00000241453; ENSG00000122025 [P36888-1]
GeneIDⁱ	2322
KEGGⁱ	hsa:2322
UCSC genome browser More...UCSCⁱ	uc001urw.3 human [P36888-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P36888	receptor-type tyrosine-protein kinase FLT3		Yangtze finless porpoise		1136	UniRef90_P36888
Stem cell tyrosine kinase 1 (Fragment)		CALJA		12
Stem cell tyrosine kinase 1 (Fragment)		SAGFU		12
Stem cell tyrosine kinase 1 (Fragment)		SAISC		12
Stem cell tyrosine kinase 1 (Fragment)		ATEFU		12
+89
P36888-2	Uncharacterized protein		MANLE		937	UniRef90_P36888-2
UPI0002741B4D		OTOGA		953
UPI00027F5D80		PAPAN		952
UPI0002ADAD9F		NOMLE		952
UPI0005333716		RHIRO		952
+7

Protein	Similar proteins		Species	Score	Length	Source
P36888	receptor-type tyrosine-protein kinase FLT3		Yangtze finless porpoise		1136	UniRef50_P36888
Stem cell tyrosine kinase 1 (Fragment)		CALJA		12
Stem cell tyrosine kinase 1 (Fragment)		SAGFU		12
Stem cell tyrosine kinase 1 (Fragment)		SAISC		12
Stem cell tyrosine kinase 1 (Fragment)		ATEFU		12
+252
P36888-2	Receptor-type tyrosine-protein kinase FLT3		MOUSE		1000	UniRef50_P36888-2
Uncharacterized protein		MANLE		937
Fms related tyrosine kinase 3		XENTR		878
Uncharacterized protein		CAVPO		987
receptor-type tyrosine-protein kinase FLT3		DIPOR		992
+87

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U02687 mRNA Translation: AAA18947.1 Z26652 mRNA Translation: CAA81393.1 AL356915 Genomic DNA No translation available. AL445262 Genomic DNA No translation available. AL591024 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08424.1 BC126350 mRNA Translation: AAI26351.1 BC144039 mRNA Translation: AAI44040.1 BC144040 mRNA Translation: AAI44041.1 L36162 mRNA Translation: AAA35487.1
CCDSⁱ	CCDS31953.1 [P36888-1]
PIRⁱ	A36873 A39061
RefSeqⁱ	NP_004110.2, NM_004119.2 [P36888-1]
UniGeneⁱ	Hs.507590

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1RJB	X-ray	2.10	A	564-958	[»]
	3QS7	X-ray	4.30	E/F/G/H	27-436	[»]
	3QS9	X-ray	7.80	E/F/G/H	27-540	[»]
	4RT7	X-ray	3.10	A	564-958	[»]
	4XUF	X-ray	3.20	A/B	600-947	[»]
	5X02	X-ray	2.40	A	564-958	[»]
ProteinModelPortalⁱ	P36888
SMRⁱ	P36888
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108610, 14 interactors
DIPⁱ	DIP-59769N
IntActⁱ	P36888, 7 interactors
MINTⁱ	P36888
STRINGⁱ	9606.ENSP00000241453

Chemistry databases

BindingDBⁱ	P36888
ChEMBLⁱ	CHEMBL1974
DrugBankⁱ	DB06080 ABT-869 DB05213 AC220 DB05465 MLN-518 DB05216 MP470 DB09079 Nintedanib DB08901 Ponatinib DB00398 Sorafenib DB01268 Sunitinib DB05014 XL999
GuidetoPHARMACOLOGYⁱ	1807

PTM databases

iPTMnetⁱ	P36888
PhosphoSitePlusⁱ	P36888

Polymorphism and mutation databases

BioMutaⁱ	FLT3
DMDMⁱ	156630887

Proteomic databases

MaxQBⁱ	P36888
PaxDbⁱ	P36888
PeptideAtlasⁱ	P36888
PRIDEⁱ	P36888
ProteomicsDBⁱ	55226 55227 [P36888-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000241453; ENSP00000241453; ENSG00000122025 [P36888-1]
GeneIDⁱ	2322
KEGGⁱ	hsa:2322
UCSCⁱ	uc001urw.3 human [P36888-1]

Organism-specific databases

CTDⁱ	2322
DisGeNETⁱ	2322
EuPathDBⁱ	HostDB:ENSG00000122025.14
GeneCardsⁱ	FLT3
H-InvDBⁱ	HIX0037338
HGNCⁱ	HGNC:3765 FLT3
HPAⁱ	HPA047539
MalaCardsⁱ	FLT3
MIMⁱ	136351 gene 601626 phenotype
neXtProtⁱ	NX_P36888
OpenTargetsⁱ	ENSG00000122025
Orphanetⁱ	98829 'Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)' 102724 'Acute myeloid leukemia with t(8;21)(q22;q22) translocation' 98837 Acute biphenotypic leukemia 98834 Acute myeloblastic leukemia with maturation 98833 Acute myeloblastic leukemia without maturation 98832 Minimally differentiated acute myeloblastic leukemia 99860 Precursor B-cell acute lymphoblastic leukemia 99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBⁱ	PA28181
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0200 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00760000118923
HOVERGENⁱ	HBG005735
InParanoidⁱ	P36888
KOⁱ	K05092
OMAⁱ	FHRTWTE
OrthoDBⁱ	EOG091G01TL
PhylomeDBⁱ	P36888
TreeFamⁱ	TF325768

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 2681
Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-449836 Other interleukin signaling R-HSA-5673001 RAF/MAP kinase cascade
SignaLinkⁱ	P36888
SIGNORⁱ	P36888

Miscellaneous databases

ChiTaRSⁱ	FLT3 human
EvolutionaryTraceⁱ	P36888
GeneWikiⁱ	CD135
GenomeRNAiⁱ	2322
Protein Ontology More...PROⁱ	PR:P36888
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122025 Expressed in 100 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_FLT3
ExpressionAtlasⁱ	P36888 baseline and differential
Genevisibleⁱ	P36888 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR030118 FLT3 IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013151 Immunoglobulin IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR001824 Tyr_kinase_rcpt_3_CS
PANTHERⁱ	PTHR24416:SF356 PTHR24416:SF356, 1 hit
Pfamⁱ	View protein in Pfam PF00047 ig, 1 hit PF07714 Pkinase_Tyr, 1 hit
SMARTⁱ	View protein in SMART SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00240 RECEPTOR_TYR_KIN_III, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FLT3_HUMAN
Accessionⁱ	P36888Primary (citable) accession number: P36888 Secondary accession number(s): A0AVG9 , B7ZLT7, B7ZLT8, F5H0A0, Q13414
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	August 21, 2007
	Last modified:	September 12, 2018
	This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P36888 (FLT3_HUMAN)

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Receptor-type tyrosine-protein kinase FLT3

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Organism-specific databases

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ