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UniProtKB - P36269 (GGT5_HUMAN)

Entry version 188 (02 Dec 2020)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

Glutathione hydrolase 5 proenzyme

Gene

GGT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656).2 Publications

Miscellaneous

A previous study reported that GSH and oxidized glutathione (GSSG) are not substrates for murine GGT5 (By similarity). However, this result contrasts with two studies reported that GSH is indeed a substrate for GGT5 (PubMed:21447318, PubMed:1676842).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by serine-borate.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10.5 µM for glutathione1 Publication
  2. KM=10.2 µM for leukotriene C41 Publication
  3. KM=18.2 µM for S-methylglutathione1 Publication
  4. KM=14.8 µM for S-(4-nitro-benzyl)glutathione1 Publication
  5. KM=43 µM for oxidized glutathione1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glutathione metabolism

    This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

    Pathwayi: leukotriene D4 biosynthesis

    This protein is involved in the pathway leukotriene D4 biosynthesis, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway leukotriene D4 biosynthesis and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei110GlutamateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei388NucleophileBy similarity1
    Binding sitei406GlutamateBy similarity1
    Binding sitei427GlutamateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Hydrolase, Protease, Transferase
    Biological processGlutathione biosynthesis, Leukotriene biosynthesis

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS01949-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.3.2.2, 2681
    3.4.19.13, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P36269

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-174403, Glutathione synthesis and recycling
    R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
    R-HSA-5423646, Aflatoxin activation and detoxification
    R-HSA-9664535, LTC4-CYSLTR mediated IL4 production

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00204
    UPA00880

    Protein family/group databases

    MEROPS protease database

    More...    MEROPSi    		T03.002

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000001455

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glutathione hydrolase 5 proenzyme (EC:3.4.19.133 Publications)
    Alternative name(s):
    Gamma-glutamyl transpeptidase-related enzyme1 Publication
    Short name:
    GGT-rel1 Publication
    Gamma-glutamyltransferase 5 (EC:2.3.2.21 Publication)
    Short name:
    GGT 5
    Gamma-glutamyltransferase-like activity 11 Publication
    Gamma-glutamyltranspeptidase 5
    Leukotriene-C4 hydrolase (EC:3.4.19.141 Publication)
    Cleaved into the following 2 chains:
    Glutathione hydrolase 5 heavy chain
    Glutathione hydrolase 5 light chain
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:GGT5
    Synonyms:GGTLA1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000099998.17

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:4260, GGT5

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		137168, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P36269

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicBy similarity8
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinBy similarityAdd BLAST21
    Topological domaini30 – 586ExtracellularBy similarityAdd BLAST557

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		2687

    Open Targets

    More...    OpenTargetsi    		ENSG00000099998

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA162389442

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P36269, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		GGT5

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		116242493

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000110721 – 387Glutathione hydrolase 5 heavy chainBy similarityAdd BLAST387
    ChainiPRO_0000011073388 – 586Glutathione hydrolase 5 light chainBy similarityAdd BLAST199

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi550N-linked (GlcNAc...) asparagine1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Cleaved by autocatalysis into a large and a small subunit.By similarity
    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein, Zymogen

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P36269

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P36269

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P36269

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P36269

    PeptideAtlas

    More...    PeptideAtlasi    		P36269

    PRoteomics IDEntifications database

    More...    PRIDEi    		P36269

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		55177 [P36269-1]
    55178 [P36269-2]
    55179 [P36269-3]

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		P36269, 8 sites, 4 O-linked glycans (2 sites)

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P36269

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P36269

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000099998, Expressed in endocervix and 172 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P36269, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P36269, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000099998, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterodimer composed of the light and heavy chains. The active site is located in the light chain.

    By similarity

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		108954, 6 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P36269, 5 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000381340

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P36269, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P36269

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni469 – 470Glutamate bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the gamma-glutamyltransferase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG2410, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000155794

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_014813_4_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P36269

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		CGMGPPS

    Database of Orthologous Groups

    More...    OrthoDBi    		1419292at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P36269

    TreeFam database of animal gene trees

    More...    TreeFami    		TF313608

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.246.130, 1 hit
    3.60.20.40, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR043138, GGT_lsub_C
    IPR000101, GGT_peptidase
    IPR043137, GGT_ssub
    IPR029055, Ntn_hydrolases_N

    The PANTHER Classification System

    More...    PANTHERi    		PTHR11686, PTHR11686, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF56235, SSF56235, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00462, G_GLU_TRANSPEPTIDASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P36269-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS 
            60         70         80         90        100
    KVCSDIGRAI LQQQGSPVDA TIAALVCTSV VNPQSMGLGG GVIFTIYNVT 
           110        120        130        140        150
    TGKVEVINAR ETVPASHAPS LLDQCAQALP LGTGAQWIGV PGELRGYAEA 
           160        170        180        190        200
    HRRHGRLPWA QLFQPTIALL RGGHVVAPVL SRFLHNSILR PSLQASTLRQ 
           210        220        230        240        250
    LFFNGTEPLR PQDPLPWPAL ATTLETVATE GVEVFYTGRL GQMLVEDIAK 
           260        270        280        290        300
    EGSQLTLQDL AKFQPEVVDA LEVPLGDYTL YSPPPPAGGA ILSFILNVLR 
           310        320        330        340        350
    GFNFSTESMA RPEGRVNVYH HLVETLKFAK GQRWRLGDPR SHPKLQNASR 
           360        370        380        390        400
    DLLGETLAQL IRQQIDGRGD HQLSHYSLAE AWGHGTGTSH VSVLGEDGSA 
           410        420        430        440        450
    VAATSTINTP FGAMVYSPRT GIILNNELLD LCERCPRGSG TTPSPVSGDR 
           460        470        480        490        500
    VGGAPGRCWP PVPGERSPSS MVPSILINKA QGSKLVIGGA GGELIISAVA 
           510        520        530        540        550
    QAIMSKLWLG FDLRAAIAAP ILHVNSKGCV EYEPNFSQEV QRGLQDRGQN 
           560        570        580 
    QTQRPFFLNV VQAVSQEGAC VYAVSDLRKS GEAAGY
    Length:586
    Mass (Da):62,261
    Last modified:October 17, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE37B3CE516F5788
    GO
    Isoform 2 (identifier: P36269-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         101-132: Missing.

    Show »
    Length:554
    Mass (Da):58,992
    Checksum:i86001882BE5A0D10
    GO
    Isoform 3 (identifier: P36269-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         445-445: P → PA

    Show »
    Length:587
    Mass (Da):62,332
    Checksum:iC7F2285F9FFF1A22
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    C9JU68C9JU68_HUMAN
    Glutathione hydrolase 5 proenzyme
    GGT5
    		73Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C1X2H7C1X2_HUMAN
    Glutathione hydrolase 5 proenzyme
    GGT5
    		220Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAB55910 differs from that shown. Reason: Frameshift.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti408N → Y in CAB55910 (PubMed:17974005).Curated1
    Sequence conflicti437R → W in AAA58503 (PubMed:1676842).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02800611L → I. Corresponds to variant dbSNP:rs5760274Ensembl.1
    Natural variantiVAR_028007330K → R2 PublicationsCorresponds to variant dbSNP:rs2275984Ensembl.1
    Natural variantiVAR_028008332Q → H. Corresponds to variant dbSNP:rs6004105Ensembl.1
    Natural variantiVAR_024455475I → V. Corresponds to variant dbSNP:rs7288201Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008146101 – 132Missing in isoform 2. 1 PublicationAdd BLAST32
    Alternative sequenceiVSP_043470445P → PA in isoform 3. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		M64099 mRNA Translation: AAA58503.1
    AL117414 mRNA Translation: CAB55910.1 Frameshift.
    BT009808 mRNA Translation: AAP88810.1
    CT841518 mRNA Translation: CAJ86448.1
    AK292006 mRNA Translation: BAF84695.1
    AP000353 Genomic DNA No translation available.
    AP000354 Genomic DNA No translation available.
    CH471095 Genomic DNA Translation: EAW59643.1
    BC011362 mRNA Translation: AAH11362.1
    BC073999 mRNA Translation: AAH73999.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS13825.1 [P36269-1]
    CCDS42989.1 [P36269-2]
    CCDS42990.1 [P36269-3]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A41125
    T17220

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001093251.1, NM_001099781.2 [P36269-3]
    NP_001093252.1, NM_001099782.2 [P36269-2]
    NP_001289393.1, NM_001302464.1
    NP_001289394.1, NM_001302465.1
    NP_004112.2, NM_004121.3 [P36269-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000263112; ENSP00000263112; ENSG00000099998 [P36269-2]
    ENST00000327365; ENSP00000330080; ENSG00000099998 [P36269-1]
    ENST00000398292; ENSP00000381340; ENSG00000099998 [P36269-3]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		2687

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:2687

    UCSC genome browser

    More...    UCSCi    		uc002zzo.4, human [P36269-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		M64099 mRNA Translation: AAA58503.1
    AL117414 mRNA Translation: CAB55910.1 Frameshift.
    BT009808 mRNA Translation: AAP88810.1
    CT841518 mRNA Translation: CAJ86448.1
    AK292006 mRNA Translation: BAF84695.1
    AP000353 Genomic DNA No translation available.
    AP000354 Genomic DNA No translation available.
    CH471095 Genomic DNA Translation: EAW59643.1
    BC011362 mRNA Translation: AAH11362.1
    BC073999 mRNA Translation: AAH73999.1
    CCDSiCCDS13825.1 [P36269-1]
    CCDS42989.1 [P36269-2]
    CCDS42990.1 [P36269-3]
    PIRiA41125
    T17220
    RefSeqiNP_001093251.1, NM_001099781.2 [P36269-3]
    NP_001093252.1, NM_001099782.2 [P36269-2]
    NP_001289393.1, NM_001302464.1
    NP_001289394.1, NM_001302465.1
    NP_004112.2, NM_004121.3 [P36269-1]

    3D structure databases

    SMRiP36269
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi108954, 6 interactors
    IntActiP36269, 5 interactors
    STRINGi9606.ENSP00000381340

    Chemistry databases

    SwissLipidsiSLP:000001455

    Protein family/group databases

    MEROPSiT03.002

    PTM databases

    GlyGeniP36269, 8 sites, 4 O-linked glycans (2 sites)
    iPTMnetiP36269
    PhosphoSitePlusiP36269

    Polymorphism and mutation databases

    BioMutaiGGT5
    DMDMi116242493

    Proteomic databases

    EPDiP36269
    jPOSTiP36269
    MassIVEiP36269
    PaxDbiP36269
    PeptideAtlasiP36269
    PRIDEiP36269
    ProteomicsDBi55177 [P36269-1]
    55178 [P36269-2]
    55179 [P36269-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		285, 122 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		2687

    Genome annotation databases

    EnsembliENST00000263112; ENSP00000263112; ENSG00000099998 [P36269-2]
    ENST00000327365; ENSP00000330080; ENSG00000099998 [P36269-1]
    ENST00000398292; ENSP00000381340; ENSG00000099998 [P36269-3]
    GeneIDi2687
    KEGGihsa:2687
    UCSCiuc002zzo.4, human [P36269-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		2687
    DisGeNETi2687
    EuPathDBiHostDB:ENSG00000099998.17

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		GGT5
    HGNCiHGNC:4260, GGT5
    HPAiENSG00000099998, Low tissue specificity
    MIMi137168, gene
    neXtProtiNX_P36269
    OpenTargetsiENSG00000099998
    PharmGKBiPA162389442

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG2410, Eukaryota
    GeneTreeiENSGT00940000155794
    HOGENOMiCLU_014813_4_1_1
    InParanoidiP36269
    OMAiCGMGPPS
    OrthoDBi1419292at2759
    PhylomeDBiP36269
    TreeFamiTF313608

    Enzyme and pathway databases

    UniPathwayiUPA00204
    UPA00880
    BioCyciMetaCyc:HS01949-MONOMER
    BRENDAi2.3.2.2, 2681
    3.4.19.13, 2681
    PathwayCommonsiP36269
    ReactomeiR-HSA-174403, Glutathione synthesis and recycling
    R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
    R-HSA-5423646, Aflatoxin activation and detoxification
    R-HSA-9664535, LTC4-CYSLTR mediated IL4 production

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		2687, 10 hits in 844 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		GGT5, human

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		GGTLA1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		2687
    PharosiP36269, Tbio

    Protein Ontology

    More...    PROi    		PR:P36269
    RNActiP36269, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000099998, Expressed in endocervix and 172 other tissues
    ExpressionAtlasiP36269, baseline and differential
    GenevisibleiP36269, HS

    Family and domain databases

    Gene3Di1.10.246.130, 1 hit
    3.60.20.40, 1 hit
    InterProiView protein in InterPro
    IPR043138, GGT_lsub_C
    IPR000101, GGT_peptidase
    IPR043137, GGT_ssub
    IPR029055, Ntn_hydrolases_N
    PANTHERiPTHR11686, PTHR11686, 1 hit
    SUPFAMiSSF56235, SSF56235, 1 hit
    PROSITEiView protein in PROSITE
    PS00462, G_GLU_TRANSPEPTIDASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGT5_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36269
    Secondary accession number(s): Q53XM9
    , Q6GMP0, Q96FC1, Q9UFM5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 17, 2006
    Last modified: December 2, 2020
    This is version 188 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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