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Protein

Dipeptide and tripeptide permease B

Gene

dtpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.1 Publication

Miscellaneous

Although DtpB appears to represent a system of lower affinity, there is an obvious redundancy in substrate specificity as compared with DtpA.

Enzyme regulationi

Inhibited by CCCP but unaffected by sodium depletion.1 Publication

GO - Molecular functioni

  • antibiotic transmembrane transporter activity Source: EcoCyc
  • dipeptide transmembrane transporter activity Source: EcoCyc
  • peptide:proton symporter activity Source: EcoCyc
  • proton transmembrane transporter activity Source: EcoCyc
  • tripeptide transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • antibiotic transport Source: EcoCyc
  • dipeptide transmembrane transport Source: EcoCyc
  • protein transport Source: UniProtKB-KW
  • proton transmembrane transport Source: EcoCyc
  • tripeptide transmembrane transport Source: EcoCyc

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YHIP-MONOMER
MetaCyc:YHIP-MONOMER

Protein family/group databases

TCDBi2.A.17.1.3 the proton-dependent oligopeptide transporter (pot/ptr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide and tripeptide permease B
Gene namesi
Name:dtpB
Synonyms:yhiP
Ordered Locus Names:b3496, JW3463
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12232 dtpB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 52PeriplasmicSequence analysis4
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 82CytoplasmicSequence analysis9
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 106PeriplasmicSequence analysis3
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 146CytoplasmicSequence analysisAdd BLAST19
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 172PeriplasmicSequence analysis5
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 210CytoplasmicSequence analysisAdd BLAST17
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 233PeriplasmicSequence analysis2
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 267CytoplasmicSequence analysisAdd BLAST13
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 311PeriplasmicSequence analysisAdd BLAST23
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 350CytoplasmicSequence analysisAdd BLAST18
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 380PeriplasmicSequence analysis9
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 411CytoplasmicSequence analysis10
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 456PeriplasmicSequence analysisAdd BLAST24
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 489CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643291 – 489Dipeptide and tripeptide permease BAdd BLAST489

Proteomic databases

PaxDbiP36837
PRIDEiP36837

Interactioni

Protein-protein interaction databases

BioGridi4261541, 185 interactors
DIPiDIP-12369N
IntActiP36837, 1 interactor
STRINGi316385.ECDH10B_3672

Structurei

3D structure databases

ProteinModelPortaliP36837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DUX Bacteria
COG3104 LUCA
HOGENOMiHOG000243449
InParanoidiP36837
KOiK03305
OMAiQQPKPFF
PhylomeDBiP36837

Family and domain databases

CDDicd06174 MFS, 1 hit
HAMAPiMF_01879 PTR2_DtpB_subfam, 1 hit
InterProiView protein in InterPro
IPR023778 AA/pep_transptr_DtpB
IPR005279 Dipep/tripep_permease
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PTHR11654:SF102 PTHR11654:SF102, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00924 yjdL_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P36837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTTPMGML QQPRPFFMIF FVELWERFGY YGVQGVLAVF FVKQLGFSQE
60 70 80 90 100
QAFVTFGAFA ALVYGLISIG GYVGDHLLGT KRTIVLGALV LAIGYFMTGM
110 120 130 140 150
SLLKPDLIFI ALGTIAVGNG LFKANPASLL SKCYPPKDPR LDGAFTLFYM
160 170 180 190 200
SINIGSLIAL SLAPVIADRF GYSVTYNLCG AGLIIALLVY IACRGMVKDI
210 220 230 240 250
GSEPDFRPMS FSKLLYVLLG SVVMIFVCAW LMHNVEVANL VLIVLSIVVT
260 270 280 290 300
IIFFRQAFKL DKTGRNKMFV AFVLMLEAVV FYILYAQMPT SLNFFAINNV
310 320 330 340 350
HHEILGFSIN PVSFQALNPF WVVLASPILA GIYTHLGNKG KDLSMPMKFT
360 370 380 390 400
LGMFMCSLGF LTAAAAGMWF ADAQGLTSPW FIVLVYLFQS LGELFISALG
410 420 430 440 450
LAMIAALVPQ HLMGFILGMW FLTQAAAFLL GGYVATFTAV PDNITDPLET
460 470 480
LPVYTNVFGK IGLVTLGVAV VMLLMVPWLK RMIATPESH
Length:489
Mass (Da):53,575
Last modified:November 1, 1997 - v2
Checksum:i80AB5CE4E3880448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18472.1
U00096 Genomic DNA Translation: AAC76521.1
AP009048 Genomic DNA Translation: BAE77798.1
PIRiC65147
RefSeqiNP_417953.1, NC_000913.3
WP_001098652.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76521; AAC76521; b3496
BAE77798; BAE77798; BAE77798
GeneIDi948006
KEGGiecj:JW3463
eco:b3496
PATRICifig|511145.12.peg.3598

Similar proteinsi

Entry informationi

Entry nameiDTPB_ECOLI
AccessioniPrimary (citable) accession number: P36837
Secondary accession number(s): P76706, Q2M7F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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