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Protein

Gap junction alpha-5 protein

Gene

GJA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-190861 Gap junction assembly

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P36382

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-40
Short name:
Cx40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GJA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000265107.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4279 GJA5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
121013 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P36382

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 164CytoplasmicSequence analysisAdd BLAST67
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 205ExtracellularSequence analysisAdd BLAST20
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 358CytoplasmicSequence analysisAdd BLAST132

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Atrial standstill 1 (ATRST1)1 Publication
The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry. A rare GJA5 genotype has been detected in combination with a mutation in SCN5A in a large family with atrial standstill.
Disease descriptionA rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm.
See also OMIM:108770
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03501388P → S in ATRST1; somatic. 1 PublicationCorresponds to variant dbSNP:rs121434558EnsemblClinVar.1
Natural variantiVAR_03501496A → S in ATRST1. 1 PublicationCorresponds to variant dbSNP:rs121434557EnsemblClinVar.1
Atrial fibrillation, familial, 11 (ATFB11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
See also OMIM:614049
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06624985V → I in ATFB11. 1 PublicationCorresponds to variant dbSNP:rs387906613EnsemblClinVar.1
Natural variantiVAR_066250221L → I in ATFB11. 1 PublicationCorresponds to variant dbSNP:rs387906614EnsemblClinVar.1
Natural variantiVAR_066251229L → M in ATFB11. 1 PublicationCorresponds to variant dbSNP:rs387906615EnsemblClinVar.1

Keywords - Diseasei

Atrial fibrillation, Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2702

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
GJA5

MalaCards human disease database

More...
MalaCardsi
GJA5
MIMi108770 phenotype
614049 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000265107

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
334 Familial atrial fibrillation
3303 Tetralogy of Fallot

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28690

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
8928556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000578191 – 358Gap junction alpha-5 proteinAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei353PhosphoserineBy similarity1
Modified residuei357PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36382

PeptideAtlas

More...
PeptideAtlasi
P36382

PRoteomics IDEntifications database

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PRIDEi
P36382

ProteomicsDB human proteome resource

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ProteomicsDBi
55180

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36382

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P36382

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000265107 Expressed in 147 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_GJA5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P36382 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P36382 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB013080

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

A connexon is composed of a hexamer of connexins.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108969, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P36382, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000271348

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P36382

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P36382

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231127

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG009576

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36382

KEGG Orthology (KO)

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KOi
K07614

Identification of Orthologs from Complete Genome Data

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OMAi
ECQLPGP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0FKH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P36382

TreeFam database of animal gene trees

More...
TreeFami
TF329606

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1440.80, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000500 Connexin
IPR002264 Connexin40
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
IPR031862 Cx40_C

The PANTHER Classification System

More...
PANTHERi
PTHR11984 PTHR11984, 1 hit
PTHR11984:SF13 PTHR11984:SF13, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00029 Connexin, 1 hit
PF16791 Connexin40_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00206 CONNEXIN
PR01135 CONNEXINA5

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118220 SSF118220, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P36382-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDWSFLGNF LEEVHKHSTV VGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMQEKRKLRE AERAKEVRGS GSYEYPVAEK AELSCWEEGN GRIALQGTLL
160 170 180 190 200
NTYVCSILIR TTMEVGFIVG QYFIYGIFLT TLHVCRRSPC PHPVNCYVSR
210 220 230 240 250
PTEKNVFIVF MLAVAALSLL LSLAELYHLG WKKIRQRFVK PRQHMAKCQL
260 270 280 290 300
SGPSVGIVQS CTPPPDFNQC LENGPGGKFF NPFSNNMASQ QNTDNLVTEQ
310 320 330 340 350
VRGQEQTPGE GFIQVRYGQK PEVPNGVSPG HRLPHGYHSD KRRLSKASSK

ARSDDLSV
Length:358
Mass (Da):40,380
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE9DD863C130229A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1Y3A0A0B4J1Y3_HUMAN
Gap junction protein
GJA5
251Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06624985V → I in ATFB11. 1 PublicationCorresponds to variant dbSNP:rs387906613EnsemblClinVar.1
Natural variantiVAR_03501388P → S in ATRST1; somatic. 1 PublicationCorresponds to variant dbSNP:rs121434558EnsemblClinVar.1
Natural variantiVAR_03501496A → S in ATRST1. 1 PublicationCorresponds to variant dbSNP:rs121434557EnsemblClinVar.1
Natural variantiVAR_066250221L → I in ATFB11. 1 PublicationCorresponds to variant dbSNP:rs387906614EnsemblClinVar.1
Natural variantiVAR_066251229L → M in ATFB11. 1 PublicationCorresponds to variant dbSNP:rs387906615EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U03486 Genomic DNA Translation: AAA60457.2
L34954 Genomic DNA Translation: AAA91833.1
AF151979 Genomic DNA Translation: AAD37801.1
BT019415 mRNA Translation: AAV38222.1
BT019416 mRNA Translation: AAV38223.1
AL365260 Genomic DNA Translation: CAI14124.1
AL365260 Genomic DNA Translation: CAI14125.1
BC013313 mRNA Translation: AAH13313.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS929.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38429

NCBI Reference Sequences

More...
RefSeqi
NP_005257.2, NM_005266.6
NP_859054.1, NM_181703.3
XP_005273008.1, XM_005272951.4
XP_016856533.1, XM_017001044.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.447968

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000579774; ENSP00000463851; ENSG00000265107
ENST00000621517; ENSP00000484552; ENSG00000265107

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2702

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2702

UCSC genome browser

More...
UCSCi
uc057kfi.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03486 Genomic DNA Translation: AAA60457.2
L34954 Genomic DNA Translation: AAA91833.1
AF151979 Genomic DNA Translation: AAD37801.1
BT019415 mRNA Translation: AAV38222.1
BT019416 mRNA Translation: AAV38223.1
AL365260 Genomic DNA Translation: CAI14124.1
AL365260 Genomic DNA Translation: CAI14125.1
BC013313 mRNA Translation: AAH13313.1
CCDSiCCDS929.1
PIRiI38429
RefSeqiNP_005257.2, NM_005266.6
NP_859054.1, NM_181703.3
XP_005273008.1, XM_005272951.4
XP_016856533.1, XM_017001044.1
UniGeneiHs.447968

3D structure databases

ProteinModelPortaliP36382
SMRiP36382
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108969, 6 interactors
IntActiP36382, 23 interactors
STRINGi9606.ENSP00000271348

PTM databases

iPTMnetiP36382
PhosphoSitePlusiP36382

Polymorphism and mutation databases

DMDMi8928556

Proteomic databases

PaxDbiP36382
PeptideAtlasiP36382
PRIDEiP36382
ProteomicsDBi55180

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2702
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000579774; ENSP00000463851; ENSG00000265107
ENST00000621517; ENSP00000484552; ENSG00000265107
GeneIDi2702
KEGGihsa:2702
UCSCiuc057kfi.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2702
DisGeNETi2702
EuPathDBiHostDB:ENSG00000265107.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GJA5
GeneReviewsiGJA5
HGNCiHGNC:4279 GJA5
HPAiCAB013080
MalaCardsiGJA5
MIMi108770 phenotype
121013 gene
614049 phenotype
neXtProtiNX_P36382
OpenTargetsiENSG00000265107
Orphaneti334 Familial atrial fibrillation
3303 Tetralogy of Fallot
PharmGKBiPA28690

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
GeneTreeiENSGT00940000159859
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP36382
KOiK07614
OMAiECQLPGP
OrthoDBiEOG091G0FKH
PhylomeDBiP36382
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-HSA-190861 Gap junction assembly
SIGNORiP36382

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GJA5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GJA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2702

Protein Ontology

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PROi
PR:P36382

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000265107 Expressed in 147 organ(s), highest expression level in placenta
CleanExiHS_GJA5
ExpressionAtlasiP36382 baseline and differential
GenevisibleiP36382 HS

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002264 Connexin40
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
IPR031862 Cx40_C
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF13 PTHR11984:SF13, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF16791 Connexin40_C, 1 hit
PRINTSiPR00206 CONNEXIN
PR01135 CONNEXINA5
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCXA5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36382
Secondary accession number(s): Q5T3B6, Q5U0N6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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