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Entry version 154 (02 Jun 2021)
Sequence version 2 (11 Jul 2012)
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Protein

DNA repair protein rad16

Gene

rad16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endonuclease that specifically degrades single-stranded DNA and which is involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Required for double strand break-induced interchromosomal gene conversion.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-5696395, Formation of Incision Complex in GG-NER
R-SPO-5696400, Dual Incision in GG-NER
R-SPO-6782135, Dual incision in TC-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein rad16 (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rad16
Synonyms:rad10, rad20, swi9
ORF Names:SPCC970.01
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPCC970.01, rad16

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPCC970.01

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi659E → K in swi9. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988561 – 877DNA repair protein rad16Add BLAST877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei71Phosphoserine; by CK2Sequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P36617

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36617

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of rad16 and swi10.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
275343, 32 interactors

Database of interacting proteins

More...
DIPi
DIP-61015N

Protein interaction database and analysis system

More...
IntActi
P36617, 4 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC970.01.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P36617

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini652 – 732ERCC4Add BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni440 – 490DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi440 – 457Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi475 – 489Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0442, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002265_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36617

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHKILQA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006166, ERCC4_domain
IPR011335, Restrct_endonuc-II-like
IPR010994, RuvA_2-like
IPR006167, XPF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02732, ERCC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00891, ERCC4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781, SSF47781, 1 hit
SSF52980, SSF52980, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00596, rad1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36617-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METKVHLPLA YQQQVFNELI EEDGLCVIAP GLSLLQIAAN VLSYFAVPGS
60 70 80 90 100
LLLLVGANVD DIELIQHEME SHLEKKLITV NTETMSVDKR EKSYLEGGIF
110 120 130 140 150
AITSRILVMD LLTKIIPTEK ITGIVLLHAD RVVSTGTVAF IMRLYRETNK
160 170 180 190 200
TGFIKAFSDD PEQFLMGINA LSHCLRCLFL RHVFIYPRFH VVVAESLEKS
210 220 230 240 250
PANVVELNVN LSDSQKTIQS CLLTCIESTM RELRRLNSAY LDMEDWNIES
260 270 280 290 300
ALHRSFDVIV RRQLDSVWHR VSPKTKQLVG DLSTLKFLLS ALVCYDCVSF
310 320 330 340 350
LKLLDTLVLS VNVSSYPSNA QPSPWLMLDA ANKMIRVARD RVYKESEGPN
360 370 380 390 400
MDAIPILEEQ PKWSVLQDVL NEVCHETMLA DTDAETSNNS IMIMCADERT
410 420 430 440 450
CLQLRDYLST VTYDNKDSLK NMNSKLVDYF QWREQYRKMS KSIKKPEPSK
460 470 480 490 500
EREASNTTSR KGVPPSKRRR VRGGNNATSR TTSDNTDAND SFSRDLRLEK
510 520 530 540 550
ILLSHLSKRY EPEVGNDAFE VIDDFNSIYI YSYNGERDEL VLNNLRPRYV
560 570 580 590 600
IMFDSDPNFI RRVEVYKATY PKRSLRVYFM YYGGSIEEQK YLFSVRREKD
610 620 630 640 650
SFSRLIKERS NMAIVLTADS ERFESQESKF LRNVNTRIAG GGQLSITNEK
660 670 680 690 700
PRVIVDLREF RSSLPSILHG NNFSVIPCQL LVGDYILSPK ICVERKSIRD
710 720 730 740 750
LIQSLSNGRL YSQCEAMTEY YEIPVLLIEF EQHQSFTSPP FSDLSSEIGK
760 770 780 790 800
NDVQSKLVLL TLSFPNLRIV WSSSAYVTSI IFQDLKAMEQ EPDPASAASI
810 820 830 840 850
GLEAGQDSTN TYNQAPLDLL MGLPYITMKN YRNVFYGGVK DIQEASETSE
860 870
RKWSELIGPE AGRRLYSFFR KQLKDYE
Length:877
Mass (Da):100,264
Last modified:July 11, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB08764366A445CF6
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA50599 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X71595 Genomic DNA Translation: CAA50599.1 Sequence problems.
CU329672 Genomic DNA Translation: CAA20694.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A56213

NCBI Reference Sequences

More...
RefSeqi
NP_587855.2, NM_001022848.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC970.01.1; SPCC970.01.1:pep; SPCC970.01

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2538760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC970.01

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71595 Genomic DNA Translation: CAA50599.1 Sequence problems.
CU329672 Genomic DNA Translation: CAA20694.2
PIRiA56213
RefSeqiNP_587855.2, NM_001022848.2

3D structure databases

SMRiP36617
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi275343, 32 interactors
DIPiDIP-61015N
IntActiP36617, 4 interactors
STRINGi4896.SPCC970.01.1

Proteomic databases

MaxQBiP36617
PaxDbiP36617

Genome annotation databases

EnsemblFungiiSPCC970.01.1; SPCC970.01.1:pep; SPCC970.01
GeneIDi2538760
KEGGispo:SPCC970.01

Organism-specific databases

PomBaseiSPCC970.01, rad16
VEuPathDBiFungiDB:SPCC970.01

Phylogenomic databases

eggNOGiKOG0442, Eukaryota
HOGENOMiCLU_002265_2_0_1
InParanoidiP36617
OMAiFHKILQA

Enzyme and pathway databases

ReactomeiR-SPO-5696395, Formation of Incision Complex in GG-NER
R-SPO-5696400, Dual Incision in GG-NER
R-SPO-6782135, Dual incision in TC-NER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P36617

Family and domain databases

InterProiView protein in InterPro
IPR006166, ERCC4_domain
IPR011335, Restrct_endonuc-II-like
IPR010994, RuvA_2-like
IPR006167, XPF
PfamiView protein in Pfam
PF02732, ERCC4, 1 hit
SMARTiView protein in SMART
SM00891, ERCC4, 1 hit
SUPFAMiSSF47781, SSF47781, 1 hit
SSF52980, SSF52980, 1 hit
TIGRFAMsiTIGR00596, rad1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAD16_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36617
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 11, 2012
Last modified: June 2, 2021
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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