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Protein

Heat shock cognate protein 80

Gene

HSC80

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATPBy similarity1
Binding sitei80ATPBy similarity1
Binding sitei125ATP; via amide nitrogenBy similarity1
Binding sitei371ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock cognate protein 80
Gene namesi
Name:HSC80
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629491 – 699Heat shock cognate protein 80Add BLAST699

Proteomic databases

PaxDbiP36181
PRIDEiP36181

Expressioni

Tissue specificityi

Most abundantly expressed in roots and apical shoots. Low expression in mature leaves.

Developmental stagei

Increasing levels of expression observed in developing ovaries, floral shoots and roots. Levels decrease with maturation.

Inductioni

Heat treatment increases expression 3-fold in mature leaves. Has little effect on developing shoot apices.

Gene expression databases

ExpressionAtlasiP36181 baseline and differential

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4081.Solyc07g065840.2.1

Structurei

3D structure databases

ProteinModelPortaliP36181
SMRiP36181
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi695 – 699TPR repeat-binding5

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
COG0326 LUCA
InParanoidiP36181
KOiK04079
OMAiKSIYCIT
OrthoDBiEOG093604DD

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

P36181-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDVETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES
60 70 80 90 100
LTDKSKLDGQ PELFIHIIPD KANNTLTIID SGIGMTKADL VNNLGTIARS
110 120 130 140 150
GTKEFMEALA AGADVSMIGQ FGVGFYSAYL VAEKVVVTTK HNDDEQYVWE
160 170 180 190 200
SQAGGSFTVT RDTSGENLGR GTKMVLYLKE DQLEYLEERR LKDLIKKHSE
210 220 230 240 250
FISYPISLWV EKTIEKEISD DEEEEEKKDE EGKVEEVDEE KEKEEKKKKK
260 270 280 290 300
VKEVSNEWSL VNKQKPIWMR KPEEITKEEY AAFYKSLTND WEEHLAVKHF
310 320 330 340 350
SVEGQLEFKA VLFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCDELIP
360 370 380 390 400
EYLSFVKGIV DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CVELFFEIAE
410 420 430 440 450
NKEDYNKFYE AFSKNLKLGI HEDSQNRAKF AELLRYHSTK SGDEMTSLKD
460 470 480 490 500
YVTRMKEGQN DIYYITGESK KAVENSPFLE KLKKKGYEVL YMVDAIDEYS
510 520 530 540 550
IGQLKEFEGK KLVSATKEGL KLDESEDEKK KQEELKEKFE GLCKVMKDVL
560 570 580 590 600
GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL RDSSMAGYMS
610 620 630 640 650
SKKTMEINPE NSIMDELRKR ADADKNDKSV KDLVLLLFET ALLTSGFSLE
660 670 680 690
EPNTFGNRIH RMLKLGLSID EESGDADADM PALEDPEADA EGSKMEEVD
Length:699
Mass (Da):80,136
Last modified:June 1, 1994 - v1
Checksum:iBDF2357946AC6DEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96549 Genomic DNA Translation: AAB01376.1
PIRiT07037
RefSeqiNP_001234439.1, NM_001247510.1
UniGeneiLes.1146

Genome annotation databases

EnsemblPlantsiSolyc07g065840.2.1; Solyc07g065840.2.1; Solyc07g065840.2
GeneIDi543903
GrameneiSolyc07g065840.2.1; Solyc07g065840.2.1; Solyc07g065840.2
KEGGisly:543903

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96549 Genomic DNA Translation: AAB01376.1
PIRiT07037
RefSeqiNP_001234439.1, NM_001247510.1
UniGeneiLes.1146

3D structure databases

ProteinModelPortaliP36181
SMRiP36181
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc07g065840.2.1

Proteomic databases

PaxDbiP36181
PRIDEiP36181

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSolyc07g065840.2.1; Solyc07g065840.2.1; Solyc07g065840.2
GeneIDi543903
GrameneiSolyc07g065840.2.1; Solyc07g065840.2.1; Solyc07g065840.2
KEGGisly:543903

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
COG0326 LUCA
InParanoidiP36181
KOiK04079
OMAiKSIYCIT
OrthoDBiEOG093604DD

Gene expression databases

ExpressionAtlasiP36181 baseline and differential

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP80_SOLLC
AccessioniPrimary (citable) accession number: P36181
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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