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Entry version 87 (07 Oct 2020)
Sequence version 3 (05 Dec 2018)
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Protein

RNA2 polyprotein

Gene
N/A
Organism
Squash mosaic virus (strain melon) (SqMV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for viral RNA2 accumulation. May function by recruiting the RNA1-encoded polyprotein that contains the replication protein to RNA2 and enable its replication.By similarity
Transports the viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids. Binds to GTP and to single-stranded RNA and single-stranded DNA in a non-sequence-specific manner.By similarity
Together with the small capsid protein, forms an icosahedral capsid (T=3) enclosing the viral positive strand RNA genome, with a diameter of approximately 300 Angstroms. The capsid is formed from 60 copies each of the large and the small capsid protein. The large capsid protein interacts with the viral RNA.By similarity
Together with the large capsid protein, forms an icosahedral capsid (T=3) enclosing the viral positive strand RNA genome, with a diameter of approximately 300 Angstroms. The capsid is formed from 60 copies each of the large and the small capsid protein. The small capsid protein forms the turrets at the fivefold axes of the viral particle.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding, Suppressor of RNA silencing, Viral movement protein
Biological processTransport
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA2 polyprotein
Alternative name(s):
Genome polyprotein M
M RNA polyprotein
Middle component RNA polyprotein
P2
Cleaved into the following 4 chains:
Movement protein
Short name:
MP
Large capsid protein
Short name:
LCP
Alternative name(s):
42k coat protein
Coat protein VP42
L subunit
Large coat protein
Small capsid protein
Short name:
SCP
Alternative name(s):
22k coat protein
Coat protein VP22
S subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSquash mosaic virus (strain melon) (SqMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36401 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesSecoviridaeComovirinaeComovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiChenopodium album (Fat-hen) [TaxID: 3559]
Citrullus lanatus (Watermelon) (Citrullus vulgaris) [TaxID: 3654]
Cucurbita pepo (Vegetable marrow) (Summer squash) [TaxID: 3663]
Ecballium elaterium (Squirting cucumber) (Momordica elaterium) [TaxID: 3679]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host cell junction, T=3 icosahedral capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004458541 – 1009RNA2 polyproteinAdd BLAST1009
ChainiPRO_00004458551 – 90VP58Add BLAST90
ChainiPRO_000003703791 – 451Movement proteinAdd BLAST361
ChainiPRO_0000037038452 – 825Large capsid proteinAdd BLAST374
ChainiPRO_0000037039826 – 1009Small capsid proteinAdd BLAST184

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages by picornain 3C-like protease in vivo yield mature proteins.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei451 – 452Cleavage; by viral protease1 Publication2
Sitei825 – 826Cleavage; by viral protease1 Publication2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P36341

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the large capsid protein.

By similarity

Interacts with the small capsid protein. Homomultimer; assembles as pentons.

Interacts with the movement protein (via C-terminus).

By similarity

Interacts (via C-terminus) with the large capsid protein.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei468Interaction with the viral RNABy similarity1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P36341

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni387 – 393Involved in tubule formation by the movement proteinBy similarity7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a beta-sheet structure called beta-barrel jelly roll.By similarity
Contains a beta-sheet structure called beta-barrel jelly roll.By similarity
The C-terminus is involved in binding to the large capsid protein, and hence to the virion.By similarity

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003181, Como_LCP
IPR003182, RNA2_polyprotein
IPR029053, Viral_coat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02247, Como_LCP, 1 hit
PF02248, Como_SCP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P36341-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWHFCEQVYE CFEGYHRDYS VQTVPVEYLA SHYIVNKFRP DPLAVLWLFC
60 70 80 90 100
LGIWWEIIQI LHHLFQYKEP ALFVGSCQNL AAFLEKKYSM EVIQKEGLAA
110 120 130 140 150
SALKDKERLT EKAVVNQPLS NLIPHSNKMY ERSKSLLSGL KRGLIKQKEI
160 170 180 190 200
AFDKLMGGST IDFQHIPTGT LTPGENKVLD IPIVPQHLLT STNITDYHQA
210 220 230 240 250
NKKNANGATA LHVGAIEVIM DCFTSPDSNI CGGMLLVDTA HLNPDNAIRS
260 270 280 290 300
VFVAPFIGGR PIRVLLFPDT LVEIAPNMNS RFKLLCTTSN GDVAPDFNLA
310 320 330 340 350
MVKVNVAGCA VSLTRTYTPT AYLEQELIKE KGAIVQYLNR HTFSMHRNNQ
360 370 380 390 400
MTKEEMQKQR LSFRLESALT LQEKHPLHAT FCKSTNFVYK IGGDAKEGSN
410 420 430 440 450
GNLTVNESQL SSHSPSAHVL HKHNNSGDNE VEFSEIGVVV PGAGRTKAYG
460 470 480 490 500
QNELDLAQLS LDDTSSLRGT ALQTKLATSR IILSKTMVGN TVLREDLLAT
510 520 530 540 550
FLQDSNERAA IDLIRTHVIR GKIRCVASIN VPENTGCALA ICFNSGITGA
560 570 580 590 600
ADTDIYTTSS QDAIVWNPAC EKAVELTFNP NPCGDAWNFV FLQQTKAHFA
610 620 630 640 650
VQCVTGWTTT PLTDLALVLT WHIDRSLCVP KTLTISSAHA SFPINRWMGK
660 670 680 690 700
LSFPQGPARV LKRMPLAIGG GAGTKDAILM NMPNAVISLH RYFRGDFVFE
710 720 730 740 750
ITKMSSPYIK ATIAFFIAFG DITEEMTNLE SFPHKLVQFA EIQGRTTITF
760 770 780 790 800
TQSEFLTAWS TQVLSTVNPQ KDGCPHLYAL LHDSATSTIE GNFVIGVKLL
810 820 830 840 850
DIRNYRAYGH NPGFEGARLL GISGQSTMVQ QLGTYNPIWM VRTPLESTAQ
860 870 880 890 900
QNFASFTADL MESTISGDST GNWNITVYPS PIANLLKVAA WKKGTIRFQL
910 920 930 940 950
ICRGAAVKQS DWAASARIDL INNLSNKALP ARSWYITKPR GGDIEFDLEI
960 970 980 990 1000
AGPNNGFEMA NSSWAFQTTW YLEIAIDNPK QFTLFELNAC LMEDFEVAGN

TLNPPILLS
Length:1,009
Mass (Da):111,788
Last modified:December 5, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDA33BB41F01B628
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti315R → K in strain Melon. Curated1
Natural varianti562D → N in strain Melon. Curated1
Natural varianti740A → R in strain Melon. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M96148 Genomic RNA No translation available.
MF166754 Genomic RNA Translation: ASA69625.1
MF166755 Genomic RNA Translation: ASA69626.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A48356

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96148 Genomic RNA No translation available.
MF166754 Genomic RNA Translation: ASA69625.1
MF166755 Genomic RNA Translation: ASA69626.1
PIRiA48356

3D structure databases

SMRiP36341
ModBaseiSearch...

Proteomic databases

PRIDEiP36341

Family and domain databases

Gene3Di2.60.120.20, 2 hits
InterProiView protein in InterPro
IPR003181, Como_LCP
IPR003182, RNA2_polyprotein
IPR029053, Viral_coat
PfamiView protein in Pfam
PF02247, Como_LCP, 1 hit
PF02248, Como_SCP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL2_SQMVM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36341
Secondary accession number(s): A0A1Z2TIL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 5, 2018
Last modified: October 7, 2020
This is version 87 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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