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UniProtKB - P36402 (TCF7_HUMAN)

Entry version 195 (11 Dec 2019)
Sequence version 3 (14 Oct 2008)
Previous versions | rss
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Protein

Transcription factor 7

Gene

TCF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi269 – 337HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-4086398 Ca2+ pathway
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-4641265 Repression of WNT target genes
R-HSA-8951430 RUNX3 regulates WNT signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P36402

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor 7
Short name:
TCF-7
Alternative name(s):
T-cell-specific transcription factor 1
Short name:
T-cell factor 1
Short name:
TCF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCF7
Synonyms:TCF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000081059.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:11639 TCF7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		189908 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P36402

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6932

Open Targets

More...OpenTargetsi		ENSG00000081059

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36392

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P36402 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TCF7

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572716

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000486121 – 384Transcription factor 7Add BLAST384

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P36402

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P36402

MaxQB - The MaxQuant DataBase

More...MaxQBi		P36402

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P36402

PeptideAtlas

More...PeptideAtlasi		P36402

PRoteomics IDEntifications database

More...PRIDEi		P36402

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55182 [P36402-1]
55183 [P36402-10]
55184 [P36402-11]
55185 [P36402-12]
55186 [P36402-13]
55187 [P36402-14]
55188 [P36402-15]
55189 [P36402-16]
55190 [P36402-2]
55191 [P36402-3]
55192 [P36402-4]
55193 [P36402-5]
55194 [P36402-6]
55195 [P36402-7]
55196 [P36402-8]
55197 [P36402-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P36402

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P36402

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TCF7L2 and CTNNB1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000081059 Expressed in 236 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P36402 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P36402 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB019403
HPA058863
HPA070505

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439 PubMed:9783587).

Interacts with TLE5, TLE1, TLE2, TLE3 and TLE4 (PubMed:9783587, PubMed:11266540).

Interacts with MLLT11 (PubMed:26079538).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112794, 6 interactors

Protein interaction database and analysis system

More...IntActi		P36402, 4 interactors

Molecular INTeraction database

More...MINTi		P36402

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340347

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P36402 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P36402

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59CTNNB1-bindingAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi344 – 348Nuclear localization signalSequence analysis5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCF/LEF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3248 Eukaryota
ENOG41109RU LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000116032

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P36402

KEGG Orthology (KO)

More...KOi		K02620

Database of Orthologous Groups

More...OrthoDBi		807716at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P36402

TreeFam database of animal gene trees

More...TreeFami		TF318448

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.30.10, 1 hit
4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028785 Tcf7

The PANTHER Classification System

More...PANTHERi		PTHR10373 PTHR10373, 1 hit
PTHR10373:SF33 PTHR10373:SF33, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 16 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: 2 series of isoforms, L and S, are produced by alternative promoter usage. Additional isoforms seem to exist.

This entry has 16 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4L (identifier: P36402-1) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE 
        60         70         80         90        100
LKSSLVNESE GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP 
       110        120        130        140        150
EPLEDGLKAP ECTSGMYKET VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA 
       160        170        180        190        200
NQPPHGVPQL SLYEHFNSPH PTPAPADISQ KQVHRPLQTP DLSGFYSLTS 
       210        220        230        240        250
GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS GKQELQPFDR 
       260        270        280        290        300
NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 
       310        320        330        340        350
QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR 
       360        370        380 
EKHQESTTET NWPRELKDGN GQESLSMSSS SSPA
Length:384
Mass (Da):41,642
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5088C962F2FD0C00
GO
Isoform 4S (identifier: P36402-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Show »
Length:269
Mass (Da):30,264
Checksum:iA90EE1E4E0BEE297
GO
Isoform 1L (identifier: P36402-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4L.Curated
Show »
Length:495
Mass (Da):54,125
Checksum:i4CDFAA0BD5A4F7B5
GO
Isoform 1S (identifier: P36402-4) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4S.Curated
Show »
Length:380
Mass (Da):42,748
Checksum:i886503B2EBAFB4AB
GO
Isoform 5L (identifier: P36402-9) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

Note: Produced by alternative splicing of isoform 4L.Curated
Show »
Length:365
Mass (Da):39,681
Checksum:iA9CFD9CEC784F0D3
GO
Isoform 5S (identifier: P36402-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

Note: Produced by alternative splicing of isoform 4S.Curated
Show »
Length:250
Mass (Da):28,304
Checksum:iDDB6697E17A5DDAC
GO
Isoform 6L (identifier: P36402-11) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4L.Curated
Show »
Length:494
Mass (Da):53,969
Checksum:i497A6AF1BCC0E439
GO
Isoform 6S (identifier: P36402-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4S.Curated
Show »
Length:379
Mass (Da):42,592
Checksum:i83D3D3CFB783FAAC
GO
Isoform 7L (identifier: P36402-13) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

Note: Produced by alternative splicing of isoform 4L.Curated
Show »
Length:369
Mass (Da):39,933
Checksum:iB742838D4DCA35EE
GO
Isoform 7S (identifier: P36402-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

Note: Produced by alternative splicing of isoform 4S.Curated
Show »
Length:254
Mass (Da):28,556
Checksum:i18750F35A9B3855E
GO
Isoform 8L (identifier: P36402-15) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

Note: Produced by alternative splicing of isoform 4L.Curated
Show »
Length:370
Mass (Da):40,347
Checksum:i02C826CE6F741E3B
GO
Isoform 8S (identifier: P36402-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

Note: Produced by alternative splicing of isoform 4S.Curated
Show »
Length:255
Mass (Da):28,970
Checksum:iF7671142D790678B
GO
Isoform 2L (identifier: P36402-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

Note: Produced by alternative splicing of isoform 4L.Curated
Show »
Length:384
Mass (Da):41,552
Checksum:i004644F8B23D9484
GO
Isoform 2S (identifier: P36402-6) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

Note: Produced by alternative splicing of isoform 4S.Curated
Show »
Length:269
Mass (Da):30,175
Checksum:iF9C06C7EA07E7A13
GO
Isoform 3L (identifier: P36402-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

Note: Produced by alternative splicing of isoform 4L.Curated
Show »
Length:383
Mass (Da):41,668
Checksum:iD6C1D30018F796DA
GO
Isoform 3S (identifier: P36402-8) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

Note: Produced by alternative splicing of isoform 4S.Curated
Show »
Length:268
Mass (Da):30,291
Checksum:i60E955125B190163
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WNT5B7WNT5_HUMAN
Transcription factor 7
TCF7 hCG_16589
481Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG75E5RG75_HUMAN
Transcription factor 7
TCF7
147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBC8H0YBC8_HUMAN
Transcription factor 7
TCF7
204Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHL1E5RHL1_HUMAN
Transcription factor 7
TCF7
143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAR8H0YAR8_HUMAN
Transcription factor 7
TCF7
147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG34E5RG34_HUMAN
Transcription factor 7
TCF7
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGQ1E5RGQ1_HUMAN
Transcription factor 7
TCF7
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ51E5RJ51_HUMAN
Transcription factor 7
TCF7
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBM1H0YBM1_HUMAN
Transcription factor 7
TCF7
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBP2H0YBP2_HUMAN
Transcription factor 7
TCF7
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA87441 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21D → N in AAF00616 (PubMed:10489374).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0069611 – 115Missing in isoform 1S, isoform 2S, isoform 3S, isoform 4S, isoform 5S, isoform 6S, isoform 7S and isoform 8S. 2 PublicationsAdd BLAST115
Alternative sequenceiVSP_006960359 – 384ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRRKKKCIRYLPGEGRC PSPVPSDDSALGCPGSPAPQ DSPSYHLLPRFPTELLTSPA ERHLHPQVSPLLSASQPQGP HRPPAAPCRAHRYSNRNLRD RWPSRHRTPGRLQEPTP in isoform 1L and isoform 1S. CuratedAdd BLAST26
Alternative sequenceiVSP_002191359 – 384ETNWP…SSSPA → GGKRNAFGTYPEKAAAPAPF LPMTVL in isoform 2L and isoform 2S. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_002192359 – 384ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCR in isoform 3L and isoform 3S. CuratedAdd BLAST26
Alternative sequenceiVSP_012160359 – 384ETNWP…SSSPA → DNSLHYS in isoform 5L and isoform 5S. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012161359 – 384ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRKKKCIRYLPGEGRCP SPVPSDDSALGCPGSPAPQD SPSYHLLPRFPTELLTSPAE RHLHPQVSPLLSASQPQGPH RPPAAPCRAHRYSNRNLRDR WPSRHRTPGRLQEPTP in isoform 6L and isoform 6S. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012162359 – 384ETNWP…SSSPA → DGIPACTILSP in isoform 7L and isoform 7S. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012163359 – 384ETNWP…SSSPA → QLEDWDGWARKP in isoform 8L and isoform 8S. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X59869 mRNA Translation: CAA42526.1
X59870 mRNA Translation: CAA42527.1
X59871 mRNA Translation: CAA42528.1
X63901 Genomic DNA Translation: CAB56795.1
Z47361 mRNA Translation: CAA87439.1
Z47362 mRNA Translation: CAA87440.1
Z47363 mRNA Translation: CAA87441.1 Sequence problems.
Z47364 mRNA Translation: CAA87442.1
AK093530 mRNA Translation: BAG52735.1
CH471062 Genomic DNA Translation: EAW62277.1
BC048769 mRNA Translation: AAH48769.1
BC072023 mRNA Translation: AAH72023.1
AF163776 Genomic DNA Translation: AAF00616.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4169.1 [P36402-5]
CCDS4170.1 [P36402-6]
CCDS43362.1 [P36402-8]
CCDS47263.2 [P36402-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A38095
B38095
C38095
D38095
S61796

NCBI Reference Sequences

More...RefSeqi		NP_001128323.2, NM_001134851.3 [P36402-2]
NP_001333354.1, NM_001346425.1
NP_001333379.1, NM_001346450.1
NP_003193.2, NM_003202.4 [P36402-5]
NP_963963.1, NM_201632.4 [P36402-6]
NP_963965.1, NM_201634.4 [P36402-8]
NP_998813.1, NM_213648.4 [P36402-6]
XP_006714747.1, XM_006714684.2 [P36402-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342854; ENSP00000340347; ENSG00000081059 [P36402-5]
ENST00000378560; ENSP00000367822; ENSG00000081059 [P36402-8]
ENST00000395023; ENSP00000378469; ENSG00000081059 [P36402-6]
ENST00000518915; ENSP00000430179; ENSG00000081059 [P36402-2]
ENST00000520958; ENSP00000429547; ENSG00000081059 [P36402-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6932

UCSC genome browser

More...UCSCi		uc003kyt.4 human [P36402-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59869 mRNA Translation: CAA42526.1
X59870 mRNA Translation: CAA42527.1
X59871 mRNA Translation: CAA42528.1
X63901 Genomic DNA Translation: CAB56795.1
Z47361 mRNA Translation: CAA87439.1
Z47362 mRNA Translation: CAA87440.1
Z47363 mRNA Translation: CAA87441.1 Sequence problems.
Z47364 mRNA Translation: CAA87442.1
AK093530 mRNA Translation: BAG52735.1
CH471062 Genomic DNA Translation: EAW62277.1
BC048769 mRNA Translation: AAH48769.1
BC072023 mRNA Translation: AAH72023.1
AF163776 Genomic DNA Translation: AAF00616.1
CCDSiCCDS4169.1 [P36402-5]
CCDS4170.1 [P36402-6]
CCDS43362.1 [P36402-8]
CCDS47263.2 [P36402-2]
PIRiA38095
B38095
C38095
D38095
S61796
RefSeqiNP_001128323.2, NM_001134851.3 [P36402-2]
NP_001333354.1, NM_001346425.1
NP_001333379.1, NM_001346450.1
NP_003193.2, NM_003202.4 [P36402-5]
NP_963963.1, NM_201632.4 [P36402-6]
NP_963965.1, NM_201634.4 [P36402-8]
NP_998813.1, NM_213648.4 [P36402-6]
XP_006714747.1, XM_006714684.2 [P36402-9]

3D structure databases

SMRiP36402
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112794, 6 interactors
IntActiP36402, 4 interactors
MINTiP36402
STRINGi9606.ENSP00000340347

PTM databases

iPTMnetiP36402
PhosphoSitePlusiP36402

Polymorphism and mutation databases

BioMutaiTCF7
DMDMi209572716

Proteomic databases

jPOSTiP36402
MassIVEiP36402
MaxQBiP36402
PaxDbiP36402
PeptideAtlasiP36402
PRIDEiP36402
ProteomicsDBi55182 [P36402-1]
55183 [P36402-10]
55184 [P36402-11]
55185 [P36402-12]
55186 [P36402-13]
55187 [P36402-14]
55188 [P36402-15]
55189 [P36402-16]
55190 [P36402-2]
55191 [P36402-3]
55192 [P36402-4]
55193 [P36402-5]
55194 [P36402-6]
55195 [P36402-7]
55196 [P36402-8]
55197 [P36402-9]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6932

Genome annotation databases

EnsembliENST00000342854; ENSP00000340347; ENSG00000081059 [P36402-5]
ENST00000378560; ENSP00000367822; ENSG00000081059 [P36402-8]
ENST00000395023; ENSP00000378469; ENSG00000081059 [P36402-6]
ENST00000518915; ENSP00000430179; ENSG00000081059 [P36402-2]
ENST00000520958; ENSP00000429547; ENSG00000081059 [P36402-6]
GeneIDi6932
KEGGihsa:6932
UCSCiuc003kyt.4 human [P36402-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6932
DisGeNETi6932
EuPathDBiHostDB:ENSG00000081059.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		TCF7
HGNCiHGNC:11639 TCF7
HPAiCAB019403
HPA058863
HPA070505
MIMi189908 gene
neXtProtiNX_P36402
OpenTargetsiENSG00000081059
PharmGKBiPA36392

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00940000159831
HOGENOMiHOG000116032
InParanoidiP36402
KOiK02620
OrthoDBi807716at2759
PhylomeDBiP36402
TreeFamiTF318448

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-4086398 Ca2+ pathway
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-4641265 Repression of WNT target genes
R-HSA-8951430 RUNX3 regulates WNT signaling
SIGNORiP36402

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TCF7 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TCF7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6932
PharosiP36402 Tbio

Protein Ontology

More...PROi		PR:P36402
RNActiP36402 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000081059 Expressed in 236 organ(s), highest expression level in thymus
ExpressionAtlasiP36402 baseline and differential
GenevisibleiP36402 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028785 Tcf7
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF33 PTHR10373:SF33, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCF7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36402
Secondary accession number(s): B3KSH3, Q86WR9, Q9UKI4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 14, 2008
Last modified: December 11, 2019
This is version 195 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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