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UniProtKB - P36871 (PGM1_HUMAN)
Protein
Phosphoglucomutase-1
Gene
PGM1
Organism
Homo sapiens (Human)
Status
Functioni
This enzyme participates in both the breakdown and synthesis of glucose.
2 PublicationsCatalytic activityi
- EC:5.4.2.22 Publications
Cofactori
Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication
Activity regulationi
Glucose-1,6-bisphosphate enhances phosphorylation of the active site Ser-117, and thereby increases enzyme activity.1 Publication
Kineticsi
- KM=80 µM for alpha-D-glucose 1-phosphate1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 23 | Alpha-D-glucose 1,6-bisphosphateBy similarity | 1 | |
Active sitei | 117 | Phosphoserine intermediate1 Publication | 1 | |
Metal bindingi | 117 | Magnesium; via phosphate groupe1 Publication | 1 | |
Binding sitei | 117 | Alpha-D-glucose 1,6-bisphosphateBy similarity | 1 | |
Metal bindingi | 288 | MagnesiumCombined sources1 Publication | 1 | |
Metal bindingi | 290 | MagnesiumCombined sources1 Publication | 1 | |
Metal bindingi | 292 | MagnesiumCombined sources1 Publication | 1 | |
Binding sitei | 292 | Alpha-D-glucose 1,6-bisphosphateBy similarity | 1 | |
Binding sitei | 293 | Alpha-D-glucose 1,6-bisphosphateBy similarity | 1 | |
Binding sitei | 357 | Alpha-D-glucose 1,6-bisphosphateBy similarity | 1 | |
Binding sitei | 376 | Alpha-D-glucose 1,6-bisphosphateBy similarity | 1 | |
Binding sitei | 378 | Alpha-D-glucose 1,6-bisphosphateBy similarity | 1 | |
Binding sitei | 389 | Alpha-D-glucose 1,6-bisphosphateBy similarity | 1 |
GO - Molecular functioni
- magnesium ion binding Source: UniProtKB
- phosphoglucomutase activity Source: UniProtKB
GO - Biological processi
- carbohydrate metabolic process Source: GO_Central
- gluconeogenesis Source: UniProtKB
- glucose metabolic process Source: UniProtKB
- glycolytic process Source: UniProtKB
Keywordsi
Molecular function | Isomerase |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 5.4.2.2, 2681 |
PathwayCommonsi | P36871 |
Reactomei | R-HSA-3322077, Glycogen synthesis R-HSA-5609974, Defective PGM1 causes PGM1-CDG (CDG1t) R-HSA-6798695, Neutrophil degranulation |
SABIO-RKi | P36871 |
SignaLinki | P36871 |
SIGNORi | P36871 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoglucomutase-1 (EC:5.4.2.22 Publications)Short name: PGM 1 Alternative name(s): Glucose phosphomutase 1 |
Gene namesi | Name:PGM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8905, PGM1 |
MIMi | 171900, gene |
neXtProti | NX_P36871 |
VEuPathDBi | HostDB:ENSG00000079739 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- ficolin-1-rich granule lumen Source: Reactome
- tertiary granule lumen Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Congenital disorder of glycosylation 1T (CDG1T)6 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071635 | 19 | T → A in CDG1T; reduces strongly phosphoglucomutase activity. 2 PublicationsCorresponds to variant dbSNP:rs1320810473Ensembl. | 1 | |
Natural variantiVAR_071636 | 38 | N → Y in CDG1T; reduces strongly solubility; increases aggregation. 2 PublicationsCorresponds to variant dbSNP:rs587777402EnsemblClinVar. | 1 | |
Natural variantiVAR_071637 | 41 | Q → R in CDG1T; reduces solubility; increases aggregation. 2 PublicationsCorresponds to variant dbSNP:rs1300651770EnsemblClinVar. | 1 | |
Natural variantiVAR_071638 | 62 | D → H in CDG1T; reduces solubility; reduces strongly phosphoglucomutase activity. 2 PublicationsCorresponds to variant dbSNP:rs587777403EnsemblClinVar. | 1 | |
Natural variantiVAR_062280 | 115 | T → A in CDG1T; reduces mildly phosphoglucomutase activity. 3 PublicationsCorresponds to variant dbSNP:rs121918371EnsemblClinVar. | 1 | |
Natural variantiVAR_069219 | 121 | G → R in CDG1T; there is 7% enzyme residual phosphoglucomutase activity. 3 PublicationsCorresponds to variant dbSNP:rs398122912EnsemblClinVar. | 1 | |
Natural variantiVAR_071639 | 263 | D → G in CDG1T; reduces strongly phosphoglucomutase activity. 2 PublicationsCorresponds to variant dbSNP:rs1465877146Ensembl. | 1 | |
Natural variantiVAR_071640 | 263 | D → Y in CDG1T; reduces strongly phosphoglucomutase activity. 2 PublicationsCorresponds to variant dbSNP:rs587777404EnsemblClinVar. | 1 | |
Natural variantiVAR_071641 | 291 | G → R in CDG1T; reduces strongly phosphoglucomutase activity. 3 PublicationsCorresponds to variant dbSNP:rs772768778Ensembl. | 1 | |
Natural variantiVAR_071642 | 330 | G → R in CDG1T; decreases mildly solubility. 2 PublicationsCorresponds to variant dbSNP:rs777164338Ensembl. | 1 | |
Natural variantiVAR_071643 | 377 | E → K in CDG1T; decreases strongly solubility. 2 Publications | 1 | |
Natural variantiVAR_071644 | 388 | E → K in CDG1T; decreases strongly solubility. 2 PublicationsCorresponds to variant dbSNP:rs1301021797Ensembl. | 1 | |
Natural variantiVAR_071645 | 516 | L → P in CDG1T; decreases strongly solubility. 2 PublicationsCorresponds to variant dbSNP:rs587777401EnsemblClinVar. | 1 |
Keywords - Diseasei
Congenital disorder of glycosylation, Disease variant, Glycogen storage diseaseOrganism-specific databases
DisGeNETi | 5236 |
GeneReviewsi | PGM1 |
MalaCardsi | PGM1 |
MIMi | 614921, phenotype |
OpenTargetsi | ENSG00000079739 |
Orphaneti | 319646, PGM1-CDG |
PharmGKBi | PA33242 |
Miscellaneous databases
Pharosi | P36871, Tbio |
Chemistry databases
DrugBanki | DB02835, Alpha-D-Glucose 1,6-Bisphosphate DB04397, Alpha-D-Glucose-1-Phosphate-6-Vanadate DB06773, Human calcitonin |
Genetic variation databases
BioMutai | PGM1 |
DMDMi | 585670 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000147776 | 1 – 562 | Phosphoglucomutase-1Add BLAST | 562 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
Modified residuei | 16 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 115 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 117 | PhosphoserineCombined sources1 Publication | 1 | ||
Modified residuei | 134 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 185 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 201 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 206 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 213 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 349 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 353 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 369 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 378 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 419 | N6-succinyllysineBy similarity | 1 | ||
Modified residuei | 467 | Phosphothreonine; by PAK11 Publication | 1 | ||
Modified residuei | 477 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 485 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 505 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 507 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 509 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 541 | PhosphoserineBy similarity | 1 | ||
Isoform 2 (identifier: P36871-2) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Post-translational modificationi
Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-255 CPTAC-256 CPTAC-988 |
EPDi | P36871 |
jPOSTi | P36871 |
MassIVEi | P36871 |
MaxQBi | P36871 |
PeptideAtlasi | P36871 |
PRIDEi | P36871 |
ProteomicsDBi | 4816 55222 [P36871-1] 55223 [P36871-2] |
TopDownProteomicsi | P36871-1 [P36871-1] |
2D gel databases
REPRODUCTION-2DPAGEi | P36871 |
PTM databases
GlyGeni | P36871, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P36871 |
MetOSitei | P36871 |
PhosphoSitePlusi | P36871 |
SwissPalmi | P36871 |
Expressioni
Gene expression databases
Bgeei | ENSG00000079739, Expressed in skeletal muscle tissue and 246 other tissues |
ExpressionAtlasi | P36871, baseline and differential |
Genevisiblei | P36871, HS |
Organism-specific databases
HPAi | ENSG00000079739, Group enriched (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Monomer.
Binary interactionsi
P36871
With | #Exp. | IntAct |
---|---|---|
TINF2 [Q9BSI4] | 2 | EBI-2861475,EBI-717399 |
Protein-protein interaction databases
BioGRIDi | 111256, 81 interactors |
DIPi | DIP-60903N |
IntActi | P36871, 34 interactors |
STRINGi | 9606.ENSP00000360124 |
Miscellaneous databases
RNActi | P36871, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P36871 |
SMRi | P36871 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the phosphohexose mutase family.Curated
Phylogenomic databases
eggNOGi | KOG0625, Eukaryota |
GeneTreei | ENSGT00940000155542 |
HOGENOMi | CLU_009330_0_1_1 |
InParanoidi | P36871 |
OMAi | DTRFMSE |
OrthoDBi | 446752at2759 |
PhylomeDBi | P36871 |
TreeFami | TF300350 |
Family and domain databases
DisProti | DP02748 |
InterProi | View protein in InterPro IPR005844, A-D-PHexomutase_a/b/a-I IPR016055, A-D-PHexomutase_a/b/a-I/II/III IPR005845, A-D-PHexomutase_a/b/a-II IPR005846, A-D-PHexomutase_a/b/a-III IPR036900, A-D-PHexomutase_C_sf IPR016066, A-D-PHexomutase_CS IPR005841, Alpha-D-phosphohexomutase_SF IPR045244, PGM |
PANTHERi | PTHR22573, PTHR22573, 1 hit |
Pfami | View protein in Pfam PF02878, PGM_PMM_I, 1 hit PF02879, PGM_PMM_II, 1 hit PF02880, PGM_PMM_III, 1 hit |
PRINTSi | PR00509, PGMPMM |
SUPFAMi | SSF53738, SSF53738, 3 hits SSF55957, SSF55957, 1 hit |
PROSITEi | View protein in PROSITE PS00710, PGM_PMM, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P36871-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVKIVTVKTQ AYQDQKPGTS GLRKRVKVFQ SSANYAENFI QSIISTVEPA
60 70 80 90 100
QRQEATLVVG GDGRFYMKEA IQLIARIAAA NGIGRLVIGQ NGILSTPAVS
110 120 130 140 150
CIIRKIKAIG GIILTASHNP GGPNGDFGIK FNISNGGPAP EAITDKIFQI
160 170 180 190 200
SKTIEEYAVC PDLKVDLGVL GKQQFDLENK FKPFTVEIVD SVEAYATMLR
210 220 230 240 250
SIFDFSALKE LLSGPNRLKI RIDAMHGVVG PYVKKILCEE LGAPANSAVN
260 270 280 290 300
CVPLEDFGGH HPDPNLTYAA DLVETMKSGE HDFGAAFDGD GDRNMILGKH
310 320 330 340 350
GFFVNPSDSV AVIAANIFSI PYFQQTGVRG FARSMPTSGA LDRVASATKI
360 370 380 390 400
ALYETPTGWK FFGNLMDASK LSLCGEESFG TGSDHIREKD GLWAVLAWLS
410 420 430 440 450
ILATRKQSVE DILKDHWQKY GRNFFTRYDY EEVEAEGANK MMKDLEALMF
460 470 480 490 500
DRSFVGKQFS ANDKVYTVEK ADNFEYSDPV DGSISRNQGL RLIFTDGSRI
510 520 530 540 550
VFRLSGTGSA GATIRLYIDS YEKDVAKINQ DPQVMLAPLI SIALKVSQLQ
560
ERTGRTAPTV IT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITK7 | A0A3B3ITK7_HUMAN | Phosphoglucomutase-1 | PGM1 | 584 | Annotation score: |
Sequence cautioni
The sequence AAH90856 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 134 | S → C in AAH67763 (PubMed:15489334).Curated | 1 |
Polymorphismi
Many polymorphic variants of PGM1 exist. 8 different alleles are known: PGM1*1+, PGM1*1-, PGM1*2+, PGM1*2-, PGM1*3+, PGM1*3-, PGM1*7+ and PGM1*7-. The sequence of PGM1*1+ is shown here.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071635 | 19 | T → A in CDG1T; reduces strongly phosphoglucomutase activity. 2 PublicationsCorresponds to variant dbSNP:rs1320810473Ensembl. | 1 | |
Natural variantiVAR_071636 | 38 | N → Y in CDG1T; reduces strongly solubility; increases aggregation. 2 PublicationsCorresponds to variant dbSNP:rs587777402EnsemblClinVar. | 1 | |
Natural variantiVAR_071637 | 41 | Q → R in CDG1T; reduces solubility; increases aggregation. 2 PublicationsCorresponds to variant dbSNP:rs1300651770EnsemblClinVar. | 1 | |
Natural variantiVAR_071638 | 62 | D → H in CDG1T; reduces solubility; reduces strongly phosphoglucomutase activity. 2 PublicationsCorresponds to variant dbSNP:rs587777403EnsemblClinVar. | 1 | |
Natural variantiVAR_006090 | 68 | K → M in allele PGM1*7+, allele PGM1*7-, allele PGM1*3+ and allele PGM1*3-; phosphoglucomutase activity is similar to wild-type. 2 PublicationsCorresponds to variant dbSNP:rs200390982Ensembl. | 1 | |
Natural variantiVAR_050496 | 88 | I → V. Corresponds to variant dbSNP:rs855314EnsemblClinVar. | 1 | |
Natural variantiVAR_062280 | 115 | T → A in CDG1T; reduces mildly phosphoglucomutase activity. 3 PublicationsCorresponds to variant dbSNP:rs121918371EnsemblClinVar. | 1 | |
Natural variantiVAR_069219 | 121 | G → R in CDG1T; there is 7% enzyme residual phosphoglucomutase activity. 3 PublicationsCorresponds to variant dbSNP:rs398122912EnsemblClinVar. | 1 | |
Natural variantiVAR_006091 | 221 | R → C in allele PGM1*2+, allele PGM1*2-, allele PGM1*3+ and allele PGM1*3-; phosphoglucomutase activity is similar to wild-type. 5 PublicationsCorresponds to variant dbSNP:rs1126728EnsemblClinVar. | 1 | |
Natural variantiVAR_071639 | 263 | D → G in CDG1T; reduces strongly phosphoglucomutase activity. 2 PublicationsCorresponds to variant dbSNP:rs1465877146Ensembl. | 1 | |
Natural variantiVAR_071640 | 263 | D → Y in CDG1T; reduces strongly phosphoglucomutase activity. 2 PublicationsCorresponds to variant dbSNP:rs587777404EnsemblClinVar. | 1 | |
Natural variantiVAR_071641 | 291 | G → R in CDG1T; reduces strongly phosphoglucomutase activity. 3 PublicationsCorresponds to variant dbSNP:rs772768778Ensembl. | 1 | |
Natural variantiVAR_071642 | 330 | G → R in CDG1T; decreases mildly solubility. 2 PublicationsCorresponds to variant dbSNP:rs777164338Ensembl. | 1 | |
Natural variantiVAR_071643 | 377 | E → K in CDG1T; decreases strongly solubility. 2 Publications | 1 | |
Natural variantiVAR_071644 | 388 | E → K in CDG1T; decreases strongly solubility. 2 PublicationsCorresponds to variant dbSNP:rs1301021797Ensembl. | 1 | |
Natural variantiVAR_006092 | 420 | Y → H in allele PGM1*1-, allele PGM1*2-, allele PGM1*3- and allele PGM1*7-; phosphoglucomutase activity is similar to wild-type. 6 PublicationsCorresponds to variant dbSNP:rs11208257EnsemblClinVar. | 1 | |
Natural variantiVAR_034380 | 501 | V → I. Corresponds to variant dbSNP:rs6676290EnsemblClinVar. | 1 | |
Natural variantiVAR_071645 | 516 | L → P in CDG1T; decreases strongly solubility. 2 PublicationsCorresponds to variant dbSNP:rs587777401EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045204 | 1 – 197 | Missing in isoform 3. 1 PublicationAdd BLAST | 197 | |
Alternative sequenceiVSP_004686 | 1 – 77 | MVKIV…LIARI → MSDFEEWISGTYRKMEEGPL PLLTFATAPYHDQKPGTSGL RKKTYYFEEKPCYLENFIQS IFFSIDLKDRQGSSLVVGGD GRYFNKSAIETIVQM in isoform 2. CuratedAdd BLAST | 77 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83088 mRNA Translation: AAA60080.1 BT006961 mRNA Translation: AAP35607.1 AK298505 mRNA Translation: BAG60712.1 AK312254 mRNA Translation: BAG35186.1 AL109925 Genomic DNA No translation available. BC001756 mRNA Translation: AAH01756.3 BC019920 mRNA Translation: AAH19920.1 BC067763 mRNA Translation: AAH67763.2 BC090856 mRNA Translation: AAH90856.1 Different initiation. S67989 Genomic DNA Translation: AAB29177.2 S67998 Genomic DNA Translation: AAB29178.1 |
CCDSi | CCDS53323.1 [P36871-2] CCDS53324.1 [P36871-3] CCDS625.1 [P36871-1] |
PIRi | A41801 S39397 |
RefSeqi | NP_001166289.1, NM_001172818.1 [P36871-2] NP_001166290.1, NM_001172819.1 [P36871-3] NP_002624.2, NM_002633.2 [P36871-1] |
Genome annotation databases
Ensembli | ENST00000371083.4; ENSP00000360124.4; ENSG00000079739.17 [P36871-2] ENST00000371084.8; ENSP00000360125.3; ENSG00000079739.17 ENST00000540265.5; ENSP00000443449.1; ENSG00000079739.17 [P36871-3] |
GeneIDi | 5236 |
KEGGi | hsa:5236 |
MANE-Selecti | ENST00000371084.8; ENSP00000360125.3; NM_002633.3; NP_002624.2 |
UCSCi | uc001dbh.5, human [P36871-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83088 mRNA Translation: AAA60080.1 BT006961 mRNA Translation: AAP35607.1 AK298505 mRNA Translation: BAG60712.1 AK312254 mRNA Translation: BAG35186.1 AL109925 Genomic DNA No translation available. BC001756 mRNA Translation: AAH01756.3 BC019920 mRNA Translation: AAH19920.1 BC067763 mRNA Translation: AAH67763.2 BC090856 mRNA Translation: AAH90856.1 Different initiation. S67989 Genomic DNA Translation: AAB29177.2 S67998 Genomic DNA Translation: AAB29178.1 |
CCDSi | CCDS53323.1 [P36871-2] CCDS53324.1 [P36871-3] CCDS625.1 [P36871-1] |
PIRi | A41801 S39397 |
RefSeqi | NP_001166289.1, NM_001172818.1 [P36871-2] NP_001166290.1, NM_001172819.1 [P36871-3] NP_002624.2, NM_002633.2 [P36871-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5EPC | X-ray | 1.85 | A/B | 1-562 | [»] | |
5F9C | X-ray | 2.50 | A/B | 1-562 | [»] | |
5HSH | X-ray | 2.65 | A/B | 1-562 | [»] | |
5JN5 | X-ray | 1.75 | A/B | 1-562 | [»] | |
5TR2 | X-ray | 2.50 | A/B | 1-562 | [»] | |
5VBI | X-ray | 1.75 | A/B | 1-562 | [»] | |
5VEC | X-ray | 2.20 | A/B | 1-562 | [»] | |
5VG7 | X-ray | 1.95 | A/B | 1-562 | [»] | |
5VIN | X-ray | 2.60 | A/B | 1-562 | [»] | |
6SNO | X-ray | 2.70 | A | 2-562 | [»] | |
6SNP | X-ray | 2.75 | A | 2-562 | [»] | |
6SNQ | X-ray | 2.70 | A | 2-562 | [»] | |
6UIQ | X-ray | 2.30 | A/B | 1-562 | [»] | |
6UO6 | X-ray | 2.15 | A/B | 1-562 | [»] | |
AlphaFoldDBi | P36871 | |||||
SMRi | P36871 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111256, 81 interactors |
DIPi | DIP-60903N |
IntActi | P36871, 34 interactors |
STRINGi | 9606.ENSP00000360124 |
Chemistry databases
DrugBanki | DB02835, Alpha-D-Glucose 1,6-Bisphosphate DB04397, Alpha-D-Glucose-1-Phosphate-6-Vanadate DB06773, Human calcitonin |
PTM databases
GlyGeni | P36871, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P36871 |
MetOSitei | P36871 |
PhosphoSitePlusi | P36871 |
SwissPalmi | P36871 |
Genetic variation databases
BioMutai | PGM1 |
DMDMi | 585670 |
2D gel databases
REPRODUCTION-2DPAGEi | P36871 |
Proteomic databases
CPTACi | CPTAC-255 CPTAC-256 CPTAC-988 |
EPDi | P36871 |
jPOSTi | P36871 |
MassIVEi | P36871 |
MaxQBi | P36871 |
PeptideAtlasi | P36871 |
PRIDEi | P36871 |
ProteomicsDBi | 4816 55222 [P36871-1] 55223 [P36871-2] |
TopDownProteomicsi | P36871-1 [P36871-1] |
Protocols and materials databases
Antibodypediai | 3314, 241 antibodies from 26 providers |
DNASUi | 5236 |
Genome annotation databases
Ensembli | ENST00000371083.4; ENSP00000360124.4; ENSG00000079739.17 [P36871-2] ENST00000371084.8; ENSP00000360125.3; ENSG00000079739.17 ENST00000540265.5; ENSP00000443449.1; ENSG00000079739.17 [P36871-3] |
GeneIDi | 5236 |
KEGGi | hsa:5236 |
MANE-Selecti | ENST00000371084.8; ENSP00000360125.3; NM_002633.3; NP_002624.2 |
UCSCi | uc001dbh.5, human [P36871-1] |
Organism-specific databases
CTDi | 5236 |
DisGeNETi | 5236 |
GeneCardsi | PGM1 |
GeneReviewsi | PGM1 |
HGNCi | HGNC:8905, PGM1 |
HPAi | ENSG00000079739, Group enriched (skeletal muscle, tongue) |
MalaCardsi | PGM1 |
MIMi | 171900, gene 614921, phenotype |
neXtProti | NX_P36871 |
OpenTargetsi | ENSG00000079739 |
Orphaneti | 319646, PGM1-CDG |
PharmGKBi | PA33242 |
VEuPathDBi | HostDB:ENSG00000079739 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0625, Eukaryota |
GeneTreei | ENSGT00940000155542 |
HOGENOMi | CLU_009330_0_1_1 |
InParanoidi | P36871 |
OMAi | DTRFMSE |
OrthoDBi | 446752at2759 |
PhylomeDBi | P36871 |
TreeFami | TF300350 |
Enzyme and pathway databases
BRENDAi | 5.4.2.2, 2681 |
PathwayCommonsi | P36871 |
Reactomei | R-HSA-3322077, Glycogen synthesis R-HSA-5609974, Defective PGM1 causes PGM1-CDG (CDG1t) R-HSA-6798695, Neutrophil degranulation |
SABIO-RKi | P36871 |
SignaLinki | P36871 |
SIGNORi | P36871 |
Miscellaneous databases
BioGRID-ORCSi | 5236, 13 hits in 1073 CRISPR screens |
ChiTaRSi | PGM1, human |
GeneWikii | PGM1 |
GenomeRNAii | 5236 |
Pharosi | P36871, Tbio |
PROi | PR:P36871 |
RNActi | P36871, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000079739, Expressed in skeletal muscle tissue and 246 other tissues |
ExpressionAtlasi | P36871, baseline and differential |
Genevisiblei | P36871, HS |
Family and domain databases
DisProti | DP02748 |
InterProi | View protein in InterPro IPR005844, A-D-PHexomutase_a/b/a-I IPR016055, A-D-PHexomutase_a/b/a-I/II/III IPR005845, A-D-PHexomutase_a/b/a-II IPR005846, A-D-PHexomutase_a/b/a-III IPR036900, A-D-PHexomutase_C_sf IPR016066, A-D-PHexomutase_CS IPR005841, Alpha-D-phosphohexomutase_SF IPR045244, PGM |
PANTHERi | PTHR22573, PTHR22573, 1 hit |
Pfami | View protein in Pfam PF02878, PGM_PMM_I, 1 hit PF02879, PGM_PMM_II, 1 hit PF02880, PGM_PMM_III, 1 hit |
PRINTSi | PR00509, PGMPMM |
SUPFAMi | SSF53738, SSF53738, 3 hits SSF55957, SSF55957, 1 hit |
PROSITEi | View protein in PROSITE PS00710, PGM_PMM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGM1_HUMAN | |
Accessioni | P36871Primary (citable) accession number: P36871 Secondary accession number(s): B2R5N9 Q9NTY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 213 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families