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Entry version 195 (26 Feb 2020)
Sequence version 1 (01 Jun 1994)
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Protein

E3 ubiquitin-protein ligase TRIM23

Gene

TRIM23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).2 Publications
(Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri31 – 76RING-type; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri122 – 168B box-type; degeneratePROSITE-ProRule annotationAdd BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi411 – 418GTPBy similarity8
Nucleotide bindingi454 – 458GTPBy similarity5
Nucleotide bindingi513 – 516GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processHost-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM23 (EC:2.3.2.27)
Alternative name(s):
ADP-ribosylation factor domain-containing protein 1
GTP-binding protein ARD-1
RING finger protein 46
RING-type E3 ubiquitin transferase TRIM23Curated
Tripartite motif-containing protein 23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM23
Synonyms:ARD1, ARFD1, RNF46
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:660 TRIM23

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601747 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P36406

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi34C → A: Loss of E3 ubiquitin-protein ligase activity. 1 Publication1
Mutagenesisi53H → A: Loss of E3 ubiquitin-protein ligase activity. 1 Publication1
Mutagenesisi418T → N: Maintains GTPase activity. Increases interaction with PSCD1. 1 Publication1
Mutagenesisi458K → I: Suppresses GTPase activity. Decreases interaction with PSCD1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
373

Open Targets

More...
OpenTargetsi
ENSG00000113595

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24943

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P36406 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM23

Domain mapping of disease mutations (DMDM)

More...
DMDMi
543839

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002074831 – 574E3 ubiquitin-protein ligase TRIM23Add BLAST574

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P36406

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P36406

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P36406

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P36406

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36406

PeptideAtlas

More...
PeptideAtlasi
P36406

PRoteomics IDEntifications database

More...
PRIDEi
P36406

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55200 [P36406-1]
55201 [P36406-2]
55202 [P36406-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36406

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P36406

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113595 Expressed in corpus callosum and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P36406 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P36406 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039605

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with PSCD1.

Interacts with UBE2D2 (PubMed:28681414).

Interacts with TBK1 (via N-terminal kinase domain) and p62/SQSTM1.

3 Publications

(Microbial infection) Interacts with human cytomegalovirus protein UL144; this interaction might cause autoubiquitination of TRAF6, leading to NF-kappa-B activation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-740098,EBI-740098
A0A0S2Z3G13EBI-740098,EBI-16430749
Q96IX93EBI-740098,EBI-744859
P299725EBI-740098,EBI-745213
Q8N6T33EBI-740098,EBI-716933
Q9NR813EBI-740098,EBI-10312733
Q8N5M16EBI-740098,EBI-1166928
Q999335EBI-740098,EBI-1030678
Q0VDD74EBI-740098,EBI-741210
Q9H7E93EBI-740098,EBI-715389
Q9H2573EBI-740098,EBI-751319
Q8IYE0-23EBI-740098,EBI-10247802
Q86WR03EBI-740098,EBI-2690264
Q86Y333EBI-740098,EBI-10260504
Q018505EBI-740098,EBI-1181367
Q96M913EBI-740098,EBI-742422
P106064EBI-740098,EBI-1053725
Q02930-33EBI-740098,EBI-10192698
O957153EBI-740098,EBI-2798068
O436023EBI-740098,EBI-8646694
Q145653EBI-740098,EBI-930865
Q9NQL93EBI-740098,EBI-9679045
Q926083EBI-740098,EBI-448771
Q96CJ13EBI-740098,EBI-1245604
Q8N2X65EBI-740098,EBI-749333
Q9BQ895EBI-740098,EBI-1752811
Q8N9E05EBI-740098,EBI-10268158
Q96PV7-23EBI-740098,EBI-10292648
Q86UY53EBI-740098,EBI-1384254
Q86YD75EBI-740098,EBI-6658203
Q8TES7-63EBI-740098,EBI-10244131
C0H5X23EBI-740098,EBI-10176227
A0A0S2Z4D93EBI-740098,EBI-16430771
P237693EBI-740098,EBI-2806671
P550405EBI-740098,EBI-744104
Q8NEA93EBI-740098,EBI-745707
O958725EBI-740098,EBI-751540
Q929173EBI-740098,EBI-746309
Q96CS23EBI-740098,EBI-2514791
P090222EBI-740098,EBI-3957603From Mus musculus.
P090675EBI-740098,EBI-3893317
Q9UBY93EBI-740098,EBI-739361
Q8NA545EBI-740098,EBI-10220600
Q150403EBI-740098,EBI-2510602
Q929933EBI-740098,EBI-399080
Q9BVG83EBI-740098,EBI-2125614
Q9P2K65EBI-740098,EBI-739890
P025388EBI-740098,EBI-702198
O002143EBI-740098,EBI-740058
Q96FQ73EBI-740098,EBI-10286106
P257913EBI-740098,EBI-739696
Q8NDC45EBI-740098,EBI-10269566
Q9BYD33EBI-740098,EBI-721368
Q9BRJ23EBI-740098,EBI-2514313
Q6P4443EBI-740098,EBI-10252703
Q9HC983EBI-740098,EBI-740364
Q9UMS03EBI-740098,EBI-725252
Q9NPJ83EBI-740098,EBI-752122
O431893EBI-740098,EBI-530034
O759283EBI-740098,EBI-348555
O004593EBI-740098,EBI-346930
P783373EBI-740098,EBI-748265
Q995693EBI-740098,EBI-726447
Q9UGP5-23EBI-740098,EBI-10320765
Q133563EBI-740098,EBI-7705988
Q6NYC83EBI-740098,EBI-2557469
P257865EBI-740098,EBI-359352
Q9BTL35EBI-740098,EBI-744023
Q63HN8-63EBI-740098,EBI-10248548
A0A0S2Z4G93EBI-740098,EBI-16428950
Q7L4I2-23EBI-740098,EBI-10256202
Q14D333EBI-740098,EBI-10217913
Q9H7883EBI-740098,EBI-747035
Q9H788-23EBI-740098,EBI-10308083
Q8IUQ43EBI-740098,EBI-747107
P122363EBI-740098,EBI-356254
Q9H0W85EBI-740098,EBI-2872322
O958635EBI-740098,EBI-1045459
O436233EBI-740098,EBI-9876238
P14678-23EBI-740098,EBI-372475
O605045EBI-740098,EBI-741237
Q9NZD83EBI-740098,EBI-742688
B7ZLI83EBI-740098,EBI-10176124
G2XKQ03EBI-740098,EBI-10175576
Q5VWN6-23EBI-740098,EBI-10172380
Q9NU195EBI-740098,EBI-8787464
Q0P5Q03EBI-740098,EBI-10226570
P215805EBI-740098,EBI-527670
Q130773EBI-740098,EBI-359224
Q0P6H73EBI-740098,EBI-10226710
Q141343EBI-740098,EBI-702370
Q8IWZ53EBI-740098,EBI-5235829
Q9BYV62EBI-740098,EBI-2341179
Q128155EBI-740098,EBI-2349743
Q63HK53EBI-740098,EBI-9053916
Q86UY03EBI-740098,EBI-2825190
Q7KZS03EBI-740098,EBI-10180829
Q9Y2K63EBI-740098,EBI-2511991
Q9BRU93EBI-740098,EBI-5457544
Q64LD23EBI-740098,EBI-744560
Q53FD03EBI-740098,EBI-740767
Q8TBZ85EBI-740098,EBI-10273713
Q9P0T46EBI-740098,EBI-745520
A0A0S2Z5X43EBI-740098,EBI-16429014
A0A0S2Z6P03EBI-740098,EBI-16429989

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106868, 170 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P36406

Protein interaction database and analysis system

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IntActi
P36406, 217 interactors

Molecular INTeraction database

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MINTi
P36406

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000231524

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P36406 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P36406

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni390 – 574ARF-likeAdd BLAST185

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili352 – 379Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity. This domain is catalytically active as a dimer.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the small GTPase superfamily. Arf family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 76RING-type; degeneratePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri122 – 168B box-type; degeneratePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0070 Eukaryota
KOG4185 Eukaryota
ENOG410ZGPK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158562

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_033905_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36406

KEGG Orthology (KO)

More...
KOi
K07963

Identification of Orthologs from Complete Genome Data

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OMAi
SHTASMY

Database of Orthologous Groups

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OrthoDBi
1362554at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P36406

TreeFam database of animal gene trees

More...
TreeFami
TF320703

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003649 Bbox_C
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR013087 Znf_C2H2_type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00025 Arf, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00328 SAR1GTPBP

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00231 small_GTP, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51417 ARF, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: P36406-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATLVVNKLG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL
60 70 80 90 100
CGHTVCHDCL TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE
110 120 130 140 150
RLQNGPIGQY GAAEESIGIS GESIIRCDED EAHLASVYCT VCATHLCSEC
160 170 180 190 200
SQVTHSTKTL AKHRRVPLAD KPHEKTMCSQ HQVHAIEFVC LEEGCQTSPL
210 220 230 240 250
MCCVCKEYGK HQGHKHSVLE PEANQIRASI LDMAHCIRTF TEEISDYSRK
260 270 280 290 300
LVGIVQHIEG GEQIVEDGIG MAHTEHVPGT AENARSCIRA YFYDLHETLC
310 320 330 340 350
RQEEMALSVV DAHVREKLIW LRQQQEDMTI LLSEVSAACL HCEKTLQQDD
360 370 380 390 400
CRVVLAKQEI TRLLETLQKQ QQQFTEVADH IQLDASIPVT FTKDNRVHIG
410 420 430 440 450
PKMEIRVVTL GLDGAGKTTI LFKLKQDEFM QPIPTIGFNV ETVEYKNLKF
460 470 480 490 500
TIWDVGGKHK LRPLWKHYYL NTQAVVFVVD SSHRDRISEA HSELAKLLTE
510 520 530 540 550
KELRDALLLI FANKQDVAGA LSVEEITELL SLHKLCCGRS WYIQGCDARS
560 570
GMGLYEGLDW LSRQLVAAGV LDVA
Length:574
Mass (Da):64,067
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB85923B29BF0320
GO
Isoform Beta (identifier: P36406-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-574: GMGLYEGLDWLSRQLVAAGVLDVA → VFQIICDQYTGKEVVTEKG

Show »
Length:569
Mass (Da):63,690
Checksum:i21399953A4224B7A
GO
Isoform Gamma (identifier: P36406-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     541-574: WYIQGCDARSGMGLYEGLDWLSRQLVAAGVLDVA → CFSDNM

Show »
Length:546
Mass (Da):61,068
Checksum:iD21D92EED6E967A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBN4D6RBN4_HUMAN
E3 ubiquitin-protein ligase TRIM23
TRIM23
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9E9D6R9E9_HUMAN
E3 ubiquitin-protein ligase TRIM23
TRIM23
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD22D6RD22_HUMAN
E3 ubiquitin-protein ligase TRIM23
TRIM23
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048320480D → N. Corresponds to variant dbSNP:rs34046496Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000297541 – 574WYIQG…VLDVA → CFSDNM in isoform Gamma. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_000296551 – 574GMGLY…VLDVA → VFQIICDQYTGKEVVTEKG in isoform Beta. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L04510 mRNA Translation: AAA35940.1
AF230397 mRNA Translation: AAG50176.1
AF230398 mRNA Translation: AAG50177.1
AF230399 mRNA Translation: AAG50178.1
BC022510 mRNA Translation: AAH22510.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3986.1 [P36406-3]
CCDS3987.1 [P36406-1]
CCDS43322.1 [P36406-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A46054

NCBI Reference Sequences

More...
RefSeqi
NP_001647.1, NM_001656.3 [P36406-1]
NP_150230.1, NM_033227.2 [P36406-2]
NP_150231.1, NM_033228.2 [P36406-3]
XP_016864933.1, XM_017009444.1 [P36406-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000231524; ENSP00000231524; ENSG00000113595 [P36406-1]
ENST00000274327; ENSP00000274327; ENSG00000113595 [P36406-3]
ENST00000381018; ENSP00000370406; ENSG00000113595 [P36406-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
373

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:373

UCSC genome browser

More...
UCSCi
uc003jtw.4 human [P36406-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04510 mRNA Translation: AAA35940.1
AF230397 mRNA Translation: AAG50176.1
AF230398 mRNA Translation: AAG50177.1
AF230399 mRNA Translation: AAG50178.1
BC022510 mRNA Translation: AAH22510.1
CCDSiCCDS3986.1 [P36406-3]
CCDS3987.1 [P36406-1]
CCDS43322.1 [P36406-2]
PIRiA46054
RefSeqiNP_001647.1, NM_001656.3 [P36406-1]
NP_150230.1, NM_033227.2 [P36406-2]
NP_150231.1, NM_033228.2 [P36406-3]
XP_016864933.1, XM_017009444.1 [P36406-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VZVX-ray1.81A/B/C1-123[»]
5VZWX-ray2.28F/G1-123[»]
SMRiP36406
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106868, 170 interactors
CORUMiP36406
IntActiP36406, 217 interactors
MINTiP36406
STRINGi9606.ENSP00000231524

PTM databases

iPTMnetiP36406
PhosphoSitePlusiP36406

Polymorphism and mutation databases

BioMutaiTRIM23
DMDMi543839

Proteomic databases

EPDiP36406
jPOSTiP36406
MassIVEiP36406
MaxQBiP36406
PaxDbiP36406
PeptideAtlasiP36406
PRIDEiP36406
ProteomicsDBi55200 [P36406-1]
55201 [P36406-2]
55202 [P36406-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
373

Genome annotation databases

EnsembliENST00000231524; ENSP00000231524; ENSG00000113595 [P36406-1]
ENST00000274327; ENSP00000274327; ENSG00000113595 [P36406-3]
ENST00000381018; ENSP00000370406; ENSG00000113595 [P36406-2]
GeneIDi373
KEGGihsa:373
UCSCiuc003jtw.4 human [P36406-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
373
DisGeNETi373

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM23
HGNCiHGNC:660 TRIM23
HPAiHPA039605
MIMi601747 gene
neXtProtiNX_P36406
OpenTargetsiENSG00000113595
PharmGKBiPA24943

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
KOG4185 Eukaryota
ENOG410ZGPK LUCA
GeneTreeiENSGT00940000158562
HOGENOMiCLU_033905_0_0_1
InParanoidiP36406
KOiK07963
OMAiSHTASMY
OrthoDBi1362554at2759
PhylomeDBiP36406
TreeFamiTF320703

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRIM23

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
373
PharosiP36406 Tbio

Protein Ontology

More...
PROi
PR:P36406
RNActiP36406 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113595 Expressed in corpus callosum and 210 other tissues
ExpressionAtlasiP36406 baseline and differential
GenevisibleiP36406 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR013087 Znf_C2H2_type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
PRINTSiPR00328 SAR1GTPBP
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00184 RING, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI23_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36406
Secondary accession number(s): Q9BZY4, Q9BZY5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 26, 2020
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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