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UniProtKB - P36508 (ZNF76_HUMAN)
Protein
Zinc finger protein 76
Gene
ZNF76
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 165 – 189 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 195 – 219 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 225 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 255 – 279 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 285 – 309 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 315 – 339 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 345 – 368 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase III Source: ProtInc
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P36508 |
SignaLinki | P36508 |
SIGNORi | P36508 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 76Alternative name(s): Zinc finger protein 523 |
Gene namesi | Name:ZNF76 Synonyms:D6S229E, ZNF523 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13149, ZNF76 |
MIMi | 194549, gene |
neXtProti | NX_P36508 |
VEuPathDBi | HostDB:ENSG00000065029 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7629 |
OpenTargetsi | ENSG00000065029 |
PharmGKBi | PA37723 |
Miscellaneous databases
Pharosi | P36508, Tbio |
Genetic variation databases
BioMutai | ZNF76 |
DMDMi | 20455531 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047386 | 1 – 570 | Zinc finger protein 76Add BLAST | 570 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 24 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | P36508 |
MassIVEi | P36508 |
MaxQBi | P36508 |
PaxDbi | P36508 |
PeptideAtlasi | P36508 |
PRIDEi | P36508 |
ProteomicsDBi | 55204 [P36508-1] 55205 [P36508-2] |
PTM databases
iPTMneti | P36508 |
PhosphoSitePlusi | P36508 |
Expressioni
Tissue specificityi
Testis.
Gene expression databases
Bgeei | ENSG00000065029, Expressed in left lobe of thyroid gland and 219 other tissues |
ExpressionAtlasi | P36508, baseline and differential |
Genevisiblei | P36508, HS |
Organism-specific databases
HPAi | ENSG00000065029, Low tissue specificity |
Interactioni
Binary interactionsi
P36508
Protein-protein interaction databases
BioGRIDi | 113448, 103 interactors |
IntActi | P36508, 85 interactors |
MINTi | P36508 |
STRINGi | 9606.ENSP00000363064 |
Miscellaneous databases
RNActi | P36508, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 34 – 45 | 1Add BLAST | 12 | |
Repeati | 62 – 73 | 2Add BLAST | 12 | |
Repeati | 88 – 99 | 3Add BLAST | 12 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 99 | 3 X 12 AA approximate repeatsAdd BLAST | 66 | |
Regioni | 365 – 401 | DisorderedSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 165 – 189 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 195 – 219 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 225 – 249 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 255 – 279 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 285 – 309 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 315 – 339 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 345 – 368 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160911 |
HOGENOMi | CLU_027168_0_0_1 |
InParanoidi | P36508 |
OMAi | HITFLSE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P36508 |
TreeFami | TF333498 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: P36508-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ
60 70 80 90 100
KEALSFEDGQ PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH
110 120 130 140 150
PVAVPSESTI LAVQTEVGLE DLAAEDDEGF SADAVVALEQ YASKVLHDSQ
160 170 180 190 200
IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP
210 220 230 240 250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT
260 270 280 290 300
GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
310 320 330 340 350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC
360 370 380 390 400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK
410 420 430 440 450
RPRIAYLSEV KEERDDIPAQ VAMVTEEDGA PQVALITQDG AQQVSLSPED
460 470 480 490 500
LQALGSAISM VTQHGSTTLT IPSPDADLAT SGTHTVTMVS ADGTQTQPVT
510 520 530 540 550
IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ QTLEEAINVA
560 570
TAAMQQGAVT LETTVSESGC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C513 | H7C513_HUMAN | Zinc finger protein 76 | ZNF76 | 101 | Annotation score: | ||
E7EX64 | E7EX64_HUMAN | Zinc finger protein 76 | ZNF76 | 340 | Annotation score: | ||
F8W971 | F8W971_HUMAN | Zinc finger protein 76 | ZNF76 | 151 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 334 – 335 | KH → ND in AAA98739 (PubMed:1427894).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033546 | 48 | T → M. Corresponds to variant dbSNP:rs2228265Ensembl. | 1 | |
Natural variantiVAR_033547 | 272 | R → C. Corresponds to variant dbSNP:rs33959228Ensembl. | 1 | |
Natural variantiVAR_033548 | 403 | R → Q. Corresponds to variant dbSNP:rs35582935Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006894 | 444 – 498 | Missing in isoform 1. 1 PublicationAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91592 mRNA Translation: AAA98739.1 BT007316 mRNA Translation: AAP35980.1 BC000133 mRNA Translation: AAH00133.1 BC002549 mRNA Translation: AAH02549.1 |
CCDSi | CCDS4801.1 [P36508-1] CCDS75435.1 [P36508-2] |
PIRi | A44256 |
RefSeqi | NP_001278961.1, NM_001292032.1 [P36508-2] NP_003418.2, NM_003427.4 [P36508-1] XP_016866738.1, XM_017011249.1 [P36508-1] |
Genome annotation databases
Ensembli | ENST00000339411; ENSP00000344097; ENSG00000065029 [P36508-2] ENST00000373953; ENSP00000363064; ENSG00000065029 |
GeneIDi | 7629 |
KEGGi | hsa:7629 |
MANE-Selecti | ENST00000373953.8; ENSP00000363064.3; NM_003427.5; NP_003418.2 |
UCSCi | uc003oki.2, human [P36508-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91592 mRNA Translation: AAA98739.1 BT007316 mRNA Translation: AAP35980.1 BC000133 mRNA Translation: AAH00133.1 BC002549 mRNA Translation: AAH02549.1 |
CCDSi | CCDS4801.1 [P36508-1] CCDS75435.1 [P36508-2] |
PIRi | A44256 |
RefSeqi | NP_001278961.1, NM_001292032.1 [P36508-2] NP_003418.2, NM_003427.4 [P36508-1] XP_016866738.1, XM_017011249.1 [P36508-1] |
3D structure databases
SMRi | P36508 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113448, 103 interactors |
IntActi | P36508, 85 interactors |
MINTi | P36508 |
STRINGi | 9606.ENSP00000363064 |
PTM databases
iPTMneti | P36508 |
PhosphoSitePlusi | P36508 |
Genetic variation databases
BioMutai | ZNF76 |
DMDMi | 20455531 |
Proteomic databases
jPOSTi | P36508 |
MassIVEi | P36508 |
MaxQBi | P36508 |
PaxDbi | P36508 |
PeptideAtlasi | P36508 |
PRIDEi | P36508 |
ProteomicsDBi | 55204 [P36508-1] 55205 [P36508-2] |
Protocols and materials databases
Antibodypediai | 15181, 133 antibodies from 25 providers |
DNASUi | 7629 |
Genome annotation databases
Ensembli | ENST00000339411; ENSP00000344097; ENSG00000065029 [P36508-2] ENST00000373953; ENSP00000363064; ENSG00000065029 |
GeneIDi | 7629 |
KEGGi | hsa:7629 |
MANE-Selecti | ENST00000373953.8; ENSP00000363064.3; NM_003427.5; NP_003418.2 |
UCSCi | uc003oki.2, human [P36508-1] |
Organism-specific databases
CTDi | 7629 |
DisGeNETi | 7629 |
GeneCardsi | ZNF76 |
HGNCi | HGNC:13149, ZNF76 |
HPAi | ENSG00000065029, Low tissue specificity |
MIMi | 194549, gene |
neXtProti | NX_P36508 |
OpenTargetsi | ENSG00000065029 |
PharmGKBi | PA37723 |
VEuPathDBi | HostDB:ENSG00000065029 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160911 |
HOGENOMi | CLU_027168_0_0_1 |
InParanoidi | P36508 |
OMAi | HITFLSE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P36508 |
TreeFami | TF333498 |
Enzyme and pathway databases
PathwayCommonsi | P36508 |
SignaLinki | P36508 |
SIGNORi | P36508 |
Miscellaneous databases
BioGRID-ORCSi | 7629, 8 hits in 1068 CRISPR screens |
ChiTaRSi | ZNF76, human |
GeneWikii | ZNF76 |
GenomeRNAii | 7629 |
Pharosi | P36508, Tbio |
PROi | PR:P36508 |
RNActi | P36508, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000065029, Expressed in left lobe of thyroid gland and 219 other tissues |
ExpressionAtlasi | P36508, baseline and differential |
Genevisiblei | P36508, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF76_HUMAN | |
Accessioni | P36508Primary (citable) accession number: P36508 Secondary accession number(s): Q9BQB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | May 2, 2002 | |
Last modified: | February 23, 2022 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families