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Protein

Fibroblast growth factor 7

Gene

Fgf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Heparin-binding, Mitogen

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190377 FGFR2b ligand binding and activation
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 7
Short name:
FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name:
HBGF-7
Keratinocyte growth factor
Short name:
KGF
Gene namesi
Name:Fgf7
Synonyms:Fgf-7, Kgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95521 Fgf7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000000896632 – 194Fibroblast growth factor 7Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP36363
PRIDEiP36363

PTM databases

iPTMnetiP36363
PhosphoSitePlusiP36363

Expressioni

Gene expression databases

BgeeiENSMUSG00000027208
CleanExiMM_FGF7
ExpressionAtlasiP36363 baseline and differential
GenevisibleiP36363 MM

Interactioni

Subunit structurei

Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199652, 1 interactor
IntActiP36363, 1 interactor
STRINGi10090.ENSMUSP00000069681

Structurei

3D structure databases

ProteinModelPortaliP36363
SMRiP36363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP36363
KOiK04358
OMAiCSKHERH
OrthoDBiEOG091G0NAY
PhylomeDBiP36363
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028247 FGF7
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF20 PTHR11486:SF20, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKWILTRIL PTLLYRSCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE
60 70 80 90 100
RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI
110 120 130 140 150
RTVAVGIVAI KGVESEYYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT
160 170 180 190
YASAKWTHSG GEMFVALNQK GIPVKGKKTK KEQKTAHFLP MAIT
Length:194
Mass (Da):22,347
Last modified:June 1, 1994 - v1
Checksum:i805C30D4B1D27C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22703 mRNA Translation: CAA80403.1
U58503 Genomic DNA Translation: AAB01343.1
BC052847 mRNA Translation: AAH52847.1
CCDSiCCDS16681.1
PIRiI48610
RefSeqiNP_032034.1, NM_008008.4
UniGeneiMm.330557

Genome annotation databases

EnsembliENSMUST00000064794; ENSMUSP00000069681; ENSMUSG00000027208
ENSMUST00000110442; ENSMUSP00000106072; ENSMUSG00000027208
GeneIDi14178
KEGGimmu:14178
UCSCiuc008mdj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFGF7_MOUSE
AccessioniPrimary (citable) accession number: P36363
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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