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Protein

Curved DNA-binding protein

Gene

cbpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM.

Miscellaneous

It binds to curved DNA in a sequence-nonspecific fashion.

GO - Molecular functioni

  • bent DNA binding Source: EcoliWiki
  • unfolded protein binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionChaperone, DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12193-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Curved DNA-binding protein
Gene namesi
Name:cbpA
Ordered Locus Names:b1000, JW0985
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12193 cbpA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001699881 – 306Curved DNA-binding proteinAdd BLAST306

Proteomic databases

PaxDbiP36659
PRIDEiP36659

Expressioni

Inductioni

In late stationary phase, by phosphate-starvation conditions.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
dnaKP0A6Y85EBI-546131,EBI-542092

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4261259, 672 interactors
851888, 1 interactor
DIPiDIP-9249N
IntActiP36659, 50 interactors
STRINGi316385.ECDH10B_1072

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 10Combined sources5
Helixi18 – 32Combined sources15
Turni34 – 36Combined sources3
Beta strandi39 – 41Combined sources3
Helixi42 – 56Combined sources15
Helixi59 – 70Combined sources12

3D structure databases

ProteinModelPortaliP36659
SMRiP36659
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36659

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 69JAdd BLAST65

Phylogenomic databases

eggNOGiENOG4105DVC Bacteria
COG2214 LUCA
HOGENOMiHOG000226716
InParanoidiP36659
KOiK05516
OMAiKEGMMDH
PhylomeDBiP36659

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
HAMAPiMF_01154 CbpA, 1 hit
InterProiView protein in InterPro
IPR023859 DNA-bd_curved-DNA
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P36659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKDYYAIM GVKPTDDLKT IKTAYRRLAR KYHPDVSKEP DAEARFKEVA
60 70 80 90 100
EAWEVLSDEQ RRAEYDQMWQ HRNDPQFNRQ FHHGDGQSFN AEDFDDIFSS
110 120 130 140 150
IFGQHARQSR QRPATRGHDI EIEVAVFLEE TLTEHKRTIS YNLPVYNAFG
160 170 180 190 200
MIEQEIPKTL NVKIPAGVGN GQRIRLKGQG TPGENGGPNG DLWLVIHIAP
210 220 230 240 250
HPLFDIVGQD LEIVVPVSPW EAALGAKVTV PTLKESILLT IPPGSQAGQR
260 270 280 290 300
LRVKGKGLVS KKQTGDLYAV LKIVMPPKPD ENTAALWQQL ADAQSSFDPR

KDWGKA
Length:306
Mass (Da):34,455
Last modified:November 1, 1997 - v2
Checksum:iA3893D2BFDE75803
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti294 – 306QSSFD…DWGKA → PVVF in BAA03950 (PubMed:8302830).CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16500 Genomic DNA Translation: BAA03950.1
U00096 Genomic DNA Translation: AAC74085.1
AP009048 Genomic DNA Translation: BAA36142.1
PIRiF64841
RefSeqiNP_415520.1, NC_000913.3
WP_000420621.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74085; AAC74085; b1000
BAA36142; BAA36142; BAA36142
GeneIDi947572
KEGGiecj:JW0985
eco:b1000
PATRICifig|1411691.4.peg.1271

Similar proteinsi

Entry informationi

Entry nameiCBPA_ECOLI
AccessioniPrimary (citable) accession number: P36659
Secondary accession number(s): P77250
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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