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Protein

Serine/threonine-protein phosphatase ppe1

Gene

ppe1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Negatively regulates mis12.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Manganese 1By similarity1
Metal bindingi53Manganese 1By similarity1
Metal bindingi79Manganese 1By similarity1
Metal bindingi79Manganese 2By similarity1
Metal bindingi111Manganese 2By similarity1
Active sitei112Proton donorBy similarity1
Metal bindingi161Manganese 2By similarity1
Metal bindingi235Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: PomBase

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • negative regulation of mitotic sister chromatid segregation Source: PomBase
  • positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: PomBase
  • positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway Source: PomBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Cell shape, Mitosis
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase ppe1 (EC:3.1.3.16)
Alternative name(s):
Phosphatase esp1
Gene namesi
Name:ppe1
Synonyms:esp1, ppx1
ORF Names:SPCC1739.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1739.12
PomBaseiSPCC1739.12 ppe1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588821 – 305Serine/threonine-protein phosphatase ppe1Add BLAST305

Proteomic databases

MaxQBiP36614
PaxDbiP36614
PRIDEiP36614

PTM databases

iPTMnetiP36614

Interactioni

Subunit structurei

Interacts with sts5, ekc1 and mis12.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ekc1O745112EBI-1153118,EBI-1153096

Protein-protein interaction databases

BioGridi275341, 31 interactors
IntActiP36614, 2 interactors
STRINGi4896.SPCC1739.12.1

Structurei

3D structure databases

ProteinModelPortaliP36614
SMRiP36614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172696
KOiK15427
OMAiKYCCRVF
OrthoDBiEOG092C2R40
PhylomeDBiP36614

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P36614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDLDEWIAT VRKCKYLPEH QLKRLCEMVK VILMEESNIQ PVRTPVTVCG
60 70 80 90 100
DIHGQFYDLL ELFRVGGELP STNYIFMGDF VDRGYFSLET FTLFMLLKAR
110 120 130 140 150
YPDKITLLRG NHESRQITQV YGFYDECQTK YGNANVWKYC CQVFDFLTLA
160 170 180 190 200
AVIDNKILCV HGGLSPEVRT LDQIRILARA QEIPHEGSFC DLMWSDPEDI
210 220 230 240 250
ESWTVSPRGA GWLFGSKVTT EFSQINDLTL IARAHQLVQE GYKYHFADKN
260 270 280 290 300
LVTVWSAPNY CYRCGNVASV MKVDESLEPE FRIFSAVADE DRTVPPSRKR

SEYFI
Length:305
Mass (Da):35,259
Last modified:June 1, 1994 - v1
Checksum:i001980A1CC7646D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13712 Genomic DNA Translation: BAA02865.1
Z18925 Genomic DNA Translation: CAA79358.1
CU329672 Genomic DNA Translation: CAA20786.1
PIRiA47727
RefSeqiNP_588420.1, NM_001023411.2

Genome annotation databases

EnsemblFungiiSPCC1739.12.1; SPCC1739.12.1:pep; SPCC1739.12
GeneIDi2538758
KEGGispo:SPCC1739.12

Similar proteinsi

Entry informationi

Entry nameiPPE1_SCHPO
AccessioniPrimary (citable) accession number: P36614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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