UniProtKB - P36771 (LRHA_ECOLI)
Protein
Probable HTH-type transcriptional regulator LrhA
Gene
lrhA
Organism
Escherichia coli (strain K12)
Status
Functioni
Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 28 – 47 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- bacterial-type cis-regulatory region sequence-specific DNA binding Source: EcoCyc
- DNA-binding transcription factor activity Source: GO_Central
- sequence-specific DNA binding Source: EcoliWiki
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: EcoCyc
- positive regulation of transcription, DNA-templated Source: EcoCyc
- regulation of transcription, DNA-templated Source: GO_Central
- transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12123-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable HTH-type transcriptional regulator LrhA |
Gene namesi | Name:lrhA Synonyms:genR Ordered Locus Names:b2289, JW2284 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105663 | 1 – 312 | Probable HTH-type transcriptional regulator LrhAAdd BLAST | 312 |
Proteomic databases
jPOSTi | P36771 |
PaxDbi | P36771 |
PRIDEi | P36771 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262973, 16 interactors 851110, 1 interactor |
IntActi | P36771, 1 interactor |
STRINGi | 511145.b2289 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 68 | HTH lysR-typePROSITE-ProRule annotationAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the LysR transcriptional regulatory family.Curated
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_1_3_6 |
InParanoidi | P36771 |
PhylomeDBi | P36771 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
PRINTSi | PR00039, HTHLYSR |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
i Sequence
Sequence statusi: Complete.
P36771-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISANRPIIN LDLDLLRTFV AVADLNTFAA AAAAVCRTQS AVSQQMQRLE
60 70 80 90 100
QLVGKELFAR HGRNKLLTEH GIQLLGYARK ILRFNDEACS SLMFSNLQGV
110 120 130 140 150
LTIGASDESA DTILPFLLNR VSSVYPKLAL DVRVKRNAYM AEMLESQEVD
160 170 180 190 200
LMVTTHRPSA FKALNLRTSP THWYCAAEYI LQKGEPIPLV LLDDPSPFRD
210 220 230 240 250
MVLATLNKAD IPWRLAYVAS TLPAVRAAVK AGLGVTARPV EMMSPDLRVL
260 270 280 290 300
SGVDGLPPLP DTEYLLCYDP SSNNELAQVI YQAMESYHNP WQYSPMSAPE
310
GDDSLLIERD IE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 291 – 312 | WQYSP…ERDIE → CNTAQCLLRKGMIH in CAA52637 (PubMed:7565112).CuratedAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74546 Genomic DNA Translation: CAA52637.1 U00096 Genomic DNA Translation: AAC75349.1 AP009048 Genomic DNA Translation: BAA16124.2 |
PIRi | G65000 |
RefSeqi | NP_416792.1, NC_000913.3 WP_000622280.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75349; AAC75349; b2289 BAA16124; BAA16124; BAA16124 |
GeneIDi | 946769 |
KEGGi | ecj:JW2284 eco:b2289 |
PATRICi | fig|1411691.4.peg.4446 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74546 Genomic DNA Translation: CAA52637.1 U00096 Genomic DNA Translation: AAC75349.1 AP009048 Genomic DNA Translation: BAA16124.2 |
PIRi | G65000 |
RefSeqi | NP_416792.1, NC_000913.3 WP_000622280.1, NZ_LN832404.1 |
3D structure databases
SMRi | P36771 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262973, 16 interactors 851110, 1 interactor |
IntActi | P36771, 1 interactor |
STRINGi | 511145.b2289 |
Proteomic databases
jPOSTi | P36771 |
PaxDbi | P36771 |
PRIDEi | P36771 |
Genome annotation databases
EnsemblBacteriai | AAC75349; AAC75349; b2289 BAA16124; BAA16124; BAA16124 |
GeneIDi | 946769 |
KEGGi | ecj:JW2284 eco:b2289 |
PATRICi | fig|1411691.4.peg.4446 |
Organism-specific databases
EchoBASEi | EB2044 |
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_1_3_6 |
InParanoidi | P36771 |
PhylomeDBi | P36771 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12123-MONOMER |
Miscellaneous databases
PHI-basei | PHI:7647 |
PROi | PR:P36771 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
PRINTSi | PR00039, HTHLYSR |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRHA_ECOLI | |
Accessioni | P36771Primary (citable) accession number: P36771 Secondary accession number(s): P76490, P76934 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | November 1, 1997 | |
Last modified: | October 7, 2020 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families