UniProtKB - P36402 (TCF7_HUMAN)
Transcription factor 7
TCF7
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 269 – 337 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- beta-catenin binding Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- beta-catenin-TCF complex assembly Source: Reactome
- canonical Wnt signaling pathway Source: GO_Central
- cellular response to interleukin-4 Source: UniProtKB
- gamma-delta T cell differentiation Source: UniProtKB
- immune response Source: ProtInc
- regulation of gamma-delta T cell differentiation Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- T cell receptor V(D)J recombination Source: InterPro
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | P36402 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402, Deactivation of the beta-catenin transactivating complex R-HSA-4086398, Ca2+ pathway R-HSA-4411364, Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4641265, Repression of WNT target genes R-HSA-8951430, RUNX3 regulates WNT signaling |
SIGNORi | P36402 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor 7Short name: TCF-7 Alternative name(s): T-cell-specific transcription factor 1 Short name: T-cell factor 1 Short name: TCF-1 |
Gene namesi | Name:TCF7 Synonyms:TCF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11639, TCF7 |
MIMi | 189908, gene |
neXtProti | NX_P36402 |
VEuPathDBi | HostDB:ENSG00000081059.19 |
Subcellular locationi
Nucleus
Nucleus
- beta-catenin-TCF complex Source: GO_Central
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6932 |
OpenTargetsi | ENSG00000081059 |
PharmGKBi | PA36392 |
Miscellaneous databases
Pharosi | P36402, Tbio |
Genetic variation databases
BioMutai | TCF7 |
DMDMi | 209572716 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048612 | 1 – 384 | Transcription factor 7Add BLAST | 384 |
Proteomic databases
jPOSTi | P36402 |
MassIVEi | P36402 |
MaxQBi | P36402 |
PaxDbi | P36402 |
PeptideAtlasi | P36402 |
PRIDEi | P36402 |
ProteomicsDBi | 55182 [P36402-1] 55183 [P36402-10] 55184 [P36402-11] 55185 [P36402-12] 55186 [P36402-13] 55187 [P36402-14] 55188 [P36402-15] 55189 [P36402-16] 55190 [P36402-2] 55191 [P36402-3] 55192 [P36402-4] 55193 [P36402-5] 55194 [P36402-6] 55195 [P36402-7] 55196 [P36402-8] 55197 [P36402-9] |
PTM databases
iPTMneti | P36402 |
PhosphoSitePlusi | P36402 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000081059, Expressed in thymus and 248 other tissues |
ExpressionAtlasi | P36402, baseline and differential |
Genevisiblei | P36402, HS |
Organism-specific databases
HPAi | ENSG00000081059, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439 PubMed:9783587).
Interacts with TLE5, TLE1, TLE2, TLE3 and TLE4 (PubMed:9783587, PubMed:11266540).
Interacts with MLLT11 (PubMed:26079538). Long isoform interacts (via N-terminus) with SOX13; inhibits WNT-mediated transcriptional activity (PubMed:17218525, PubMed:20028982).
6 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- beta-catenin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112794, 10 interactors |
IntActi | P36402, 4 interactors |
MINTi | P36402 |
STRINGi | 9606.ENSP00000340347 |
Miscellaneous databases
RNActi | P36402, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 59 | CTNNB1-bindingAdd BLAST | 59 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 344 – 348 | Nuclear localization signalSequence analysis | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3248, Eukaryota |
GeneTreei | ENSGT00940000159831 |
HOGENOMi | CLU_013229_5_0_1 |
InParanoidi | P36402 |
OMAi | LLMHYPA |
OrthoDBi | 807716at2759 |
PhylomeDBi | P36402 |
TreeFami | TF318448 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR027397, Catenin-bd_sf IPR013558, CTNNB1-bd_N IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR024940, TCF/LEF IPR028785, Tcf7 |
PANTHERi | PTHR10373, PTHR10373, 1 hit PTHR10373:SF33, PTHR10373:SF33, 1 hit |
Pfami | View protein in Pfam PF08347, CTNNB1_binding, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
s (16+)i Sequence
Sequence statusi: Complete.
This entry describes 16 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 16 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE
60 70 80 90 100
LKSSLVNESE GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP
110 120 130 140 150
EPLEDGLKAP ECTSGMYKET VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA
160 170 180 190 200
NQPPHGVPQL SLYEHFNSPH PTPAPADISQ KQVHRPLQTP DLSGFYSLTS
210 220 230 240 250
GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS GKQELQPFDR
260 270 280 290 300
NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN
310 320 330 340 350
QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR
360 370 380
EKHQESTTET NWPRELKDGN GQESLSMSSS SSPA
The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP
The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP
The sequence of this isoform differs from the canonical sequence as follows:
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS
The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DNSLHYS
The sequence of this isoform differs from the canonical sequence as follows:
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP
The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRA...TPGRLQEPTP
The sequence of this isoform differs from the canonical sequence as follows:
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP
The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DGIPACTILSP
The sequence of this isoform differs from the canonical sequence as follows:
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP
The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → QLEDWDGWARKP
The sequence of this isoform differs from the canonical sequence as follows:
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL
The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → GGKRNAFGTYPEKAAAPAPFLPMTVL
The sequence of this isoform differs from the canonical sequence as follows:
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR
The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.
359-384: ETNWPRELKDGNGQESLSMSSSSSPA → DPGSPKKCRARFGLNQQTDWCGPCR
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7WNT5 | B7WNT5_HUMAN | Transcription factor 7 | TCF7 hCG_16589 | 481 | Annotation score: | ||
E5RG75 | E5RG75_HUMAN | Transcription factor 7 | TCF7 | 147 | Annotation score: | ||
H0YBC8 | H0YBC8_HUMAN | Transcription factor 7 | TCF7 | 204 | Annotation score: | ||
E5RHL1 | E5RHL1_HUMAN | Transcription factor 7 | TCF7 | 143 | Annotation score: | ||
H0YAR8 | H0YAR8_HUMAN | Transcription factor 7 | TCF7 | 147 | Annotation score: | ||
E5RG34 | E5RG34_HUMAN | Transcription factor 7 | TCF7 | 153 | Annotation score: | ||
E5RGQ1 | E5RGQ1_HUMAN | Transcription factor 7 | TCF7 | 167 | Annotation score: | ||
E5RJ51 | E5RJ51_HUMAN | Transcription factor 7 | TCF7 | 122 | Annotation score: | ||
H0YBM1 | H0YBM1_HUMAN | Transcription factor 7 | TCF7 | 71 | Annotation score: | ||
H0YBP2 | H0YBP2_HUMAN | Transcription factor 7 | TCF7 | 105 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | D → N in AAF00616 (PubMed:10489374).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006961 | 1 – 115 | Missing in isoform 1S, isoform 2S, isoform 3S, isoform 4S, isoform 5S, isoform 6S, isoform 7S and isoform 8S. 2 PublicationsAdd BLAST | 115 | |
Alternative sequenceiVSP_006960 | 359 – 384 | ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRRKKKCIRYLPGEGRC PSPVPSDDSALGCPGSPAPQ DSPSYHLLPRFPTELLTSPA ERHLHPQVSPLLSASQPQGP HRPPAAPCRAHRYSNRNLRD RWPSRHRTPGRLQEPTP in isoform 1L and isoform 1S. CuratedAdd BLAST | 26 | |
Alternative sequenceiVSP_002191 | 359 – 384 | ETNWP…SSSPA → GGKRNAFGTYPEKAAAPAPF LPMTVL in isoform 2L and isoform 2S. 2 PublicationsAdd BLAST | 26 | |
Alternative sequenceiVSP_002192 | 359 – 384 | ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCR in isoform 3L and isoform 3S. CuratedAdd BLAST | 26 | |
Alternative sequenceiVSP_012160 | 359 – 384 | ETNWP…SSSPA → DNSLHYS in isoform 5L and isoform 5S. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_012161 | 359 – 384 | ETNWP…SSSPA → DPGSPKKCRARFGLNQQTDW CGPCRKKKCIRYLPGEGRCP SPVPSDDSALGCPGSPAPQD SPSYHLLPRFPTELLTSPAE RHLHPQVSPLLSASQPQGPH RPPAAPCRAHRYSNRNLRDR WPSRHRTPGRLQEPTP in isoform 6L and isoform 6S. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_012162 | 359 – 384 | ETNWP…SSSPA → DGIPACTILSP in isoform 7L and isoform 7S. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_012163 | 359 – 384 | ETNWP…SSSPA → QLEDWDGWARKP in isoform 8L and isoform 8S. 1 PublicationAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59869 mRNA Translation: CAA42526.1 X59870 mRNA Translation: CAA42527.1 X59871 mRNA Translation: CAA42528.1 X63901 Genomic DNA Translation: CAB56795.1 Z47361 mRNA Translation: CAA87439.1 Z47362 mRNA Translation: CAA87440.1 Z47363 mRNA Translation: CAA87441.1 Sequence problems. Z47364 mRNA Translation: CAA87442.1 AK093530 mRNA Translation: BAG52735.1 CH471062 Genomic DNA Translation: EAW62277.1 BC048769 mRNA Translation: AAH48769.1 BC072023 mRNA Translation: AAH72023.1 AF163776 Genomic DNA Translation: AAF00616.1 |
CCDSi | CCDS4169.1 [P36402-5] CCDS4170.1 [P36402-6] CCDS43362.1 [P36402-8] CCDS47263.2 [P36402-2] |
PIRi | A38095 B38095 C38095 D38095 S61796 |
RefSeqi | NP_001128323.2, NM_001134851.3 [P36402-2] NP_001333354.1, NM_001346425.1 NP_001333379.1, NM_001346450.1 NP_003193.2, NM_003202.4 [P36402-5] NP_963963.1, NM_201632.4 [P36402-6] NP_963965.1, NM_201634.4 [P36402-8] NP_998813.1, NM_213648.4 [P36402-6] XP_006714747.1, XM_006714684.2 [P36402-9] |
Genome annotation databases
Ensembli | ENST00000342854; ENSP00000340347; ENSG00000081059 [P36402-5] ENST00000378560; ENSP00000367822; ENSG00000081059 [P36402-8] ENST00000395023; ENSP00000378469; ENSG00000081059 [P36402-6] ENST00000518915; ENSP00000430179; ENSG00000081059 [P36402-2] ENST00000520958; ENSP00000429547; ENSG00000081059 [P36402-6] |
GeneIDi | 6932 |
KEGGi | hsa:6932 |
UCSCi | uc003kyt.4, human [P36402-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59869 mRNA Translation: CAA42526.1 X59870 mRNA Translation: CAA42527.1 X59871 mRNA Translation: CAA42528.1 X63901 Genomic DNA Translation: CAB56795.1 Z47361 mRNA Translation: CAA87439.1 Z47362 mRNA Translation: CAA87440.1 Z47363 mRNA Translation: CAA87441.1 Sequence problems. Z47364 mRNA Translation: CAA87442.1 AK093530 mRNA Translation: BAG52735.1 CH471062 Genomic DNA Translation: EAW62277.1 BC048769 mRNA Translation: AAH48769.1 BC072023 mRNA Translation: AAH72023.1 AF163776 Genomic DNA Translation: AAF00616.1 |
CCDSi | CCDS4169.1 [P36402-5] CCDS4170.1 [P36402-6] CCDS43362.1 [P36402-8] CCDS47263.2 [P36402-2] |
PIRi | A38095 B38095 C38095 D38095 S61796 |
RefSeqi | NP_001128323.2, NM_001134851.3 [P36402-2] NP_001333354.1, NM_001346425.1 NP_001333379.1, NM_001346450.1 NP_003193.2, NM_003202.4 [P36402-5] NP_963963.1, NM_201632.4 [P36402-6] NP_963965.1, NM_201634.4 [P36402-8] NP_998813.1, NM_213648.4 [P36402-6] XP_006714747.1, XM_006714684.2 [P36402-9] |
3D structure databases
SMRi | P36402 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112794, 10 interactors |
IntActi | P36402, 4 interactors |
MINTi | P36402 |
STRINGi | 9606.ENSP00000340347 |
PTM databases
iPTMneti | P36402 |
PhosphoSitePlusi | P36402 |
Genetic variation databases
BioMutai | TCF7 |
DMDMi | 209572716 |
Proteomic databases
jPOSTi | P36402 |
MassIVEi | P36402 |
MaxQBi | P36402 |
PaxDbi | P36402 |
PeptideAtlasi | P36402 |
PRIDEi | P36402 |
ProteomicsDBi | 55182 [P36402-1] 55183 [P36402-10] 55184 [P36402-11] 55185 [P36402-12] 55186 [P36402-13] 55187 [P36402-14] 55188 [P36402-15] 55189 [P36402-16] 55190 [P36402-2] 55191 [P36402-3] 55192 [P36402-4] 55193 [P36402-5] 55194 [P36402-6] 55195 [P36402-7] 55196 [P36402-8] 55197 [P36402-9] |
Protocols and materials databases
Antibodypediai | 14629, 483 antibodies |
DNASUi | 6932 |
Genome annotation databases
Ensembli | ENST00000342854; ENSP00000340347; ENSG00000081059 [P36402-5] ENST00000378560; ENSP00000367822; ENSG00000081059 [P36402-8] ENST00000395023; ENSP00000378469; ENSG00000081059 [P36402-6] ENST00000518915; ENSP00000430179; ENSG00000081059 [P36402-2] ENST00000520958; ENSP00000429547; ENSG00000081059 [P36402-6] |
GeneIDi | 6932 |
KEGGi | hsa:6932 |
UCSCi | uc003kyt.4, human [P36402-1] |
Organism-specific databases
CTDi | 6932 |
DisGeNETi | 6932 |
GeneCardsi | TCF7 |
HGNCi | HGNC:11639, TCF7 |
HPAi | ENSG00000081059, Tissue enriched (lymphoid) |
MIMi | 189908, gene |
neXtProti | NX_P36402 |
OpenTargetsi | ENSG00000081059 |
PharmGKBi | PA36392 |
VEuPathDBi | HostDB:ENSG00000081059.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3248, Eukaryota |
GeneTreei | ENSGT00940000159831 |
HOGENOMi | CLU_013229_5_0_1 |
InParanoidi | P36402 |
OMAi | LLMHYPA |
OrthoDBi | 807716at2759 |
PhylomeDBi | P36402 |
TreeFami | TF318448 |
Enzyme and pathway databases
PathwayCommonsi | P36402 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402, Deactivation of the beta-catenin transactivating complex R-HSA-4086398, Ca2+ pathway R-HSA-4411364, Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4641265, Repression of WNT target genes R-HSA-8951430, RUNX3 regulates WNT signaling |
SIGNORi | P36402 |
Miscellaneous databases
BioGRID-ORCSi | 6932, 15 hits in 1020 CRISPR screens |
ChiTaRSi | TCF7, human |
GeneWikii | TCF7 |
GenomeRNAii | 6932 |
Pharosi | P36402, Tbio |
PROi | PR:P36402 |
RNActi | P36402, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000081059, Expressed in thymus and 248 other tissues |
ExpressionAtlasi | P36402, baseline and differential |
Genevisiblei | P36402, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR027397, Catenin-bd_sf IPR013558, CTNNB1-bd_N IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR024940, TCF/LEF IPR028785, Tcf7 |
PANTHERi | PTHR10373, PTHR10373, 1 hit PTHR10373:SF33, PTHR10373:SF33, 1 hit |
Pfami | View protein in Pfam PF08347, CTNNB1_binding, 1 hit PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCF7_HUMAN | |
Accessioni | P36402Primary (citable) accession number: P36402 Secondary accession number(s): B3KSH3, Q86WR9, Q9UKI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | October 14, 2008 | |
Last modified: | April 7, 2021 | |
This is version 203 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families