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Protein

Prostatic glandular kallikrein-6

Gene

Klk6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.118 5301

Protein family/group databases

MEROPSiS01.288

Names & Taxonomyi

Protein namesi
Recommended name:
Prostatic glandular kallikrein-6 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein-8
Short name:
rGK-8
P1 kallikrein
Tissue kallikrein
Gene namesi
Name:Klk6
Synonyms:Klk-8, Klk8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305359 Klk6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002800719 – 24Activation peptideCurated6
ChainiPRO_000002800825 – 261Prostatic glandular kallikrein-6Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP36374

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066639

Structurei

3D structure databases

ProteinModelPortaliP36374
SMRiP36374
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP36374
PhylomeDBiP36374

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLILFLIL SLGWNDAAPP GQSRIIGGFN CEKNSQPWQV AVYHFNEPQC
60 70 80 90 100
GGVLIHPSWV ITAAHCYSVN YQVWLGRNNL LEDEPFAQHR LVSQSFPHPG
110 120 130 140 150
FNLDIIKNHT RKPGNDYSND LMLLHLKTPA DITDGVKVID LPTEEPKVGS
160 170 180 190 200
TCLTSGWGSI TPLKWEFPDD LQCVNIHLLS NEKCIKAYND EVTDVMLCAG
210 220 230 240 250
EMDGGKDICK GDSGGPLICD GVLQGITSWG SMPCGEPNKP SVYTKLIKFT
260
SWMKKVMKEN P
Length:261
Mass (Da):29,013
Last modified:June 1, 1994 - v1
Checksum:iCA8F12151B04E337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27217, M27215, M27216 Genomic DNA Translation: AAA42036.1
PIRiA34079

Genome annotation databases

UCSCiRGD:1305359 rat

Similar proteinsi

Entry informationi

Entry nameiKLK6_RAT
AccessioniPrimary (citable) accession number: P36374
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 10, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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