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Protein

Arrestin-C

Gene

ARR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: Ensembl
  • regulation of protein phosphorylation Source: Ensembl
  • signal transduction Source: ProtInc
  • visual perception Source: ProtInc

Keywordsi

Biological processSensory transduction, Vision

Enzyme and pathway databases

SignaLinkiP36575

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-C
Alternative name(s):
Cone arrestin
Short name:
C-arrestin
Short name:
cArr
Retinal cone arrestin-3
X-arrestin
Gene namesi
Name:ARR3
Synonyms:ARRX, CAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000120500.17
HGNCiHGNC:710 ARR3
MIMi301770 gene
neXtProtiNX_P36575

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi407
MalaCardsiARR3
OpenTargetsiENSG00000120500
PharmGKBiPA25004

Polymorphism and mutation databases

BioMutaiARR3
DMDMi93189450

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002052031 – 388Arrestin-CAdd BLAST388

Proteomic databases

EPDiP36575
MaxQBiP36575
PaxDbiP36575
PeptideAtlasiP36575
PRIDEiP36575
ProteomicsDBi55214
55215 [P36575-2]

PTM databases

PhosphoSitePlusiP36575

Expressioni

Tissue specificityi

Inner and outer segments, and the inner plexiform regions of the retina.

Gene expression databases

BgeeiENSG00000120500
CleanExiHS_ARR3
ExpressionAtlasiP36575 baseline and differential
GenevisibleiP36575 HS

Organism-specific databases

HPAiHPA063129

Interactioni

Subunit structurei

Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106900, 10 interactors
IntActiP36575, 11 interactors
MINTiP36575
STRINGi9606.ENSP00000311538

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEHmodel-A1-356[»]
2A34model-A1-388[»]
ProteinModelPortaliP36575
SMRiP36575
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3865 Eukaryota
ENOG410XR0F LUCA
GeneTreeiENSGT00390000013152
HOGENOMiHOG000231319
HOVERGENiHBG002399
InParanoidiP36575
KOiK13801
PhylomeDBiP36575
TreeFamiTF314260

Family and domain databases

Gene3Di2.60.40.640, 1 hit
2.60.40.840, 1 hit
InterProiView protein in InterPro
IPR033042 ARR3
IPR000698 Arrestin
IPR011021 Arrestin-like_N
IPR014752 Arrestin_C
IPR011022 Arrestin_C-like
IPR017864 Arrestin_CS
IPR014753 Arrestin_N
IPR014756 Ig_E-set
PANTHERiPTHR11792 PTHR11792, 1 hit
PTHR11792:SF19 PTHR11792:SF19, 1 hit
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
PRINTSiPR00309 ARRESTIN
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit
SUPFAMiSSF81296 SSF81296, 2 hits
PROSITEiView protein in PROSITE
PS00295 ARRESTINS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P36575-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYLKCRKLF
60 70 80 90 100
VMLTCAFRYG RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER
110 120 130 140 150
LLHKLGDNAY PFTLQMVTNL PCSVTLQPGP EDAGKPCGID FEVKSFCAEN
160 170 180 190 200
PEETVSKRDY VRLVVRKVQF APPEAGPGPS AQTIRRFLLS AQPLQLQAWM
210 220 230 240 250
DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL YSLDKYTKTV
260 270 280 290 300
FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS
310 320 330 340 350
TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH
360 370 380
PKPSHEAASS EDIVIEEFTR KGEEESQKAV EAEGDEGS
Length:388
Mass (Da):42,778
Last modified:March 7, 2006 - v2
Checksum:i491F4EE4EE1ADA0D
GO
Isoform 2 (identifier: P36575-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-388: SSEDIVIEEFTRKGEEESQKAVEAEGDEGS → R

Show »
Length:359
Mass (Da):39,667
Checksum:i3210415593EA6B38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19G → V in CAG33130 (Ref. 7) Curated1
Sequence conflicti93P → A no nucleotide entry (PubMed:8224247).Curated1
Sequence conflicti93P → A in AAB84302 (PubMed:8612728).Curated1
Sequence conflicti93P → A in AAC27524 (PubMed:8612728).Curated1
Sequence conflicti217I → V in AAC78395 (PubMed:8308033).Curated1
Sequence conflicti356 – 357EA → AS in CAI41490 (PubMed:15772651).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02552044L → F1 PublicationCorresponds to variant dbSNP:rs11548182Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017495359 – 388SSEDI…GDEGS → R in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03626 mRNA Translation: AAC78395.1
AF033105 mRNA Translation: AAB84302.1
AF076512
, AF076497, AF076498, AF076499, AF076500, AF076501, AF076502, AF076503, AF076504, AF076505, AF076506, AF076507, AF076508, AF076509, AF076510, AF076511 Genomic DNA Translation: AAC27524.1
EU883571 mRNA Translation: ACG60645.1
CR456849 mRNA Translation: CAG33130.1
AL357752 Genomic DNA Translation: CAI41490.1
AL357752 Genomic DNA Translation: CAI41491.1
BC012096 mRNA Translation: AAH12096.1
CCDSiCCDS14399.1 [P36575-1]
PIRiS38943
RefSeqiNP_004303.2, NM_004312.2 [P36575-1]
UniGeneiHs.308

Genome annotation databases

EnsembliENST00000307959; ENSP00000311538; ENSG00000120500 [P36575-1]
ENST00000374495; ENSP00000363619; ENSG00000120500 [P36575-2]
GeneIDi407
KEGGihsa:407
UCSCiuc004dya.4 human [P36575-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARRC_HUMAN
AccessioniPrimary (citable) accession number: P36575
Secondary accession number(s): B5B0B9
, Q5JT23, Q5JT24, Q6IBF5, Q96EN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 7, 2006
Last modified: June 20, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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