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Entry version 203 (13 Nov 2019)
Sequence version 5 (01 Nov 1997)
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Protein

Neuronal acetylcholine receptor subunit alpha-7

Gene

CHRNA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P36544

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P36544

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.9.1.7 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHRNA7
Synonyms:NACHRA7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1960 CHRNA7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
118511 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P36544

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 230ExtracellularSequence analysisAdd BLAST208
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei231 – 255HelicalSequence analysisAdd BLAST25
Transmembranei262 – 280HelicalSequence analysisAdd BLAST19
Transmembranei296 – 317HelicalSequence analysisAdd BLAST22
Topological domaini318 – 469CytoplasmicSequence analysisAdd BLAST152
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi139Q → S: 115-fold more potently inhibited by the alpha-conotoxin ImI; but no change in inhibition by the alpha-conotoxin ImII. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1139
89832

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CHRNA7

MalaCards human disease database

More...
MalaCardsi
CHRNA7

Open Targets

More...
OpenTargetsi
ENSG00000175344

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
199318 15q13.3 microdeletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA114
PA26483

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P36544

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2492

Drug and drug target database

More...
DrugBanki
DB03128 Acetylcholine
DB00915 Amantadine
DB01351 Amobarbital
DB01352 Aprobarbital
DB01483 Barbital
DB01496 Barbituric acid derivative
DB00237 Butabarbital
DB00241 Butalbital
DB01353 Butobarbital
DB09061 Cannabidiol
DB00122 Choline
DB14006 Choline salicylate
DB09028 Cytisine
DB00514 Dextromethorphan
DB11726 Encenicline
DB07720 Epibatidine
DB00898 Ethanol
DB00674 Galantamine
DB05708 GTS-21
DB01354 Heptabarbital
DB01355 Hexobarbital
DB05137 Lobeline
DB00657 Mecamylamine
DB14009 Medical Cannabis
DB00463 Metharbital
DB00849 Methylphenobarbital
DB14011 Nabiximols
DB00184 Nicotine
DB00312 Pentobarbital
DB01174 Phenobarbital
DB00794 Primidone
DB05740 RPI-78M
DB00418 Secobarbital
DB00306 Talbutal
DB00599 Thiopental
DB01199 Tubocurarine
DB01273 Varenicline

DrugCentral

More...
DrugCentrali
P36544

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
468

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHRNA7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2506127

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000036623 – 502Neuronal acetylcholine receptor subunit alpha-7Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi150 ↔ 164By similarity
Disulfide bondi212 ↔ 213Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P36544

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P36544

PeptideAtlas

More...
PeptideAtlasi
P36544

PRoteomics IDEntifications database

More...
PRIDEi
P36544

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55211 [P36544-1]
55212 [P36544-2]
70632

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36544

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P36544

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P36544

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175344 Expressed in 85 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P36544 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P36544 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033624
HPA029422

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homopentamer (By similarity).

Interacts with RIC3; which is required for proper folding and assembly (PubMed:15504725, PubMed:16120769).

Interacts with LYPD6 (PubMed:27344019).

Interacts with the alpha-conotoxin RgIA (By similarity).

Interacts with alpha-conotoxins ImI and ImII (PubMed:15609996).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107561, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-236 Neuronal nicotinic acetylcholine receptor complex, alpha7
CPX-240 Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P36544

Protein interaction database and analysis system

More...
IntActi
P36544, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000407546

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P36544

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P36544

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3645 Eukaryota
ENOG410XQGR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154617

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36544

KEGG Orthology (KO)

More...
KOi
K04809

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCTPTTD

Database of Orthologous Groups

More...
OrthoDBi
845098at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P36544

TreeFam database of animal gene trees

More...
TreeFami
TF315605

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.170.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR18945 PTHR18945, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00254 NICOTINICR
PR00252 NRIONCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00860 LIC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P36544-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRCSPGGVWL ALAASLLHVS LQGEFQRKLY KELVKNYNPL ERPVANDSQP
60 70 80 90 100
LTVYFSLSLL QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN VSEYPGVKTV
110 120 130 140 150
RFPDGQIWKP DILLYNSADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC
160 170 180 190 200
YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG
210 220 230 240 250
IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP CVLISALALL
260 270 280 290 300
VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST
310 320 330 340 350
MIIVGLSVVV TVIVLQYHHH DPDGGKMPKW TRVILLNWCA WFLRMKRPGE
360 370 380 390 400
DKVRPACQHK QRRCSLASVE MSAVAPPPAS NGNLLYIGFR GLDGVHCVPT
410 420 430 440 450
PDSGVVCGRM ACSPTHDEHL LHGGQPPEGD PDLAKILEEV RYIANRFRCQ
460 470 480 490 500
DESEAVCSEW KFAACVVDRL CLMAFSVFTI ICTIGILMSA PNFVEAVSKD

FA
Length:502
Mass (Da):56,449
Last modified:November 1, 1997 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD94B3A482EAA0E42
GO
Isoform 2 (identifier: P36544-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-18: H → HGKATASPPSTPPWDPGHIPGASVRPAPGP

Note: No experimental confirmation available.
Show »
Length:531
Mass (Da):59,235
Checksum:i824BAFD78601D1FD
GO
Isoform 3 (identifier: P36544-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-102: SWTDHYLQWNVSEYPGVKTVRF → AYSRVPATSMYAGFPLMCSTAN
     103-502: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:102
Mass (Da):11,485
Checksum:i7A5F2F181F009A9E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GW47A0A1B0GW47_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
284Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTT9A0A1B0GTT9_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
318Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV44A0A1B0GV44_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV25A0A1B0GV25_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
302Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW52A0A1B0GW52_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
210Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV43A0A1B0GV43_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
423Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVH2A0A1B0GVH2_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
440Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUR5A0A1B0GUR5_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU04A0A1B0GU04_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU11A0A1B0GU11_HUMAN
Neuronal acetylcholine receptor sub...
CHRNA7
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH37571 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11A → G in CAA49778 (PubMed:8145738).Curated1
Sequence conflicti58S → N in AAA83561 (Ref. 2) Curated1
Sequence conflicti58S → N in AAK68111 (Ref. 6) Curated1
Sequence conflicti134S → P in AAA83561 (Ref. 2) Curated1
Sequence conflicti134S → P in AAK68111 (Ref. 6) Curated1
Sequence conflicti364C → S in CAA80672 (PubMed:8188270).Curated1
Sequence conflicti375A → G in CAA49778 (PubMed:8145738).Curated1
Sequence conflicti409 – 413RMACS → AWPAP in CAA80672 (PubMed:8188270).Curated5

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 54157.68 Da from positions 23 - 502. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04301918H → HGKATASPPSTPPWDPGHIP GASVRPAPGP in isoform 2. 1 Publication1
Alternative sequenceiVSP_05810781 – 102SWTDH…KTVRF → AYSRVPATSMYAGFPLMCST AN in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_058108103 – 502Missing in isoform 3. 1 PublicationAdd BLAST400

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X70297 mRNA Translation: CAA49778.1
U40583 mRNA Translation: AAA83561.1
U62436 mRNA Translation: AAB40114.1
Y08420 mRNA Translation: CAA69697.1
AF385585 mRNA Translation: AAK68111.1
AK292069 mRNA Translation: BAF84758.1
AK294229 mRNA Translation: BAG57531.1
AC004460 Genomic DNA No translation available.
AC009562 Genomic DNA No translation available.
AC012236 Genomic DNA No translation available.
AC021316 Genomic DNA No translation available.
AC026150 Genomic DNA No translation available.
AC026951 Genomic DNA No translation available.
AC058803 Genomic DNA No translation available.
AC068448 Genomic DNA No translation available.
AC079969 Genomic DNA No translation available.
AC087481 Genomic DNA No translation available.
AC090829 Genomic DNA No translation available.
AC091057 Genomic DNA No translation available.
AC104266 Genomic DNA No translation available.
AC104759 Genomic DNA No translation available.
BC037571 mRNA Translation: AAH37571.1 Sequence problems.
BC101345 mRNA Translation: AAI01346.1
L25827 mRNA No translation available.
Z23141 mRNA Translation: CAA80672.1
AF332758 Genomic DNA Translation: AAK19515.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10027.1 [P36544-1]
CCDS53924.1 [P36544-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
G02259
I37185 ACHUA7

NCBI Reference Sequences

More...
RefSeqi
NP_000737.1, NM_000746.5 [P36544-1]
NP_001177384.1, NM_001190455.2 [P36544-2]
NP_683709.1, NM_148911.1
XP_005254807.1, XM_005254750.2
XP_016877373.1, XM_017021884.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306901; ENSP00000303727; ENSG00000175344 [P36544-1]
ENST00000437966; ENSP00000399087; ENSG00000175344 [P36544-3]
ENST00000454250; ENSP00000407546; ENSG00000175344 [P36544-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1139
89832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1139

UCSC genome browser

More...
UCSCi
uc001zft.5 human [P36544-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70297 mRNA Translation: CAA49778.1
U40583 mRNA Translation: AAA83561.1
U62436 mRNA Translation: AAB40114.1
Y08420 mRNA Translation: CAA69697.1
AF385585 mRNA Translation: AAK68111.1
AK292069 mRNA Translation: BAF84758.1
AK294229 mRNA Translation: BAG57531.1
AC004460 Genomic DNA No translation available.
AC009562 Genomic DNA No translation available.
AC012236 Genomic DNA No translation available.
AC021316 Genomic DNA No translation available.
AC026150 Genomic DNA No translation available.
AC026951 Genomic DNA No translation available.
AC058803 Genomic DNA No translation available.
AC068448 Genomic DNA No translation available.
AC079969 Genomic DNA No translation available.
AC087481 Genomic DNA No translation available.
AC090829 Genomic DNA No translation available.
AC091057 Genomic DNA No translation available.
AC104266 Genomic DNA No translation available.
AC104759 Genomic DNA No translation available.
BC037571 mRNA Translation: AAH37571.1 Sequence problems.
BC101345 mRNA Translation: AAI01346.1
L25827 mRNA No translation available.
Z23141 mRNA Translation: CAA80672.1
AF332758 Genomic DNA Translation: AAK19515.1
CCDSiCCDS10027.1 [P36544-1]
CCDS53924.1 [P36544-2]
PIRiG02259
I37185 ACHUA7
RefSeqiNP_000737.1, NM_000746.5 [P36544-1]
NP_001177384.1, NM_001190455.2 [P36544-2]
NP_683709.1, NM_148911.1
XP_005254807.1, XM_005254750.2
XP_016877373.1, XM_017021884.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MAWNMR-A228-326[»]
A467-495[»]
5AFHX-ray2.40A/B/C/D/E23-227[»]
5AFJX-ray2.20A/B/C/D/E23-227[»]
5AFKX-ray2.38A/B/C/D/E23-227[»]
5AFLX-ray2.38A/B/C/D/E23-227[»]
5AFMX-ray2.85A/B/C/D/E23-227[»]
5AFNX-ray2.15A/B/C/D/E23-227[»]
SMRiP36544
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107561, 4 interactors
ComplexPortaliCPX-236 Neuronal nicotinic acetylcholine receptor complex, alpha7
CPX-240 Neuronal nicotinic acetylcholine receptor complex, alpha7-beta2
CORUMiP36544
IntActiP36544, 9 interactors
STRINGi9606.ENSP00000407546

Chemistry databases

BindingDBiP36544
ChEMBLiCHEMBL2492
DrugBankiDB03128 Acetylcholine
DB00915 Amantadine
DB01351 Amobarbital
DB01352 Aprobarbital
DB01483 Barbital
DB01496 Barbituric acid derivative
DB00237 Butabarbital
DB00241 Butalbital
DB01353 Butobarbital
DB09061 Cannabidiol
DB00122 Choline
DB14006 Choline salicylate
DB09028 Cytisine
DB00514 Dextromethorphan
DB11726 Encenicline
DB07720 Epibatidine
DB00898 Ethanol
DB00674 Galantamine
DB05708 GTS-21
DB01354 Heptabarbital
DB01355 Hexobarbital
DB05137 Lobeline
DB00657 Mecamylamine
DB14009 Medical Cannabis
DB00463 Metharbital
DB00849 Methylphenobarbital
DB14011 Nabiximols
DB00184 Nicotine
DB00312 Pentobarbital
DB01174 Phenobarbital
DB00794 Primidone
DB05740 RPI-78M
DB00418 Secobarbital
DB00306 Talbutal
DB00599 Thiopental
DB01199 Tubocurarine
DB01273 Varenicline
DrugCentraliP36544
GuidetoPHARMACOLOGYi468

Protein family/group databases

TCDBi1.A.9.1.7 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

iPTMnetiP36544
PhosphoSitePlusiP36544
SwissPalmiP36544

Polymorphism and mutation databases

BioMutaiCHRNA7
DMDMi2506127

Proteomic databases

jPOSTiP36544
MassIVEiP36544
PeptideAtlasiP36544
PRIDEiP36544
ProteomicsDBi55211 [P36544-1]
55212 [P36544-2]
70632

Genome annotation databases

EnsembliENST00000306901; ENSP00000303727; ENSG00000175344 [P36544-1]
ENST00000437966; ENSP00000399087; ENSG00000175344 [P36544-3]
ENST00000454250; ENSP00000407546; ENSG00000175344 [P36544-2]
GeneIDi1139
89832
KEGGihsa:1139
UCSCiuc001zft.5 human [P36544-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1139
89832
DisGeNETi1139
89832

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHRNA7
GeneReviewsiCHRNA7
HGNCiHGNC:1960 CHRNA7
HPAiCAB033624
HPA029422
MalaCardsiCHRNA7
MIMi118511 gene
neXtProtiNX_P36544
OpenTargetsiENSG00000175344
Orphaneti199318 15q13.3 microdeletion syndrome
PharmGKBiPA114
PA26483

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00940000154617
HOGENOMiHOG000006756
InParanoidiP36544
KOiK04809
OMAiHCTPTTD
OrthoDBi845098at2759
PhylomeDBiP36544
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
SignaLinkiP36544
SIGNORiP36544

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CHRNA7 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CHRFAM7A
CHRNA7
PharosiP36544

Protein Ontology

More...
PROi
PR:P36544

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175344 Expressed in 85 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiP36544 baseline and differential
GenevisibleiP36544 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACHA7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36544
Secondary accession number(s): A8K7Q4
, B4DFS0, Q15826, Q8IUZ4, Q96RH2, Q99555, Q9BXH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 13, 2019
This is version 203 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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