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Protein

Chymotrypsin BII

Gene
N/A
Organism
Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease with chymotryptic and collagenolytic activities.

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Charge relay systemBy similarity1
Active sitei132Charge relay systemBy similarity1
Active sitei223Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processCollagen degradation

Protein family/group databases

MEROPSiS01.122

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin BII (EC:3.4.21.1)
OrganismiPenaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei)
Taxonomic identifieri6689 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaePenaeus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PropeptideiPRO_000002765216 – 45Activation peptide1 PublicationAdd BLAST30
ChainiPRO_000002765346 – 271Chymotrypsin BIIAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 87PROSITE-ProRule annotation
Disulfide bondi196 ↔ 209PROSITE-ProRule annotation
Disulfide bondi219 ↔ 245PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP36178
SMRiP36178
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 268Peptidase S1PROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P36178-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGKLSLLLV CVAVASGNPA AGKPWHWKSP KPLVDPRIHV NATPRIVGGV
60 70 80 90 100
EATPHSWPHQ AALFIDDMYF CGGSLISSEW VLTAAHCMDG AGFVEVVLGA
110 120 130 140 150
HNIRQNEASQ VSITSTDFFT HENWNSWLLT NDIALIKLPS PVSLNSNIKT
160 170 180 190 200
VKLPSSDVAV GTTVTPTGWG RPLDSAGGIS DVLRQVDVPI MTNDDCDAVY
210 220 230 240 250
GIVGNGVVCI DSEGGKGTCN GDSGGPLNLN GMTYGITSFG SSAGCEVGYP
260 270
DAFTRVYYYL DWIEQKTGVT P
Length:271
Mass (Da):28,723
Last modified:June 1, 1994 - v1
Checksum:i2254D7C7E63FA2E1
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP36178
SMRiP36178
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.122

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTRB2_PENVA
AccessioniPrimary (citable) accession number: P36178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 10, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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