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Protein

Zinc finger protein 76

Gene

ZNF76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiP36508

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 76
Alternative name(s):
Zinc finger protein 523
Gene namesi
Name:ZNF76
Synonyms:D6S229E, ZNF523
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000065029.14
HGNCiHGNC:13149 ZNF76
MIMi194549 gene
neXtProtiNX_P36508

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065029
PharmGKBiPA37723

Polymorphism and mutation databases

BioMutaiZNF76
DMDMi20455531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473861 – 570Zinc finger protein 76Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP36508
MaxQBiP36508
PaxDbiP36508
PeptideAtlasiP36508
PRIDEiP36508
ProteomicsDBi55204
55205 [P36508-2]

PTM databases

iPTMnetiP36508
PhosphoSitePlusiP36508

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSG00000065029 Expressed in 206 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ZNF76
ExpressionAtlasiP36508 baseline and differential
GenevisibleiP36508 HS

Organism-specific databases

HPAiHPA030090
HPA030091

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113448, 14 interactors
IntActiP36508, 85 interactors
MINTiP36508
STRINGi9606.ENSP00000363064

Structurei

3D structure databases

ProteinModelPortaliP36508
SMRiP36508
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 451Add BLAST12
Repeati62 – 732Add BLAST12
Repeati88 – 993Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 993 X 12 AA approximate repeatsAdd BLAST66

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000118073
HOVERGENiHBG053078
InParanoidiP36508
KOiK20828
OMAiSMVTQHS
OrthoDBiEOG091G0N38
PhylomeDBiP36508
TreeFamiTF333498

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: P36508-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ
60 70 80 90 100
KEALSFEDGQ PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH
110 120 130 140 150
PVAVPSESTI LAVQTEVGLE DLAAEDDEGF SADAVVALEQ YASKVLHDSQ
160 170 180 190 200
IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP
210 220 230 240 250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT
260 270 280 290 300
GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
310 320 330 340 350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC
360 370 380 390 400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK
410 420 430 440 450
RPRIAYLSEV KEERDDIPAQ VAMVTEEDGA PQVALITQDG AQQVSLSPED
460 470 480 490 500
LQALGSAISM VTQHGSTTLT IPSPDADLAT SGTHTVTMVS ADGTQTQPVT
510 520 530 540 550
IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ QTLEEAINVA
560 570
TAAMQQGAVT LETTVSESGC
Length:570
Mass (Da):61,831
Last modified:May 2, 2002 - v2
Checksum:i333C99E0E79D86C2
GO
Isoform 1 (identifier: P36508-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-498: Missing.

Note: No experimental confirmation available.
Show »
Length:515
Mass (Da):56,324
Checksum:i473D193AE00E7FB1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX64E7EX64_HUMAN
Zinc finger protein 76
ZNF76
340Annotation score:
F8W971F8W971_HUMAN
Zinc finger protein 76
ZNF76
151Annotation score:
H7C513H7C513_HUMAN
Zinc finger protein 76
ZNF76
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti334 – 335KH → ND in AAA98739 (PubMed:1427894).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03354648T → M. Corresponds to variant dbSNP:rs2228265Ensembl.1
Natural variantiVAR_033547272R → C. Corresponds to variant dbSNP:rs33959228Ensembl.1
Natural variantiVAR_033548403R → Q. Corresponds to variant dbSNP:rs35582935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006894444 – 498Missing in isoform 1. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91592 mRNA Translation: AAA98739.1
BT007316 mRNA Translation: AAP35980.1
BC000133 mRNA Translation: AAH00133.1
BC002549 mRNA Translation: AAH02549.1
CCDSiCCDS4801.1 [P36508-1]
CCDS75435.1 [P36508-2]
PIRiA44256
RefSeqiNP_001278961.1, NM_001292032.1 [P36508-2]
NP_003418.2, NM_003427.4 [P36508-1]
XP_016866738.1, XM_017011249.1 [P36508-1]
UniGeneiHs.388024

Genome annotation databases

EnsembliENST00000339411; ENSP00000344097; ENSG00000065029 [P36508-2]
ENST00000373953; ENSP00000363064; ENSG00000065029 [P36508-1]
GeneIDi7629
KEGGihsa:7629
UCSCiuc003oki.2 human [P36508-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91592 mRNA Translation: AAA98739.1
BT007316 mRNA Translation: AAP35980.1
BC000133 mRNA Translation: AAH00133.1
BC002549 mRNA Translation: AAH02549.1
CCDSiCCDS4801.1 [P36508-1]
CCDS75435.1 [P36508-2]
PIRiA44256
RefSeqiNP_001278961.1, NM_001292032.1 [P36508-2]
NP_003418.2, NM_003427.4 [P36508-1]
XP_016866738.1, XM_017011249.1 [P36508-1]
UniGeneiHs.388024

3D structure databases

ProteinModelPortaliP36508
SMRiP36508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113448, 14 interactors
IntActiP36508, 85 interactors
MINTiP36508
STRINGi9606.ENSP00000363064

PTM databases

iPTMnetiP36508
PhosphoSitePlusiP36508

Polymorphism and mutation databases

BioMutaiZNF76
DMDMi20455531

Proteomic databases

EPDiP36508
MaxQBiP36508
PaxDbiP36508
PeptideAtlasiP36508
PRIDEiP36508
ProteomicsDBi55204
55205 [P36508-2]

Protocols and materials databases

DNASUi7629
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339411; ENSP00000344097; ENSG00000065029 [P36508-2]
ENST00000373953; ENSP00000363064; ENSG00000065029 [P36508-1]
GeneIDi7629
KEGGihsa:7629
UCSCiuc003oki.2 human [P36508-1]

Organism-specific databases

CTDi7629
EuPathDBiHostDB:ENSG00000065029.14
GeneCardsiZNF76
HGNCiHGNC:13149 ZNF76
HPAiHPA030090
HPA030091
MIMi194549 gene
neXtProtiNX_P36508
OpenTargetsiENSG00000065029
PharmGKBiPA37723
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOGENOMiHOG000118073
HOVERGENiHBG053078
InParanoidiP36508
KOiK20828
OMAiSMVTQHS
OrthoDBiEOG091G0N38
PhylomeDBiP36508
TreeFamiTF333498

Enzyme and pathway databases

SIGNORiP36508

Miscellaneous databases

ChiTaRSiZNF76 human
GeneWikiiZNF76
GenomeRNAii7629
PROiPR:P36508
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065029 Expressed in 206 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ZNF76
ExpressionAtlasiP36508 baseline and differential
GenevisibleiP36508 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF76_HUMAN
AccessioniPrimary (citable) accession number: P36508
Secondary accession number(s): Q9BQB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 2, 2002
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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