UniProtKB - P36873 (PP1G_HUMAN)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
PPP1CC
Functioni
Miscellaneous
Caution
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 64 | Manganese 12 Publications | 1 | |
Metal bindingi | 66 | Manganese 12 Publications | 1 | |
Metal bindingi | 92 | Manganese 12 Publications | 1 | |
Metal bindingi | 92 | Manganese 22 Publications | 1 | |
Metal bindingi | 124 | Manganese 22 Publications | 1 | |
Active sitei | 125 | Proton donor1 Publication | 1 | |
Metal bindingi | 173 | Manganese 22 Publications | 1 | |
Metal bindingi | 248 | Manganese 22 Publications | 1 | |
Sitei | 273 | Inhibition by microcystin toxin binding | 1 |
GO - Molecular functioni
- lamin binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- phosphatase activity Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein kinase binding Source: UniProtKB
- protein N-terminus binding Source: MGI
- protein phosphatase 1 binding Source: Ensembl
- protein serine/threonine phosphatase activity Source: UniProtKB
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
- RNA binding Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- circadian regulation of gene expression Source: UniProtKB
- entrainment of circadian clock by photoperiod Source: UniProtKB
- glycogen metabolic process Source: UniProtKB-KW
- MAPK cascade Source: Reactome
- mitotic spindle organization Source: Reactome
- neuron differentiation Source: Ensembl
- positive regulation of glial cell proliferation Source: Ensembl
- protein dephosphorylation Source: MGI
- regulation of circadian rhythm Source: UniProtKB
- regulation of nucleocytoplasmic transport Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Biological process | Biological rhythms, Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.3.16, 2681 |
PathwayCommonsi | P36873 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-163560, Triglyceride catabolism R-HSA-2173788, Downregulation of TGF-beta receptor signaling R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-400253, Circadian Clock R-HSA-5663220, RHO GTPases Activate Formins R-HSA-5673000, RAF activation R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation R-HSA-9660537, Signaling by MRAS-complex mutants |
SignaLinki | P36873 |
SIGNORi | P36873 |
Protein family/group databases
MoonDBi | P36873, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (EC:3.1.3.16)Short name: PP-1G Alternative name(s): Protein phosphatase 1C catalytic subunit |
Gene namesi | Name:PPP1CC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9283, PPP1CC |
MIMi | 176914, gene |
neXtProti | NX_P36873 |
VEuPathDBi | HostDB:ENSG00000186298.11 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus
- nucleolus 3 Publications
- nucleoplasm 1 Publication
- Nucleus speckle 1 Publication
Cytoskeleton
- microtubule organizing center 1 Publication
Mitochondrion
- Mitochondrion 1 Publication
Other locations
- kinetochore 1 Publication
- Cleavage furrow 1 Publication
- Midbody 1 Publication
Note: Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). Colocalizes with DYNLT4 in the microtubule organizing center (MTOC)(PubMed:23789093).By similarity5 Publications
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial outer membrane Source: Ensembl
- mitochondrion Source: UniProtKB
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleolus Source: UniProtKB
- nucleus Source: UniProtKB
Plasma Membrane
- cleavage furrow Source: UniProtKB-SubCell
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- dendritic spine Source: Ensembl
- focal adhesion Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- midbody Source: UniProtKB-SubCell
- presynapse Source: Ensembl
- protein phosphatase type 1 complex Source: InterPro
- protein-containing complex Source: UniProtKB
- PTW/PP1 phosphatase complex Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Mitochondrion, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 125 | H → A: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 273 | C → A, S or L: Abolishes interaction with microcystin toxin. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5501 |
OpenTargetsi | ENSG00000186298 |
PharmGKBi | PA33611 |
Miscellaneous databases
Pharosi | P36873, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4438 |
DrugBanki | DB02169, 9,10-Deepithio-9,10-Didehydroacanthifolicin DB02860, Calyculin A DB04738, Motuporin |
Genetic variation databases
BioMutai | PPP1CC |
DMDMi | 548573 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000058787 | 2 – 323 | Serine/threonine-protein phosphatase PP1-gamma catalytic subunitAdd BLAST | 322 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources2 Publications | 1 | |
Modified residuei | 307 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 311 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, PhosphoproteinProteomic databases
EPDi | P36873 |
jPOSTi | P36873 |
MassIVEi | P36873 |
MaxQBi | P36873 |
PaxDbi | P36873 |
PeptideAtlasi | P36873 |
PRIDEi | P36873 |
ProteomicsDBi | 55224 [P36873-1] 55225 [P36873-2] |
TopDownProteomicsi | P36873-1 [P36873-1] P36873-2 [P36873-2] |
PTM databases
CarbonylDBi | P36873 |
DEPODi | PPP1CC |
iPTMneti | P36873 |
MetOSitei | P36873 |
PhosphoSitePlusi | P36873 |
SwissPalmi | P36873 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000186298, Expressed in heart right ventricle and 252 other tissues |
ExpressionAtlasi | P36873, baseline and differential |
Genevisiblei | P36873, HS |
Organism-specific databases
HPAi | ENSG00000186298, Low tissue specificity |
Interactioni
Subunit structurei
PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen.
Interacts with cyanobacterial toxin microcystin; disulfide-linked.
Interacts with PPP1R3B and PPP1R7.
Isoform 2 interacts with SPZ1 (By similarity).
Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1.
Part of a complex containing PPP1R15B, PP1 and NCK1/2.
Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation.
Interacts with PPP1R42; the interaction is direct (By similarity).
Interacts with NOM1 and PPP1R8.
Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC.
Interacts with PPP1R8.
Interacts with isoform 1 and isoform 4 NEK2.
Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner.
Interacts with FOXP3.
Interacts with TMEM225 (via RVxF motif) (By similarity).
Interacts with MKI67 (PubMed:24867636).
Interacts with RRP1B; this targets PPP1CC to the nucleolus (PubMed:20926688).
Interacts with PPP1R2B (PubMed:23506001).
Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (PubMed:23846654).
Interacts with DYNLT4 (PubMed:23789093).
By similarity19 PublicationsBinary interactionsi
Hide detailsP36873
Isoform 1 [P36873-1]
With | #Exp. | IntAct |
---|---|---|
NEK2 [P51955] | 2 | EBI-356289,EBI-633182 |
TCTEX1D4 [Q5JR98] | 2 | EBI-356289,EBI-4311709 |
TOR1AIP1 - isoform 3 [Q5JTV8-3] | 4 | EBI-356289,EBI-21448143 |
TP53 [P04637] | 2 | EBI-356289,EBI-366083 |
Isoform 2 [P36873-2]
GO - Molecular functioni
- lamin binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- protein kinase binding Source: UniProtKB
- protein N-terminus binding Source: MGI
- protein phosphatase 1 binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111495, 665 interactors |
DIPi | DIP-749N |
IntActi | P36873, 273 interactors |
MINTi | P36873 |
STRINGi | 9606.ENSP00000341779 |
Chemistry databases
BindingDBi | P36873 |
Miscellaneous databases
RNActi | P36873, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P36873 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P36873 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0374, Eukaryota |
GeneTreei | ENSGT00940000153472 |
HOGENOMi | CLU_004962_0_0_1 |
InParanoidi | P36873 |
OMAi | EEHEIRY |
OrthoDBi | 766640at2759 |
PhylomeDBi | P36873 |
TreeFami | TF354243 |
Family and domain databases
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR037981, PPP1CC IPR006186, Ser/Thr-sp_prot-phosphatase IPR031675, STPPase_N |
PANTHERi | PTHR11668:SF204, PTHR11668:SF204, 1 hit |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit PF16891, STPPase_N, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP
60 70 80 90 100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK
160 170 180 190 200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL
210 220 230 240 250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV
260 270 280 290 300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE
310 320
KKKPNATRPV TPPRGMITKQ AKK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W0W8 | F8W0W8_HUMAN | Serine/threonine-protein phosphatas... | PPP1CC | 332 | Annotation score: | ||
F8VR82 | F8VR82_HUMAN | Serine/threonine-protein phosphatas... | PPP1CC | 270 | Annotation score: | ||
F8VYE8 | F8VYE8_HUMAN | Serine/threonine-protein phosphatas... | PPP1CC | 304 | Annotation score: | ||
A0A087WYY5 | A0A087WYY5_HUMAN | Serine/threonine-protein phosphatas... | PPP1CC | 140 | Annotation score: | ||
F8W0V8 | F8W0V8_HUMAN | Protein phosphatase 1C catalytic su... | PPP1CC | 54 | Annotation score: | ||
F8W1A0 | F8W1A0_HUMAN | Protein-serine/threonine phosphatas... | PPP1CC | 83 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051734 | 152 | F → S. Corresponds to variant dbSNP:rs11558237Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005094 | 315 – 323 | GMITKQAKK → VASGLNPSIQKASNYRNNTV LYE in isoform 2. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74008 mRNA Translation: CAA52169.1 BC014073 mRNA Translation: AAH14073.1 L07395 mRNA Translation: AAA19823.1 |
CCDSi | CCDS58279.1 [P36873-2] CCDS9150.1 [P36873-1] |
PIRi | S35699 S35700 |
RefSeqi | NP_001231903.1, NM_001244974.1 [P36873-2] NP_002701.1, NM_002710.3 [P36873-1] |
Genome annotation databases
Ensembli | ENST00000335007; ENSP00000335084; ENSG00000186298 [P36873-1] ENST00000340766; ENSP00000341779; ENSG00000186298 [P36873-2] |
GeneIDi | 5501 |
KEGGi | hsa:5501 |
UCSCi | uc001tru.4, human [P36873-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight The things we forget - Issue 32 of March 2003 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74008 mRNA Translation: CAA52169.1 BC014073 mRNA Translation: AAH14073.1 L07395 mRNA Translation: AAA19823.1 |
CCDSi | CCDS58279.1 [P36873-2] CCDS9150.1 [P36873-1] |
PIRi | S35699 S35700 |
RefSeqi | NP_001231903.1, NM_001244974.1 [P36873-2] NP_002701.1, NM_002710.3 [P36873-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IT6 | X-ray | 2.00 | A/B | 1-323 | [»] | |
1JK7 | X-ray | 1.90 | A | 1-323 | [»] | |
1U32 | X-ray | 2.00 | A | 6-298 | [»] | |
2BCD | X-ray | 2.10 | A | 1-323 | [»] | |
2BDX | X-ray | 2.30 | A | 1-323 | [»] | |
4UT2 | X-ray | 1.96 | A/B | 1-323 | [»] | |
4UT3 | X-ray | 2.19 | A/B | 1-323 | [»] | |
5INB | X-ray | 1.30 | A | 7-308 | [»] | |
5J28 | X-ray | 2.00 | A/B | 7-308 | [»] | |
SMRi | P36873 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111495, 665 interactors |
DIPi | DIP-749N |
IntActi | P36873, 273 interactors |
MINTi | P36873 |
STRINGi | 9606.ENSP00000341779 |
Chemistry databases
BindingDBi | P36873 |
ChEMBLi | CHEMBL4438 |
DrugBanki | DB02169, 9,10-Deepithio-9,10-Didehydroacanthifolicin DB02860, Calyculin A DB04738, Motuporin |
Protein family/group databases
MoonDBi | P36873, Predicted |
PTM databases
CarbonylDBi | P36873 |
DEPODi | PPP1CC |
iPTMneti | P36873 |
MetOSitei | P36873 |
PhosphoSitePlusi | P36873 |
SwissPalmi | P36873 |
Genetic variation databases
BioMutai | PPP1CC |
DMDMi | 548573 |
Proteomic databases
EPDi | P36873 |
jPOSTi | P36873 |
MassIVEi | P36873 |
MaxQBi | P36873 |
PaxDbi | P36873 |
PeptideAtlasi | P36873 |
PRIDEi | P36873 |
ProteomicsDBi | 55224 [P36873-1] 55225 [P36873-2] |
TopDownProteomicsi | P36873-1 [P36873-1] P36873-2 [P36873-2] |
Protocols and materials databases
Antibodypediai | 2879, 426 antibodies |
DNASUi | 5501 |
Genome annotation databases
Ensembli | ENST00000335007; ENSP00000335084; ENSG00000186298 [P36873-1] ENST00000340766; ENSP00000341779; ENSG00000186298 [P36873-2] |
GeneIDi | 5501 |
KEGGi | hsa:5501 |
UCSCi | uc001tru.4, human [P36873-1] |
Organism-specific databases
CTDi | 5501 |
DisGeNETi | 5501 |
GeneCardsi | PPP1CC |
HGNCi | HGNC:9283, PPP1CC |
HPAi | ENSG00000186298, Low tissue specificity |
MIMi | 176914, gene |
neXtProti | NX_P36873 |
OpenTargetsi | ENSG00000186298 |
PharmGKBi | PA33611 |
VEuPathDBi | HostDB:ENSG00000186298.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0374, Eukaryota |
GeneTreei | ENSGT00940000153472 |
HOGENOMi | CLU_004962_0_0_1 |
InParanoidi | P36873 |
OMAi | EEHEIRY |
OrthoDBi | 766640at2759 |
PhylomeDBi | P36873 |
TreeFami | TF354243 |
Enzyme and pathway databases
BRENDAi | 3.1.3.16, 2681 |
PathwayCommonsi | P36873 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-163560, Triglyceride catabolism R-HSA-2173788, Downregulation of TGF-beta receptor signaling R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-400253, Circadian Clock R-HSA-5663220, RHO GTPases Activate Formins R-HSA-5673000, RAF activation R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation R-HSA-9660537, Signaling by MRAS-complex mutants |
SignaLinki | P36873 |
SIGNORi | P36873 |
Miscellaneous databases
BioGRID-ORCSi | 5501, 32 hits in 1002 CRISPR screens |
ChiTaRSi | PPP1CC, human |
EvolutionaryTracei | P36873 |
GeneWikii | PPP1CC |
GenomeRNAii | 5501 |
Pharosi | P36873, Tchem |
PROi | PR:P36873 |
RNActi | P36873, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186298, Expressed in heart right ventricle and 252 other tissues |
ExpressionAtlasi | P36873, baseline and differential |
Genevisiblei | P36873, HS |
Family and domain databases
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR037981, PPP1CC IPR006186, Ser/Thr-sp_prot-phosphatase IPR031675, STPPase_N |
PANTHERi | PTHR11668:SF204, PTHR11668:SF204, 1 hit |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit PF16891, STPPase_N, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP1G_HUMAN | |
Accessioni | P36873Primary (citable) accession number: P36873 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | April 7, 2021 | |
This is version 236 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries