UniProtKB - P36222 (CH3L1_HUMAN)
Protein
Chitinase-3-like protein 1
Gene
CHI3L1
Organism
Homo sapiens (Human)
Status
Functioni
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.4 Publications
Caution
Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 141 | Chitooligosaccharide | 1 | |
Binding sitei | 263 | Chitooligosaccharide | 1 | |
Binding sitei | 352 | Chitooligosaccharide | 1 |
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- chitin binding Source: UniProtKB
- extracellular matrix structural constituent Source: UniProtKB
GO - Biological processi
- activation of NF-kappaB-inducing kinase activity Source: UniProtKB
- apoptotic process Source: UniProtKB-KW
- carbohydrate metabolic process Source: InterPro
- cartilage development Source: UniProtKB
- cellular response to interleukin-1 Source: Ensembl
- cellular response to tumor necrosis factor Source: UniProtKB
- inflammatory response Source: UniProtKB
- interleukin-8 secretion Source: UniProtKB
- lung development Source: UniProtKB
- neutrophil degranulation Source: Reactome
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
- positive regulation of protein kinase B signaling Source: UniProtKB
- response to interleukin-1 Source: UniProtKB
- response to interleukin-6 Source: UniProtKB
- response to mechanical stimulus Source: UniProtKB
- response to tumor necrosis factor Source: UniProtKB
Keywordsi
Molecular function | Antimicrobial |
Biological process | Apoptosis, Inflammatory response |
Ligand | Lectin |
Enzyme and pathway databases
Reactomei | R-HSA-6798695 Neutrophil degranulation |
SIGNORi | P36222 |
Protein family/group databases
CAZyi | GH18 Glycoside Hydrolase Family 18 |
UniLectini | P36222 |
Names & Taxonomyi
Protein namesi | Recommended name: Chitinase-3-like protein 1Alternative name(s): 39 kDa synovial protein Cartilage glycoprotein 39 Short name: CGP-39 Short name: GP-39 Short name: hCGP-39 YKL-40 |
Gene namesi | Name:CHI3L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000133048.12 |
HGNCi | HGNC:1932 CHI3L1 |
MIMi | 601525 gene |
neXtProti | NX_P36222 |
Subcellular locationi
Extracellular region or secreted
- extracellular space 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Other locations
- Cytoplasm By similarity
- perinuclear region By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular matrix Source: UniProtKB
- extracellular region Source: GO_Central
- extracellular space Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- specific granule lumen Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, SecretedPathology & Biotechi
Involvement in diseasei
Asthma-related traits 7 (ASRT7)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAsthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
See also OMIM:611960Schizophrenia (SCZD)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
See also OMIM:181500Keywords - Diseasei
Asthma, SchizophreniaOrganism-specific databases
DisGeNETi | 1116 |
MalaCardsi | CHI3L1 |
MIMi | 181500 phenotype 611960 phenotype |
OpenTargetsi | ENSG00000133048 |
PharmGKBi | PA26463 |
Polymorphism and mutation databases
BioMutai | CHI3L1 |
DMDMi | 84028186 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 2 PublicationsAdd BLAST | 21 | |
ChainiPRO_0000011965 | 22 – 383 | Chitinase-3-like protein 1Add BLAST | 362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 51 | |||
Glycosylationi | 60 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 300 ↔ 364 |
Post-translational modificationi
Glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P36222 |
jPOSTi | P36222 |
PaxDbi | P36222 |
PeptideAtlasi | P36222 |
PRIDEi | P36222 |
ProteomicsDBi | 55174 |
PTM databases
iPTMneti | P36222 |
PhosphoSitePlusi | P36222 |
Expressioni
Tissue specificityi
Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.2 Publications
Inductioni
Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells.2 Publications
Gene expression databases
Bgeei | ENSG00000133048 Expressed in 201 organ(s), highest expression level in liver |
ExpressionAtlasi | P36222 baseline and differential |
Genevisiblei | P36222 HS |
Interactioni
Subunit structurei
Monomer.2 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 107540, 7 interactors |
IntActi | P36222, 3 interactors |
STRINGi | 9606.ENSP00000255409 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HJV | X-ray | 2.75 | A/B/C/D | 22-383 | [»] | |
1HJW | X-ray | 2.30 | A/B | 22-383 | [»] | |
1HJX | X-ray | 1.85 | A/B/C/D | 22-383 | [»] | |
1LA7 | model | - | A | 22-383 | [»] | |
1NWR | X-ray | 2.70 | A/B/C/D | 22-383 | [»] | |
1NWS | X-ray | 2.70 | A/B/C/D | 22-383 | [»] | |
1NWT | X-ray | 2.50 | A/B/C/D | 22-383 | [»] | |
1NWU | X-ray | 2.20 | A/B/C/D | 22-383 | [»] | |
ProteinModelPortali | P36222 | |||||
SMRi | P36222 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P36222 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 71 | Chitooligosaccharide binding | 2 | |
Regioni | 97 – 100 | Chitooligosaccharide binding | 4 | |
Regioni | 204 – 207 | Chitooligosaccharide binding | 4 | |
Regioni | 324 – 338 | Important for AKT1 activation and IL8 productionBy similarityAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 18 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2806 Eukaryota COG3325 LUCA |
GeneTreei | ENSGT00940000161815 |
HOGENOMi | HOG000111109 |
HOVERGENi | HBG011684 |
InParanoidi | P36222 |
KOi | K17523 |
OMAi | DWYNPMT |
OrthoDBi | 1289629at2759 |
PhylomeDBi | P36222 |
TreeFami | TF315610 |
Family and domain databases
Gene3Di | 3.10.50.10, 1 hit |
InterProi | View protein in InterPro IPR028538 CHI3L1 IPR011583 Chitinase_II IPR029070 Chitinase_insertion_sf IPR001223 Glyco_hydro18_cat IPR017853 Glycoside_hydrolase_SF |
PANTHERi | PTHR11177:SF202 PTHR11177:SF202, 1 hit |
Pfami | View protein in Pfam PF00704 Glyco_hydro_18, 1 hit |
SMARTi | View protein in SMART SM00636 Glyco_18, 1 hit |
SUPFAMi | SSF51445 SSF51445, 1 hit SSF54556 SSF54556, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P36222-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVKASQTGF VVLVLLQCCS AYKLVCYYTS WSQYREGDGS CFPDALDRFL
60 70 80 90 100
CTHIIYSFAN ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN
110 120 130 140 150
FGSQRFSKIA SNTQSRRTFI KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF
160 170 180 190 200
TTLIKEMKAE FIKEAQPGKK QLLLSAALSA GKVTIDSSYD IAKISQHLDF
210 220 230 240 250
ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA VGYMLRLGAP
260 270 280 290 300
ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC
310 320 330 340 350
DFLRGATVHR ILGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM
360 370 380
VWALDLDDFQ GSFCGQDLRF PLTNAIKDAL AAT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y3U8 | H0Y3U8_HUMAN | Chitinase-3-like protein 1 | CHI3L1 | 152 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019838 | 145 | R → G2 PublicationsCorresponds to variant dbSNP:rs880633Ensembl. | 1 | |
Natural variantiVAR_019839 | 311 | I → T2 PublicationsCorresponds to variant dbSNP:rs1049407Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80927 mRNA Translation: AAA16074.1 Y08374 Y08378 Genomic DNA Translation: CAA69661.1 BT007223 mRNA Translation: AAP35887.1 AK312911 mRNA Translation: BAG35757.1 CH471067 Genomic DNA Translation: EAW91467.1 BC008568 mRNA Translation: AAH08568.1 BC038354 mRNA Translation: AAH38354.1 BC039132 mRNA Translation: AAH39132.1 |
CCDSi | CCDS1435.1 |
PIRi | A49562 |
RefSeqi | NP_001267.2, NM_001276.2 |
UniGenei | Hs.382202 Hs.733359 |
Genome annotation databases
Ensembli | ENST00000255409; ENSP00000255409; ENSG00000133048 |
GeneIDi | 1116 |
KEGGi | hsa:1116 |
UCSCi | uc001gzi.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80927 mRNA Translation: AAA16074.1 Y08374 Y08378 Genomic DNA Translation: CAA69661.1 BT007223 mRNA Translation: AAP35887.1 AK312911 mRNA Translation: BAG35757.1 CH471067 Genomic DNA Translation: EAW91467.1 BC008568 mRNA Translation: AAH08568.1 BC038354 mRNA Translation: AAH38354.1 BC039132 mRNA Translation: AAH39132.1 |
CCDSi | CCDS1435.1 |
PIRi | A49562 |
RefSeqi | NP_001267.2, NM_001276.2 |
UniGenei | Hs.382202 Hs.733359 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HJV | X-ray | 2.75 | A/B/C/D | 22-383 | [»] | |
1HJW | X-ray | 2.30 | A/B | 22-383 | [»] | |
1HJX | X-ray | 1.85 | A/B/C/D | 22-383 | [»] | |
1LA7 | model | - | A | 22-383 | [»] | |
1NWR | X-ray | 2.70 | A/B/C/D | 22-383 | [»] | |
1NWS | X-ray | 2.70 | A/B/C/D | 22-383 | [»] | |
1NWT | X-ray | 2.50 | A/B/C/D | 22-383 | [»] | |
1NWU | X-ray | 2.20 | A/B/C/D | 22-383 | [»] | |
ProteinModelPortali | P36222 | |||||
SMRi | P36222 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 107540, 7 interactors |
IntActi | P36222, 3 interactors |
STRINGi | 9606.ENSP00000255409 |
Protein family/group databases
CAZyi | GH18 Glycoside Hydrolase Family 18 |
UniLectini | P36222 |
PTM databases
iPTMneti | P36222 |
PhosphoSitePlusi | P36222 |
Polymorphism and mutation databases
BioMutai | CHI3L1 |
DMDMi | 84028186 |
Proteomic databases
EPDi | P36222 |
jPOSTi | P36222 |
PaxDbi | P36222 |
PeptideAtlasi | P36222 |
PRIDEi | P36222 |
ProteomicsDBi | 55174 |
Protocols and materials databases
DNASUi | 1116 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000255409; ENSP00000255409; ENSG00000133048 |
GeneIDi | 1116 |
KEGGi | hsa:1116 |
UCSCi | uc001gzi.3 human |
Organism-specific databases
CTDi | 1116 |
DisGeNETi | 1116 |
EuPathDBi | HostDB:ENSG00000133048.12 |
GeneCardsi | CHI3L1 |
HGNCi | HGNC:1932 CHI3L1 |
MalaCardsi | CHI3L1 |
MIMi | 181500 phenotype 601525 gene 611960 phenotype |
neXtProti | NX_P36222 |
OpenTargetsi | ENSG00000133048 |
PharmGKBi | PA26463 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2806 Eukaryota COG3325 LUCA |
GeneTreei | ENSGT00940000161815 |
HOGENOMi | HOG000111109 |
HOVERGENi | HBG011684 |
InParanoidi | P36222 |
KOi | K17523 |
OMAi | DWYNPMT |
OrthoDBi | 1289629at2759 |
PhylomeDBi | P36222 |
TreeFami | TF315610 |
Enzyme and pathway databases
Reactomei | R-HSA-6798695 Neutrophil degranulation |
SIGNORi | P36222 |
Miscellaneous databases
ChiTaRSi | CHI3L1 human |
EvolutionaryTracei | P36222 |
GeneWikii | CHI3L1 |
GenomeRNAii | 1116 |
PROi | PR:P36222 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133048 Expressed in 201 organ(s), highest expression level in liver |
ExpressionAtlasi | P36222 baseline and differential |
Genevisiblei | P36222 HS |
Family and domain databases
Gene3Di | 3.10.50.10, 1 hit |
InterProi | View protein in InterPro IPR028538 CHI3L1 IPR011583 Chitinase_II IPR029070 Chitinase_insertion_sf IPR001223 Glyco_hydro18_cat IPR017853 Glycoside_hydrolase_SF |
PANTHERi | PTHR11177:SF202 PTHR11177:SF202, 1 hit |
Pfami | View protein in Pfam PF00704 Glyco_hydro_18, 1 hit |
SMARTi | View protein in SMART SM00636 Glyco_18, 1 hit |
SUPFAMi | SSF51445 SSF51445, 1 hit SSF54556 SSF54556, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CH3L1_HUMAN | |
Accessioni | P36222Primary (citable) accession number: P36222 Secondary accession number(s): B2R7B0 Q96HI7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 13, 2019 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations