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UniProtKB - P36537 (UDB10_HUMAN)

Protein

UDP-glucuronosyltransferase 2B10

Gene

UGT2B10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • lipid metabolic process Source: ProtInc
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B10 (EC:2.4.1.17)
Short name:
UDPGT 2B10
Gene namesi
Name:UGT2B10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109181.11
HGNCiHGNC:12544 UGT2B10
MIMi600070 gene
neXtProtiNX_P36537

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi7365
OpenTargetsiENSG00000109181
PharmGKBiPA37186

Chemistry databases

ChEMBLiCHEMBL6160

Polymorphism and mutation databases

BioMutaiUGT2B10
DMDMi549155

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003603424 – 528UDP-glucuronosyltransferase 2B10Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei134N6-succinyllysineBy similarity1
Glycosylationi314N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP36537
PaxDbiP36537
PeptideAtlasiP36537
PRIDEiP36537
ProteomicsDBi55206

PTM databases

iPTMnetiP36537
PhosphoSitePlusiP36537

Expressioni

Gene expression databases

BgeeiENSG00000109181 Expressed in 22 organ(s), highest expression level in liver
CleanExiHS_UGT2B10

Organism-specific databases

HPAiHPA045108

Interactioni

Protein-protein interaction databases

BioGridi113212, 1 interactor
IntActiP36537, 1 interactor
STRINGi9606.ENSP00000265403

Chemistry databases

BindingDBiP36537

Structurei

3D structure databases

ProteinModelPortaliP36537
SMRiP36537
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiP36537
KOiK00699
OMAiKEMTNKN
OrthoDBiEOG091G03YY
PhylomeDBiP36537
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P36537-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH 
        60         70         80         90        100
EVTVLASSAS ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ 
       110        120        130        140        150
KDTFWLPFSQ EQEILWAIND IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD 
       160        170        180        190        200
AYLPCGELLA ELFNIPFVYS HSFSPGYSFE RHSGGFIFPP SYVPVVMSKL 
       210        220        230        240        250
SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG RPTTLSETMR 
       260        270        280        290        300
KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE 
       310        320        330        340        350
NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT 
       360        370        380        390        400
RLYKWIPQND LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD 
       410        420        430        440        450
NIAHMKAKGA AVRVDFNTMS STDLLNALKT VINDPSYKEN IMKLSRIQHD 
       460        470        480        490        500
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH NLTWFQYHSL DVIGFLLACV 
       510        520 
ATVLFIITKC CLFCFWKFAR KGKKGKRD
Length:528
Mass (Da):60,774
Last modified:June 1, 1994 - v1
Checksum:i5E6EA3DBC032C2E0
GO
Isoform 2 (identifier: P36537-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-239: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):50,688
Checksum:i449302F7572B0544
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054337156 – 239Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63359 mRNA Translation: CAA44961.1
AK292738 mRNA Translation: BAF85427.1
AK298432 mRNA Translation: BAG60653.1
AC021146 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05577.1
BC113649 mRNA Translation: AAI13650.1
CCDSiCCDS75135.1 [P36537-2]
CCDS75136.1 [P36537-1]
PIRiJN0620
RefSeqiNP_001066.1, NM_001075.5 [P36537-1]
NP_001138239.1, NM_001144767.2 [P36537-2]
NP_001277020.1, NM_001290091.1
UniGeneiHs.201634

Genome annotation databases

EnsembliENST00000265403; ENSP00000265403; ENSG00000109181 [P36537-1]
ENST00000458688; ENSP00000413420; ENSG00000109181 [P36537-2]
ENST00000615213; ENSP00000478760; ENSG00000275190 [P36537-1]
ENST00000627047; ENSP00000486876; ENSG00000275190 [P36537-2]
GeneIDi7365
KEGGihsa:7365
UCSCiuc003hee.4 human [P36537-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63359 mRNA Translation: CAA44961.1
AK292738 mRNA Translation: BAF85427.1
AK298432 mRNA Translation: BAG60653.1
AC021146 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05577.1
BC113649 mRNA Translation: AAI13650.1
CCDSiCCDS75135.1 [P36537-2]
CCDS75136.1 [P36537-1]
PIRiJN0620
RefSeqiNP_001066.1, NM_001075.5 [P36537-1]
NP_001138239.1, NM_001144767.2 [P36537-2]
NP_001277020.1, NM_001290091.1
UniGeneiHs.201634

3D structure databases

ProteinModelPortaliP36537
SMRiP36537
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113212, 1 interactor
IntActiP36537, 1 interactor
STRINGi9606.ENSP00000265403

Chemistry databases

BindingDBiP36537
ChEMBLiCHEMBL6160

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

PTM databases

iPTMnetiP36537
PhosphoSitePlusiP36537

Polymorphism and mutation databases

BioMutaiUGT2B10
DMDMi549155

Proteomic databases

MaxQBiP36537
PaxDbiP36537
PeptideAtlasiP36537
PRIDEiP36537
ProteomicsDBi55206

Protocols and materials databases

DNASUi7365
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265403; ENSP00000265403; ENSG00000109181 [P36537-1]
ENST00000458688; ENSP00000413420; ENSG00000109181 [P36537-2]
ENST00000615213; ENSP00000478760; ENSG00000275190 [P36537-1]
ENST00000627047; ENSP00000486876; ENSG00000275190 [P36537-2]
GeneIDi7365
KEGGihsa:7365
UCSCiuc003hee.4 human [P36537-1]

Organism-specific databases

CTDi7365
DisGeNETi7365
EuPathDBiHostDB:ENSG00000109181.11
GeneCardsiUGT2B10
HGNCiHGNC:12544 UGT2B10
HPAiHPA045108
MIMi600070 gene
neXtProtiNX_P36537
OpenTargetsiENSG00000109181
PharmGKBiPA37186
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiP36537
KOiK00699
OMAiKEMTNKN
OrthoDBiEOG091G03YY
PhylomeDBiP36537
TreeFamiTF315472

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation

Miscellaneous databases

ChiTaRSiUGT2B10 human
GeneWikiiUGT2B10
GenomeRNAii7365
PROiPR:P36537
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109181 Expressed in 22 organ(s), highest expression level in liver
CleanExiHS_UGT2B10

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUDB10_HUMAN
AccessioniPrimary (citable) accession number: P36537
Secondary accession number(s): A8K9M3, B4DPP1, Q14CR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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