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UniProtKB - P36269 (GGT5_HUMAN)

Entry version 192 (29 Sep 2021)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

Glutathione hydrolase 5 proenzyme

Gene

GGT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318).

Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318).

May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318).

Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656).

2 Publications

Miscellaneous

A previous study reported that GSH and oxidized glutathione (GSSG) are not substrates for murine GGT5 (By similarity). However, this result contrasts with two studies reported that GSH is indeed a substrate for GGT5 (PubMed:21447318, PubMed:1676842).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by serine-borate.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10.5 µM for glutathione1 Publication
  2. KM=10.2 µM for leukotriene C41 Publication
  3. KM=18.2 µM for S-methylglutathione1 Publication
  4. KM=14.8 µM for S-(4-nitro-benzyl)glutathione1 Publication
  5. KM=43 µM for oxidized glutathione1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

Pathwayi: leukotriene D4 biosynthesis

This protein is involved in the pathway leukotriene D4 biosynthesis, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway leukotriene D4 biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei110GlutamateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei388NucleophileBy similarity1
Binding sitei406GlutamateBy similarity1
Binding sitei427GlutamateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Hydrolase, Protease, Transferase
Biological processGlutathione biosynthesis, Leukotriene biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS01949-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.2.2, 2681
3.4.19.13, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P36269

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-174403, Glutathione synthesis and recycling
R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-5423646, Aflatoxin activation and detoxification
R-HSA-9664535, LTC4-CYSLTR mediated IL4 production

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00204
UPA00880

Protein family/group databases

MEROPS protease database

More...MEROPSi		T03.002

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001455

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione hydrolase 5 proenzyme (EC:3.4.19.133 Publications)
Alternative name(s):
Gamma-glutamyl transpeptidase-related enzyme1 Publication
Short name:
GGT-rel1 Publication
Gamma-glutamyltransferase 5 (EC:2.3.2.21 Publication)
Short name:
GGT 5
Gamma-glutamyltransferase-like activity 11 Publication
Gamma-glutamyltranspeptidase 5
Leukotriene-C4 hydrolase (EC:3.4.19.141 Publication)
Cleaved into the following 2 chains:
Glutathione hydrolase 5 heavy chain
Glutathione hydrolase 5 light chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GGT5
Synonyms:GGTLA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4260, GGT5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		137168, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P36269

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000099998

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicBy similarity8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29Helical; Signal-anchor for type II membrane proteinBy similarityAdd BLAST21
Topological domaini30 – 586ExtracellularBy similarityAdd BLAST557

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2687

Open Targets

More...OpenTargetsi		ENSG00000099998

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162389442

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P36269, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GGT5

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242493

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000110721 – 387Glutathione hydrolase 5 heavy chainBy similarityAdd BLAST387
ChainiPRO_0000011073388 – 586Glutathione hydrolase 5 light chainBy similarityAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by autocatalysis into a large and a small subunit.By similarity
Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P36269

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P36269

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P36269

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P36269

PeptideAtlas

More...PeptideAtlasi		P36269

PRoteomics IDEntifications database

More...PRIDEi		P36269

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55177 [P36269-1]
55178 [P36269-2]
55179 [P36269-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P36269, 8 sites, 4 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P36269

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P36269

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000099998, Expressed in endocervix and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P36269, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P36269, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000099998, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108954, 6 interactors

Protein interaction database and analysis system

More...IntActi		P36269, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000381340

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P36269, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P36269

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni469 – 470Glutamate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2410, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155794

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014813_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P36269

Identification of Orthologs from Complete Genome Data

More...OMAi		RMGTSHV

Database of Orthologous Groups

More...OrthoDBi		1419292at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P36269

TreeFam database of animal gene trees

More...TreeFami		TF313608

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.246.130, 1 hit
3.60.20.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043138, GGT_lsub_C
IPR000101, GGT_peptidase
IPR043137, GGT_ssub
IPR029055, Ntn_hydrolases_N

The PANTHER Classification System

More...PANTHERi		PTHR11686, PTHR11686, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56235, SSF56235, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00462, G_GLU_TRANSPEPTIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P36269-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS 
        60         70         80         90        100
KVCSDIGRAI LQQQGSPVDA TIAALVCTSV VNPQSMGLGG GVIFTIYNVT 
       110        120        130        140        150
TGKVEVINAR ETVPASHAPS LLDQCAQALP LGTGAQWIGV PGELRGYAEA 
       160        170        180        190        200
HRRHGRLPWA QLFQPTIALL RGGHVVAPVL SRFLHNSILR PSLQASTLRQ 
       210        220        230        240        250
LFFNGTEPLR PQDPLPWPAL ATTLETVATE GVEVFYTGRL GQMLVEDIAK 
       260        270        280        290        300
EGSQLTLQDL AKFQPEVVDA LEVPLGDYTL YSPPPPAGGA ILSFILNVLR 
       310        320        330        340        350
GFNFSTESMA RPEGRVNVYH HLVETLKFAK GQRWRLGDPR SHPKLQNASR 
       360        370        380        390        400
DLLGETLAQL IRQQIDGRGD HQLSHYSLAE AWGHGTGTSH VSVLGEDGSA 
       410        420        430        440        450
VAATSTINTP FGAMVYSPRT GIILNNELLD LCERCPRGSG TTPSPVSGDR 
       460        470        480        490        500
VGGAPGRCWP PVPGERSPSS MVPSILINKA QGSKLVIGGA GGELIISAVA 
       510        520        530        540        550
QAIMSKLWLG FDLRAAIAAP ILHVNSKGCV EYEPNFSQEV QRGLQDRGQN 
       560        570        580 
QTQRPFFLNV VQAVSQEGAC VYAVSDLRKS GEAAGY
Length:586
Mass (Da):62,261
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE37B3CE516F5788
GO
Isoform 2 (identifier: P36269-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-132: Missing.

Show »
Length:554
Mass (Da):58,992
Checksum:i86001882BE5A0D10
GO
Isoform 3 (identifier: P36269-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-445: P → PA

Show »
Length:587
Mass (Da):62,332
Checksum:iC7F2285F9FFF1A22
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JU68C9JU68_HUMAN
Glutathione hydrolase 5 proenzyme
GGT5
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1X2H7C1X2_HUMAN
Glutathione hydrolase 5 proenzyme
GGT5
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB55910 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti408N → Y in CAB55910 (PubMed:17974005).Curated1
Sequence conflicti437R → W in AAA58503 (PubMed:1676842).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02800611L → I. Corresponds to variant dbSNP:rs5760274Ensembl.1
Natural variantiVAR_028007330K → R2 PublicationsCorresponds to variant dbSNP:rs2275984Ensembl.1
Natural variantiVAR_028008332Q → H. Corresponds to variant dbSNP:rs6004105Ensembl.1
Natural variantiVAR_024455475I → V. Corresponds to variant dbSNP:rs7288201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008146101 – 132Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_043470445P → PA in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M64099 mRNA Translation: AAA58503.1
AL117414 mRNA Translation: CAB55910.1 Frameshift.
BT009808 mRNA Translation: AAP88810.1
CT841518 mRNA Translation: CAJ86448.1
AK292006 mRNA Translation: BAF84695.1
AP000353 Genomic DNA No translation available.
AP000354 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59643.1
BC011362 mRNA Translation: AAH11362.1
BC073999 mRNA Translation: AAH73999.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13825.1 [P36269-1]
CCDS42989.1 [P36269-2]
CCDS42990.1 [P36269-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A41125
T17220

NCBI Reference Sequences

More...RefSeqi		NP_001093251.1, NM_001099781.2 [P36269-3]
NP_001093252.1, NM_001099782.2 [P36269-2]
NP_001289393.1, NM_001302464.1
NP_001289394.1, NM_001302465.1
NP_004112.2, NM_004121.3 [P36269-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263112; ENSP00000263112; ENSG00000099998 [P36269-2]
ENST00000327365; ENSP00000330080; ENSG00000099998 [P36269-1]
ENST00000398292; ENSP00000381340; ENSG00000099998 [P36269-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2687

UCSC genome browser

More...UCSCi		uc002zzo.4, human [P36269-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64099 mRNA Translation: AAA58503.1
AL117414 mRNA Translation: CAB55910.1 Frameshift.
BT009808 mRNA Translation: AAP88810.1
CT841518 mRNA Translation: CAJ86448.1
AK292006 mRNA Translation: BAF84695.1
AP000353 Genomic DNA No translation available.
AP000354 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59643.1
BC011362 mRNA Translation: AAH11362.1
BC073999 mRNA Translation: AAH73999.1
CCDSiCCDS13825.1 [P36269-1]
CCDS42989.1 [P36269-2]
CCDS42990.1 [P36269-3]
PIRiA41125
T17220
RefSeqiNP_001093251.1, NM_001099781.2 [P36269-3]
NP_001093252.1, NM_001099782.2 [P36269-2]
NP_001289393.1, NM_001302464.1
NP_001289394.1, NM_001302465.1
NP_004112.2, NM_004121.3 [P36269-1]

3D structure databases

SMRiP36269
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108954, 6 interactors
IntActiP36269, 5 interactors
STRINGi9606.ENSP00000381340

Chemistry databases

SwissLipidsiSLP:000001455

Protein family/group databases

MEROPSiT03.002

PTM databases

GlyGeniP36269, 8 sites, 4 O-linked glycans (2 sites)
iPTMnetiP36269
PhosphoSitePlusiP36269

Genetic variation databases

BioMutaiGGT5
DMDMi116242493

Proteomic databases

EPDiP36269
jPOSTiP36269
MassIVEiP36269
PaxDbiP36269
PeptideAtlasiP36269
PRIDEiP36269
ProteomicsDBi55177 [P36269-1]
55178 [P36269-2]
55179 [P36269-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		285, 127 antibodies

The DNASU plasmid repository

More...DNASUi		2687

Genome annotation databases

EnsembliENST00000263112; ENSP00000263112; ENSG00000099998 [P36269-2]
ENST00000327365; ENSP00000330080; ENSG00000099998 [P36269-1]
ENST00000398292; ENSP00000381340; ENSG00000099998 [P36269-3]
GeneIDi2687
KEGGihsa:2687
UCSCiuc002zzo.4, human [P36269-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2687
DisGeNETi2687

GeneCards: human genes, protein and diseases

More...GeneCardsi		GGT5
HGNCiHGNC:4260, GGT5
HPAiENSG00000099998, Low tissue specificity
MIMi137168, gene
neXtProtiNX_P36269
OpenTargetsiENSG00000099998
PharmGKBiPA162389442
VEuPathDBiHostDB:ENSG00000099998

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2410, Eukaryota
GeneTreeiENSGT00940000155794
HOGENOMiCLU_014813_4_1_1
InParanoidiP36269
OMAiRMGTSHV
OrthoDBi1419292at2759
PhylomeDBiP36269
TreeFamiTF313608

Enzyme and pathway databases

UniPathwayiUPA00204
UPA00880
BioCyciMetaCyc:HS01949-MONOMER
BRENDAi2.3.2.2, 2681
3.4.19.13, 2681
PathwayCommonsiP36269
ReactomeiR-HSA-174403, Glutathione synthesis and recycling
R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-5423646, Aflatoxin activation and detoxification
R-HSA-9664535, LTC4-CYSLTR mediated IL4 production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2687, 12 hits in 1014 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GGT5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GGTLA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2687
PharosiP36269, Tbio

Protein Ontology

More...PROi		PR:P36269
RNActiP36269, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000099998, Expressed in endocervix and 172 other tissues
ExpressionAtlasiP36269, baseline and differential
GenevisibleiP36269, HS

Family and domain databases

Gene3Di1.10.246.130, 1 hit
3.60.20.40, 1 hit
InterProiView protein in InterPro
IPR043138, GGT_lsub_C
IPR000101, GGT_peptidase
IPR043137, GGT_ssub
IPR029055, Ntn_hydrolases_N
PANTHERiPTHR11686, PTHR11686, 1 hit
SUPFAMiSSF56235, SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00462, G_GLU_TRANSPEPTIDASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGT5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36269
Secondary accession number(s): Q53XM9
, Q6GMP0, Q96FC1, Q9UFM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 17, 2006
Last modified: September 29, 2021
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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