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UniProtKB - P36369 (K1B26_MOUSE)
Protein
Kallikrein 1-related peptidase b26
Gene
Klk1b26
Organism
Mus musculus (Mouse)
Status
Functioni
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Prorenin-converting enzyme cleaves mouse REN-2 prorenin at a dibasic site to yield mature renin.
Catalytic activityi
- Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. EC:3.4.21.35
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 65 | Charge relay system | 1 | |
Active sitei | 120 | Charge relay system | 1 | |
Active sitei | 213 | Charge relay system | 1 |
GO - Molecular functioni
- endopeptidase activity Source: MGI
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: MGI
- peptidase activity Source: MGI
- serine-type endopeptidase activity Source: MGI
GO - Biological processi
- brain renin-angiotensin system Source: MGI
- regulation of systemic arterial blood pressure Source: GO_Central
- zymogen activation Source: MGI
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
Reactomei | R-MMU-1592389, Activation of Matrix Metalloproteinases |
Protein family/group databases
MEROPSi | S01.173 |
Names & Taxonomyi
Protein namesi | Recommended name: Kallikrein 1-related peptidase b26 (EC:3.4.21.35)Alternative name(s): Glandular kallikrein K26 Short name: mGK-26 Prorenin-converting enzyme 2 Short name: PRECE-2 Tissue kallikrein 26 |
Gene namesi | Name:Klk1b26 Synonyms:Klk-26, Klk26 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:891981, Klk1b26 |
VEuPathDBi | HostDB:ENSMUSG00000053719 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: MGI
Nucleus
- nucleus Source: MGI
Other locations
- protein-containing complex Source: MGI
- secretory granule Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | CuratedAdd BLAST | 18 | |
PropeptideiPRO_0000027993 | 19 – 24 | Activation peptide | 6 | |
ChainiPRO_0000027994 | 25 – 261 | Kallikrein 1-related peptidase b26Add BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 173 | PROSITE-ProRule annotation | ||
Disulfide bondi | 50 ↔ 66 | PROSITE-ProRule annotation | ||
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Disulfide bondi | 152 ↔ 219 | PROSITE-ProRule annotation | ||
Disulfide bondi | 184 ↔ 198 | PROSITE-ProRule annotation | ||
Disulfide bondi | 209 ↔ 234 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
MaxQBi | P36369 |
PaxDbi | P36369 |
PRIDEi | P36369 |
ProteomicsDBi | 268931 |
PTM databases
GlyGeni | P36369, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053719, Expressed in submandibular gland and 102 other tissues |
Genevisiblei | P36369, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000047488 |
Miscellaneous databases
RNActi | P36369, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 258 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 234 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT01020000230389 |
HOGENOMi | CLU_006842_1_1_1 |
InParanoidi | P36369 |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P36369 |
TreeFami | TF331065 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P36369-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWFLILFPAL SLGGIDAAPP LQSRVVGGFN CEKNSQPWQV AVYYQKEHIC
60 70 80 90 100
GGVLLDRNWV LTAAHCYVDQ YEVWLGKNKL FQEEPSAQHR LVSKSFPHPG
110 120 130 140 150
FNMSLLMLQT TPPGADFSND LMLLRLSKPA DITDVVKPIA LPTKEPKPGS
160 170 180 190 200
TCLASGWGSI TPTRWQKSDD LQCVFITLLP NENCAKVYLQ KVTDVMLCAG
210 220 230 240 250
EMGGGKDTCA GDSGGPLICD GILQGTTSNG PEPCGKPGVP AIYTNLIKFN
260
SWIKDTMMKN A
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 – 115 | GA → EY (PubMed:6174512).Curated | 2 | |
Sequence conflicti | 117 | F → Y (PubMed:6174512).Curated | 1 | |
Sequence conflicti | 144 | K → E in CAA24211 (PubMed:6174512).Curated | 1 | |
Sequence conflicti | 148 | P → L in CAA24211 (PubMed:6174512).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01831 mRNA Translation: AAA37540.1 X63327 mRNA Translation: CAA44931.1 BC024688 mRNA Translation: AAH24688.1 BC138704 mRNA Translation: AAI38705.1 V00828 mRNA Translation: CAA24211.1 |
CCDSi | CCDS39938.1 |
PIRi | A00940, EGMSB |
RefSeqi | NP_034774.1, NM_010644.3 |
Genome annotation databases
Ensembli | ENSMUST00000048945; ENSMUSP00000047488; ENSMUSG00000053719 |
GeneIDi | 16618 |
KEGGi | mmu:16618 |
UCSCi | uc009gof.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K01831 mRNA Translation: AAA37540.1 X63327 mRNA Translation: CAA44931.1 BC024688 mRNA Translation: AAH24688.1 BC138704 mRNA Translation: AAI38705.1 V00828 mRNA Translation: CAA24211.1 |
CCDSi | CCDS39938.1 |
PIRi | A00940, EGMSB |
RefSeqi | NP_034774.1, NM_010644.3 |
3D structure databases
SMRi | P36369 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000047488 |
Protein family/group databases
MEROPSi | S01.173 |
PTM databases
GlyGeni | P36369, 1 site |
Proteomic databases
MaxQBi | P36369 |
PaxDbi | P36369 |
PRIDEi | P36369 |
ProteomicsDBi | 268931 |
Protocols and materials databases
DNASUi | 16618 |
Genome annotation databases
Ensembli | ENSMUST00000048945; ENSMUSP00000047488; ENSMUSG00000053719 |
GeneIDi | 16618 |
KEGGi | mmu:16618 |
UCSCi | uc009gof.3, mouse |
Organism-specific databases
CTDi | 16618 |
MGIi | MGI:891981, Klk1b26 |
VEuPathDBi | HostDB:ENSMUSG00000053719 |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT01020000230389 |
HOGENOMi | CLU_006842_1_1_1 |
InParanoidi | P36369 |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P36369 |
TreeFami | TF331065 |
Enzyme and pathway databases
Reactomei | R-MMU-1592389, Activation of Matrix Metalloproteinases |
Miscellaneous databases
BioGRID-ORCSi | 16618, 1 hit in 63 CRISPR screens |
PROi | PR:P36369 |
RNActi | P36369, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053719, Expressed in submandibular gland and 102 other tissues |
Genevisiblei | P36369, MM |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | K1B26_MOUSE | |
Accessioni | P36369Primary (citable) accession number: P36369 Secondary accession number(s): B9EI06, P00753, P00754 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families