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UniProtKB - P36402 (TCF7_HUMAN)

Protein

Transcription factor 7

Gene

TCF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi269 – 337HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-4086398 Ca2+ pathway
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-4641265 Repression of WNT target genes
R-HSA-8951430 RUNX3 regulates WNT signaling
SIGNORiP36402

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 7
Short name:
TCF-7
Alternative name(s):
T-cell-specific transcription factor 1
Short name:
T-cell factor 1
Short name:
TCF-1
Gene namesi
Name:TCF7
Synonyms:TCF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000081059.19
HGNCiHGNC:11639 TCF7
MIMi189908 gene
neXtProtiNX_P36402

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6932
OpenTargetsiENSG00000081059
PharmGKBiPA36392

Polymorphism and mutation databases

BioMutaiTCF7
DMDMi209572716

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000486121 – 384Transcription factor 7Add BLAST384

Proteomic databases

MaxQBiP36402
PaxDbiP36402
PeptideAtlasiP36402
PRIDEiP36402
ProteomicsDBi55182
55183 [P36402-10]
55184 [P36402-11]
55185 [P36402-12]
55186 [P36402-13]
55187 [P36402-14]
55188 [P36402-15]
55189 [P36402-16]
55190 [P36402-2]
55191 [P36402-3]
55192 [P36402-4]
55193 [P36402-5]
55194 [P36402-6]
55195 [P36402-7]
55196 [P36402-8]
55197 [P36402-9]

PTM databases

iPTMnetiP36402
PhosphoSitePlusiP36402

Expressioni

Tissue specificityi

Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.1 Publication

Inductioni

By TCF7L2 and CTNNB1.1 Publication

Gene expression databases

BgeeiENSG00000081059 Expressed in 236 organ(s), highest expression level in thymus
CleanExiHS_TCF7
ExpressionAtlasiP36402 baseline and differential
GenevisibleiP36402 HS

Organism-specific databases

HPAiCAB019403
HPA058863
HPA070505

Interactioni

Subunit structurei

Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439 PubMed:9783587). Interacts with AES, TLE1, TLE2, TLE3 and TLE4 (PubMed:9783587, PubMed:11266540). Interacts with MLLT11 (PubMed:26079538).4 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112794, 3 interactors
IntActiP36402, 4 interactors
MINTiP36402
STRINGi9606.ENSP00000340347

Structurei

3D structure databases

ProteinModelPortaliP36402
SMRiP36402
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 59CTNNB1-bindingAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi344 – 348Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the TCF/LEF family.Curated

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00390000009964
HOGENOMiHOG000116032
HOVERGENiHBG000419
InParanoidiP36402
KOiK02620
PhylomeDBiP36402
TreeFamiTF318448

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028785 Tcf7
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF33 PTHR10373:SF33, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequences (16+)i

Sequence statusi: Complete.

This entry describes 16 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: 2 series of isoforms, L and S, are produced by alternative promoter usage. Additional isoforms seem to exist.

This entry has 16 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4L (identifier: P36402-1) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE 
        60         70         80         90        100
LKSSLVNESE GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP 
       110        120        130        140        150
EPLEDGLKAP ECTSGMYKET VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA 
       160        170        180        190        200
NQPPHGVPQL SLYEHFNSPH PTPAPADISQ KQVHRPLQTP DLSGFYSLTS 
       210        220        230        240        250
GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS GKQELQPFDR 
       260        270        280        290        300
NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN 
       310        320        330        340        350
QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR 
       360        370        380 
EKHQESTTET NWPRELKDGN GQESLSMSSS SSPA
Length:384
Mass (Da):41,642
Last modified:October 14, 2008 - v3
Checksum:i5088C962F2FD0C00
GO
Isoform 4S (identifier: P36402-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Show »
Length:269
Mass (Da):30,264
Checksum:iA90EE1E4E0BEE297
GO
Isoform 1L (identifier: P36402-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4L.
Show »
Length:495
Mass (Da):54,125
Checksum:i4CDFAA0BD5A4F7B5
GO
Isoform 1S (identifier: P36402-4) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4S.
Show »
Length:380
Mass (Da):42,748
Checksum:i886503B2EBAFB4AB
GO
Isoform 5L (identifier: P36402-9) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

Note: Produced by alternative splicing of isoform 4L.
Show »
Length:365
Mass (Da):39,681
Checksum:iA9CFD9CEC784F0D3
GO
Isoform 5S (identifier: P36402-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS

Note: Produced by alternative splicing of isoform 4S.
Show »
Length:250
Mass (Da):28,304
Checksum:iDDB6697E17A5DDAC
GO
Isoform 6L (identifier: P36402-11) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4L.
Show »
Length:494
Mass (Da):53,969
Checksum:i497A6AF1BCC0E439
GO
Isoform 6S (identifier: P36402-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP

Note: Produced by alternative splicing of isoform 4S.
Show »
Length:379
Mass (Da):42,592
Checksum:i83D3D3CFB783FAAC
GO
Isoform 7L (identifier: P36402-13) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

Note: Produced by alternative splicing of isoform 4L.
Show »
Length:369
Mass (Da):39,933
Checksum:iB742838D4DCA35EE
GO
Isoform 7S (identifier: P36402-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP

Note: Produced by alternative splicing of isoform 4S.
Show »
Length:254
Mass (Da):28,556
Checksum:i18750F35A9B3855E
GO
Isoform 8L (identifier: P36402-15) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

Note: Produced by alternative splicing of isoform 4L.
Show »
Length:370
Mass (Da):40,347
Checksum:i02C826CE6F741E3B
GO
Isoform 8S (identifier: P36402-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP

Note: Produced by alternative splicing of isoform 4S.
Show »
Length:255
Mass (Da):28,970
Checksum:iF7671142D790678B
GO
Isoform 2L (identifier: P36402-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

Note: Produced by alternative splicing of isoform 4L.
Show »
Length:384
Mass (Da):41,552
Checksum:i004644F8B23D9484
GO
Isoform 2S (identifier: P36402-6) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL

Note: Produced by alternative splicing of isoform 4S.
Show »
Length:269
Mass (Da):30,175
Checksum:iF9C06C7EA07E7A13
GO
Isoform 3L (identifier: P36402-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

Note: Produced by alternative splicing of isoform 4L.
Show »
Length:383
Mass (Da):41,668
Checksum:iD6C1D30018F796DA
GO
Isoform 3S (identifier: P36402-8) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR

Note: Produced by alternative splicing of isoform 4S.
Show »
Length:268
Mass (Da):30,291
Checksum:i60E955125B190163
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WNT5B7WNT5_HUMAN
Transcription factor 7 (T-cell spec...
TCF7 hCG_16589
481Annotation score:
E5RHL1E5RHL1_HUMAN
Transcription factor 7
TCF7
143Annotation score:
E5RG75E5RG75_HUMAN
Transcription factor 7
TCF7
147Annotation score:
H0YAR8H0YAR8_HUMAN
Transcription factor 7
TCF7
147Annotation score:
H0YBC8H0YBC8_HUMAN
Transcription factor 7
TCF7
204Annotation score:
E5RJ51E5RJ51_HUMAN
Transcription factor 7
TCF7
122Annotation score:
E5RG34E5RG34_HUMAN
Transcription factor 7
TCF7
153Annotation score:
E5RGQ1E5RGQ1_HUMAN
Transcription factor 7
TCF7
167Annotation score:
H0YBM1H0YBM1_HUMAN
Transcription factor 7
TCF7
71Annotation score:
H0YBP2H0YBP2_HUMAN
Transcription factor 7
TCF7
105Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence CAA87441 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21D → N in AAF00616 (PubMed:10489374).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069611 – 115Missing in isoform 1S, isoform 2S, isoform 3S, isoform 4S, isoform 5S, isoform 6S, isoform 7S and isoform 8S. 2 PublicationsAdd BLAST115
Alternative sequenceiVSP_006960359 – 384ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRRKKKCIRYLPGEGRC PSPVPSDDSALGCPGSPAPQ DSPSYHLLPRFPTELLTSPA ERHLHPQVSPLLSASQPQGP HRPPAAPCRAHRYSNRNLRD RWPSRHRTPGRLQEPTP in isoform 1L and isoform 1S. CuratedAdd BLAST26
Alternative sequenceiVSP_002191359 – 384ETNWP…SSSPA → GGKRNAFGTYPEKAAAPAPF LPMTVL in isoform 2L and isoform 2S. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_002192359 – 384ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCR in isoform 3L and isoform 3S. CuratedAdd BLAST26
Alternative sequenceiVSP_012160359 – 384ETNWP…SSSPA → DNSLHYS in isoform 5L and isoform 5S. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012161359 – 384ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRKKKCIRYLPGEGRCP SPVPSDDSALGCPGSPAPQD SPSYHLLPRFPTELLTSPAE RHLHPQVSPLLSASQPQGPH RPPAAPCRAHRYSNRNLRDR WPSRHRTPGRLQEPTP in isoform 6L and isoform 6S. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012162359 – 384ETNWP…SSSPA → DGIPACTILSP in isoform 7L and isoform 7S. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012163359 – 384ETNWP…SSSPA → QLEDWDGWARKP in isoform 8L and isoform 8S. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59869 mRNA Translation: CAA42526.1
X59870 mRNA Translation: CAA42527.1
X59871 mRNA Translation: CAA42528.1
X63901 Genomic DNA Translation: CAB56795.1
Z47361 mRNA Translation: CAA87439.1
Z47362 mRNA Translation: CAA87440.1
Z47363 mRNA Translation: CAA87441.1 Sequence problems.
Z47364 mRNA Translation: CAA87442.1
AK093530 mRNA Translation: BAG52735.1
CH471062 Genomic DNA Translation: EAW62277.1
BC048769 mRNA Translation: AAH48769.1
BC072023 mRNA Translation: AAH72023.1
AF163776 Genomic DNA Translation: AAF00616.1
CCDSiCCDS4169.1 [P36402-5]
CCDS4170.1 [P36402-6]
CCDS43362.1 [P36402-8]
CCDS47263.2 [P36402-2]
PIRiA38095
B38095
C38095
D38095
S61796
RefSeqiNP_001128323.2, NM_001134851.3 [P36402-2]
NP_001333354.1, NM_001346425.1
NP_001333379.1, NM_001346450.1
NP_003193.2, NM_003202.4 [P36402-5]
NP_963963.1, NM_201632.4 [P36402-6]
NP_963965.1, NM_201634.4 [P36402-8]
NP_998813.1, NM_213648.4 [P36402-6]
XP_006714747.1, XM_006714684.2 [P36402-9]
UniGeneiHs.573153

Genome annotation databases

EnsembliENST00000342854; ENSP00000340347; ENSG00000081059 [P36402-5]
ENST00000378560; ENSP00000367822; ENSG00000081059 [P36402-8]
ENST00000395023; ENSP00000378469; ENSG00000081059 [P36402-6]
ENST00000518915; ENSP00000430179; ENSG00000081059 [P36402-2]
ENST00000520958; ENSP00000429547; ENSG00000081059 [P36402-6]
GeneIDi6932
KEGGihsa:6932
UCSCiuc003kyt.4 human [P36402-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59869 mRNA Translation: CAA42526.1
X59870 mRNA Translation: CAA42527.1
X59871 mRNA Translation: CAA42528.1
X63901 Genomic DNA Translation: CAB56795.1
Z47361 mRNA Translation: CAA87439.1
Z47362 mRNA Translation: CAA87440.1
Z47363 mRNA Translation: CAA87441.1 Sequence problems.
Z47364 mRNA Translation: CAA87442.1
AK093530 mRNA Translation: BAG52735.1
CH471062 Genomic DNA Translation: EAW62277.1
BC048769 mRNA Translation: AAH48769.1
BC072023 mRNA Translation: AAH72023.1
AF163776 Genomic DNA Translation: AAF00616.1
CCDSiCCDS4169.1 [P36402-5]
CCDS4170.1 [P36402-6]
CCDS43362.1 [P36402-8]
CCDS47263.2 [P36402-2]
PIRiA38095
B38095
C38095
D38095
S61796
RefSeqiNP_001128323.2, NM_001134851.3 [P36402-2]
NP_001333354.1, NM_001346425.1
NP_001333379.1, NM_001346450.1
NP_003193.2, NM_003202.4 [P36402-5]
NP_963963.1, NM_201632.4 [P36402-6]
NP_963965.1, NM_201634.4 [P36402-8]
NP_998813.1, NM_213648.4 [P36402-6]
XP_006714747.1, XM_006714684.2 [P36402-9]
UniGeneiHs.573153

3D structure databases

ProteinModelPortaliP36402
SMRiP36402
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112794, 3 interactors
IntActiP36402, 4 interactors
MINTiP36402
STRINGi9606.ENSP00000340347

PTM databases

iPTMnetiP36402
PhosphoSitePlusiP36402

Polymorphism and mutation databases

BioMutaiTCF7
DMDMi209572716

Proteomic databases

MaxQBiP36402
PaxDbiP36402
PeptideAtlasiP36402
PRIDEiP36402
ProteomicsDBi55182
55183 [P36402-10]
55184 [P36402-11]
55185 [P36402-12]
55186 [P36402-13]
55187 [P36402-14]
55188 [P36402-15]
55189 [P36402-16]
55190 [P36402-2]
55191 [P36402-3]
55192 [P36402-4]
55193 [P36402-5]
55194 [P36402-6]
55195 [P36402-7]
55196 [P36402-8]
55197 [P36402-9]

Protocols and materials databases

DNASUi6932
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342854; ENSP00000340347; ENSG00000081059 [P36402-5]
ENST00000378560; ENSP00000367822; ENSG00000081059 [P36402-8]
ENST00000395023; ENSP00000378469; ENSG00000081059 [P36402-6]
ENST00000518915; ENSP00000430179; ENSG00000081059 [P36402-2]
ENST00000520958; ENSP00000429547; ENSG00000081059 [P36402-6]
GeneIDi6932
KEGGihsa:6932
UCSCiuc003kyt.4 human [P36402-1]

Organism-specific databases

CTDi6932
DisGeNETi6932
EuPathDBiHostDB:ENSG00000081059.19
GeneCardsiTCF7
HGNCiHGNC:11639 TCF7
HPAiCAB019403
HPA058863
HPA070505
MIMi189908 gene
neXtProtiNX_P36402
OpenTargetsiENSG00000081059
PharmGKBiPA36392
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00390000009964
HOGENOMiHOG000116032
HOVERGENiHBG000419
InParanoidiP36402
KOiK02620
PhylomeDBiP36402
TreeFamiTF318448

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-4086398 Ca2+ pathway
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
R-HSA-4641265 Repression of WNT target genes
R-HSA-8951430 RUNX3 regulates WNT signaling
SIGNORiP36402

Miscellaneous databases

ChiTaRSiTCF7 human
GeneWikiiTCF7
GenomeRNAii6932
PROiPR:P36402
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081059 Expressed in 236 organ(s), highest expression level in thymus
CleanExiHS_TCF7
ExpressionAtlasiP36402 baseline and differential
GenevisibleiP36402 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR027397 Catenin_binding_dom_sf
IPR013558 CTNNB1-bd_N
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
IPR028785 Tcf7
PANTHERiPTHR10373 PTHR10373, 1 hit
PTHR10373:SF33 PTHR10373:SF33, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCF7_HUMAN
AccessioniPrimary (citable) accession number: P36402
Secondary accession number(s): B3KSH3, Q86WR9, Q9UKI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 188 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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