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UniProtKB - P36619 (PMD1_SCHPO)
Protein
Leptomycin B resistance protein pmd1
Gene
pmd1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
May be a transmembrane transporter of the mating factor, namely P-factor or M-factor. Confers resistance to leptomycin B and to several other antifungal drugs.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 455 – 462 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1154 – 1161 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type xenobiotic transporter activity Source: PomBase
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
- transmembrane transport Source: GO_Central
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: PomBase
Keywordsi
Biological process | Antibiotic resistance |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-1369007, Mitochondrial ABC transporters R-SPO-159418, Recycling of bile acids and salts R-SPO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-SPO-382556, ABC-family proteins mediated transport |
Protein family/group databases
TCDBi | 3.A.1.201.18, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Leptomycin B resistance protein pmd1 |
Gene namesi | Name:pmd1 ORF Names:SPCC663.03 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC663.03, pmd1 |
VEuPathDBi | FungiDB:SPCC663.03 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: PomBase
Vacuole
- fungal-type vacuole Source: PomBase
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 91 | CytoplasmicSequence analysisAdd BLAST | 91 | |
Transmembranei | 92 – 115 | HelicalPROSITE-ProRule annotationAdd BLAST | 24 | |
Transmembranei | 138 – 162 | HelicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Transmembranei | 220 – 237 | HelicalPROSITE-ProRule annotationAdd BLAST | 18 | |
Transmembranei | 244 – 264 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 320 – 346 | HelicalPROSITE-ProRule annotationAdd BLAST | 27 | |
Transmembranei | 354 – 374 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 375 – 788 | CytoplasmicSequence analysisAdd BLAST | 414 | |
Transmembranei | 789 – 809 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 835 – 859 | HelicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Transmembranei | 916 – 935 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Transmembranei | 940 – 957 | HelicalPROSITE-ProRule annotationAdd BLAST | 18 | |
Transmembranei | 1022 – 1040 | HelicalPROSITE-ProRule annotationAdd BLAST | 19 | |
Transmembranei | 1054 – 1072 | HelicalPROSITE-ProRule annotationAdd BLAST | 19 | |
Topological domaini | 1073 – 1362 | CytoplasmicSequence analysisAdd BLAST | 290 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093452 | 1 – 1362 | Leptomycin B resistance protein pmd1Add BLAST | 1362 |
Proteomic databases
MaxQBi | P36619 |
PaxDbi | P36619 |
PRIDEi | P36619 |
PTM databases
iPTMneti | P36619 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 275293, 8 interactors |
STRINGi | 4896.SPCC663.03.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 385 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 291 | |
Domaini | 420 – 665 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 246 | |
Domaini | 795 – 1083 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 289 | |
Domaini | 1119 – 1356 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 238 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 748 – 768 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0055, Eukaryota |
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | P36619 |
OMAi | LFMLPMT |
PhylomeDBi | P36619 |
Family and domain databases
Gene3Di | 1.20.1560.10, 3 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 2 hits |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P36619-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLHSKKSTS TVKDNEHSLD LSIKSIPSNE KNFSTEKSEN EASESHVVDV
60 70 80 90 100
VKDPFEQYTP EEQEILYKQI NDTPAKLSGY PRILSYADKW DIMLQLAGTI
110 120 130 140 150
TGIGAGLGMP LMSLVSGQLA QAFTDLASGK GASSFQHTVD HFCLYFIYIA
160 170 180 190 200
IGVFGCSYIY TVTFIIAGER IARRIRQDYL HAILSQNIGY FDRLGAGEIT
210 220 230 240 250
TRITTDTNFI QDGLGEKVGL VFFAIATFVS GFVIAFIRHW KFTLILSSMF
260 270 280 290 300
PAICGGIGLG VPFITKNTKG QIAVVAESST FVEEVFSNIR NAFAFGTQDI
310 320 330 340 350
LAKLYNKYLI TAQRFGINKA IAMGLMVGWM FFVAYGVYGL AFWEGGRLLH
360 370 380 390 400
AGDLDVSKLI GCFFAVLIAS YSLANISPKM QSFVSCASAA KKIFDTIDRV
410 420 430 440 450
SPINAFTPTG DVVKDIKGEI ELKNIRFVYP TRPEVLVLDN FSLVCPSGKI
460 470 480 490 500
TALVGASGSG KSTIIGLVER FYDPIGGQVF LDGKDLRTLN VASLRNQISL
510 520 530 540 550
VQQEPVLFAT TVFENITYGL PDTIKGTLSK EELERRVYDA AKLANAYDFI
560 570 580 590 600
MTLPEQFSTN VGQRGFLMSG GQKQRIAIAR AVISDPKILL LDEATSALDS
610 620 630 640 650
KSEVLVQKAL DNASRSRTTI VIAHRLSTIR NADNIVVVNA GKIVEQGSHN
660 670 680 690 700
ELLDLNGAYA RLVEAQKLSG GEKDQEMVEE ELEDAPREIP ITSFGDDDED
710 720 730 740 750
NDMASLEAPM MSHNTDTDTL NNKLNEKDNV VFEDKTLQHV ASEIVPNLPP
760 770 780 790 800
ADVGELNEEP KKSKKSKKNN HEINSLTALW FIHSFVRTMI EIICLLIGIL
810 820 830 840 850
ASMICGAAYP VQAAVFARFL NIFTDLSSTD FLHKVNVFAV YWLILAIVQF
860 870 880 890 900
FAYAISNFAM TYAMEAVLQR IRYHLFRTLL RQDVEFFDRS ENTVGAITTS
910 920 930 940 950
LSTKIQSLEG LSGPTLGTFF QILTNIISVT ILSLATGWKL GLVTLSTSPV
960 970 980 990 1000
IITAGYYRVR ALDQVQEKLS AAYKESAAFA CESTSAIRTV ASLNREENVF
1010 1020 1030 1040 1050
AEYCDSLIKP GRESAIASLK SGLFFSAAQG VTFLINALTF WYGSTLMRKG
1060 1070 1080 1090 1100
EYNIVQFYTC FIAIVFGIQQ AGQFFGYSAD VTKAKAAAGE IKYLSESKPK
1110 1120 1130 1140 1150
IDTWSTEGKK VESLQSAAIE FRQVEFSYPT RRHIKVLRGL NLTVKPGQFV
1160 1170 1180 1190 1200
AFVGSSGCGK STTIGLIERF YDCDNGAVLV DGVNVRDYNI NDYRKQIALV
1210 1220 1230 1240 1250
SQEPTLYQGT VRENIVLGAS KDVSEEEMIE ACKKANIHEF ILGLPNGYNT
1260 1270 1280 1290 1300
LCGQKGSSLS GGQKQRIAIA RALIRNPKIL LLDEATSALD SHSEKVVQEA
1310 1320 1330 1340 1350
LNAASQGRTT VAIAHRLSSI QDADCIFVFD GGVIAEAGTH AELVKQRGRY
1360
YELVVEQGLN KA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1334 – 1335 | IA → TC in BAA01537 (PubMed:1349418).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10695 Genomic DNA Translation: BAA01537.1 CU329672 Genomic DNA Translation: CAA20363.1 |
PIRi | T41534 |
RefSeqi | NP_588265.1, NM_001023255.2 |
Genome annotation databases
EnsemblFungii | SPCC663.03.1; SPCC663.03.1:pep; SPCC663.03 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10695 Genomic DNA Translation: BAA01537.1 CU329672 Genomic DNA Translation: CAA20363.1 |
PIRi | T41534 |
RefSeqi | NP_588265.1, NM_001023255.2 |
3D structure databases
SMRi | P36619 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 275293, 8 interactors |
STRINGi | 4896.SPCC663.03.1 |
Protein family/group databases
TCDBi | 3.A.1.201.18, the atp-binding cassette (abc) superfamily |
PTM databases
iPTMneti | P36619 |
Proteomic databases
MaxQBi | P36619 |
PaxDbi | P36619 |
PRIDEi | P36619 |
Genome annotation databases
EnsemblFungii | SPCC663.03.1; SPCC663.03.1:pep; SPCC663.03 |
Organism-specific databases
PomBasei | SPCC663.03, pmd1 |
VEuPathDBi | FungiDB:SPCC663.03 |
Phylogenomic databases
eggNOGi | KOG0055, Eukaryota |
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | P36619 |
OMAi | LFMLPMT |
PhylomeDBi | P36619 |
Enzyme and pathway databases
Reactomei | R-SPO-1369007, Mitochondrial ABC transporters R-SPO-159418, Recycling of bile acids and salts R-SPO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-SPO-382556, ABC-family proteins mediated transport |
Miscellaneous databases
PROi | PR:P36619 |
Family and domain databases
Gene3Di | 1.20.1560.10, 3 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 2 hits |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PMD1_SCHPO | |
Accessioni | P36619Primary (citable) accession number: P36619 Secondary accession number(s): O74513 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 11, 2001 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families