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Protein

Protein E6

Gene

E6

Organism
Human papillomavirus type 15
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri27 – 64UniRule annotationAdd BLAST38
Zinc fingeri101 – 137UniRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Modulation of host cell apoptosis by virus, Transcription, Transcription regulation, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E6UniRule annotation
Gene namesi
Name:E6UniRule annotation
OrganismiHuman papillomavirus type 15
Taxonomic identifieri10606 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeFirstpapillomavirinaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008232 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001333351 – 141Protein E6Add BLAST141

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host BAK1.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP36804
SMRiP36804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E6 protein family.UniRule annotationCurated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri27 – 64UniRule annotationAdd BLAST38
Zinc fingeri101 – 137UniRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG0900011D

Family and domain databases

Gene3Di3.30.240.40, 2 hits
HAMAPiMF_04006 HPV_E6, 1 hit
InterProiView protein in InterPro
IPR001334 E6
IPR038575 E6_sf
PfamiView protein in Pfam
PF00518 E6, 1 hit
SUPFAMiSSF161229 SSF161229, 2 hits

Sequencei

Sequence statusi: Complete.

P36804-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRPKPFSVQ QLADTLCIPL VDILLPCRFC QRFLTYIELV SLNRKGLQLI
60 70 80 90 100
WTEEDFVFAC CSSCAFATAQ FEFSNFYEQS VCSWEIEIVE QKPVGDIIIR
110 120 130 140
CKFCLKKLDL IEKLDICYKE EQFHKVRRNW KGLCRHCRAI E
Length:141
Mass (Da):16,684
Last modified:June 1, 1994 - v1
Checksum:iC31B4F33CBF6ED86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74468 Genomic DNA Translation: CAA52506.1
PIRiS36473

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74468 Genomic DNA Translation: CAA52506.1
PIRiS36473

3D structure databases

ProteinModelPortaliP36804
SMRiP36804
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900011D

Family and domain databases

Gene3Di3.30.240.40, 2 hits
HAMAPiMF_04006 HPV_E6, 1 hit
InterProiView protein in InterPro
IPR001334 E6
IPR038575 E6_sf
PfamiView protein in Pfam
PF00518 E6, 1 hit
SUPFAMiSSF161229 SSF161229, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiVE6_HPV15
AccessioniPrimary (citable) accession number: P36804
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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