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Entry version 193 (11 Dec 2019)
Sequence version 1 (01 Jun 1994)
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Protein

Protein phosphatase PP2A 55 kDa regulatory subunit

Gene

tws

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment.

Caution

It is uncertain whether Met-1, Met-18, Met-33 or Met-44 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein phosphatase regulator activity Source: FlyBase

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-209155 Phosphorylation of AXN and APC
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209396 Phosphorylation of ARM
R-DME-209413 Assembly of the 'destruction complex'
R-DME-209440 Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-2995383 Initiation of Nuclear Envelope Reformation
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-69231 Cyclin D associated events in G1
R-DME-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P36872

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase PP2A 55 kDa regulatory subunit
Short name:
PR55
Alternative name(s):
Protein phosphatase PP2A regulatory subunit B
Protein twins
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tws
Synonyms:aar, Pp2A-85F
ORF Names:CG6235
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004889 tws

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000714371 – 499Protein phosphatase PP2A 55 kDa regulatory subunitAdd BLAST499

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36872

PRoteomics IDEntifications database

More...
PRIDEi
P36872

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004889 Expressed in 40 organ(s), highest expression level in adult hindgut (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P36872 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P36872 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit (PR65) (subunit A). The core complex associates with a third, variable subunit (subunit B), which confers distinct properties to the holoenzyme.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
71024, 31 interactors

Database of interacting proteins

More...
DIPi
DIP-19897N

Protein interaction database and analysis system

More...
IntActi
P36872, 31 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081665

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P36872

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati79 – 118WD 1Add BLAST40
Repeati144 – 185WD 2Add BLAST42
Repeati228 – 266WD 3Add BLAST39
Repeati277 – 317WD 4Add BLAST41
Repeati336 – 374WD 5Add BLAST39
Repeati391 – 432WD 6Add BLAST42
Repeati467 – 498WD 7Add BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1354 Eukaryota
COG5170 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182864

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36872

KEGG Orthology (KO)

More...
KOi
K04354

Identification of Orthologs from Complete Genome Data

More...
OMAi
HPISCNW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P36872

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11871 PTHR11871, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037309 PP2A_PR55, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00600 PP2APR55

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: P36872-1) [UniParc]FASTAAdd to basket
Also known as: F

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRWGRQSPV LEPPDPQMQT TPPPPTLPPR TFMRQSSITK IGNMLNTAIN
60 70 80 90 100
INGAKKPASN GEASWCFSQI KGALDDDVTD ADIISCVEFN HDGELLATGD
110 120 130 140 150
KGGRVVIFQR DPASKAANPR RGEYNVYSTF QSHEPEFDYL KSLEIEEKIN
160 170 180 190 200
KIRWLQQKNP VHFLLSTNDK TVKLWKVSER DKSFGGYNTK EENGLIRDPQ
210 220 230 240 250
NVTALRVPSV KQIPLLVEAS PRRTFANAHT YHINSISVNS DQETFLSADD
260 270 280 290 300
LRINLWHLEV VNQSYNIVDI KPTNMEELTE VITAAEFHPT ECNVFVYSSS
310 320 330 340 350
KGTIRLCDMR SAALCDRHSK QFEEPENPTN RSFFSEIISS ISDVKLSNSG
360 370 380 390 400
RYMISRDYLS IKVWDLHMET KPIETYPVHE YLRAKLCSLY ENDCIFDKFE
410 420 430 440 450
CCWNGKDSSI MTGSYNNFFR VFDRNSKKDV TLEASRDIIK PKTVLKPRKV
460 470 480 490
CTGGKRKKDE ISVDCLDFNK KILHTAWHPE ENIIAVAATN NLFIFQDKF
Length:499
Mass (Da):56,967
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD871A7E3058B7286
GO
Isoform B (identifier: P36872-2) [UniParc]FASTAAdd to basket
Also known as: C, D, E, G, H

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     57-59: PAS → MAG

Show »
Length:443
Mass (Da):50,789
Checksum:i83E944093F5BC640
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LGZ3A0A0B4LGZ3_DROME
Serine/threonine-protein phosphatas...
tws 06, 1466, 2414, aar, B
499Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti211K → M in AAA99871 (PubMed:8382567).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0051051 – 56Missing in isoform B. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_00510657 – 59PAS → MAG in isoform B. 2 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D13004 mRNA Translation: BAA02367.1
L07581 mRNA Translation: AAA99870.1
L07583 mRNA Translation: AAA99871.1
L07585 Genomic DNA No translation available.
L07586, L12544 Genomic DNA Translation: AAB00371.1
L07586, L12544 Genomic DNA Translation: AAB00372.1
AE014297 Genomic DNA Translation: AAF54498.1
AE014297 Genomic DNA Translation: AAF54499.3
AE014297 Genomic DNA Translation: AAN13455.1
AE014297 Genomic DNA Translation: AAN13456.1
AE014297 Genomic DNA Translation: AAN13457.1
AE014297 Genomic DNA Translation: AAN13458.1
AE014297 Genomic DNA Translation: AAN13459.1
AE014297 Genomic DNA Translation: AAN13460.1
AY061152 mRNA Translation: AAL28700.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45778

NCBI Reference Sequences

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RefSeqi
NP_001287269.1, NM_001300340.1 [P36872-1]
NP_476880.1, NM_057532.4 [P36872-1]
NP_476881.1, NM_057533.3 [P36872-2]
NP_599111.1, NM_134284.3 [P36872-2]
NP_599112.1, NM_134285.2 [P36872-2]
NP_599113.1, NM_134286.3 [P36872-2]
NP_731451.1, NM_169329.2 [P36872-1]
NP_731452.1, NM_169330.2 [P36872-2]
NP_731453.1, NM_169331.2 [P36872-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082186; FBpp0081664; FBgn0004889 [P36872-1]
FBtr0082187; FBpp0081665; FBgn0004889 [P36872-1]
FBtr0082188; FBpp0081666; FBgn0004889 [P36872-2]
FBtr0082189; FBpp0081667; FBgn0004889 [P36872-2]
FBtr0082190; FBpp0081668; FBgn0004889 [P36872-2]
FBtr0082191; FBpp0081669; FBgn0004889 [P36872-2]
FBtr0082192; FBpp0081670; FBgn0004889 [P36872-2]
FBtr0082193; FBpp0081671; FBgn0004889 [P36872-2]
FBtr0345177; FBpp0311386; FBgn0004889 [P36872-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
47877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6235

UCSC genome browser

More...
UCSCi
CG6235-RC d. melanogaster
CG6235-RF d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13004 mRNA Translation: BAA02367.1
L07581 mRNA Translation: AAA99870.1
L07583 mRNA Translation: AAA99871.1
L07585 Genomic DNA No translation available.
L07586, L12544 Genomic DNA Translation: AAB00371.1
L07586, L12544 Genomic DNA Translation: AAB00372.1
AE014297 Genomic DNA Translation: AAF54498.1
AE014297 Genomic DNA Translation: AAF54499.3
AE014297 Genomic DNA Translation: AAN13455.1
AE014297 Genomic DNA Translation: AAN13456.1
AE014297 Genomic DNA Translation: AAN13457.1
AE014297 Genomic DNA Translation: AAN13458.1
AE014297 Genomic DNA Translation: AAN13459.1
AE014297 Genomic DNA Translation: AAN13460.1
AY061152 mRNA Translation: AAL28700.1
PIRiA45778
RefSeqiNP_001287269.1, NM_001300340.1 [P36872-1]
NP_476880.1, NM_057532.4 [P36872-1]
NP_476881.1, NM_057533.3 [P36872-2]
NP_599111.1, NM_134284.3 [P36872-2]
NP_599112.1, NM_134285.2 [P36872-2]
NP_599113.1, NM_134286.3 [P36872-2]
NP_731451.1, NM_169329.2 [P36872-1]
NP_731452.1, NM_169330.2 [P36872-2]
NP_731453.1, NM_169331.2 [P36872-2]

3D structure databases

SMRiP36872
ModBaseiSearch...

Protein-protein interaction databases

BioGridi71024, 31 interactors
DIPiDIP-19897N
IntActiP36872, 31 interactors
STRINGi7227.FBpp0081665

Proteomic databases

PaxDbiP36872
PRIDEiP36872

Genome annotation databases

EnsemblMetazoaiFBtr0082186; FBpp0081664; FBgn0004889 [P36872-1]
FBtr0082187; FBpp0081665; FBgn0004889 [P36872-1]
FBtr0082188; FBpp0081666; FBgn0004889 [P36872-2]
FBtr0082189; FBpp0081667; FBgn0004889 [P36872-2]
FBtr0082190; FBpp0081668; FBgn0004889 [P36872-2]
FBtr0082191; FBpp0081669; FBgn0004889 [P36872-2]
FBtr0082192; FBpp0081670; FBgn0004889 [P36872-2]
FBtr0082193; FBpp0081671; FBgn0004889 [P36872-2]
FBtr0345177; FBpp0311386; FBgn0004889 [P36872-1]
GeneIDi47877
KEGGidme:Dmel_CG6235
UCSCiCG6235-RC d. melanogaster
CG6235-RF d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
47877
FlyBaseiFBgn0004889 tws

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
GeneTreeiENSGT00950000182864
InParanoidiP36872
KOiK04354
OMAiHPISCNW
PhylomeDBiP36872

Enzyme and pathway databases

ReactomeiR-DME-209155 Phosphorylation of AXN and APC
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209396 Phosphorylation of ARM
R-DME-209413 Assembly of the 'destruction complex'
R-DME-209440 Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-2995383 Initiation of Nuclear Envelope Reformation
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-69231 Cyclin D associated events in G1
R-DME-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkiP36872

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
tws fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
47877

Protein Ontology

More...
PROi
PR:P36872

Gene expression databases

BgeeiFBgn0004889 Expressed in 40 organ(s), highest expression level in adult hindgut (Drosophila)
ExpressionAtlasiP36872 baseline and differential
GenevisibleiP36872 DM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei2ABA_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36872
Secondary accession number(s): A4V2M9
, A4V2N0, Q9VH21, Q9VH22
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 11, 2019
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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