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Protein

Antigen peptide transporter 2

Gene

Tap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi502 – 509ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity, Peptide transport, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen peptide transporter 2
Short name:
APT2
Alternative name(s):
ATP-binding cassette sub-family B member 3
Histocompatibility antigen modifier 2
Gene namesi
Name:Tap2
Synonyms:Abcb3, Ham-2, Ham2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98484 Tap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6LumenalSequence analysis6
Transmembranei7 – 27Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini28 – 56CytoplasmicSequence analysisAdd BLAST29
Transmembranei57 – 77Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini78 – 98LumenalSequence analysisAdd BLAST21
Transmembranei99 – 119Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini120 – 147CytoplasmicSequence analysisAdd BLAST28
Transmembranei148 – 168Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini169 – 186LumenalSequence analysisAdd BLAST18
Transmembranei187 – 207Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini208 – 265CytoplasmicSequence analysisAdd BLAST58
Transmembranei266 – 286Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini287 – 292LumenalSequence analysis6
Transmembranei293 – 313Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini314 – 373CytoplasmicSequence analysisAdd BLAST60
Transmembranei374 – 394Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini395 – 407LumenalSequence analysisAdd BLAST13
Transmembranei408 – 428Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini429 – 702CytoplasmicSequence analysisAdd BLAST274

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933301 – 702Antigen peptide transporter 2Add BLAST702

Proteomic databases

EPDiP36371
PaxDbiP36371
PeptideAtlasiP36371
PRIDEiP36371

PTM databases

iPTMnetiP36371
PhosphoSitePlusiP36371

Expressioni

Gene expression databases

BgeeiENSMUSG00000024339 Expressed in 132 organ(s), highest expression level in thymus
ExpressionAtlasiP36371 baseline and differential
GenevisibleiP36371 MM

Interactioni

Subunit structurei

Heterodimer of TAP1 and TAP2.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203967, 2 interactors
IntActiP36371, 3 interactors
MINTiP36371
STRINGi10090.ENSMUSP00000025197

Structurei

3D structure databases

ProteinModelPortaliP36371
SMRiP36371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 434ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST284
Domaini467 – 701ABC transporterPROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni300 – 388Involved in peptide-binding siteBy similarityAdd BLAST89
Regioni413 – 432Involved in peptide-binding siteBy similarityAdd BLAST20

Domaini

The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
HOVERGENiHBG008358
InParanoidiP36371
KOiK05654
OMAiGDLMNRI
OrthoDBiEOG091G05Q7
PhylomeDBiP36371
TreeFamiTF105197

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR005293 Tap2/ABCB3
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PRINTSiPR01897 TAP2PROTEIN
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00958 3a01208, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P36371-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSYLRPWV SLLLADMALL GLLQGSLGNL LPQGLPGLWI EGTLRLGVLW
60 70 80 90 100
GLLKVGELLG LVGTLLPLLC LATPLFFSLR ALVGGTASTS VVRVASASWG
110 120 130 140 150
WLLAGYGAVA LSWAVWAVLS PAGVQEKEPG QENRTLMKRL LKLSRPDLPF
160 170 180 190 200
LIAAFFFLVV AVWGETLIPR YSGRVIDILG GDFDPDAFAS AIFFMCLFSV
210 220 230 240 250
GSSFSAGCRG GSFLFTMSRI NLRIREQLFS SLLRQDLGFF QETKTGELNS
260 270 280 290 300
RLSSDTSLMS RWLPFNANIL LRSLVKVVGL YFFMLQVSPR LTFLSLLDLP
310 320 330 340 350
LTIAAEKVYN PRHQAVLKEI QDAVAKAGQV VREAVGGLQT VRSFGAEEQE
360 370 380 390 400
VSHYKEALER CRQLWWRRDL EKDVYLVIRR VMALGMQVLI LNCGVQQILA
410 420 430 440 450
GEVTRGGLLS FLLYQEEVGQ YVRNLVYMYG DMLSNVGAAE KVFSYLDRKP
460 470 480 490 500
NLPQPGILAP PWLEGRVEFQ DVSFSYPRRP EKPVLQGLTF TLHPGTVTAL
510 520 530 540 550
VGPNGSGKST VAALLQNLYQ PTGGQLLLDG EPLTEYDHHY LHRQVVLVGQ
560 570 580 590 600
EPVLFSGSVK DNIAYGLRDC EDAQVMAAAQ AACADDFIGE MTNGINTEIG
610 620 630 640 650
EKGGQLAVGQ KQRLAIARAL VRNPRVLILD EATSALDAQC EQALQNWRSQ
660 670 680 690 700
GDRTMLVIAH RLHTVQNADQ VLVLKQGRLV EHDQLRDGQD VYAHLVQQRL

EA
Length:702
Mass (Da):77,445
Last modified:June 1, 1994 - v1
Checksum:iF93DFA38B057AC0A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6X8J6A6X8J6_MOUSE
Antigen peptide transporter 2
Tap2 RP23-123G8.1-004
91Annotation score:
A0A1B0GXB3A0A1B0GXB3_MOUSE
Antigen peptide transporter 2
Tap2
24Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90459 mRNA Translation: AAA39609.1
CCDSiCCDS28644.1
PIRiA44135
RefSeqiNP_035660.3, NM_011530.3
UniGeneiMm.14814

Genome annotation databases

EnsembliENSMUST00000025197; ENSMUSP00000025197; ENSMUSG00000024339
GeneIDi21355
KEGGimmu:21355
UCSCiuc008cbx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90459 mRNA Translation: AAA39609.1
CCDSiCCDS28644.1
PIRiA44135
RefSeqiNP_035660.3, NM_011530.3
UniGeneiMm.14814

3D structure databases

ProteinModelPortaliP36371
SMRiP36371
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203967, 2 interactors
IntActiP36371, 3 interactors
MINTiP36371
STRINGi10090.ENSMUSP00000025197

PTM databases

iPTMnetiP36371
PhosphoSitePlusiP36371

Proteomic databases

EPDiP36371
PaxDbiP36371
PeptideAtlasiP36371
PRIDEiP36371

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025197; ENSMUSP00000025197; ENSMUSG00000024339
GeneIDi21355
KEGGimmu:21355
UCSCiuc008cbx.2 mouse

Organism-specific databases

CTDi6891
MGIiMGI:98484 Tap2

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
HOVERGENiHBG008358
InParanoidiP36371
KOiK05654
OMAiGDLMNRI
OrthoDBiEOG091G05Q7
PhylomeDBiP36371
TreeFamiTF105197

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

PROiPR:P36371
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024339 Expressed in 132 organ(s), highest expression level in thymus
ExpressionAtlasiP36371 baseline and differential
GenevisibleiP36371 MM

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR013305 ABC_Tap-like
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR005293 Tap2/ABCB3
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PRINTSiPR01897 TAP2PROTEIN
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00958 3a01208, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAP2_MOUSE
AccessioniPrimary (citable) accession number: P36371
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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