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Protein

Inactive glutathione hydrolase 2

Gene

GGT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107GlutamateBy similarity1
Active sitei381NucleophileBy similarity1
Binding sitei399GlutamateBy similarity1
Binding sitei420GlutamateBy similarity1

GO - Molecular functioni

  • glutathione hydrolase activity Source: GO_Central
  • peptidyltransferase activity Source: GO_Central

GO - Biological processi

Protein family/group databases

MEROPSiT03.015

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive glutathione hydrolase 2
Alternative name(s):
Gamma-glutamyltransferase 2
Inactive gamma-glutamyltranspeptidase 2
Short name:
GGT 2
Gene namesi
Name:GGT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000133475.16
HGNCiHGNC:4251 GGT2
MIMi137181 gene
neXtProtiNX_P36268

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi192W → C: No effect on the absence of autocatalytic cleavage and catalytic activity; when associated with E-193. 1 Publication1
Mutagenesisi193Y → E: No effect on the absence of autocatalytic cleavage and catalytic activity; when associated with C-192. 1 Publication1

Organism-specific databases

DisGeNETi728441

Polymorphism and mutation databases

DMDMi189047137

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000042554131 – 569Inactive glutathione hydrolase 2Add BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi511N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Not cleaved by autocatalysis into a large and a small subunit resulting in loss of cell membrane localization and catalytic activity.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP36268
MaxQBiP36268
PaxDbiP36268
PeptideAtlasiP36268
PRIDEiP36268
ProteomicsDBi55175
55176 [P36268-2]

PTM databases

GlyConnecti1396
iPTMnetiP36268
PhosphoSitePlusiP36268

Expressioni

Tissue specificityi

Highly expressed in fetal and adult kidney and liver.

Gene expression databases

BgeeiENSG00000133475 Expressed in 38 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_GGT2
ExpressionAtlasiP36268 baseline and differential
GenevisibleiP36268 HS

Organism-specific databases

HPAiHPA045635
HPA047534
HPA065444

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385721

Structurei

3D structure databases

ProteinModelPortaliP36268
SMRiP36268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni451 – 452Glutamate bindingBy similarity2

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
HOGENOMiHOG000175620
HOVERGENiHBG005835
InParanoidiP36268
OrthoDBiEOG091G03Y3
PhylomeDBiP36268
TreeFamiTF313608

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
PANTHERiPTHR11686 PTHR11686, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00462 G_GLU_TRANSPEPTIDASE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P36268-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAMAADAKQC
60 70 80 90 100
LEIGRDTLRD GGSAVDAAIA ALLCVGLMNA HSMGIGVGLF LTIYNSTTGK
110 120 130 140 150
AEVINAREVA PRLAFASMFN SSEQSQKGGL SVAVPGEIRG YELAHQRHGR
160 170 180 190 200
LPWARLFQPS IQLARQGFPV GKGLAAVLEN KRTVIEQQPV LWYVFCRDRK
210 220 230 240 250
VLREGERLTL PRLADTYEML AIEGAQAFYN GSLMAQIVKD IQAAGGIVTA
260 270 280 290 300
EDLNNYRAEL IEHPLNISLG DAVLYMPSAR LSGPVLALIL NILKGYNFSR
310 320 330 340 350
ESVETPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF
360 370 380 390 400
AAQLRSQISD HTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI
410 420 430 440 450
NLYFGSKVCS PVSGILFNNE WTTSALPAFT NEFGAPPSPA NFIQPGKQPL
460 470 480 490 500
LSMCLTIMVG QDGQVRMVVG AAGGTQITTD TALAIIYNLW FGYDVKRAVE
510 520 530 540 550
EPRLHNKLLP NVTTVERNID QAVTAALETR HHHTQIASTF IAVVQAIVRT
560
AGGWAAALDS RKGGEPAGY
Length:569
Mass (Da):61,771
Last modified:May 20, 2008 - v3
Checksum:i96458403C83B9FFF
GO
Isoform 2 (identifier: P36268-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     404-413: Missing.

Show »
Length:559
Mass (Da):60,779
Checksum:iBDDD7E3BC6876EA6
GO
Isoform 3 (identifier: P36268-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-193: WY → CPLCPGE

Show »
Length:574
Mass (Da):62,121
Checksum:iF2FCCF4EA709AEF9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCK8B5MCK8_HUMAN
Inactive glutathione hydrolase 2
GGT2
559Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053716192 – 193WY → CPLCPGE in isoform 3. Curated2
Alternative sequenceiVSP_033757404 – 413Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000550 Genomic DNA No translation available.
BG743316 mRNA No translation available.
AA632626 mRNA No translation available.
M30479
, M30475, M30476, M30477, M30478 Genomic DNA Translation: AAA52765.1
M30474 mRNA Translation: AAA52548.1
PIRiA36742
UniGeneiHs.568255

Genome annotation databases

EnsembliENST00000401924; ENSP00000385721; ENSG00000133475
ENST00000424627; ENSP00000402035; ENSG00000133475
UCSCiuc062byb.1 human [P36268-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000550 Genomic DNA No translation available.
BG743316 mRNA No translation available.
AA632626 mRNA No translation available.
M30479
, M30475, M30476, M30477, M30478 Genomic DNA Translation: AAA52765.1
M30474 mRNA Translation: AAA52548.1
PIRiA36742
UniGeneiHs.568255

3D structure databases

ProteinModelPortaliP36268
SMRiP36268
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000385721

Protein family/group databases

MEROPSiT03.015

PTM databases

GlyConnecti1396
iPTMnetiP36268
PhosphoSitePlusiP36268

Polymorphism and mutation databases

DMDMi189047137

Proteomic databases

EPDiP36268
MaxQBiP36268
PaxDbiP36268
PeptideAtlasiP36268
PRIDEiP36268
ProteomicsDBi55175
55176 [P36268-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401924; ENSP00000385721; ENSG00000133475
ENST00000424627; ENSP00000402035; ENSG00000133475
UCSCiuc062byb.1 human [P36268-1]

Organism-specific databases

DisGeNETi728441
EuPathDBiHostDB:ENSG00000133475.16
GeneCardsiGGT2
H-InvDBiHIX0037636
HIX0041197
HGNCiHGNC:4251 GGT2
HPAiHPA045635
HPA047534
HPA065444
MIMi137181 gene
neXtProtiNX_P36268
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
HOGENOMiHOG000175620
HOVERGENiHBG005835
InParanoidiP36268
OrthoDBiEOG091G03Y3
PhylomeDBiP36268
TreeFamiTF313608

Miscellaneous databases

PROiPR:P36268
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133475 Expressed in 38 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_GGT2
ExpressionAtlasiP36268 baseline and differential
GenevisibleiP36268 HS

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
PANTHERiPTHR11686 PTHR11686, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00462 G_GLU_TRANSPEPTIDASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGGT2_HUMAN
AccessioniPrimary (citable) accession number: P36268
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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