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UniProtKB - P36334 (SPIKE_CVHOC)

Entry version 122 (02 Dec 2020)
Sequence version 1 (01 Jun 1994)
Previous versions | rss
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Protein

Spike glycoprotein

Gene

S

Organism
Human coronavirus OC43 (HCoV-OC43)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection.
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.UniRule annotation
mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.UniRule annotation
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • host cell surface receptor binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virulence, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spike glycoproteinUniRule annotation
Short name:
S glycoproteinUniRule annotation
Alternative name(s):
E2UniRule annotation
Peplomer proteinUniRule annotation
Cleaved into the following 3 chains:
Spike protein S1UniRule annotation
Spike protein S2UniRule annotation
Spike protein S2'UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUniRule annotation
ORF Names:3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman coronavirus OC43 (HCoV-OC43)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31631 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000180344 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000007552 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini14 – 1297ExtracellularUniRule annotationAdd BLAST1284
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1298 – 1318HelicalUniRule annotationAdd BLAST21
Topological domaini1319 – 1353CytoplasmicUniRule annotationAdd BLAST35

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 13UniRule annotationAdd BLAST13
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003720514 – 1353Spike glycoproteinAdd BLAST1340
ChainiPRO_000003720614 – 758Spike protein S1Add BLAST745
ChainiPRO_0000037207759 – 1353Spike protein S2Add BLAST595
ChainiPRO_0000444081904 – 1353Spike protein S2'UniRule annotationAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi21 ↔ 169PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi133N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi146N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi164 ↔ 197PROSITE-ProRule annotation
Disulfide bondi176 ↔ 256PROSITE-ProRule annotation
Glycosylationi202N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi290 ↔ 300PROSITE-ProRule annotation
Disulfide bondi335 ↔ 360PROSITE-ProRule annotation
Glycosylationi363N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi378 ↔ 431PROSITE-ProRule annotation
Disulfide bondi390 ↔ 605PROSITE-ProRule annotation
Glycosylationi441N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi496N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi639N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi666N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi686N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi704N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi729N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi778N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi927N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi928 ↔ 939UniRule annotation
Glycosylationi1184N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1214N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1224N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1243N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1257N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1278N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins. The precursor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins. Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor.UniRule annotation
The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei758 – 759Cleavage; by hostBy similarity2
Sitei903 – 904CleavageUniRule annotation2

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P36334

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 302BetaCoV S1-NTDPROSITE-ProRule annotationAdd BLAST288
Domaini333 – 607BetaCoV S1-CTDPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni318 – 624Receptor-binding domainUniRule annotationAdd BLAST307
Regioni904 – 925Fusion peptide 1UniRule annotationAdd BLAST22
Regioni923 – 943Fusion peptide 2UniRule annotationAdd BLAST21
Regioni1004 – 1054Heptad repeat 1UniRule annotationAdd BLAST51
Regioni1248 – 1286Heptad repeat 2UniRule annotationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1033 – 1077UniRule annotationAdd BLAST45
Coiled coili1259 – 1287UniRule annotationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1349 – 1353KxHxxUniRule annotation5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1319 – 1336Cys-richAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Fusion peptide 1 (FP1) and fusion peptide 2 (FP2) function cooperatively and have a membrane-ordering effect on lipid headgroups and shallow hydrophobic regions of target bilayers. They are considered as two domains of an extended, bipartite FP. The membrane-ordering activity is calcium-dependent and also dependent on correct folding, which is maintained by an internal disulfide bond in FP2.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the betacoronaviruses spike protein family.UniRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.790, 1 hit
2.60.120.960, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_04099, BETA_CORONA_SPIKE, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032500, bCoV_S1_N
IPR042578, BETA_CORONA_SPIKE
IPR043607, CoV_S1_C
IPR043473, S2_sf_CoV
IPR027400, S_HR2_CoV
IPR043002, Spike_N_sf
IPR018548, Spike_rcpt-bd_bCoV
IPR036326, Spike_rcpt-bd_sf_CoV
IPR002552, Spike_S2_CoV
IPR043614, Spike_S2_CoV_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16451, bCoV_S1_N, 1 hit
PF09408, bCoV_S1_RBD, 1 hit
PF19209, CoV_S1_C, 1 hit
PF01601, CoV_S2, 1 hit
PF19214, CoV_S2_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111474, SSF111474, 2 hits
SSF143587, SSF143587, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51921, BCOV_S1_CTD, 1 hit
PS51922, BCOV_S1_NTD, 1 hit
PS51923, COV_S2_HR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P36334-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLILLISLP TAFAVIGDLK CTSDNINDKD TGPPPISTDT VDVTNGLGTY 
        60         70         80         90        100
YVLDRVYLNT TLFLNGYYPT SGSTYRNMAL KGSVLLSRLW FKPPFLSDFI 
       110        120        130        140        150
NGIFAKVKNT KVIKDRVMYS EFPAITIGST FVNTSYSVVV QPRTINSTQD 
       160        170        180        190        200
GDNKLQGLLE VSVCQYNMCE YPQTICHPNL GNHRKELWHL DTGVVSCLYK 
       210        220        230        240        250
RNFTYDVNAD YLYFHFYQEG GTFYAYFTDT GVVTKFLFNV YLGMALSHYY 
       260        270        280        290        300
VMPLTCNSKL TLEYWVTPLT SRQYLLAFNQ DGIIFNAEDC MSDFMSEIKC 
       310        320        330        340        350
KTQSIAPPTG VYELNGYTVQ PIADVYRRKP NLPNCNIEAW LNDKSVPSPL 
       360        370        380        390        400
NWERKTFSNC NFNMSSLMSF IQADSFTCNN IDAAKIYGMC FSSITIDKFA 
       410        420        430        440        450
IPNGRKVDLQ LGNLGYLQSF NYRIDTTATS CQLYYNLPAA NVSVSRFNPS 
       460        470        480        490        500
TWNKRFGFIE DSVFKPRPAG VLTNHDVVYA QHCFKAPKNF CPCKLNGSCV 
       510        520        530        540        550
GSGPGKNNGI GTCPAGTNYL TCDNLCTPDP ITFTGTYKCP QTKSLVGIGE 
       560        570        580        590        600
HCSGLAVKSD YCGGNSCTCR PQAFLGWSAD SCLQGDKCNI FANFILHDVN 
       610        620        630        640        650
SGLTCSTDLQ KANTDIILGV CVNYDLYGIL GQGIFVEVNA TYYNSWQNLL 
       660        670        680        690        700
YDSNGNLYGF RDYIINRTFM IRSCYSGRVS AAFHANSSEP ALLFRNIKCN 
       710        720        730        740        750
YVFNNSLTRQ LQPINYFDSY LGCVVNAYNS TAISVQTCDL TVGSGYCVDY 
       760        770        780        790        800
SKNRRSRGAI TTGYRFTNFE PFTVNSVNDS LEPVGGLYEI QIPSEFTIGN 
       810        820        830        840        850
MVEFIQTSSP KVTIDCAAFV CGDYAACKSQ LVEYGSFCDN INAILTEVNE 
       860        870        880        890        900
LLDTTQLQVA NSLMNGVTLS TKLKDGVNFN VDDINFSPVL GCLGSECSKA 
       910        920        930        940        950
SSRSAIEDLL FDKVKLSDVG FVEAYNNCTG GAEIRDLICV QSYKGIKVLP 
       960        970        980        990       1000
PLLSENQISG YTLAATSASL FPPWTAAAGV PFYLNVQYRI NGLGVTMDVL 
      1010       1020       1030       1040       1050
SQNQKLIANA FNNALYAIQE GFDATNSALV KIQAVVNANA EALNNLLQQL 
      1060       1070       1080       1090       1100
SNRFGAISAS LQEILSRLDA LEAEAQIDRL INGRLTALNA YVSQQLSDST 
      1110       1120       1130       1140       1150
LVKFSAAQAM EKVNECVKSQ SSRINFCGNG NHIISLVQNA PYGLYFIHFS 
      1160       1170       1180       1190       1200
YVPTKYVTAR VSPGLCIAGD RGIAPKSGYF VNVNNTWMYT GSGYYYPEPI 
      1210       1220       1230       1240       1250
TENNVVVMST CAVNYTKAPY VMLNTSIPNL PDFKEELDQW FKNQTSVAPD 
      1260       1270       1280       1290       1300
LSLDYINVTF LDLQVEMNRL QEAIKVLNQS YINLKDIGTY EYYVKWPWYV 
      1310       1320       1330       1340       1350
WLLICLAGVA MLVLLFFICC CTGCGTSCFK KCGGCCDDYT GYQELVIKTS 

HDD
Length:1,353
Mass (Da):150,089
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B1CE3CBDB1A902A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB27260 differs from that shown. Unknown reason.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti11 – 13TAF → MAL in strain: Isolate VA. 3
Natural varianti23 – 25SDN → TVA in strain: Isolate VA. 3
Natural varianti23 – 25SDN → TVS in strain: Isolate CU. 3
Natural varianti25N → TSY in strain: Isolate AT and Isolate ATCC VR-759. 1
Natural varianti29K → I in strain: Isolate CU. 1
Natural varianti29K → V in strain: Isolate VA. 1
Natural varianti33 – 36PPPI → VPST in strain: Isolate VA. 4
Natural varianti33 – 35PPP → APS in strain: Isolate CU. 3
Natural varianti40T → I in strain: Isolate CU and Isolate VA. 1
Natural varianti62L → F in strain: Isolate AT. 1
Natural varianti63F → L in strain: Isolate AT, Isolate CU and Isolate VA. 1
Natural varianti83 – 84SV → TL in strain: Isolate CU and Isolate VA. 2
Natural varianti115D → H in strain: Isolate VA. 1
Natural varianti115D → K in strain: Isolate CU. 1
Natural varianti116R → G in strain: Isolate AT, Isolate CU and Isolate VA. 1
Natural varianti143 – 151RTINSTQDG → HTTNL in strain: Isolate CU and Isolate VA. 9
Natural varianti152D → Y in strain: Isolate AT and Isolate ATCC VR-759. 1
Natural varianti161V → I in strain: Isolate CU and Isolate VA. 1
Natural varianti167N → T in strain: Isolate CU and Isolate VA. 1
Natural varianti173Q → H in strain: Isolate CU. 1
Natural varianti173Q → N in strain: Isolate VA. 1
Natural varianti183 – 185HRK → RRV in strain: Isolate CU and Isolate VA. 3
Natural varianti190L → W in strain: Isolate CU and Isolate VA. 1
Natural varianti222T → I in strain: Isolate VA. 1
Natural varianti244 – 245MA → TV in strain: Isolate CU and Isolate VA. 2
Natural varianti248H → Y in strain: Isolate VA. 1
Natural varianti252M → L in strain: Isolate CU. 1
Natural varianti259 – 260KL → AM in strain: Isolate CU, Isolate ATCC VR-759 and Isolate VA. 2
Natural varianti260L → VKNGF in strain: Isolate AT and Isolate ATCC VR-759. 1
Natural varianti272R → K in strain: Isolate CU and Isolate VA. 1
Natural varianti283I → V in strain: Isolate CU and Isolate VA. 1
Natural varianti288E → V in strain: Isolate AT, Isolate ATCC VR-759, Isolate CU and Isolate VA. 1
Natural varianti291M → K in strain: Isolate CU and Isolate VA. 1
Natural varianti303Q → L in strain: Isolate CU and Isolate VA. 1
Natural varianti308P → S in strain: Isolate CU and Isolate VA. 1
Natural varianti329K → I in strain: Isolate CU and Isolate VA. 1
Natural varianti330P → L in strain: Isolate ATCC VR-759. 1
Natural varianti334N → D in strain: Isolate CU and Isolate VA. 1
Natural varianti451T → I in strain: Isolate VA. 1
Natural varianti454K → R in strain: Isolate CU and Isolate VA. 1
Natural varianti459 – 461IED → TEQ in strain: Isolate CU and Isolate VA. 3
Natural varianti467R → Q in strain: Isolate CU and Isolate VA. 1
Natural varianti469 – 474AGVLTN → VGVFTH in strain: Isolate CU. 6
Natural varianti472 – 474LTN → FTD in strain: Isolate VA. 3
Natural varianti488K → T in strain: Isolate CU and Isolate VA. 1
Natural varianti496N → D in strain: Isolate CU and Isolate VA. 1
Natural varianti499 – 536CVGSG…TFTGT → LCVGNGPGIDAGYKNSGIGT CPAGTNYLTCHNAAQCDCLC TPDPITSKSTGP in strain: Isolate CU and Isolate VA. Add BLAST38
Natural varianti533F → FKA in strain: Isolate AT and Isolate ATCC VR-759. 1
Natural varianti544S → Y in strain: Isolate CU and Isolate VA. 1
Natural varianti557V → I in strain: Isolate CU and Isolate VA. 1
Natural varianti566S → P in strain: Isolate AT, Isolate CU and Isolate VA. 1
Natural varianti570R → Q in strain: Isolate CU and Isolate VA. 1
Natural varianti579A → V in strain: Isolate CU and Isolate VA. 1
Natural varianti587K → R in strain: Isolate CU and Isolate VA. 1
Natural varianti603L → T in strain: Isolate CU and Isolate VA. 1
Natural varianti612A → S in strain: Isolate CU and Isolate VA. 1
Natural varianti630L → T in strain: Isolate CU and Isolate VA. 1
Natural varianti641T → P in strain: Isolate CU and Isolate VA. 1
Natural varianti664 – 665II → LT in strain: Isolate CU and Isolate VA. 2
Natural varianti665I → T in strain: Isolate AT and Isolate ATCC VR-759. 1
Natural varianti694F → S in strain: Isolate AT. 1
Natural varianti700N → S in strain: Isolate CU. 1
Natural varianti706 – 708SLT → TLS in strain: Isolate CU and Isolate VA. 3
Natural varianti728Y → D in strain: Isolate CU and Isolate VA. 1
Natural varianti732 – 734AIS → SSV in strain: Isolate CU. 3
Natural varianti733 – 734IS → SA in strain: Isolate VA. 2
Natural varianti752 – 753KN → TK in strain: Isolate CU and Isolate VA. 2
Natural varianti758G → R in strain: Isolate CU and Isolate VA. 1
Natural varianti783P → H in strain: Isolate VA. 1
Natural varianti802V → E in strain: Isolate AT, Isolate ATCC VR-759, Isolate CU and Isolate VA. 1
Natural varianti817A → S in strain: Isolate CU and Isolate VA. 1
Natural varianti824Y → C in strain: Isolate VA. 1
Natural varianti833E → G in strain: Isolate AT. 1
Natural varianti884I → V in strain: Isolate VA. 1
Natural varianti896E → C in strain: Isolate CU. 1
Natural varianti898 – 900SKA → NKV in strain: Isolate CU and Isolate VA. 3
Natural varianti912D → S in strain: Isolate CU and Isolate VA. 1
Natural varianti915K → R in strain: Isolate VA. 1
Natural varianti933E → G in strain: Isolate VA. 1
Natural varianti944K → N in strain: Isolate CU and Isolate VA. 1
Natural varianti955E → D in strain: Isolate VA. 1
Natural varianti955E → V in strain: Isolate CU. 1
Natural varianti969S → N in strain: Isolate VA. 1
Natural varianti973P → L in strain: Isolate ATCC VR-759. 1
Natural varianti975T → S in strain: Isolate CU and Isolate VA. 1
Natural varianti993L → I in strain: Isolate CU and Isolate VA. 1
Natural varianti1012N → S in strain: Isolate CU. 1
Natural varianti1016Y → D in strain: Isolate AT, Isolate CU and Isolate VA. 1
Natural varianti1039N → D in strain: Isolate VA. 1
Natural varianti1058S → G in strain: Isolate CU. 1
Natural varianti1059A → S in strain: Isolate CU and Isolate VA. 1
Natural varianti1074E → Q in strain: Isolate CU and Isolate VA. 1
Natural varianti1089N → D in strain: Isolate VA. 1
Natural varianti1160R → K in strain: Isolate CU and Isolate VA. 1
Natural varianti1189Y → F in strain: Isolate CU and Isolate VA. 1
Natural varianti1193G → R in strain: Isolate VA. 1
Natural varianti1197P → L in strain: Isolate AT. 1
Natural varianti1202E → G in strain: Isolate CU and Isolate VA. 1
Natural varianti1211C → W in strain: Isolate AT. 1
Natural varianti1220Y → D in strain: Isolate CU and Isolate VA. 1
Natural varianti1225 – 1227TSI → IST in strain: Isolate CU and Isolate VA. 3
Natural varianti1231P → H in strain: Isolate CU. 1
Natural varianti1246S → L in strain: Isolate VA. 1
Natural varianti1265V → D in strain: Isolate CU and Isolate VA. 1
Natural varianti1305 – 1306CL → GF in strain: Isolate CU and Isolate VA. 2
Natural varianti1331K → I in strain: Isolate CU. 1
Natural varianti1342Y → H in strain: Isolate CU and Isolate VA. 1
Natural varianti1352 – 1353DD → EG in strain: Isolate VA. 2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L14643 Genomic RNA Translation: AAA03055.1
S62886 Genomic RNA Translation: AAB27260.2 Sequence problems.
Z21849 Genomic RNA Translation: CAA79896.1
Z32768 Genomic RNA Translation: CAA83660.1
Z32769 Genomic RNA Translation: CAA83661.1
AY585228 Genomic RNA Translation: AAT84354.1
AY391777 Genomic RNA Translation: AAR01015.1

Protein sequence database of the Protein Information Resource

More...PIRi		A37474
JQ2168
S29998
S44240
S44241

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14643 Genomic RNA Translation: AAA03055.1
S62886 Genomic RNA Translation: AAB27260.2 Sequence problems.
Z21849 Genomic RNA Translation: CAA79896.1
Z32768 Genomic RNA Translation: CAA83660.1
Z32769 Genomic RNA Translation: CAA83661.1
AY585228 Genomic RNA Translation: AAT84354.1
AY391777 Genomic RNA Translation: AAR01015.1
PIRiA37474
JQ2168
S29998
S44240
S44241

3D structure databases

SMRiP36334
ModBaseiSearch...

Family and domain databases

Gene3Di1.20.5.790, 1 hit
2.60.120.960, 1 hit
HAMAPiMF_04099, BETA_CORONA_SPIKE, 1 hit
InterProiView protein in InterPro
IPR032500, bCoV_S1_N
IPR042578, BETA_CORONA_SPIKE
IPR043607, CoV_S1_C
IPR043473, S2_sf_CoV
IPR027400, S_HR2_CoV
IPR043002, Spike_N_sf
IPR018548, Spike_rcpt-bd_bCoV
IPR036326, Spike_rcpt-bd_sf_CoV
IPR002552, Spike_S2_CoV
IPR043614, Spike_S2_CoV_C
PfamiView protein in Pfam
PF16451, bCoV_S1_N, 1 hit
PF09408, bCoV_S1_RBD, 1 hit
PF19209, CoV_S1_C, 1 hit
PF01601, CoV_S2, 1 hit
PF19214, CoV_S2_C, 1 hit
SUPFAMiSSF111474, SSF111474, 2 hits
SSF143587, SSF143587, 1 hit
PROSITEiView protein in PROSITE
PS51921, BCOV_S1_CTD, 1 hit
PS51922, BCOV_S1_NTD, 1 hit
PS51923, COV_S2_HR1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIKE_CVHOC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36334
Secondary accession number(s): Q66199
, Q66290, Q66291, Q696Q6, Q6TNF9, Q86623
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 2, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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