UniProtKB - P36578 (RL4_HUMAN)
Protein
60S ribosomal protein L4
Gene
RPL4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: ProtInc
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P36578 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L4Alternative name(s): 60S ribosomal protein L1 Large ribosomal subunit protein uL41 Publication |
Gene namesi | Name:RPL4 Synonyms:RPL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10353, RPL4 |
MIMi | 180479, gene |
neXtProti | NX_P36578 |
VEuPathDBi | HostDB:ENSG00000174444.14 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: UniProtKB
Endoplasmic reticulum
- rough endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
- ribonucleoprotein complex Source: MGI
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6124 |
OpenTargetsi | ENSG00000174444 |
PharmGKBi | PA34749 |
Miscellaneous databases
Pharosi | P36578, Tbio |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Genetic variation databases
BioMutai | RPL4 |
DMDMi | 22002063 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000129350 | 2 – 427 | 60S ribosomal protein L4Add BLAST | 426 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 14 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 97 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 106 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 239 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 259 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 266 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 290 | PhosphoserineBy similarity | 1 | |
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Modified residuei | 300 | CitrullineBy similarity | 1 | |
Cross-linki | 327 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 333 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 353 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 364 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 364 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Modified residuei | 365 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Citrullinated by PADI4.By similarity
Keywords - PTMi
Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P36578 |
jPOSTi | P36578 |
MassIVEi | P36578 |
MaxQBi | P36578 |
PaxDbi | P36578 |
PeptideAtlasi | P36578 |
PRIDEi | P36578 |
ProteomicsDBi | 55216 |
TopDownProteomicsi | P36578 |
2D gel databases
SWISS-2DPAGEi | P36578 |
PTM databases
iPTMneti | P36578 |
MetOSitei | P36578 |
PhosphoSitePlusi | P36578 |
SwissPalmi | P36578 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174444, Expressed in cortical plate and 140 other tissues |
ExpressionAtlasi | P36578, baseline and differential |
Genevisiblei | P36578, HS |
Organism-specific databases
HPAi | ENSG00000174444, Low tissue specificity |
Interactioni
Subunit structurei
May bind IPO9 with low affinity.
Interacts with RBM3 (By similarity).
By similarityBinary interactionsi
Hide detailsP36578
Protein-protein interaction databases
BioGRIDi | 112044, 305 interactors |
ComplexPortali | CPX-5183, 60S cytosolic large ribosomal subunit |
CORUMi | P36578 |
DIPi | DIP-27559N |
IntActi | P36578, 116 interactors |
MINTi | P36578 |
STRINGi | 9606.ENSP00000311430 |
Miscellaneous databases
RNActi | P36578, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 364 – 427 | Lys-richAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uL4 family.Curated
Phylogenomic databases
eggNOGi | KOG1475, Eukaryota |
GeneTreei | ENSGT00390000018145 |
HOGENOMi | CLU_026535_4_0_1 |
InParanoidi | P36578 |
OMAi | GRLTIWT |
OrthoDBi | 878848at2759 |
PhylomeDBi | P36578 |
TreeFami | TF300593 |
Family and domain databases
DisProti | DP01654 |
Gene3Di | 3.40.1370.10, 1 hit |
InterProi | View protein in InterPro IPR025755, Ribos_L4_C_dom IPR002136, Ribosomal_L4/L1e IPR013000, Ribosomal_L4/L1e_euk/arc_CS IPR023574, Ribosomal_L4_dom_sf |
Pfami | View protein in Pfam PF14374, Ribos_L4_asso_C, 1 hit PF00573, Ribosomal_L4, 1 hit |
SUPFAMi | SSF52166, SSF52166, 1 hit |
PROSITEi | View protein in PROSITE PS00939, RIBOSOMAL_L1E, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P36578-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ
60 70 80 90 100
PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR
110 120 130 140 150
MFAPTKTWRR WHRRVNTTQK RYAICSALAA SALPALVMSK GHRIEEVPEL
160 170 180 190 200
PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR
210 220 230 240 250
RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL APGGHVGRFC
260 270 280 290 300
IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMINTDLS RILKSPEIQR
310 320 330 340 350
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR
360 370 380 390 400
VDKAAAAAAA LQAKSDEKAA VAGKKPVVGK KGKKAAVGVK KQKKPLVGKK
410 420
AAATKKPAPE KKPAEKKPTT EEKKPAA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BM89 | H3BM89_HUMAN | 60S ribosomal protein L4 | RPL4 hCG_2004318 | 333 | Annotation score: | ||
H3BTP7 | H3BTP7_HUMAN | 60S ribosomal protein L4 | RPL4 | 170 | Annotation score: | ||
H3BU31 | H3BU31_HUMAN | 60S ribosomal protein L4 | RPL4 | 171 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | C → V in AAA60281 (PubMed:8268230).Curated | 1 | |
Sequence conflicti | 36 | I → M in AAA60281 (PubMed:8268230).Curated | 1 | |
Sequence conflicti | 63 | S → R in AAA60281 (PubMed:8268230).Curated | 1 | |
Sequence conflicti | 147 | V → F in AAA60281 (PubMed:8268230).Curated | 1 | |
Sequence conflicti | 201 | Missing in AAA60281 (PubMed:8268230).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20868 mRNA Translation: AAA60281.2 D23660 mRNA Translation: BAA04887.1 AB061820 Genomic DNA Translation: BAB79458.1 AK291117 mRNA Translation: BAF83806.1 AK291859 mRNA Translation: BAF84548.1 CH471082 Genomic DNA Translation: EAW77776.1 BC001365 mRNA Translation: AAH01365.1 BC005817 mRNA Translation: AAH05817.1 BC007748 mRNA Translation: AAH07748.1 BC007996 mRNA Translation: AAH07996.1 BC009888 mRNA Translation: AAH09888.1 BC010151 mRNA Translation: AAH10151.1 BC014653 mRNA Translation: AAH14653.1 BC066925 mRNA Translation: AAH66925.1 BC095427 mRNA Translation: AAH95427.1 |
CCDSi | CCDS10218.1 |
PIRi | T09551 |
RefSeqi | NP_000959.2, NM_000968.3 |
Genome annotation databases
Ensembli | ENST00000307961; ENSP00000311430; ENSG00000174444 |
GeneIDi | 6124 |
KEGGi | hsa:6124 |
UCSCi | uc002apv.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20868 mRNA Translation: AAA60281.2 D23660 mRNA Translation: BAA04887.1 AB061820 Genomic DNA Translation: BAB79458.1 AK291117 mRNA Translation: BAF83806.1 AK291859 mRNA Translation: BAF84548.1 CH471082 Genomic DNA Translation: EAW77776.1 BC001365 mRNA Translation: AAH01365.1 BC005817 mRNA Translation: AAH05817.1 BC007748 mRNA Translation: AAH07748.1 BC007996 mRNA Translation: AAH07996.1 BC009888 mRNA Translation: AAH09888.1 BC010151 mRNA Translation: AAH10151.1 BC014653 mRNA Translation: AAH14653.1 BC066925 mRNA Translation: AAH66925.1 BC095427 mRNA Translation: AAH95427.1 |
CCDSi | CCDS10218.1 |
PIRi | T09551 |
RefSeqi | NP_000959.2, NM_000968.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | LC | 1-427 | [»] | |
4V6X | electron microscopy | 5.00 | CC | 1-427 | [»] | |
5A8L | electron microscopy | 3.80 | H | 1-427 | [»] | |
5AJ0 | electron microscopy | 3.50 | AC | 1-427 | [»] | |
5LKS | electron microscopy | 3.60 | LC | 1-427 | [»] | |
5T2C | electron microscopy | 3.60 | F | 1-427 | [»] | |
6EK0 | electron microscopy | 2.90 | LC | 1-427 | [»] | |
6IP5 | electron microscopy | 3.90 | 1F | 1-427 | [»] | |
6IP6 | electron microscopy | 4.50 | 1F | 1-427 | [»] | |
6IP8 | electron microscopy | 3.90 | 1F | 1-427 | [»] | |
6LQM | electron microscopy | 3.09 | D | 1-427 | [»] | |
6LSR | electron microscopy | 3.13 | D | 1-427 | [»] | |
6LSS | electron microscopy | 3.23 | D | 1-427 | [»] | |
6LU8 | electron microscopy | 3.13 | D | 1-427 | [»] | |
6OLE | electron microscopy | 3.10 | C | 3-365 | [»] | |
6OLF | electron microscopy | 3.90 | C | 3-365 | [»] | |
6OLG | electron microscopy | 3.40 | AC | 3-365 | [»] | |
6OLI | electron microscopy | 3.50 | C | 3-365 | [»] | |
6OLZ | electron microscopy | 3.90 | AC | 3-365 | [»] | |
6OM0 | electron microscopy | 3.10 | C | 3-365 | [»] | |
6OM7 | electron microscopy | 3.70 | C | 3-365 | [»] | |
6QZP | electron microscopy | 2.90 | LC | 1-368 | [»] | |
6W6L | electron microscopy | 3.84 | C | 1-427 | [»] | |
6XA1 | electron microscopy | 2.80 | LC | 1-358 | [»] | |
6Y0G | electron microscopy | 3.20 | LC | 1-427 | [»] | |
6Y2L | electron microscopy | 3.00 | LC | 1-427 | [»] | |
6Y57 | electron microscopy | 3.50 | LC | 1-427 | [»] | |
6Y6X | electron microscopy | 2.80 | LC | 1-368 | [»] | |
6Z6L | electron microscopy | 3.00 | LC | 1-427 | [»] | |
6Z6M | electron microscopy | 3.10 | LC | 1-427 | [»] | |
6Z6N | electron microscopy | 2.90 | LC | 1-427 | [»] | |
6ZM7 | electron microscopy | 2.70 | LC | 1-427 | [»] | |
6ZME | electron microscopy | 3.00 | LC | 1-427 | [»] | |
6ZMI | electron microscopy | 2.60 | LC | 1-427 | [»] | |
6ZMO | electron microscopy | 3.10 | LC | 1-427 | [»] | |
SMRi | P36578 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112044, 305 interactors |
ComplexPortali | CPX-5183, 60S cytosolic large ribosomal subunit |
CORUMi | P36578 |
DIPi | DIP-27559N |
IntActi | P36578, 116 interactors |
MINTi | P36578 |
STRINGi | 9606.ENSP00000311430 |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
iPTMneti | P36578 |
MetOSitei | P36578 |
PhosphoSitePlusi | P36578 |
SwissPalmi | P36578 |
Genetic variation databases
BioMutai | RPL4 |
DMDMi | 22002063 |
2D gel databases
SWISS-2DPAGEi | P36578 |
Proteomic databases
EPDi | P36578 |
jPOSTi | P36578 |
MassIVEi | P36578 |
MaxQBi | P36578 |
PaxDbi | P36578 |
PeptideAtlasi | P36578 |
PRIDEi | P36578 |
ProteomicsDBi | 55216 |
TopDownProteomicsi | P36578 |
Protocols and materials databases
Antibodypediai | 26140, 160 antibodies |
DNASUi | 6124 |
Genome annotation databases
Ensembli | ENST00000307961; ENSP00000311430; ENSG00000174444 |
GeneIDi | 6124 |
KEGGi | hsa:6124 |
UCSCi | uc002apv.4, human |
Organism-specific databases
CTDi | 6124 |
DisGeNETi | 6124 |
GeneCardsi | RPL4 |
HGNCi | HGNC:10353, RPL4 |
HPAi | ENSG00000174444, Low tissue specificity |
MIMi | 180479, gene |
neXtProti | NX_P36578 |
OpenTargetsi | ENSG00000174444 |
PharmGKBi | PA34749 |
VEuPathDBi | HostDB:ENSG00000174444.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1475, Eukaryota |
GeneTreei | ENSGT00390000018145 |
HOGENOMi | CLU_026535_4_0_1 |
InParanoidi | P36578 |
OMAi | GRLTIWT |
OrthoDBi | 878848at2759 |
PhylomeDBi | P36578 |
TreeFami | TF300593 |
Enzyme and pathway databases
PathwayCommonsi | P36578 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 6124, 754 hits in 882 CRISPR screens |
ChiTaRSi | RPL4, human |
GeneWikii | Ribosomal_protein_L4 |
GenomeRNAii | 6124 |
Pharosi | P36578, Tbio |
PROi | PR:P36578 |
RNActi | P36578, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174444, Expressed in cortical plate and 140 other tissues |
ExpressionAtlasi | P36578, baseline and differential |
Genevisiblei | P36578, HS |
Family and domain databases
DisProti | DP01654 |
Gene3Di | 3.40.1370.10, 1 hit |
InterProi | View protein in InterPro IPR025755, Ribos_L4_C_dom IPR002136, Ribosomal_L4/L1e IPR013000, Ribosomal_L4/L1e_euk/arc_CS IPR023574, Ribosomal_L4_dom_sf |
Pfami | View protein in Pfam PF14374, Ribos_L4_asso_C, 1 hit PF00573, Ribosomal_L4, 1 hit |
SUPFAMi | SSF52166, SSF52166, 1 hit |
PROSITEi | View protein in PROSITE PS00939, RIBOSOMAL_L1E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL4_HUMAN | |
Accessioni | P36578Primary (citable) accession number: P36578 Secondary accession number(s): A8K502 Q969Z9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 208 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families