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UniProtKB - P36537 (UDB10_HUMAN)
Protein
UDP-glucuronosyltransferase 2B10
Gene
UGT2B10
Organism
Homo sapiens (Human)
Status
Functioni
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activityi
- EC:2.4.1.17
GO - Molecular functioni
- UDP-glycosyltransferase activity Source: InterPro
GO - Biological processi
- lipid metabolic process Source: ProtInc
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.4.1.17, 2681 |
PathwayCommonsi | P36537 |
Reactomei | R-HSA-156588, Glucuronidation |
SignaLinki | P36537 |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:UGT2B10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12544, UGT2B10 |
MIMi | 600070, gene |
neXtProti | NX_P36537 |
VEuPathDBi | HostDB:ENSG00000109181 |
Subcellular locationi
Endoplasmic reticulum
- Microsome membrane Curated; Single-pass membrane protein Curated
- Endoplasmic reticulum membrane Curated; Single-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 492 – 512 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 7365 |
OpenTargetsi | ENSG00000109181 |
PharmGKBi | PA37186 |
Miscellaneous databases
Pharosi | P36537, Tbio |
Chemistry databases
ChEMBLi | CHEMBL6160 |
DrugBanki | DB00321, Amitriptyline DB00924, Cyclobenzaprine DB00455, Loratadine DB11837, Osilodrostat DB06153, Pizotifen |
Genetic variation databases
BioMutai | UGT2B10 |
DMDMi | 549155 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | By similarityAdd BLAST | 23 | |
ChainiPRO_0000036034 | 24 – 528 | UDP-glucuronosyltransferase 2B10Add BLAST | 505 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 66 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 134 | N6-succinyllysineBy similarity | 1 | |
Glycosylationi | 314 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 481 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P36537 |
MassIVEi | P36537 |
MaxQBi | P36537 |
PaxDbi | P36537 |
PeptideAtlasi | P36537 |
PRIDEi | P36537 |
ProteomicsDBi | 4800 55206 [P36537-1] |
PTM databases
GlyGeni | P36537, 3 sites |
iPTMneti | P36537 |
PhosphoSitePlusi | P36537 |
Expressioni
Gene expression databases
Bgeei | ENSG00000109181, Expressed in intestine and 30 other tissues |
Organism-specific databases
HPAi | ENSG00000109181, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113212, 3 interactors |
IntActi | P36537, 1 interactor |
STRINGi | 9606.ENSP00000265403 |
Chemistry databases
BindingDBi | P36537 |
Miscellaneous databases
RNActi | P36537, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the UDP-glycosyltransferase family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1192, Eukaryota |
GeneTreei | ENSGT00940000165281 |
HOGENOMi | CLU_012949_3_0_1 |
InParanoidi | P36537 |
OMAi | MEVNCAN |
OrthoDBi | 508327at2759 |
PhylomeDBi | P36537 |
TreeFami | TF315472 |
Family and domain databases
CDDi | cd03784, GT1_Gtf-like, 1 hit |
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P36537-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH
60 70 80 90 100
EVTVLASSAS ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ
110 120 130 140 150
KDTFWLPFSQ EQEILWAIND IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD
160 170 180 190 200
AYLPCGELLA ELFNIPFVYS HSFSPGYSFE RHSGGFIFPP SYVPVVMSKL
210 220 230 240 250
SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG RPTTLSETMR
260 270 280 290 300
KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE
310 320 330 340 350
NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT
360 370 380 390 400
RLYKWIPQND LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD
410 420 430 440 450
NIAHMKAKGA AVRVDFNTMS STDLLNALKT VINDPSYKEN IMKLSRIQHD
460 470 480 490 500
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH NLTWFQYHSL DVIGFLLACV
510 520
ATVLFIITKC CLFCFWKFAR KGKKGKRD
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054337 | 156 – 239 | Missing in isoform 2. 1 PublicationAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63359 mRNA Translation: CAA44961.1 AK292738 mRNA Translation: BAF85427.1 AK298432 mRNA Translation: BAG60653.1 AC021146 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05577.1 BC113649 mRNA Translation: AAI13650.1 |
CCDSi | CCDS75135.1 [P36537-2] CCDS75136.1 [P36537-1] |
PIRi | JN0620 |
RefSeqi | NP_001066.1, NM_001075.5 [P36537-1] NP_001138239.1, NM_001144767.2 [P36537-2] NP_001277020.1, NM_001290091.1 |
Genome annotation databases
Ensembli | ENST00000265403; ENSP00000265403; ENSG00000109181 ENST00000458688; ENSP00000413420; ENSG00000109181 [P36537-2] ENST00000615213; ENSP00000478760; ENSG00000275190 ENST00000627047; ENSP00000486876; ENSG00000275190 [P36537-2] |
GeneIDi | 7365 |
KEGGi | hsa:7365 |
MANE-Selecti | ENST00000265403.12; ENSP00000265403.7; NM_001075.6; NP_001066.1 |
UCSCi | uc003hee.4, human [P36537-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63359 mRNA Translation: CAA44961.1 AK292738 mRNA Translation: BAF85427.1 AK298432 mRNA Translation: BAG60653.1 AC021146 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05577.1 BC113649 mRNA Translation: AAI13650.1 |
CCDSi | CCDS75135.1 [P36537-2] CCDS75136.1 [P36537-1] |
PIRi | JN0620 |
RefSeqi | NP_001066.1, NM_001075.5 [P36537-1] NP_001138239.1, NM_001144767.2 [P36537-2] NP_001277020.1, NM_001290091.1 |
3D structure databases
SMRi | P36537 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113212, 3 interactors |
IntActi | P36537, 1 interactor |
STRINGi | 9606.ENSP00000265403 |
Chemistry databases
BindingDBi | P36537 |
ChEMBLi | CHEMBL6160 |
DrugBanki | DB00321, Amitriptyline DB00924, Cyclobenzaprine DB00455, Loratadine DB11837, Osilodrostat DB06153, Pizotifen |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
PTM databases
GlyGeni | P36537, 3 sites |
iPTMneti | P36537 |
PhosphoSitePlusi | P36537 |
Genetic variation databases
BioMutai | UGT2B10 |
DMDMi | 549155 |
Proteomic databases
jPOSTi | P36537 |
MassIVEi | P36537 |
MaxQBi | P36537 |
PaxDbi | P36537 |
PeptideAtlasi | P36537 |
PRIDEi | P36537 |
ProteomicsDBi | 4800 55206 [P36537-1] |
Protocols and materials databases
Antibodypediai | 24201, 131 antibodies from 23 providers |
DNASUi | 7365 |
Genome annotation databases
Ensembli | ENST00000265403; ENSP00000265403; ENSG00000109181 ENST00000458688; ENSP00000413420; ENSG00000109181 [P36537-2] ENST00000615213; ENSP00000478760; ENSG00000275190 ENST00000627047; ENSP00000486876; ENSG00000275190 [P36537-2] |
GeneIDi | 7365 |
KEGGi | hsa:7365 |
MANE-Selecti | ENST00000265403.12; ENSP00000265403.7; NM_001075.6; NP_001066.1 |
UCSCi | uc003hee.4, human [P36537-1] |
Organism-specific databases
CTDi | 7365 |
DisGeNETi | 7365 |
GeneCardsi | UGT2B10 |
HGNCi | HGNC:12544, UGT2B10 |
HPAi | ENSG00000109181, Tissue enriched (liver) |
MIMi | 600070, gene |
neXtProti | NX_P36537 |
OpenTargetsi | ENSG00000109181 |
PharmGKBi | PA37186 |
VEuPathDBi | HostDB:ENSG00000109181 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1192, Eukaryota |
GeneTreei | ENSGT00940000165281 |
HOGENOMi | CLU_012949_3_0_1 |
InParanoidi | P36537 |
OMAi | MEVNCAN |
OrthoDBi | 508327at2759 |
PhylomeDBi | P36537 |
TreeFami | TF315472 |
Enzyme and pathway databases
BRENDAi | 2.4.1.17, 2681 |
PathwayCommonsi | P36537 |
Reactomei | R-HSA-156588, Glucuronidation |
SignaLinki | P36537 |
Miscellaneous databases
BioGRID-ORCSi | 7365, 6 hits in 201 CRISPR screens |
ChiTaRSi | UGT2B10, human |
GeneWikii | UGT2B10 |
GenomeRNAii | 7365 |
Pharosi | P36537, Tbio |
PROi | PR:P36537 |
RNActi | P36537, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109181, Expressed in intestine and 30 other tissues |
Family and domain databases
CDDi | cd03784, GT1_Gtf-like, 1 hit |
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UDB10_HUMAN | |
Accessioni | P36537Primary (citable) accession number: P36537 Secondary accession number(s): A8K9M3, B4DPP1, Q14CR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families