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UniProtKB - P36873 (PP1G_HUMAN)

Entry version 237 (02 Jun 2021)
Sequence version 1 (01 Jun 1994)
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Protein

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Gene

PPP1CC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

4 Publications

Miscellaneous

Microcystin toxin is bound to Cys-273 through a thioether bond.

Caution

Was originally thought to be part of the MLL5-L complex, at least composed of KMT2E, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT (PubMed:19377461). However, the corresponding article has been retracted (PubMed:24336203).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+2 PublicationsNote: Binds 2 manganese ions per subunit.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inactivated by binding to URI1. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi64Manganese 12 Publications1
Metal bindingi66Manganese 12 Publications1
Metal bindingi92Manganese 12 Publications1
Metal bindingi92Manganese 22 Publications1
Metal bindingi124Manganese 22 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei125Proton donor1 Publication1
Metal bindingi173Manganese 22 Publications1
Metal bindingi248Manganese 22 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei273Inhibition by microcystin toxin binding1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processBiological rhythms, Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.16, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P36873

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-163560, Triglyceride catabolism
R-HSA-2173788, Downregulation of TGF-beta receptor signaling
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-400253, Circadian Clock
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-5673000, RAF activation
R-HSA-68877, Mitotic Prometaphase
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
R-HSA-9660537, Signaling by MRAS-complex mutants

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P36873

SIGNOR Signaling Network Open Resource

More...SIGNORi		P36873

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P36873, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (EC:3.1.3.16)
Short name:
PP-1G
Alternative name(s):
Protein phosphatase 1C catalytic subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1CC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9283, PPP1CC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176914, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P36873

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186298.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi125H → A: Loss of activity. 1 Publication1
Mutagenesisi273C → A, S or L: Abolishes interaction with microcystin toxin. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5501

Open Targets

More...OpenTargetsi		ENSG00000186298

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33611

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P36873, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4438

Drug and drug target database

More...DrugBanki		DB02169, 9,10-Deepithio-9,10-Didehydroacanthifolicin
DB02860, Calyculin A
DB04738, Motuporin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPP1CC

Domain mapping of disease mutations (DMDM)

More...DMDMi		548573

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000587872 – 323Serine/threonine-protein phosphatase PP1-gamma catalytic subunitAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei311PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NEK2.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P36873

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P36873

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P36873

MaxQB - The MaxQuant DataBase

More...MaxQBi		P36873

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P36873

PeptideAtlas

More...PeptideAtlasi		P36873

PRoteomics IDEntifications database

More...PRIDEi		P36873

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55224 [P36873-1]
55225 [P36873-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P36873-1 [P36873-1]
P36873-2 [P36873-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P36873

DEPOD human dephosphorylation database

More...DEPODi		PPP1CC

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P36873

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P36873

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P36873

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P36873

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186298, Expressed in heart right ventricle and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P36873, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P36873, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186298, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen.

Interacts with cyanobacterial toxin microcystin; disulfide-linked.

Interacts with PPP1R3B and PPP1R7.

Isoform 2 interacts with SPZ1 (By similarity).

Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1.

Part of a complex containing PPP1R15B, PP1 and NCK1/2.

Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation.

Interacts with PPP1R42; the interaction is direct (By similarity).

Interacts with NOM1 and PPP1R8.

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC.

Interacts with PPP1R8.

Interacts with isoform 1 and isoform 4 NEK2.

Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner.

Interacts with FOXP3.

Interacts with TMEM225 (via RVxF motif) (By similarity).

Interacts with MKI67 (PubMed:24867636).

Interacts with RRP1B; this targets PPP1CC to the nucleolus (PubMed:20926688).

Interacts with PPP1R2B (PubMed:23506001).

Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (PubMed:23846654).

Interacts with DYNLT4 (PubMed:23789093).

By similarity19 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P36873
With#Exp.IntAct
BRCA1 [P38398]2EBI-356283,EBI-349905
CD2BP2 [O95400]3EBI-356283,EBI-768015
CSRNP1 [Q96S65]3EBI-356283,EBI-4311573
CSRNP2 [Q9H175]7EBI-356283,EBI-5235958
ESR1 [P03372]3EBI-356283,EBI-78473
LMTK2 [Q8IWU2]5EBI-356283,EBI-2008933
NRAC [Q8N912]3EBI-356283,EBI-12051377
OGT [O15294]11EBI-356283,EBI-539828
PPP1R11 [O60927]6EBI-356283,EBI-1048104
PPP1R15B [Q5SWA1]4EBI-356283,EBI-2815482
PPP1R16A [Q96I34]3EBI-356283,EBI-710402
PPP1R2 [P41236]7EBI-356283,EBI-1056517
PPP1R2B [Q6NXS1]5EBI-356283,EBI-10251630
PPP1R2C [O14990]3EBI-356283,EBI-12404293
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-356283,EBI-12000762
PPP1R3B [Q86XI6]3EBI-356283,EBI-3918864
PPP1R3C [Q9UQK1]4EBI-356283,EBI-2506727
PPP1R7 [Q15435]5EBI-356283,EBI-1024281
PPP1R8 - isoform Beta [Q12972-2]3EBI-356283,EBI-12252736
PPP1R9B [Q96SB3]5EBI-356283,EBI-351275
RRP1B [Q14684]9EBI-356283,EBI-372051
TP53BP2 [Q05BL1]3EBI-356283,EBI-11952721
TP53BP2 [Q13625]8EBI-356283,EBI-77642
TP53BP2 - isoform 3 [Q13625-3]3EBI-356283,EBI-10175039
TPRN - isoform 2 [Q4KMQ1-2]3EBI-356283,EBI-11978969
URI1 [O94763]17EBI-356283,EBI-357067
URI1 - isoform 1 [O94763-1]8EBI-356283,EBI-12590720
ZFYVE9 [O95405]5EBI-356283,EBI-296817
ZNF629 [Q9UEG4]3EBI-356283,EBI-9977294
Clock [O08785] from Mus musculus.2EBI-356283,EBI-79859
Isoform 1 [P36873-1]
With#Exp.IntAct
DYNLT4 [Q5JR98]2EBI-356289,EBI-4311709
NEK2 [P51955]2EBI-356289,EBI-633182
TOR1AIP1 - isoform 3 [Q5JTV8-3]4EBI-356289,EBI-21448143
TP53 [P04637]2EBI-356289,EBI-366083
Isoform 2 [P36873-2]
With#Exp.IntAct
AKAP4 [Q5JQC9]4EBI-3964623,EBI-16628643
DYNLT4 [Q5JR98]3EBI-3964623,EBI-4311709
PPP1R32 [Q7Z5V6]4EBI-3964623,EBI-4311771
RANBP9 [Q96S59]3EBI-3964623,EBI-636085
A1DRY32EBI-3964623,EBI-4311408

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111495, 668 interactors

Database of interacting proteins

More...DIPi		DIP-749N

Protein interaction database and analysis system

More...IntActi		P36873, 273 interactors

Molecular INTeraction database

More...MINTi		P36873

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341779

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P36873

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P36873, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P36873

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P36873

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni302 – 323DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0374, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153472

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004962_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P36873

Identification of Orthologs from Complete Genome Data

More...OMAi		EEHEIRY

Database of Orthologous Groups

More...OrthoDBi		766640at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P36873

TreeFam database of animal gene trees

More...TreeFami		TF354243

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.21.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like
IPR037981, PPP1CC
IPR006186, Ser/Thr-sp_prot-phosphatase
IPR031675, STPPase_N

The PANTHER Classification System

More...PANTHERi		PTHR11668:SF204, PTHR11668:SF204, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00149, Metallophos, 1 hit
PF16891, STPPase_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00114, STPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00156, PP2Ac, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00125, SER_THR_PHOSPHATASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P36873-1) [UniParc]FASTAAdd to basket
Also known as: PPPCC1, Gamma-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP 
        60         70         80         90        100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS 
       110        120        130        140        150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK 
       160        170        180        190        200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL 
       210        220        230        240        250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV 
       260        270        280        290        300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 
       310        320 
KKKPNATRPV TPPRGMITKQ AKK
Length:323
Mass (Da):36,984
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EEEF0E842188536
GO
Isoform 2 (identifier: P36873-2) [UniParc]FASTAAdd to basket
Also known as: PPPCC2, Gamma-2

The sequence of this isoform differs from the canonical sequence as follows:
     315-323: GMITKQAKK → VASGLNPSIQKASNYRNNTVLYE

Show »
Length:337
Mass (Da):38,518
Checksum:i9731E5A6C8EEBF46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W0W8F8W0W8_HUMAN
Serine/threonine-protein phosphatas...
PPP1CC
332Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VR82F8VR82_HUMAN
Serine/threonine-protein phosphatas...
PPP1CC
270Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYE8F8VYE8_HUMAN
Serine/threonine-protein phosphatas...
PPP1CC
304Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYY5A0A087WYY5_HUMAN
Serine/threonine-protein phosphatas...
PPP1CC
140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0V8F8W0V8_HUMAN
Protein phosphatase 1C catalytic su...
PPP1CC
54Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1A0F8W1A0_HUMAN
Protein-serine/threonine phosphatas...
PPP1CC
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051734152F → S. Corresponds to variant dbSNP:rs11558237Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005094315 – 323GMITKQAKK → VASGLNPSIQKASNYRNNTV LYE in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X74008 mRNA Translation: CAA52169.1
BC014073 mRNA Translation: AAH14073.1
L07395 mRNA Translation: AAA19823.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58279.1 [P36873-2]
CCDS9150.1 [P36873-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S35699
S35700

NCBI Reference Sequences

More...RefSeqi		NP_001231903.1, NM_001244974.1 [P36873-2]
NP_002701.1, NM_002710.3 [P36873-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000335007; ENSP00000335084; ENSG00000186298 [P36873-1]
ENST00000340766; ENSP00000341779; ENSG00000186298 [P36873-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5501

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5501

UCSC genome browser

More...UCSCi		uc001tru.4, human [P36873-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

The things we forget - Issue 32 of March 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74008 mRNA Translation: CAA52169.1
BC014073 mRNA Translation: AAH14073.1
L07395 mRNA Translation: AAA19823.1
CCDSiCCDS58279.1 [P36873-2]
CCDS9150.1 [P36873-1]
PIRiS35699
S35700
RefSeqiNP_001231903.1, NM_001244974.1 [P36873-2]
NP_002701.1, NM_002710.3 [P36873-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IT6X-ray2.00A/B1-323[»]
1JK7X-ray1.90A1-323[»]
1U32X-ray2.00A6-298[»]
2BCDX-ray2.10A1-323[»]
2BDXX-ray2.30A1-323[»]
4UT2X-ray1.96A/B1-323[»]
4UT3X-ray2.19A/B1-323[»]
5INBX-ray1.30A7-308[»]
5J28X-ray2.00A/B7-308[»]
SMRiP36873
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111495, 668 interactors
DIPiDIP-749N
IntActiP36873, 273 interactors
MINTiP36873
STRINGi9606.ENSP00000341779

Chemistry databases

BindingDBiP36873
ChEMBLiCHEMBL4438
DrugBankiDB02169, 9,10-Deepithio-9,10-Didehydroacanthifolicin
DB02860, Calyculin A
DB04738, Motuporin

Protein family/group databases

MoonDBiP36873, Predicted

PTM databases

CarbonylDBiP36873
DEPODiPPP1CC
iPTMnetiP36873
MetOSiteiP36873
PhosphoSitePlusiP36873
SwissPalmiP36873

Genetic variation databases

BioMutaiPPP1CC
DMDMi548573

Proteomic databases

EPDiP36873
jPOSTiP36873
MassIVEiP36873
MaxQBiP36873
PaxDbiP36873
PeptideAtlasiP36873
PRIDEiP36873
ProteomicsDBi55224 [P36873-1]
55225 [P36873-2]
TopDownProteomicsiP36873-1 [P36873-1]
P36873-2 [P36873-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2879, 427 antibodies

The DNASU plasmid repository

More...DNASUi		5501

Genome annotation databases

EnsembliENST00000335007; ENSP00000335084; ENSG00000186298 [P36873-1]
ENST00000340766; ENSP00000341779; ENSG00000186298 [P36873-2]
GeneIDi5501
KEGGihsa:5501
UCSCiuc001tru.4, human [P36873-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5501
DisGeNETi5501

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPP1CC
HGNCiHGNC:9283, PPP1CC
HPAiENSG00000186298, Low tissue specificity
MIMi176914, gene
neXtProtiNX_P36873
OpenTargetsiENSG00000186298
PharmGKBiPA33611
VEuPathDBiHostDB:ENSG00000186298.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0374, Eukaryota
GeneTreeiENSGT00940000153472
HOGENOMiCLU_004962_0_0_1
InParanoidiP36873
OMAiEEHEIRY
OrthoDBi766640at2759
PhylomeDBiP36873
TreeFamiTF354243

Enzyme and pathway databases

BRENDAi3.1.3.16, 2681
PathwayCommonsiP36873
ReactomeiR-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-163560, Triglyceride catabolism
R-HSA-2173788, Downregulation of TGF-beta receptor signaling
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-400253, Circadian Clock
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-5673000, RAF activation
R-HSA-68877, Mitotic Prometaphase
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
R-HSA-9660537, Signaling by MRAS-complex mutants
SignaLinkiP36873
SIGNORiP36873

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5501, 32 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPP1CC, human
EvolutionaryTraceiP36873

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PPP1CC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5501
PharosiP36873, Tchem

Protein Ontology

More...PROi		PR:P36873
RNActiP36873, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186298, Expressed in heart right ventricle and 253 other tissues
ExpressionAtlasiP36873, baseline and differential
GenevisibleiP36873, HS

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like
IPR037981, PPP1CC
IPR006186, Ser/Thr-sp_prot-phosphatase
IPR031675, STPPase_N
PANTHERiPTHR11668:SF204, PTHR11668:SF204, 1 hit
PfamiView protein in Pfam
PF00149, Metallophos, 1 hit
PF16891, STPPase_N, 1 hit
PRINTSiPR00114, STPHPHTASE
SMARTiView protein in SMART
SM00156, PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125, SER_THR_PHOSPHATASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP1G_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36873
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 2, 2021
This is version 237 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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