PPP1CC

Functionⁱ

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca²⁺/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).4 Publications

Miscellaneous

Microcystin toxin is bound to Cys-273 through a thioether bond.

Caution

Catalytic activityⁱ

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactorⁱ

Mn²⁺2 PublicationsNote: Binds 2 manganese ions per subunit.2 Publications

Activity regulationⁱ

Inactivated by binding to URI1. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	64	Manganese 12 Publications	1
Metal bindingⁱ	66	Manganese 12 Publications	1
Metal bindingⁱ	92	Manganese 12 Publications	1
Metal bindingⁱ	92	Manganese 22 Publications	1
Metal bindingⁱ	124	Manganese 22 Publications	1
Active siteⁱ	125	Proton donor1 Publication	1
Metal bindingⁱ	173	Manganese 22 Publications	1
Metal bindingⁱ	248	Manganese 22 Publications	1
Siteⁱ	273	Inhibition by microcystin toxin binding	1

GO - Molecular functionⁱ

lamin binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
phosphatase activity Source: UniProtKB
phosphoprotein phosphatase activity Source: Reactome
protein-containing complex binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10880350
protein N-terminus binding
Source: MGI
Inferred from direct assayⁱ
- 23789093
protein phosphatase 1 binding Source: Ensembl
protein serine/threonine phosphatase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10880350
- 17936702
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
circadian regulation of gene expression Source: UniProtKB
entrainment of circadian clock by photoperiod Source: UniProtKB
glycogen metabolic process Source: UniProtKB-KW
neuron differentiation Source: Ensembl
positive regulation of glial cell proliferation Source: Ensembl
protein dephosphorylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 22801782
regulation of circadian rhythm
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21712997
regulation of nucleocytoplasmic transport Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Biological process	Biological rhythms, Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	3.1.3.16 2681
Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-163560 Triglyceride catabolism R-HSA-2173788 Downregulation of TGF-beta receptor signaling R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-400253 Circadian Clock R-HSA-5663220 RHO GTPases Activate Formins R-HSA-68877 Mitotic Prometaphase
SignaLinkⁱ	P36873
SIGNORⁱ	P36873

Protein family/group databases

MoonDBⁱ	P36873 Predicted

MoonDBⁱ

P36873 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (EC:3.1.3.16) Short name: PP-1G Alternative name(s): Protein phosphatase 1C catalytic subunit
Gene namesⁱ	Name:PPP1CC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186298.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9283 PPP1CC
MIMⁱ	176914 gene
neXtProtⁱ	NX_P36873

Keywords - Cellular componentⁱ

Centromere, Chromosome, Cytoplasm, Kinetochore, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	125	H → A: Loss of activity. 1 Publication		1
Mutagenesisⁱ	273	C → A, S or L: Abolishes interaction with microcystin toxin. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5501
Open Targets More...OpenTargetsⁱ	ENSG00000186298
PharmGKBⁱ	PA33611

Chemistry databases

ChEMBLⁱ	CHEMBL4438
Drug and drug target database More...DrugBankⁱ	DB02860 Calyculin A DB04738 Motuporin

Polymorphism and mutation databases

BioMutaⁱ	PPP1CC
DMDMⁱ	548573

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources2 Publications
ChainⁱPRO_0000058787	2 – 323	Serine/threonine-protein phosphatase PP1-gamma catalytic subunitAdd BLAST		322

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources2 Publications	1
Modified residueⁱ	307	PhosphothreonineCombined sources	1
Modified residueⁱ	311	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by NEK2.1 Publication

Keywords - PTMⁱ

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	P36873
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36873
PaxDbⁱ	P36873
PeptideAtlas More...PeptideAtlasⁱ	P36873
PRIDEⁱ	P36873
ProteomicsDBⁱ	55224 55225 [P36873-2]
TopDownProteomicsⁱ	P36873-1 [P36873-1] P36873-2 [P36873-2]

PTM databases

CarbonylDBⁱ	P36873
DEPODⁱ	P36873
iPTMnetⁱ	P36873
PhosphoSitePlusⁱ	P36873
SwissPalmⁱ	P36873

Expressionⁱ

Inductionⁱ

Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000186298 Expressed in 241 organ(s), highest expression level in heart right ventricle
CleanExⁱ	HS_PPP1CC
ExpressionAtlasⁱ	P36873 baseline and differential
Genevisibleⁱ	P36873 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022645

HPAⁱ

CAB022645

Interactionⁱ

Subunit structureⁱ

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked. Interacts with PPP1R3B and PPP1R7. Isoform 2 interacts with SPZ1 (By similarity). Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with PPP1R42; the interaction is direct (By similarity). Interacts with NOM1 and PPP1R8. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with isoform 1 and isoform 4 NEK2. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with FOXP3. Interacts with TMEM225 (via RVxF motif) (By similarity). Interacts with MKI67 (PubMed:24867636). Interacts with RRP1B; this targets PPP1CC to the nucleolus (PubMed:20926688). Interacts with PPP1R2B (PubMed:23506001). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (PubMed:23846654).By similarity18 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	A1DRY3	2	EBI-3964623,EBI-4311408
AKAP4	Q5JQC9	4	EBI-3964623,EBI-16628643
BRCA1	P38398	2	EBI-356283,EBI-349905
CD2BP2	O95400	3	EBI-356283,EBI-768015
Clock	O08785	2	EBI-356283,EBI-79859	From Mus musculus.
CSRNP1	Q96S65	3	EBI-356283,EBI-4311573
CSRNP2	Q9H175	5	EBI-356283,EBI-5235958
OGT	O15294	11	EBI-356283,EBI-539828
PPP1R11	O60927	5	EBI-356283,EBI-1048104
PPP1R2	P41236	7	EBI-356283,EBI-1056517
PPP1R32	Q7Z5V6	4	EBI-3964623,EBI-4311771
PPP1R3C	Q9UQK1	3	EBI-356283,EBI-2506727
PPP1R7	Q15435	5	EBI-356283,EBI-1024281
PPP1R9B	Q96SB3	5	EBI-356283,EBI-351275
RANBP9	Q96S59	3	EBI-3964623,EBI-636085
RRP1B	Q14684	9	EBI-356283,EBI-372051
TCTEX1D4	Q5JR98	3	EBI-3964623,EBI-4311709
TP53	P04637	2	EBI-356289,EBI-366083
TP53BP2	Q13625	8	EBI-356283,EBI-77642
TP53BP2	Q13625-3	3	EBI-356283,EBI-10175039
URI1	O94763	17	EBI-356283,EBI-357067
URI1	O94763-1	8	EBI-356283,EBI-12590720
ZFYVE9	O95405	5	EBI-356283,EBI-296817

GO - Molecular functionⁱ

lamin binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10880350
protein N-terminus binding
Source: MGI
Inferred from direct assayⁱ
- 23789093
protein phosphatase 1 binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111495, 308 interactors
Database of interacting proteins More...DIPⁱ	DIP-749N
IntActⁱ	P36873, 236 interactors
Molecular INTeraction database More...MINTⁱ	P36873
STRINGⁱ	9606.ENSP00000335084

Chemistry databases

BindingDBⁱ

P36873

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 17	Combined sources	9
Helixⁱ	18 – 21	Combined sources	4
Helixⁱ	32 – 48	Combined sources	17
Beta strandⁱ	51 – 55	Combined sources	5
Beta strandⁱ	57 – 62	Combined sources	6
Helixⁱ	69 – 79	Combined sources	11
Beta strandⁱ	87 – 89	Combined sources	3
Beta strandⁱ	94 – 98	Combined sources	5
Helixⁱ	100 – 113	Combined sources	14
Turnⁱ	115 – 117	Combined sources	3
Beta strandⁱ	118 – 120	Combined sources	3
Helixⁱ	128 – 131	Combined sources	4
Turnⁱ	132 – 135	Combined sources	4
Helixⁱ	136 – 143	Combined sources	8
Helixⁱ	146 – 156	Combined sources	11
Beta strandⁱ	162 – 165	Combined sources	4
Turnⁱ	166 – 168	Combined sources	3
Beta strandⁱ	169 – 174	Combined sources	6
Helixⁱ	183 – 187	Combined sources	5
Beta strandⁱ	197 – 199	Combined sources	3
Helixⁱ	200 – 206	Combined sources	7
Beta strandⁱ	214 – 218	Combined sources	5
Beta strandⁱ	222 – 227	Combined sources	6
Helixⁱ	229 – 239	Combined sources	11
Beta strandⁱ	243 – 246	Combined sources	4
Beta strandⁱ	254 – 258	Combined sources	5
Turnⁱ	259 – 262	Combined sources	4
Beta strandⁱ	263 – 267	Combined sources	5
Helixⁱ	272 – 274	Combined sources	3
Beta strandⁱ	280 – 285	Combined sources	6
Beta strandⁱ	290 – 298	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P36873
SMRⁱ	P36873
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P36873

EvolutionaryTraceⁱ

P36873

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IN85 Eukaryota ENOG410XPVF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062911
HOGENOMⁱ	HOG000172697
HOVERGENⁱ	HBG000216
InParanoidⁱ	P36873
KEGG Orthology (KO) More...KOⁱ	K06269
OMAⁱ	LICDLVW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EKF
PhylomeDBⁱ	P36873
TreeFamⁱ	TF354243

Family and domain databases

Gene3Dⁱ	3.60.21.10, 1 hit
InterProⁱ	View protein in InterPro IPR004843 Calcineurin-like_PHP_ApaH IPR029052 Metallo-depent_PP-like IPR037981 PPP1CC IPR006186 Ser/Thr-sp_prot-phosphatase IPR031675 STPPase_N
PANTHERⁱ	PTHR11668:SF204 PTHR11668:SF204, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149 Metallophos, 1 hit PF16891 STPPase_N, 1 hit
PRINTSⁱ	PR00114 STPHPHTASE
SMARTⁱ	View protein in SMART SM00156 PP2Ac, 1 hit
PROSITEⁱ	View protein in PROSITE PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P36873-1) [UniParc]FASTA Add to basket

Also known as: PPPCC1, Gamma-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP 
        60         70         80         90        100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS 
       110        120        130        140        150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK 
       160        170        180        190        200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL 
       210        220        230        240        250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV 
       260        270        280        290        300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 
       310        320 
KKKPNATRPV TPPRGMITKQ AKK

Length:323

Mass (Da):36,984

Last modified:June 1, 1994 - v1

Checksum:ⁱ0EEEF0E842188536

GO

Isoform 2 (identifier: P36873-2) [UniParc]FASTA Add to basket

Also known as: PPPCC2, Gamma-2

The sequence of this isoform differs from the canonical sequence as follows:
315-323: GMITKQAKK → VASGLNPSIQKASNYRNNTVLYE

« Hide

        10         20         30         40         50
MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP 
        60         70         80         90        100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS 
       110        120        130        140        150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK 
       160        170        180        190        200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL 
       210        220        230        240        250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV 
       260        270        280        290        300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 
       310        320        330 
KKKPNATRPV TPPRVASGLN PSIQKASNYR NNTVLYE

Show »

Length:337

Mass (Da):38,518

Checksum:ⁱ9731E5A6C8EEBF46

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W0W8	F8W0W8_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase, EC 3.1.3.16	PPP1CC	332	Annotation score:
F8VYE8	F8VYE8_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase, EC 3.1.3.16	PPP1CC	304	Annotation score:
F8VR82	F8VR82_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase, EC 3.1.3.16	PPP1CC	270	Annotation score:
A0A087WYY5	A0A087WYY5_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase, EC 3.1.3.16	PPP1CC	140	Annotation score:
F8W1A0	F8W1A0_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	PPP1CC	83	Annotation score:
F8W0V8	F8W0V8_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	PPP1CC	54	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051734	152	F → S. Corresponds to variant dbSNP:rs11558237Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005094	315 – 323	GMITKQAKK → VASGLNPSIQKASNYRNNTV LYE in isoform 2. 1 Publication		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X74008 mRNA Translation: CAA52169.1 BC014073 mRNA Translation: AAH14073.1 L07395 mRNA Translation: AAA19823.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58279.1 [P36873-2] CCDS9150.1 [P36873-1]
PIRⁱ	S35699 S35700
NCBI Reference Sequences More...RefSeqⁱ	NP_001231903.1, NM_001244974.1 [P36873-2] NP_002701.1, NM_002710.3 [P36873-1]
UniGeneⁱ	Hs.79081

Genome annotation databases

Ensemblⁱ	ENST00000335007; ENSP00000335084; ENSG00000186298 [P36873-1] ENST00000340766; ENSP00000341779; ENSG00000186298 [P36873-2]
GeneIDⁱ	5501
KEGGⁱ	hsa:5501
UCSC genome browser More...UCSCⁱ	uc001tru.4 human [P36873-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P36873	Serine/threonine-protein phosphatase		HUMAN		323	UniRef100_P36873
Serine/threonine-protein phosphatase		CALJA		323
Serine/threonine-protein phosphatase		MACMU		323
Serine/threonine-protein phosphatase		PANTR		323
Serine/threonine-protein phosphatase		MACFA		323
+1
P36873-2	Serine/threonine-protein phosphatase		PANTR		337	UniRef100_A0A2I3TLI4
Serine/threonine-protein phosphatase		PONAB		337
Serine/threonine-protein phosphatase		MACMU		337
Serine/threonine-protein phosphatase		COLAP		337
Serine/threonine-protein phosphatase		PAPAN		337
+3

Protein	Similar proteins		Species	Score	Length	Source
P36873	Serine/threonine-protein phosphatase		HUMAN		323	UniRef90_P36873
Serine/threonine-protein phosphatase		CALJA		323
Serine/threonine-protein phosphatase		MACMU		323
Serine/threonine-protein phosphatase		PANTR		323
Serine/threonine-protein phosphatase		MACFA		323
+37
P36873-2	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	)	MOUSE		323	UniRef90_P63087
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		BOVIN		323
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	)	RAT		323
Serine/threonine-protein phosphatase		PIG		323
serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1		BALAS		323
+103

Protein	Similar proteins		Species	Score	Length	Source
P36873	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	)	HUMAN		330	UniRef50_P62136
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit		BOVIN		330
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	)	RABIT		330
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit		RAT		330
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit		MOUSE		330
+1167
P36873-2	Serine/threonine-protein phosphatase PP1-2		YEAST		312	UniRef50_P32598
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	)	MOUSE		323
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		BOVIN		323
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	)	RAT		323
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		CANLF		323
+1209

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

The things we forget - Issue 32 of March 2003

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X74008 mRNA Translation: CAA52169.1 BC014073 mRNA Translation: AAH14073.1 L07395 mRNA Translation: AAA19823.1
CCDSⁱ	CCDS58279.1 [P36873-2] CCDS9150.1 [P36873-1]
PIRⁱ	S35699 S35700
RefSeqⁱ	NP_001231903.1, NM_001244974.1 [P36873-2] NP_002701.1, NM_002710.3 [P36873-1]
UniGeneⁱ	Hs.79081

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IT6	X-ray	2.00	A/B	1-323	[»]
	1JK7	X-ray	1.90	A	1-323	[»]
	1U32	X-ray	2.00	A	6-298	[»]
	2BCD	X-ray	2.10	A	1-323	[»]
	2BDX	X-ray	2.30	A	1-323	[»]
	4UT2	X-ray	1.96	A/B	1-323	[»]
	4UT3	X-ray	2.19	A/B	1-323	[»]
	5INB	X-ray	1.30	A	7-308	[»]
	5J28	X-ray	2.00	A/B	7-308	[»]
ProteinModelPortalⁱ	P36873
SMRⁱ	P36873
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111495, 308 interactors
DIPⁱ	DIP-749N
IntActⁱ	P36873, 236 interactors
MINTⁱ	P36873
STRINGⁱ	9606.ENSP00000335084

Chemistry databases

BindingDBⁱ	P36873
ChEMBLⁱ	CHEMBL4438
DrugBankⁱ	DB02860 Calyculin A DB04738 Motuporin

Protein family/group databases

MoonDBⁱ	P36873 Predicted

MoonDBⁱ

P36873 Predicted

PTM databases

CarbonylDBⁱ	P36873
DEPODⁱ	P36873
iPTMnetⁱ	P36873
PhosphoSitePlusⁱ	P36873
SwissPalmⁱ	P36873

Polymorphism and mutation databases

BioMutaⁱ	PPP1CC
DMDMⁱ	548573

Proteomic databases

EPDⁱ	P36873
MaxQBⁱ	P36873
PaxDbⁱ	P36873
PeptideAtlasⁱ	P36873
PRIDEⁱ	P36873
ProteomicsDBⁱ	55224 55225 [P36873-2]
TopDownProteomicsⁱ	P36873-1 [P36873-1] P36873-2 [P36873-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5501
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000335007; ENSP00000335084; ENSG00000186298 [P36873-1] ENST00000340766; ENSP00000341779; ENSG00000186298 [P36873-2]
GeneIDⁱ	5501
KEGGⁱ	hsa:5501
UCSCⁱ	uc001tru.4 human [P36873-1]

Organism-specific databases

CTDⁱ	5501
DisGeNETⁱ	5501
EuPathDBⁱ	HostDB:ENSG00000186298.11
GeneCardsⁱ	PPP1CC
HGNCⁱ	HGNC:9283 PPP1CC
HPAⁱ	CAB022645
MIMⁱ	176914 gene
neXtProtⁱ	NX_P36873
OpenTargetsⁱ	ENSG00000186298
PharmGKBⁱ	PA33611
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IN85 Eukaryota ENOG410XPVF LUCA
GeneTreeⁱ	ENSGT00530000062911
HOGENOMⁱ	HOG000172697
HOVERGENⁱ	HBG000216
InParanoidⁱ	P36873
KOⁱ	K06269
OMAⁱ	LICDLVW
OrthoDBⁱ	EOG091G0EKF
PhylomeDBⁱ	P36873
TreeFamⁱ	TF354243

Enzyme and pathway databases

BRENDAⁱ	3.1.3.16 2681
Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-163560 Triglyceride catabolism R-HSA-2173788 Downregulation of TGF-beta receptor signaling R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-400253 Circadian Clock R-HSA-5663220 RHO GTPases Activate Formins R-HSA-68877 Mitotic Prometaphase
SignaLinkⁱ	P36873
SIGNORⁱ	P36873

Miscellaneous databases

ChiTaRSⁱ	PPP1CC human
EvolutionaryTraceⁱ	P36873
GeneWikiⁱ	PPP1CC
GenomeRNAiⁱ	5501
Protein Ontology More...PROⁱ	PR:P36873
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186298 Expressed in 241 organ(s), highest expression level in heart right ventricle
CleanExⁱ	HS_PPP1CC
ExpressionAtlasⁱ	P36873 baseline and differential
Genevisibleⁱ	P36873 HS

Family and domain databases

Gene3Dⁱ	3.60.21.10, 1 hit
InterProⁱ	View protein in InterPro IPR004843 Calcineurin-like_PHP_ApaH IPR029052 Metallo-depent_PP-like IPR037981 PPP1CC IPR006186 Ser/Thr-sp_prot-phosphatase IPR031675 STPPase_N
PANTHERⁱ	PTHR11668:SF204 PTHR11668:SF204, 1 hit
Pfamⁱ	View protein in Pfam PF00149 Metallophos, 1 hit PF16891 STPPase_N, 1 hit
PRINTSⁱ	PR00114 STPHPHTASE
SMARTⁱ	View protein in SMART SM00156 PP2Ac, 1 hit
PROSITEⁱ	View protein in PROSITE PS00125 SER_THR_PHOSPHATASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PP1G_HUMAN
Accessionⁱ	P36873Primary (citable) accession number: P36873
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 217 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniProtKB - P36873 (PP1G_HUMAN)

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Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

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Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ