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UniProtKB - P36508 (ZNF76_HUMAN)

Entry version 187 (17 Jun 2020)
Sequence version 2 (02 May 2002)
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Protein

Zinc finger protein 76

Gene

ZNF76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		P36508

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 76
Alternative name(s):
Zinc finger protein 523
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF76
Synonyms:D6S229E, ZNF523
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000065029.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:13149 ZNF76

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		194549 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P36508

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7629

Open Targets

More...OpenTargetsi		ENSG00000065029

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37723

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P36508 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF76

Domain mapping of disease mutations (DMDM)

More...DMDMi		20455531

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473861 – 570Zinc finger protein 76Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P36508

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P36508

MaxQB - The MaxQuant DataBase

More...MaxQBi		P36508

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P36508

PeptideAtlas

More...PeptideAtlasi		P36508

PRoteomics IDEntifications database

More...PRIDEi		P36508

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55204 [P36508-1]
55205 [P36508-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P36508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P36508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000065029 Expressed in left lobe of thyroid gland and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P36508 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P36508 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000065029 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P36508
With#Exp.IntAct
ACAT2 [Q9BWD1]3EBI-7254550,EBI-1047273
ALOXE3 [Q9BYJ1]3EBI-7254550,EBI-6925949
ANKRD37 [Q7Z713]3EBI-7254550,EBI-12373689
ANTKMT [Q9BQD7]3EBI-7254550,EBI-713602
ATP5PO [P48047]3EBI-7254550,EBI-355815
BLZF1 [Q9H2G9]3EBI-7254550,EBI-2548012
BOLA2B [A0A087WZT3]3EBI-7254550,EBI-12006120
C10orf55 [Q5SWW7]3EBI-7254550,EBI-12809220
C22orf15 - isoform 2 [Q8WYQ4-2]3EBI-7254550,EBI-12030460
C3orf36 [Q3SXR2]3EBI-7254550,EBI-18036948
CEACAM6 [P40199]3EBI-7254550,EBI-4314501
CEP76 [Q8TAP6]3EBI-7254550,EBI-742887
CSN3 [P07498]3EBI-7254550,EBI-2602175
DDIT4L [Q96D03]3EBI-7254550,EBI-742054
DISC1 - isoform 2 [Q9NRI5-2]3EBI-7254550,EBI-11988027
ENKD1 [Q9H0I2]3EBI-7254550,EBI-744099
EXOSC1 [Q9Y3B2]3EBI-7254550,EBI-371892
FAM228A [Q86W67]3EBI-7254550,EBI-12958227
FAM90A1 [Q86YD7]3EBI-7254550,EBI-6658203
FCRL4 [Q96PJ5]3EBI-7254550,EBI-4314687
FHL2 [Q14192]3EBI-7254550,EBI-701903
FNDC8 [Q8TC99]3EBI-7254550,EBI-12903902
FSD2 [A1L4K1]3EBI-7254550,EBI-5661036
GRAPL [Q8TC17]3EBI-7254550,EBI-18300553
IKZF3 [Q9UKT9]3EBI-7254550,EBI-747204
KCTD9 [Q7L273]3EBI-7254550,EBI-4397613
KLF15 [Q9UIH9]3EBI-7254550,EBI-2796400
KPNA3 [O00505]3EBI-7254550,EBI-358297
KRT40 [Q6A162]3EBI-7254550,EBI-10171697
KRT75 [O95678]3EBI-7254550,EBI-2949715
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-7254550,EBI-11985629
LAP3 [P28838]3EBI-7254550,EBI-2339312
LETM1 [O95202]3EBI-7254550,EBI-1052895
LHX3 - isoform B [Q9UBR4-2]5EBI-7254550,EBI-12039345
LHX4 [Q969G2]3EBI-7254550,EBI-2865388
LHX6 [Q9UPM6]3EBI-7254550,EBI-10258746
LIN37 [Q96GY3]3EBI-7254550,EBI-748884
LIN54 [Q6MZP7]3EBI-7254550,EBI-1389411
LMO1 [P25800]3EBI-7254550,EBI-8639312
MAGEA6 [P43360]3EBI-7254550,EBI-1045155
MBD3L1 [Q8WWY6]3EBI-7254550,EBI-12516603
MBD5 - isoform 2 [Q9P267-2]3EBI-7254550,EBI-17671489
MED19 - isoform 2 [A0JLT2-2]3EBI-7254550,EBI-13288755
MFAP1 [P55081]3EBI-7254550,EBI-1048159
MORN3 [Q6PF18]3EBI-7254550,EBI-9675802
MRPL12 [P52815]3EBI-7254550,EBI-358272
MTFR1L [Q9H019]3EBI-7254550,EBI-2824497
MTUS2 - isoform 2 [Q5JR59-3]3EBI-7254550,EBI-11522433
MYL10 [Q9BUA6]3EBI-7254550,EBI-17561739
NEDD9 - isoform 2 [Q14511-2]3EBI-7254550,EBI-11746523
NRIP2 [Q9BQI9]3EBI-7254550,EBI-3913975
PMPCA [Q10713]3EBI-7254550,EBI-2514696
POGZ [Q7Z3K3]3EBI-7254550,EBI-1389308
PRKAR1B [P31321]3EBI-7254550,EBI-2805516
RAB3IP - isoform 7 [Q96QF0-7]3EBI-7254550,EBI-11984839
RALY [Q53GL6]3EBI-7254550,EBI-9512693
REL - isoform 2 [Q04864-2]3EBI-7254550,EBI-10829018
RPRD1A - isoform 2 [Q96P16-3]3EBI-7254550,EBI-12840198
RPS21 [P63220]3EBI-7254550,EBI-714051
SCNM1 [Q9BWG6]3EBI-7254550,EBI-748391
SLAIN1 [Q8ND83]3EBI-7254550,EBI-10269374
SNAI2 [O43623]3EBI-7254550,EBI-9876238
SPANXN3 [Q5MJ09]3EBI-7254550,EBI-12037215
SPATA8 [Q6RVD6]3EBI-7254550,EBI-8635958
STMN3 [Q9NZ72]3EBI-7254550,EBI-725557
TASOR2 [Q5VWN6]3EBI-7254550,EBI-745958
TBC1D22B [Q9NU19]3EBI-7254550,EBI-8787464
TEKT5 [Q96M29]3EBI-7254550,EBI-10239812
TEX43 [Q6ZNM6]3EBI-7254550,EBI-18115728
TGS1 [Q96RS0]3EBI-7254550,EBI-949244
TNNI1 [P19237]3EBI-7254550,EBI-746692
USP54 - isoform 6 [Q70EL1-9]3EBI-7254550,EBI-11975223
USP7 [Q93009]3EBI-7254550,EBI-302474
VXN [Q8TAG6]3EBI-7254550,EBI-12071548
WDR83 [Q9BRX9]3EBI-7254550,EBI-7705033
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-7254550,EBI-14104088
ZC4H2 [Q9NQZ6]5EBI-7254550,EBI-747993
ZMYM6 - isoform 4 [O95789-4]3EBI-7254550,EBI-12949277
ZNF420 [Q8TAQ5]3EBI-7254550,EBI-3923307
ZNF526 [Q8TF50]3EBI-7254550,EBI-11035148
ZNF623 [O75123]3EBI-7254550,EBI-18560922

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113448, 14 interactors

Protein interaction database and analysis system

More...IntActi		P36508, 85 interactors

Molecular INTeraction database

More...MINTi		P36508

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363064

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P36508 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P36508

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 451Add BLAST12
Repeati62 – 732Add BLAST12
Repeati88 – 993Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni34 – 993 X 12 AA approximate repeatsAdd BLAST66

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 189C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri195 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri225 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri255 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri285 – 309C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri315 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri345 – 368C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160911

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027168_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P36508

KEGG Orthology (KO)

More...KOi		K20828

Identification of Orthologs from Complete Genome Data

More...OMAi		HITFLSE

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P36508

TreeFam database of animal gene trees

More...TreeFami		TF333498

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: P36508-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ 
        60         70         80         90        100
KEALSFEDGQ PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH 
       110        120        130        140        150
PVAVPSESTI LAVQTEVGLE DLAAEDDEGF SADAVVALEQ YASKVLHDSQ 
       160        170        180        190        200
IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP 
       210        220        230        240        250
SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT 
       260        270        280        290        300
GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT 
       310        320        330        340        350
NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC 
       360        370        380        390        400
GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK 
       410        420        430        440        450
RPRIAYLSEV KEERDDIPAQ VAMVTEEDGA PQVALITQDG AQQVSLSPED 
       460        470        480        490        500
LQALGSAISM VTQHGSTTLT IPSPDADLAT SGTHTVTMVS ADGTQTQPVT 
       510        520        530        540        550
IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ QTLEEAINVA 
       560        570
TAAMQQGAVT LETTVSESGC
Length:570
Mass (Da):61,831
Last modified:May 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i333C99E0E79D86C2
GO
Isoform 1 (identifier: P36508-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-498: Missing.

Show »
Length:515
Mass (Da):56,324
Checksum:i473D193AE00E7FB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C513H7C513_HUMAN
Zinc finger protein 76
ZNF76
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX64E7EX64_HUMAN
Zinc finger protein 76
ZNF76
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W971F8W971_HUMAN
Zinc finger protein 76
ZNF76
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti334 – 335KH → ND in AAA98739 (PubMed:1427894).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03354648T → M. Corresponds to variant dbSNP:rs2228265Ensembl.1
Natural variantiVAR_033547272R → C. Corresponds to variant dbSNP:rs33959228Ensembl.1
Natural variantiVAR_033548403R → Q. Corresponds to variant dbSNP:rs35582935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006894444 – 498Missing in isoform 1. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M91592 mRNA Translation: AAA98739.1
BT007316 mRNA Translation: AAP35980.1
BC000133 mRNA Translation: AAH00133.1
BC002549 mRNA Translation: AAH02549.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4801.1 [P36508-1]
CCDS75435.1 [P36508-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A44256

NCBI Reference Sequences

More...RefSeqi		NP_001278961.1, NM_001292032.1 [P36508-2]
NP_003418.2, NM_003427.4 [P36508-1]
XP_016866738.1, XM_017011249.1 [P36508-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339411; ENSP00000344097; ENSG00000065029 [P36508-2]
ENST00000373953; ENSP00000363064; ENSG00000065029 [P36508-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7629

UCSC genome browser

More...UCSCi		uc003oki.2 human [P36508-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91592 mRNA Translation: AAA98739.1
BT007316 mRNA Translation: AAP35980.1
BC000133 mRNA Translation: AAH00133.1
BC002549 mRNA Translation: AAH02549.1
CCDSiCCDS4801.1 [P36508-1]
CCDS75435.1 [P36508-2]
PIRiA44256
RefSeqiNP_001278961.1, NM_001292032.1 [P36508-2]
NP_003418.2, NM_003427.4 [P36508-1]
XP_016866738.1, XM_017011249.1 [P36508-1]

3D structure databases

SMRiP36508
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113448, 14 interactors
IntActiP36508, 85 interactors
MINTiP36508
STRINGi9606.ENSP00000363064

PTM databases

iPTMnetiP36508
PhosphoSitePlusiP36508

Polymorphism and mutation databases

BioMutaiZNF76
DMDMi20455531

Proteomic databases

jPOSTiP36508
MassIVEiP36508
MaxQBiP36508
PaxDbiP36508
PeptideAtlasiP36508
PRIDEiP36508
ProteomicsDBi55204 [P36508-1]
55205 [P36508-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15181 127 antibodies

The DNASU plasmid repository

More...DNASUi		7629

Genome annotation databases

EnsembliENST00000339411; ENSP00000344097; ENSG00000065029 [P36508-2]
ENST00000373953; ENSP00000363064; ENSG00000065029 [P36508-1]
GeneIDi7629
KEGGihsa:7629
UCSCiuc003oki.2 human [P36508-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7629
DisGeNETi7629
EuPathDBiHostDB:ENSG00000065029.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF76
HGNCiHGNC:13149 ZNF76
HPAiENSG00000065029 Low tissue specificity
MIMi194549 gene
neXtProtiNX_P36508
OpenTargetsiENSG00000065029
PharmGKBiPA37723

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000160911
HOGENOMiCLU_027168_0_0_1
InParanoidiP36508
KOiK20828
OMAiHITFLSE
OrthoDBi1318335at2759
PhylomeDBiP36508
TreeFamiTF333498

Enzyme and pathway databases

SIGNORiP36508

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7629 2 hits in 810 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF76 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZNF76

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7629
PharosiP36508 Tbio

Protein Ontology

More...PROi		PR:P36508
RNActiP36508 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000065029 Expressed in left lobe of thyroid gland and 205 other tissues
ExpressionAtlasiP36508 baseline and differential
GenevisibleiP36508 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF76_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36508
Secondary accession number(s): Q9BQB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 2, 2002
Last modified: June 17, 2020
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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