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UniProtKB - P36189 (FAS_ANSAN)
Protein
Fatty acid synthase
Gene
FASN
Organism
Anser anser anser (Western greylag goose)
Status
Functioni
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.
Catalytic activityi
- acetyl-CoA + 2n H+ + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP+EC:2.3.1.85
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 161 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- hydrolase activity Source: UniProtKB-KW
- ligase activity Source: UniProtKB-KW
- oxidoreductase activity Source: UniProtKB-KW
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Ligase, Multifunctional enzyme, Oxidoreductase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | NAD, NADP |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:FASN Synonyms:FAS |
Organismi | Anser anser anser (Western greylag goose) |
Taxonomic identifieri | 8844 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Anseriformes › Anatidae › Anserinae › Anser › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180272 | 1 – ›352 | Fatty acid synthaseAdd BLAST | ›352 |
Keywords - PTMi
PhosphopantetheineExpressioni
Inductioni
By triiodothyronine.
Interactioni
Subunit structurei
Homodimer which monomers are arranged in a head to tail fashion.
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – ›352 | Beta-ketoacyl synthaseAdd BLAST | ›352 |
Family and domain databases
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Fragment.
P36189-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDVVIAGIA GKLPESENLQ EFWEKLLNGV DMVTEDDRRW KPGMYGLPKR
60 70 80 90 100
NGKLKDISKF DASFFGVHPK QAHTMDPQLR LLLEVSYEAI LDGGINPATL
110 120 130 140 150
RGTDTGVWVG ASGSEAGEAF SQDPEQLLGY SMIGCQRAMF ANRISYFYDF
160 170 180 190 200
KGPSLSIDTA CSSSLMALEN AYKAIRNGRC SAAVVGGVNL LLKPNTSVQF
210 220 230 240 250
MKLGMLSPDG ACKVFDASGD GYCRSEAVVV VLLTKKSMAK RIYATIVNAG
260 270 280 290 300
SNTDGFKEQG VTFPSGDMQR QLVSSLHREC GIKPGDIEYV ETHGTGTKVG
310 320 330 340 350
DPQEVNGLAD LFCQCEREPL LIGSTKSNMG HPEPASGLAA LAKVVLSLEH
GL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 352 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60622 mRNA Translation: AAA49316.1 |
PIRi | A39042 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60622 mRNA Translation: AAA49316.1 |
PIRi | A39042 |
3D structure databases
AlphaFoldDBi | P36189 |
SMRi | P36189 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FAS_ANSAN | |
Accessioni | P36189Primary (citable) accession number: P36189 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |