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Protein

Fructose-bisphosphate aldolase

Gene

fba1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi1)
  3. ATP-dependent 6-phosphofructokinase (pfk1)
  4. Fructose-bisphosphate aldolase (fba1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61Glyceraldehyde 3-phosphateBy similarity1
Active sitei108Proton donorBy similarity1
Metal bindingi109Zinc 1; catalyticBy similarity1
Metal bindingi143Zinc 2By similarity1
Metal bindingi173Zinc 2By similarity1
Metal bindingi225Zinc 1; catalyticBy similarity1
Binding sitei226Dihydroxyacetone phosphate; via amide nitrogenBy similarity1
Metal bindingi264Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba1
ORF Names:SPBC19C2.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC19C2.07
PomBaseiSPBC19C2.07 fba1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001787611 – 358Fructose-bisphosphate aldolaseAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289Phosphothreonine1 Publication1
Modified residuei312Phosphothreonine1 Publication1
Modified residuei340Phosphothreonine1 Publication1
Modified residuei342Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36580
PaxDbiP36580
PRIDEiP36580

PTM databases

iPTMnetiP36580

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi277287, 8 interactors
IntActiP36580, 3 interactors
MINTiP36580
STRINGi4896.SPBC19C2.07.1

Structurei

3D structure databases

ProteinModelPortaliP36580
SMRiP36580
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 267Dihydroxyacetone phosphate bindingBy similarity3
Regioni286 – 289Dihydroxyacetone phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000227794
InParanoidiP36580
KOiK01624
OMAiELCKDCI
OrthoDBiEOG092C385G
PhylomeDBiP36580

Family and domain databases

CDDicd00946 FBP_aldolase_IIA, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000771 FBA_II
IPR006411 Fruct_bisP_bact
PANTHERiPTHR30559 PTHR30559, 1 hit
PfamiView protein in Pfam
PF01116 F_bP_aldolase, 1 hit
PIRSFiPIRSF001359 F_bP_aldolase_II, 1 hit
TIGRFAMsiTIGR00167 cbbA, 1 hit
TIGR01520 FruBisAldo_II_A, 1 hit
PROSITEiView protein in PROSITE
PS00602 ALDOLASE_CLASS_II_1, 1 hit
PS00806 ALDOLASE_CLASS_II_2, 1 hit

Sequencei

Sequence statusi: Complete.

P36580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILDIVPTG VITGDNVLKL FTYAREHGFA IPAINVTSSS TAIAALEAAR
60 70 80 90 100
EARSPIILQT SNGGAHFFAG KESSNEGQKA SIAGSIAAAH YIRSIAPFFG
110 120 130 140 150
VPVVMHSDHC AKKLLPWMDG MFEADEAYFK IHGEPLFSSH MLDLSEEPKK
160 170 180 190 200
ENIAQVKEYC KRAVPMKIWI EMEIGITGGE EDGVDNSHVS HTELYTQPED
210 220 230 240 250
IWDVYRELSS VTPYFSIAAA FGNVHGVYKP GNVKLQPALL GQHQAYVKEQ
260 270 280 290 300
LKTTNDKPVF FVFHGGSGSS VNEFRTGIKC GVVKVNIDTD TQFAYVEGVR
310 320 330 340 350
DYVLKYKDYL MTPVGNPEGA DKPNKKKFDP RVWIHEGEKT MTKRVLTALE

DFYTVNTL
Length:358
Mass (Da):39,570
Last modified:January 11, 2001 - v2
Checksum:i50111C1C0E6DD05E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13T → A in BAA04237 (PubMed:8286404).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17415 Genomic DNA Translation: BAA04237.1
CU329671 Genomic DNA Translation: CAB52034.1
PIRiT39798
T43289
RefSeqiNP_595692.1, NM_001021589.2

Genome annotation databases

EnsemblFungiiSPBC19C2.07.1; SPBC19C2.07.1:pep; SPBC19C2.07
GeneIDi2540767
KEGGispo:SPBC19C2.07

Similar proteinsi

Entry informationi

Entry nameiALF_SCHPO
AccessioniPrimary (citable) accession number: P36580
Secondary accession number(s): Q9UUD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2001
Last modified: June 20, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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