Antigen peptide transporter 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ADP binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Functional role of C-terminal sequence elements in the transporter associated with antigen processing."
    Ehses S., Leonhardt R.M., Hansen G., Knittler M.R.
    J. Immunol. 174:328-339(2005) [PubMed] [Europe PMC] [Abstract]
• ATPase activity Source: RGDInferred from direct assayⁱ
  • "Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter."
    Procko E., Ferrin-O'Connell I., Ng S.L., Gaudet R.
    Mol. Cell 24:51-62(2006) [PubMed] [Europe PMC] [Abstract]
• ATPase-coupled peptide antigen transmembrane transporter activity Source: RGDInferred from sequence orthologyⁱ
  • "The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP."
    Hewitt E.W., Lehner P.J.
    Eur. J. Immunol. 33:422-427(2003) [PubMed] [Europe PMC] [Abstract]
  • "Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter."
    Neefjes J.J., Momburg F., Hammerling G.J.
    Science 261:769-771(1993) [PubMed] [Europe PMC] [Abstract]
• ATPase-coupled peptide transmembrane transporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ATPase-coupled transmembrane transporter activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ATP binding Source: UniProtKBInferred from direct assayⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• MHC class Ib protein binding Source: RGDInferred from sequence orthologyⁱ
  • "HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern."
    Wainwright S.D., Biro P.A., Holmes C.H.
    J. Immunol. 164:319-328(2000) [PubMed] [Europe PMC] [Abstract]
• MHC class I protein binding Source: UniProtKBInferred from direct assayⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• nucleotide binding Source: RGDInferred from direct assayⁱ
  • "The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2."
    Bouabe H., Knittler M.R.
    Eur. J. Biochem. 270:4531-4546(2003) [PubMed] [Europe PMC] [Abstract]
• peptide transmembrane transporter activity Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of the antigenic peptide transporter TAP by recombinant antibodies binding to the last five residues of TAP1."
    Plewnia G., Schulze K., Hunte C., Tampe R., Koch J.
    J. Mol. Biol. 369:95-107(2007) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from direct assayⁱ
  • "Three-dimensional structure of transporter associated with antigen processing (TAP) obtained by single Particle image analysis."
    Velarde G., Ford R.C., Rosenberg M.F., Powis S.J.
    J. Biol. Chem. 276:46054-46063(2001) [PubMed] [Europe PMC] [Abstract]
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• TAP1 binding Source: UniProtKBInferred from physical interactionⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• TAP2 binding Source: UniProtKBInferred from physical interactionⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• tapasin binding Source: RGDInferred from direct assayⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adaptive immune response Source: UniProtKB-KW
• antigen processing and presentation of endogenous peptide antigen via MHC class I Source: RGDInferred from sequence orthologyⁱ
  • "Identification of sequences in the human peptide transporter subunit TAP1 required for transporter associated with antigen processing (TAP) function."
    Ritz U., Momburg F., Pircher H.P., Strand D., Huber C., Seliger B.
    Int. Immunol. 13:31-41(2001) [PubMed] [Europe PMC] [Abstract]
• antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: InterPro
• cytosol to endoplasmic reticulum transport Source: RGDInferred from sequence orthologyⁱ
  • "An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL."
    Hammond S.A., Johnson R.P., Kalams S.A., Walker B.D., Takiguchi M., Safrit J.T., Koup R.A., Siliciano R.F.
    J. Immunol. 154:6140-6156(1995) [PubMed] [Europe PMC] [Abstract]
• defense response Source: RGDInferred from sequence orthologyⁱ
  • "TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells."
    Van Kaer L., Ashton-Rickardt P.G., Ploegh H.L., Tonegawa S.
    Cell 71:1205-1214(1992) [PubMed] [Europe PMC] [Abstract]
• peptide antigen transport Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2."
    Bouabe H., Knittler M.R.
    Eur. J. Biochem. 270:4531-4546(2003) [PubMed] [Europe PMC] [Abstract]
• peptide transport Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Functional role of C-terminal sequence elements in the transporter associated with antigen processing."
    Ehses S., Leonhardt R.M., Hansen G., Knittler M.R.
    J. Immunol. 174:328-339(2005) [PubMed] [Europe PMC] [Abstract]
• protection from natural killer cell mediated cytotoxicity Source: RGDInferred from mutant phenotypeⁱ
  • "Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cells."
    Salcedo M., Momburg F., Hammerling G.J., Ljunggren H.G.
    J. Immunol. 152:1702-1708(1994) [PubMed] [Europe PMC] [Abstract]
• protein transport Source: UniProtKB-KW
• transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• MHC class Ib protein binding Source: RGDInferred from sequence orthologyⁱ
  • "HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern."
    Wainwright S.D., Biro P.A., Holmes C.H.
    J. Immunol. 164:319-328(2000) [PubMed] [Europe PMC] [Abstract]
• MHC class I protein binding Source: UniProtKBInferred from direct assayⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKBInferred from physical interactionⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• TAP1 binding Source: UniProtKBInferred from physical interactionⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• TAP2 binding Source: UniProtKBInferred from physical interactionⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]
• tapasin binding Source: RGDInferred from direct assayⁱ
  • "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits."
    Antoniou A.N., Ford S., Pilley E.S., Blake N., Powis S.J.
    Immunology 106:182-189(2002) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAAHAWPTAA LLLLLVDWLL LRPVLPGIFS LLVPEVPLLR VWAVGLSRWA 
        60         70         80         90        100
ILGLGVRGVL GVTAGARGWL AALQPLVAAL GLALPGLASF RKLSAWGALR 
       110        120        130        140        150
EGDNAGLLHW NSRLDAFVLS YVAALPAAAL WHKLGGFWAP SGHKGAGDML 
       160        170        180        190        200
CRMLGFLDSK KGRLHLVLVL LILSCLGEMA IPFFTGRITD WILQDKTAPS 
       210        220        230        240        250
FARNMWLMCI LTIASTVLEF AGDGIYNITM GHMHSRVHGE VFRAVLHQET 
       260        270        280        290        300
GFFLKNPTGS ITSRVTEDTS NVCESISDKL NLFLWYLGRG LCLLAFMIWG 
       310        320        330        340        350
SFYLTVVTLL SLPLLFLLPR RLGKVYQSLA VKVQESLAKS TQVALEALSA 
       360        370        380        390        400
MPTVRSFANE EGEAQKFRQK LEEMKPLNKK EALAYVTEVW TMSVSGMLLK 
       410        420        430        440        450
VGILYLGGQL VVRGAVSSGN LVSFVLYQLQ FTRAVEVLLS IYPSMQKSVG 
       460        470        480        490        500
ASEKIFEYLD RTPCSPLSGS LAPLNMKGLV KFQDVSFAYP NHPNVQVLQG 
       510        520        530        540        550
LTFTLYPGKV TALVGPNGSG KSTVAALLQN LYQPTGGKVL LDGEPLVQYD 
       560        570        580        590        600
HHYLHTQVAA VGQEPLLFGR SFRENIAYGL TRTPTMEEIT AVAMESGAHD 
       610        620        630        640        650
FISGFPQGYD TEVGETGNQL SGGQRQAVAL ARALIRKPRL LILDDATSAL 
       660        670        680        690        700
DAGNQLRVQR LLYESPEWAS RTVLLITQQL SLAERAHHIL FLKEGSVCEQ 
       710        720 
GTHLQLMERG GCYRSMVEAL AAPSD                            

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families