UniProtKB - P36783 (VE2_HPV14)
Regulatory protein E2
E2
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-binding transcription factor activity Source: UniProtKB-UniRule
- nucleotide binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- regulation of DNA replication Source: UniProtKB-UniRule
- transcription, DNA-templated Source: UniProtKB-UniRule
- viral DNA genome replication Source: UniProtKB-UniRule
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | DNA replication, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Regulatory protein E2UniRule annotation |
Gene namesi | Name:E2UniRule annotation |
Organismi | Human papillomavirus type 14 |
Taxonomic identifieri | 10605 [NCBI] |
Taxonomic lineagei | Viruses › Monodnaviria › Shotokuvirae › Cossaviricota › Papovaviricetes › Zurhausenvirales › Papillomaviridae › Firstpapillomavirinae › Betapapillomavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host nucleus UniRule annotation
GO - Cellular componenti
- host cell nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000133193 | 1 – 483 | Regulatory protein E2Add BLAST | 483 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | P36783 |
Interactioni
Subunit structurei
Binds DNA as homodimer.
Interacts with protein E1; this interaction greatly increases E1 DNA-binding activity.
Interacts with protein L1; this interaction enhances E2-dependent replication and transcription activation.
Interacts with protein L2; this interaction inhibits E2 transcriptional activity but not DNA replication function E2.
Interacts with protein E7; this interaction inhibits E7 oncogenic activity.
Interacts with host TAF1; this interaction modulates E2-dependent transcriptional regulation.
Interacts with host BRD4; this interaction mediates E2 transcriptional activation function. Additionally, the interaction with host BRD4 on mitotic chromosomes mediates tethering of the viral genome.
Interacts with host TOPBP1; this interaction is required for optimal viral DNA replication.
UniRule annotationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 201 | Transactivation domainUniRule annotationAdd BLAST | 201 | |
Regioni | 399 – 483 | DNA-binding domainUniRule annotationAdd BLAST | 85 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 1.10.287.30, 1 hit 2.170.200.10, 1 hit 3.30.70.330, 1 hit |
HAMAPi | MF_04001, PPV_E2, 1 hit |
InterProi | View protein in InterPro IPR035975, E2/EBNA1_C_sf IPR012677, Nucleotide-bd_a/b_plait_sf IPR000427, Papillomavirus_E2_C IPR001866, Papillomavirus_E2_N IPR033668, Reg_prot_E2 IPR036050, Regulatory_protein_E2_N IPR042503, Regulatory_protein_E2_N_1 IPR042504, Regulatory_protein_E2_N_2 |
Pfami | View protein in Pfam PF00511, PPV_E2_C, 1 hit PF00508, PPV_E2_N, 1 hit |
SUPFAMi | SSF51332, SSF51332, 1 hit SSF54957, SSF54957, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MENLSDRFNA LQDQLMNIYE TAANTLESQI EHWQTLRKEA VLLYFARQNG
60 70 80 90 100
VTRLGYQVVP TLAISEAKAK QAIGMVLQLQ SLQKSQFGSE PWSLVDTSGE
110 120 130 140 150
TFRSAPENHF KKGPVSVEVI YDNDKDNANA YTMWKHIYYQ DDDEQWHKSA
160 170 180 190 200
SGVNHTGIYY MQGTFRNYYV LFADDATRYS KTGHWEVKVN KETVFTPVTS
210 220 230 240 250
STPPESPGGQ ADSNTSSKTP TTATDSTSRL SPADSRKQSQ QANTKGRRYG
260 270 280 290 300
RRPSSRTRRT TETRQRRRSR SKSRSRSRSR SRLRSRSRSQ SSERRSRYRS
310 320 330 340 350
RSRSRQKEVS RITTTTRGRG RGSSSTSSKR SQRARGRGRG GSRGRRSSST
360 370 380 390 400
SPTSSKRSRR ESESSRQRGI SPSDVGKSLQ SVSSRNTGRL GRLLDEALDP
410 420 430 440 450
PVILVRGDPN TLRCFRNRAK QKFTGLYRAF STAWSWVAGD GTERLGRSRM
460 470 480
LISFFSFNQR RDFDQTVKYP KGVDRSFGSF DSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74467 Genomic DNA Translation: CAA52503.1 |
PIRi | S36470 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74467 Genomic DNA Translation: CAA52503.1 |
PIRi | S36470 |
3D structure databases
SMRi | P36783 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P36783 |
Family and domain databases
Gene3Di | 1.10.287.30, 1 hit 2.170.200.10, 1 hit 3.30.70.330, 1 hit |
HAMAPi | MF_04001, PPV_E2, 1 hit |
InterProi | View protein in InterPro IPR035975, E2/EBNA1_C_sf IPR012677, Nucleotide-bd_a/b_plait_sf IPR000427, Papillomavirus_E2_C IPR001866, Papillomavirus_E2_N IPR033668, Reg_prot_E2 IPR036050, Regulatory_protein_E2_N IPR042503, Regulatory_protein_E2_N_1 IPR042504, Regulatory_protein_E2_N_2 |
Pfami | View protein in Pfam PF00511, PPV_E2_C, 1 hit PF00508, PPV_E2_N, 1 hit |
SUPFAMi | SSF51332, SSF51332, 1 hit SSF54957, SSF54957, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VE2_HPV14 | |
Accessioni | P36783Primary (citable) accession number: P36783 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families