MAP2K2

Functionⁱ

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).By similarity

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactorⁱ

Mg²⁺1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	101	ATPPROSITE-ProRule annotation		1
Active siteⁱ	194	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	78 – 86	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
MAP kinase kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8388392
metal ion binding Source: UniProtKB-KW
PDZ domain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21615688
protein serine/threonine/tyrosine kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 19565474
protein serine/threonine kinase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8388392
protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein tyrosine kinase activity Source: UniProtKB-KW
scaffold protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10409742
- 21615688

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
activation of protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ERK1 and ERK2 cascade
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24375836
MAPK cascade Source: Reactome
negative regulation of gene expression
Source: UniProtKB
Inferred from genetic interactionⁱ
- 23626836
peptidyl-serine autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 8388392
positive regulation of production of miRNAs involved in gene silencing by miRNA
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24375836
positive regulation of protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8388392
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24375836
regulation of early endosome to late endosome transport
Source: UniProtKB
Traceable author statementⁱ
- 19565474
regulation of Golgi inheritance
Source: UniProtKB
Traceable author statementⁱ
- 19565474
regulation of stress-activated MAPK cascade
Source: UniProtKB
Traceable author statementⁱ
- 19565474
signal transduction by protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
stress-activated protein kinase signaling cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.12.2 2681
Reactomeⁱ	R-HSA-112411 MAPK1 (ERK2) activation R-HSA-445144 Signal transduction by L1 R-HSA-5210891 Uptake and function of anthrax toxins R-HSA-5673000 RAF activation R-HSA-5674135 MAP2K and MAPK activation R-HSA-5674499 Negative feedback regulation of MAPK pathway R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkⁱ	P36507
SIGNORⁱ	P36507

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity mitogen-activated protein kinase kinase 2 (EC:2.7.12.21 Publication) Short name: MAP kinase kinase 2 Short name: MAPKK 2 Alternative name(s): ERK activator kinase 2 MAPK/ERK kinase 2 Short name: MEK 2
Gene namesⁱ	Name:MAP2K2 Synonyms:MEK2, MKK2, PRKMK2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126934.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6842 MAP2K2
MIMⁱ	601263 gene
neXtProtⁱ	NX_P36507

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cardiofaciocutaneous syndrome 4 (CFC4)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices.

Keywords - Diseaseⁱ

Cardiomyopathy, Disease mutation, Ectodermal dysplasia, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5605
GeneReviewsⁱ	MAP2K2
MalaCards human disease database More...MalaCardsⁱ	MAP2K2
MIMⁱ	615280 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000126934
Orphanetⁱ	1340 Cardiofaciocutaneous syndrome 638 Neurofibromatosis-Noonan syndrome
PharmGKBⁱ	PA30587

Chemistry databases

ChEMBLⁱ	CHEMBL2964
Drug and drug target database More...DrugBankⁱ	DB06616 Bosutinib DB08911 Trametinib
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2063

Polymorphism and mutation databases

BioMutaⁱ	MAP2K2
DMDMⁱ	547915

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086372	1 – 400	Dual specificity mitogen-activated protein kinase kinase 2Add BLAST		400

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	23	PhosphoserineCombined sources	1
Modified residueⁱ	222	O-acetylserine; by Yersinia yopJ; alternate1 Publication	1
Modified residueⁱ	222	Phosphoserine; by RAF; alternate2 Publications	1
Modified residueⁱ	226	O-acetylserine; by Yersinia yopJ; alternate1 Publication	1
Modified residueⁱ	226	Phosphoserine; alternate1 Publication	1
Modified residueⁱ	293	PhosphoserineCombined sources	1
Modified residueⁱ	295	PhosphoserineCombined sources	1
Modified residueⁱ	306	PhosphoserineBy similarity	1
Modified residueⁱ	394	PhosphothreonineCombined sources1 Publication	1
Modified residueⁱ	396	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).By similarity

Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	10 – 11	Cleavage; by anthrax lethal factor		2

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P36507
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P36507
PaxDbⁱ	P36507
PeptideAtlas More...PeptideAtlasⁱ	P36507
PRIDEⁱ	P36507
ProteomicsDBⁱ	55203

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00003783

REPRODUCTION-2DPAGEⁱ

IPI00003783

PTM databases

iPTMnetⁱ	P36507
PhosphoSitePlusⁱ	P36507
SwissPalmⁱ	P36507

Miscellaneous databases

PMAP-CutDBⁱ	P36507

PMAP-CutDBⁱ

P36507

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000126934 Expressed in 234 organ(s), highest expression level in testis
CleanExⁱ	HS_MAP2K2
ExpressionAtlasⁱ	P36507 baseline and differential
Genevisibleⁱ	P36507 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB003835 HPA051993

HPAⁱ

CAB003835
HPA051993

Interactionⁱ

Subunit structureⁱ

Interacts with MORG1 (By similarity). Interacts with SGK1 (PubMed:19447520). Interacts with KSR1 (PubMed:10409742).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ARAF	P10398	6	EBI-1056930,EBI-365961
BRAF	P15056	6	EBI-1056930,EBI-365980
CCNDBP1	O95273	3	EBI-1056930,EBI-748961
DLG1	Q12959	10	EBI-1056930,EBI-357481
KSR1	Q8IVT5	6	EBI-1056930,EBI-486984
RAF1	P04049	3	EBI-1056930,EBI-365996

GO - Molecular functionⁱ

PDZ domain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21615688
scaffold protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10409742
- 21615688

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111591, 47 interactors
CORUMⁱ	P36507
Database of interacting proteins More...DIPⁱ	DIP-29119N
IntActⁱ	P36507, 25 interactors
Molecular INTeraction database More...MINTⁱ	P36507
STRINGⁱ	9606.ENSP00000262948

Chemistry databases

BindingDBⁱ

P36507

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	69 – 71	Combined sources	3
Beta strandⁱ	72 – 80	Combined sources	9
Beta strandⁱ	85 – 91	Combined sources	7
Turnⁱ	92 – 94	Combined sources	3
Beta strandⁱ	97 – 103	Combined sources	7
Helixⁱ	110 – 119	Combined sources	10
Helixⁱ	120 – 122	Combined sources	3
Beta strandⁱ	133 – 148	Combined sources	16
Helixⁱ	155 – 161	Combined sources	7
Beta strandⁱ	162 – 164	Combined sources	3
Helixⁱ	167 – 186	Combined sources	20
Helixⁱ	197 – 199	Combined sources	3
Beta strandⁱ	200 – 202	Combined sources	3
Beta strandⁱ	208 – 210	Combined sources	3
Helixⁱ	217 – 222	Combined sources	6
Helixⁱ	236 – 239	Combined sources	4
Helixⁱ	246 – 262	Combined sources	17
Helixⁱ	272 – 279	Combined sources	8
Helixⁱ	318 – 327	Combined sources	10
Turnⁱ	335 – 337	Combined sources	3
Helixⁱ	340 – 349	Combined sources	10
Turnⁱ	354 – 356	Combined sources	3
Helixⁱ	360 – 364	Combined sources	5
Helixⁱ	367 – 374	Combined sources	8
Helixⁱ	379 – 386	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P36507
SMRⁱ	P36507
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P36507

EvolutionaryTraceⁱ

P36507

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	72 – 369	Protein kinasePROSITE-ProRule annotationAdd BLAST		298

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	266 – 315	Pro-richAdd BLAST		50

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0581 Eukaryota ENOG410XQ5A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
InParanoidⁱ	P36507
KEGG Orthology (KO) More...KOⁱ	K04369
OMAⁱ	IAGWVCK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DEC
PhylomeDBⁱ	P36507
TreeFamⁱ	TF105137

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P36507-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELELDEQQ 
        60         70         80         90        100
KKRLEAFLTQ KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR 
       110        120        130        140        150
KLIHLEIKPA IRNQIIRELQ VLHECNSPYI VGFYGAFYSD GEISICMEHM 
       160        170        180        190        200
DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG LAYLREKHQI MHRDVKPSNI 
       210        220        230        240        250
LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMAPERLQ GTHYSVQSDI 
       260        270        280        290        300
WSMGLSLVEL AVGRYPIPPP DAKELEAIFG RPVVDGEEGE PHSISPRPRP 
       310        320        330        340        350
PGRPVSGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTP DFQEFVNKCL 
       360        370        380        390        400
IKNPAERADL KMLTNHTFIK RSEVEEVDFA GWLCKTLRLN QPGTPTRTAV

Length:400

Mass (Da):44,424

Last modified:June 1, 1994 - v1

Checksum:ⁱ3401D522515C30A5

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G5E9C7	G5E9C7_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 2 (Mitogen-activated protein kinase kinase 2, isoform CRA_b)	MAP2K2 hCG_23544	303	Annotation score:
M0R1B6	M0R1B6_HUMAN	Dual-specificity mitogen-activated ... Dual-specificity mitogen-activated protein kinase kinase 2	MAP2K2	104	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	56	A → R AA sequence (PubMed:10409742).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_035095	57	F → C in CFC4. 1 PublicationCorresponds to variant dbSNP:rs121434497EnsemblClinVar.	1
Natural variantⁱVAR_069781	57	F → V in CFC4. 1 PublicationCorresponds to variant dbSNP:rs121434498EnsemblClinVar.	1
Natural variantⁱVAR_069782	128	P → Q in CFC4; results in increased kinase activity. 1 PublicationCorresponds to variant dbSNP:rs267607230EnsemblClinVar.	1
Natural variantⁱVAR_069783	134	Y → H in CFC4. 1 PublicationCorresponds to variant dbSNP:rs121434499EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L11285 mRNA No translation available. BC000471 mRNA Translation: AAH00471.1 BC018645 mRNA Translation: AAH18645.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12120.1
PIRⁱ	A46723
NCBI Reference Sequences More...RefSeqⁱ	NP_109587.1, NM_030662.3
UniGeneⁱ	Hs.465627

Genome annotation databases

Ensemblⁱ	ENST00000262948; ENSP00000262948; ENSG00000126934
GeneIDⁱ	5605
KEGGⁱ	hsa:5605
UCSC genome browser More...UCSCⁱ	uc002lzk.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P36507	MAP2K2 isoform 1		PANTR		400	UniRef100_P36507
Mitogen-activated protein kinase kinase 2		GORGO		400
Uncharacterized protein		PANPA		392
Dual-specificity mitogen-activated protein kinase kinase 2		HUMAN		303
MAP2K2 isoform 4		PANTR		303

Protein	Similar proteins		Species	Score	Length	Source
P36507	Dual specificity mitogen-activated protein kinase kinase 2		CANLF		400	UniRef90_P36507
Dual specificity mitogen-activated protein kinase kinase 2		CHICK		398
MAP2K2 isoform 1		PANTR		400
Mitogen-activated protein kinase kinase 2		GORGO		400
Uncharacterized protein		PANPA		392
+88

Protein	Similar proteins		Species	Score	Length	Source
P36507	Dual specificity mitogen-activated protein kinase kinase 2	)	MOUSE		401	UniRef50_Q63932
Dual specificity mitogen-activated protein kinase kinase 2		RAT		400
Dual specificity mitogen-activated protein kinase kinase 1		CRIGR		393
Dual specificity mitogen-activated protein kinase kinase 2		CANLF		400
Dual specificity mitogen-activated protein kinase kinase 2		CHICK		398
+355

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L11285 mRNA No translation available. BC000471 mRNA Translation: AAH00471.1 BC018645 mRNA Translation: AAH18645.1
CCDSⁱ	CCDS12120.1
PIRⁱ	A46723
RefSeqⁱ	NP_109587.1, NM_030662.3
UniGeneⁱ	Hs.465627

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1S9I	X-ray	3.20	A/B	55-400	[»]
	4H3Q	X-ray	2.20	B	4-16	[»]
ProteinModelPortalⁱ	P36507
SMRⁱ	P36507
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111591, 47 interactors
CORUMⁱ	P36507
DIPⁱ	DIP-29119N
IntActⁱ	P36507, 25 interactors
MINTⁱ	P36507
STRINGⁱ	9606.ENSP00000262948

Chemistry databases

BindingDBⁱ	P36507
ChEMBLⁱ	CHEMBL2964
DrugBankⁱ	DB06616 Bosutinib DB08911 Trametinib
GuidetoPHARMACOLOGYⁱ	2063

PTM databases

iPTMnetⁱ	P36507
PhosphoSitePlusⁱ	P36507
SwissPalmⁱ	P36507

Polymorphism and mutation databases

BioMutaⁱ	MAP2K2
DMDMⁱ	547915

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00003783

REPRODUCTION-2DPAGEⁱ

IPI00003783

Proteomic databases

EPDⁱ	P36507
MaxQBⁱ	P36507
PaxDbⁱ	P36507
PeptideAtlasⁱ	P36507
PRIDEⁱ	P36507
ProteomicsDBⁱ	55203

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5605
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262948; ENSP00000262948; ENSG00000126934
GeneIDⁱ	5605
KEGGⁱ	hsa:5605
UCSCⁱ	uc002lzk.4 human

Organism-specific databases

CTDⁱ	5605
DisGeNETⁱ	5605
EuPathDBⁱ	HostDB:ENSG00000126934.13
GeneCardsⁱ	MAP2K2
GeneReviewsⁱ	MAP2K2
H-InvDBⁱ	HIX0033655
HGNCⁱ	HGNC:6842 MAP2K2
HPAⁱ	CAB003835 HPA051993
MalaCardsⁱ	MAP2K2
MIMⁱ	601263 gene 615280 phenotype
neXtProtⁱ	NX_P36507
OpenTargetsⁱ	ENSG00000126934
Orphanetⁱ	1340 Cardiofaciocutaneous syndrome 638 Neurofibromatosis-Noonan syndrome
PharmGKBⁱ	PA30587
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0581 Eukaryota ENOG410XQ5A LUCA
GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
InParanoidⁱ	P36507
KOⁱ	K04369
OMAⁱ	IAGWVCK
OrthoDBⁱ	EOG091G0DEC
PhylomeDBⁱ	P36507
TreeFamⁱ	TF105137

Enzyme and pathway databases

BRENDAⁱ	2.7.12.2 2681
Reactomeⁱ	R-HSA-112411 MAPK1 (ERK2) activation R-HSA-445144 Signal transduction by L1 R-HSA-5210891 Uptake and function of anthrax toxins R-HSA-5673000 RAF activation R-HSA-5674135 MAP2K and MAPK activation R-HSA-5674499 Negative feedback regulation of MAPK pathway R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
SignaLinkⁱ	P36507
SIGNORⁱ	P36507

Miscellaneous databases

ChiTaRSⁱ	MAP2K2 human
EvolutionaryTraceⁱ	P36507
GeneWikiⁱ	MAP2K2
GenomeRNAiⁱ	5605
PMAP-CutDBⁱ	P36507
Protein Ontology More...PROⁱ	PR:P36507
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000126934 Expressed in 234 organ(s), highest expression level in testis
CleanExⁱ	HS_MAP2K2
ExpressionAtlasⁱ	P36507 baseline and differential
Genevisibleⁱ	P36507 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MP2K2_HUMAN
Accessionⁱ	P36507Primary (citable) accession number: P36507
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 211 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - P36507 (MP2K2_HUMAN)

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Dual specificity mitogen-activated protein kinase kinase 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Golgi apparatus

Mitochondrion

Nucleus

Peroxisome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ